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		Research Impact of malaria during pregnancy on pregnancy outcomes in a Ugandan prospective cohort with intensive malaria screening and prompt treatment Pierre De Beaudrap, Eleanor Turyakira, Lisa J White, Carolyn Nabasumba, Benon Tumwebaze, Atis Muehlenbachs, Philippe J Guérin, Yap Boum, Rose McGready, Patrice Piola Malaria Journal 2013, 12:139 (24 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Malaria in pregnancy is a major public health problem in endemic areas of sub-Saharan Africa and has important consequences on birth outcome. In this study, the timing, parasitaemia level and number of peripherally-detected malaria infections, but not the presence of fever, were associated with adverse birth outcomes. Hence, prompt malaria detection and treatment should be offered to pregnant women, with increased focus on mothers living in remote areas.
		Research Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria Yuri C Martins, Leah Clemmer, Pamela Orjuela-Sánchez, Graziela M Zanini, Peng Kai Ong, John A Frangos, Leonardo JM Carvalho Malaria Journal 2013, 12:138 (24 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This paper presents original and interesting data on the cardiac effect of experimental cerebral malaria in mice, and that nimodipine at low doses shows a safe profile in terms of cardiovascular effects.
		Research Prevalence of molecular markers of drug resistance in an area of seasonal malaria chemoprevention in children in Senegal Aminata C Lo, Babacar Faye, El-Hadj Ba, Badara Cisse, Roger Tine, Annie Abiola, Magatte Ndiaye, Jean LA Ndiaye, Daouda Ndiaye, Cheikh Sokhna, Jules F Gomis, Yemou Dieng, Omar Faye, Omar Ndir, Paul Milligan, Matthew Cairns, Rachel Hallett, Colin Sutherland, Oumar Gaye Malaria Journal 2013, 12:137 (23 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Description of the prevalence of molecular markers of CQ/AQ and SP resistance in Senegal, where seasonal malaria chemoprevention has been introduced, and present prevalence ratio estimates derived from data collected by cross-sectional surveys in children for three consecutive years after implementation of seasonal chemoprevention.
		Research Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccine Margaret E McCoy, Hannah E Golden, Tais APF Doll, Yongkun Yang, Stephen A Kaba, Peter Burkhard, David E Lanar Malaria Journal 2013, 12:136 (22 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary An important paper describing aspects of the mechanism of action for a traditional malaria vaccine (CSP) delivered in the context of a novel and exciting platform (self-assembling protein nanoparticle).
		Research Artemisinin-based combination therapy availability and use in the private sector of five AMFm phase 1 countries Ben Davis, Joel Ladner, Kelley Sams, Ebru Tekinturhan, Donald de Korte, Joseph Saba Malaria Journal 2013, 12:135 (22 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The objective of this study was to assess anti-malarial stock and purchase patterns at private outlets in five Phase 1 countries in the Affordable Medicines Facility-malaria programme, in regard to three of the core AMFm goals: increase the affordability of quality-assured artemisinin combination therapy, increase the availability of ACT, and crowd out artemisinin monotherapies and other substandard therapies.
		Research Temporal evaluation of commitment to sexual development in Plasmodium falciparum Christopher L Peatey, Matthew WA Dixon, Donald L Gardiner, Katharine R Trenholme Malaria Journal 2013, 12:134 (22 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This paper revisits old experiments on the role of cholera toxin in inducing gametocyte production.
		Research Early parasitological response following artemisinin-containing regimens: a critical review of the literature Debashish Das, Ric N Price, Delia Bethell, Philippe J Guerin, Kasia Stepniewska Malaria Journal 2013, 12:125 (19 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A literature review of prospective clinical trials of artemisinin combination therapy trials with the aim of determining the incidence persistent parasitaemia after treatment. Although crude, the proportion of patients remaining parasitaemic on D3 has been proposed as a marker possibly signalling the presence of resistance to the artemisinin component of ACT therapy. This is the first published large review of its kind.
		Reviewer acknowledgement Reviewer acknowledgement Marcel Hommel Malaria Journal 2013, 12:83 (17 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research Urbanization and the global malaria recession Andrew J Tatem, Peter W Gething, David L Smith, Simon I Hay Malaria Journal 2013, 12:133 (17 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Article that adds significant quantitative information to our understanding of the association of malaria and urbanization worldwide.
		Research Community-directed educational intervention for malaria elimination in Bhutan: quasi-experimental study in malaria endemic areas of Sarpang district Tashi Tobgay, Deki Pem, Ugyen Dophu, Shyam P Dumre, Kesara Na-Bangchang, Cristina E Torres Malaria Journal 2013, 12:132 (17 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The findings from this study corroborate that community-directed interventions can be utilized as an effective means for improving knowledge, attitude and practice in the malaria-endemic areas of Bhutan.
		Research Treatment of fevers prior to introducing rapid diagnostic tests for malaria in registered drug shops in Uganda Anthony K Mbonye, Sham Lal, Bonnie Cundill, Kristian Schultz Hansen, Siân Clarke, Pascal Magnussen Malaria Journal 2013, 12:131 (16 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary In this setting, the proportion of malaria patients receiving appropriate ACT treatment at drug shops was low. This was due to the practice of presumptive treatment, inadequate training on malaria management and lack of knowledge that ACT was the recommended first-line treatment for malaria.
		Research Verification of clinically diagnosed cases during malaria elimination programme in Guizhou Province of China Jianhai Yin, Zhigui Xia, He Yan, Yuting Huang, Lidan Lu, Yan Geng, Ning Xiao, Jianjun Xu, Ping He, Shuisen Zhou Malaria Journal 2013, 12:130 (15 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This MS describes a study to confirm clinic based malaria diagnosis in Guizhou, China. A number of cases from those previously identified at clinics where re-evaluated by microscopy, PCR and a review of records.
		Research A member of the CPW-WPC protein family is expressed in and localized to the surface of developing ookinetes Niwat Kangwanrangsan, Mayumi Tachibana, Rachaneeporn Jenwithisuk, Takafumi Tsuboi, Suda Riengrojpitak, Motomi Torii, Tomoko Ishino Malaria Journal 2013, 12:129 (15 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary his paper reports the identification of the CPW-WPC protein family in the rodent parasite Plasmodium yoelii and describes the expression and the localization of one family member, PyCPW-WPC-1, during sexual and mosquito stages.
		Case report First case of Plasmodium knowlesi infection in a Japanese traveller returning from Malaysia Ryutaro Tanizaki, Mugen Ujiie, Yasuyuki Kato, Moritoshi Iwagami, Aki Hashimoto, Satoshi Kutsuna, Nozomi Takeshita, Kyoko Hayakawa, Shuzo Kanagawa, Shigeyuki Kano, Norio Ohmagari Malaria Journal 2013, 12:128 (15 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary There have now been many reports of knowlesi malaria in travellers returning from endemic to non-endemic countries (eg. New Zealand, Australia, Spain, Finland, Taiwan, United States). The authors report that this is the first case of knowlesi malaria in a Japanese traveller.
		Research Impact of methylene blue and atorvastatin combination therapy on the apparition of cerebral malaria in a murine model Jérome Dormoi, Sébastien Briolant, Camille Desgrouas, Bruno Pradines Malaria Journal 2013, 12:127 (15 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Evaluation of methylene blue (MB) alone, atorvastatin (AVA) alone, and MB plus AVA in mice infected with the Plasmodium berghei ANKA strain.The in vitro synergism observed between MB and AVA suggests a potential for combination therapy.
		Research A mathematical model of the impact of present and future malaria vaccines Edward A Wenger, Philip A Eckhoff Malaria Journal 2013, 12:126 (15 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A mathematical modelling exercise to evaluate the impact of a vaccine with properties like RTS,S across a range of transmission settings and in the presence of other interventions. The model makes sensible assumptions, and it is explained in terms that are reasonably easy for a non-expert to grasp.
		Opinion Entomological surveillance of behavioural resilience and resistance in residual malaria vector populations Nicodem J Govella, Prosper P Chaki, Gerry F Killeen Malaria Journal 2013, 12:124 (11 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary In this opinion piece, the authors indicate that caution should be exercised before over-interpreting most existing reports of increased frequency of behavioural traits which enable mosquitoes to evade fatal contact with insecticides: this may simply be the result of suppressing the most behaviourally vulnerable of the vector taxa that constituted the original transmission system.
		Research Field evaluation of HRP2 and pan pLDH-based immunochromatographic assay in therapeutic monitoring of uncomplicated falciparum malaria in Myanmar Myat H Nyunt, Myat P Kyaw, Kyu K Win, Khin M Myint, Khin M Nyunt Malaria Journal 2013, 12:123 (11 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Although treatment monitoring cannot be performed by HRP2, it could be assessed in this study by using a pan pLDH-based assay.
		Research Creative solutions to extraordinary challenges in clinical trials: methodology of a phase III trial of azithromycin and chloroquine fixed-dose combination in pregnant women in Africa Richa S Chandra, John Orazem, David Ubben, Stephan Duparc, Jeffery Robbins, Pol Vandenbroucke Malaria Journal 2013, 12:122 (11 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Interesting paper contributing new insights into the trials and tribulation of a major pharmaceutical industry conducting regulatory studies for malaria in high risk populations. It is noteworthy as this is the first regulatory trial with anti-malarials for use in pregnancy, and also the first for this specific indication as IP (a mixture of treatment and prevention), which itself has unique challenges for regulators.
		Commentary Discourse on malaria elimination: where do forcibly displaced persons fit in these discussions? Holly A Williams, Heiko Hering, Paul Spiegel Malaria Journal 2013, 12:121 (10 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The paper discusses the important issue of displaced persons in malaria control - a thought provoking document.
		Commentary Measuring malaria by passive case detection: a new perspective based on Zambian experience Clive J Shiff, Cristina Stoyanov, Cornelius Choobwe, Aniset Kamanga, Victor M Mukonka Malaria Journal 2013, 12:120 (10 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This is an interesting commentary piece about the potential use of health facility collected malaria rapid diagnostic test data on identifying areas of differentially higher transmission within a particular area in Zambia.
		Research Gender differences in the use of insecticide-treated nets after a universal free distribution campaign in Kano State, Nigeria: post-campaign survey results Ashley E Garley, Elizabeth Ivanovich, Erin Eckert, Svetlana Negroustoueva, Yazoume Ye Malaria Journal 2013, 12:119 (10 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary It is clear that ITN strategies not only need to address the difference in uptake between ¿sex¿ but also among other gender inequalities, such as adolescent boys, who seem to have a lower use of ITNs than any other group.
		Research Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking Gisela Henriques, Axel Martinelli, Louise Rodrigues, Katarzyna Modrzynska, Richard Fawcett, Douglas R Houston, Sofia T Borges, Umberto d’Alessandro, Halidou Tinto, Corine Karema, Paul Hunt, Pedro Cravo Malaria Journal 2013, 12:118 (5 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In the rodent malaria parasite Plasmodium chabaudi, an increased artemisinin-resistant phenotype occurs along with a mutation in a functional element of the AP2 adaptor protein complex. This suggests that endocytosis and trafficking of membrane proteins may be involved, generating new insights into possible mechanisms of resistance.
		Research Effective treatment with a tetrandrine/chloroquine combination for chloroquine-resistant falciparum malaria in Aotus monkeys Zuguang Ye, Knox Van Dyke, Richard N Rossan Malaria Journal 2013, 12:117 (2 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This appears to be the first in vivo use of the combination of tetrandrine and chloroquine for the treatment of chloroquine resistant Plasmodium falciparum. It is preliminary, but suggests that the combination may be useful.
		Methodology Discovery-2: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria Phelelani T Mpangase, Michal J Szolkiewicz, Misha le Grange, Jeanré H Smit, Pieter B Burger, Fourie Joubert Malaria Journal 2013, 12:116 (28 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary An update of the Discovery database. This database proposes to facilitate the selection of putative drug targets by mining information with specific emphasis on drug targets, structure and protein-ligand interactions.

	All
		Research Impact of malaria during pregnancy on pregnancy outcomes in a Ugandan prospective cohort with intensive malaria screening and prompt treatment Pierre De Beaudrap, Eleanor Turyakira, Lisa J White, Carolyn Nabasumba, Benon Tumwebaze, Atis Muehlenbachs, Philippe J Guérin, Yap Boum, Rose McGready, Patrice Piola Malaria Journal 2013, 12:139 (24 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Malaria in pregnancy is a major public health problem in endemic areas of sub-Saharan Africa and has important consequences on birth outcome. In this study, the timing, parasitaemia level and number of peripherally-detected malaria infections, but not the presence of fever, were associated with adverse birth outcomes. Hence, prompt malaria detection and treatment should be offered to pregnant women, with increased focus on mothers living in remote areas.
		Research Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria Yuri C Martins, Leah Clemmer, Pamela Orjuela-Sánchez, Graziela M Zanini, Peng Kai Ong, John A Frangos, Leonardo JM Carvalho Malaria Journal 2013, 12:138 (24 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This paper presents original and interesting data on the cardiac effect of experimental cerebral malaria in mice, and that nimodipine at low doses shows a safe profile in terms of cardiovascular effects.
		Research Prevalence of molecular markers of drug resistance in an area of seasonal malaria chemoprevention in children in Senegal Aminata C Lo, Babacar Faye, El-Hadj Ba, Badara Cisse, Roger Tine, Annie Abiola, Magatte Ndiaye, Jean LA Ndiaye, Daouda Ndiaye, Cheikh Sokhna, Jules F Gomis, Yemou Dieng, Omar Faye, Omar Ndir, Paul Milligan, Matthew Cairns, Rachel Hallett, Colin Sutherland, Oumar Gaye Malaria Journal 2013, 12:137 (23 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Description of the prevalence of molecular markers of CQ/AQ and SP resistance in Senegal, where seasonal malaria chemoprevention has been introduced, and present prevalence ratio estimates derived from data collected by cross-sectional surveys in children for three consecutive years after implementation of seasonal chemoprevention.
		Research Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccine Margaret E McCoy, Hannah E Golden, Tais APF Doll, Yongkun Yang, Stephen A Kaba, Peter Burkhard, David E Lanar Malaria Journal 2013, 12:136 (22 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary An important paper describing aspects of the mechanism of action for a traditional malaria vaccine (CSP) delivered in the context of a novel and exciting platform (self-assembling protein nanoparticle).
		Research Artemisinin-based combination therapy availability and use in the private sector of five AMFm phase 1 countries Ben Davis, Joel Ladner, Kelley Sams, Ebru Tekinturhan, Donald de Korte, Joseph Saba Malaria Journal 2013, 12:135 (22 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The objective of this study was to assess anti-malarial stock and purchase patterns at private outlets in five Phase 1 countries in the Affordable Medicines Facility-malaria programme, in regard to three of the core AMFm goals: increase the affordability of quality-assured artemisinin combination therapy, increase the availability of ACT, and crowd out artemisinin monotherapies and other substandard therapies.
		Research Temporal evaluation of commitment to sexual development in Plasmodium falciparum Christopher L Peatey, Matthew WA Dixon, Donald L Gardiner, Katharine R Trenholme Malaria Journal 2013, 12:134 (22 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This paper revisits old experiments on the role of cholera toxin in inducing gametocyte production.
		Research Early parasitological response following artemisinin-containing regimens: a critical review of the literature Debashish Das, Ric N Price, Delia Bethell, Philippe J Guerin, Kasia Stepniewska Malaria Journal 2013, 12:125 (19 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A literature review of prospective clinical trials of artemisinin combination therapy trials with the aim of determining the incidence persistent parasitaemia after treatment. Although crude, the proportion of patients remaining parasitaemic on D3 has been proposed as a marker possibly signalling the presence of resistance to the artemisinin component of ACT therapy. This is the first published large review of its kind.
		Reviewer acknowledgement Reviewer acknowledgement Marcel Hommel Malaria Journal 2013, 12:83 (17 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research Urbanization and the global malaria recession Andrew J Tatem, Peter W Gething, David L Smith, Simon I Hay Malaria Journal 2013, 12:133 (17 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Article that adds significant quantitative information to our understanding of the association of malaria and urbanization worldwide.
		Research Community-directed educational intervention for malaria elimination in Bhutan: quasi-experimental study in malaria endemic areas of Sarpang district Tashi Tobgay, Deki Pem, Ugyen Dophu, Shyam P Dumre, Kesara Na-Bangchang, Cristina E Torres Malaria Journal 2013, 12:132 (17 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The findings from this study corroborate that community-directed interventions can be utilized as an effective means for improving knowledge, attitude and practice in the malaria-endemic areas of Bhutan.
		Research Treatment of fevers prior to introducing rapid diagnostic tests for malaria in registered drug shops in Uganda Anthony K Mbonye, Sham Lal, Bonnie Cundill, Kristian Schultz Hansen, Siân Clarke, Pascal Magnussen Malaria Journal 2013, 12:131 (16 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary In this setting, the proportion of malaria patients receiving appropriate ACT treatment at drug shops was low. This was due to the practice of presumptive treatment, inadequate training on malaria management and lack of knowledge that ACT was the recommended first-line treatment for malaria.
		Research Verification of clinically diagnosed cases during malaria elimination programme in Guizhou Province of China Jianhai Yin, Zhigui Xia, He Yan, Yuting Huang, Lidan Lu, Yan Geng, Ning Xiao, Jianjun Xu, Ping He, Shuisen Zhou Malaria Journal 2013, 12:130 (15 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This MS describes a study to confirm clinic based malaria diagnosis in Guizhou, China. A number of cases from those previously identified at clinics where re-evaluated by microscopy, PCR and a review of records.
		Research A member of the CPW-WPC protein family is expressed in and localized to the surface of developing ookinetes Niwat Kangwanrangsan, Mayumi Tachibana, Rachaneeporn Jenwithisuk, Takafumi Tsuboi, Suda Riengrojpitak, Motomi Torii, Tomoko Ishino Malaria Journal 2013, 12:129 (15 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary his paper reports the identification of the CPW-WPC protein family in the rodent parasite Plasmodium yoelii and describes the expression and the localization of one family member, PyCPW-WPC-1, during sexual and mosquito stages.
		Case report First case of Plasmodium knowlesi infection in a Japanese traveller returning from Malaysia Ryutaro Tanizaki, Mugen Ujiie, Yasuyuki Kato, Moritoshi Iwagami, Aki Hashimoto, Satoshi Kutsuna, Nozomi Takeshita, Kyoko Hayakawa, Shuzo Kanagawa, Shigeyuki Kano, Norio Ohmagari Malaria Journal 2013, 12:128 (15 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary There have now been many reports of knowlesi malaria in travellers returning from endemic to non-endemic countries (eg. New Zealand, Australia, Spain, Finland, Taiwan, United States). The authors report that this is the first case of knowlesi malaria in a Japanese traveller.
		Research Impact of methylene blue and atorvastatin combination therapy on the apparition of cerebral malaria in a murine model Jérome Dormoi, Sébastien Briolant, Camille Desgrouas, Bruno Pradines Malaria Journal 2013, 12:127 (15 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Evaluation of methylene blue (MB) alone, atorvastatin (AVA) alone, and MB plus AVA in mice infected with the Plasmodium berghei ANKA strain.The in vitro synergism observed between MB and AVA suggests a potential for combination therapy.
		Research A mathematical model of the impact of present and future malaria vaccines Edward A Wenger, Philip A Eckhoff Malaria Journal 2013, 12:126 (15 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A mathematical modelling exercise to evaluate the impact of a vaccine with properties like RTS,S across a range of transmission settings and in the presence of other interventions. The model makes sensible assumptions, and it is explained in terms that are reasonably easy for a non-expert to grasp.
		Opinion Entomological surveillance of behavioural resilience and resistance in residual malaria vector populations Nicodem J Govella, Prosper P Chaki, Gerry F Killeen Malaria Journal 2013, 12:124 (11 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary In this opinion piece, the authors indicate that caution should be exercised before over-interpreting most existing reports of increased frequency of behavioural traits which enable mosquitoes to evade fatal contact with insecticides: this may simply be the result of suppressing the most behaviourally vulnerable of the vector taxa that constituted the original transmission system.
		Research Field evaluation of HRP2 and pan pLDH-based immunochromatographic assay in therapeutic monitoring of uncomplicated falciparum malaria in Myanmar Myat H Nyunt, Myat P Kyaw, Kyu K Win, Khin M Myint, Khin M Nyunt Malaria Journal 2013, 12:123 (11 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Although treatment monitoring cannot be performed by HRP2, it could be assessed in this study by using a pan pLDH-based assay.
		Research Creative solutions to extraordinary challenges in clinical trials: methodology of a phase III trial of azithromycin and chloroquine fixed-dose combination in pregnant women in Africa Richa S Chandra, John Orazem, David Ubben, Stephan Duparc, Jeffery Robbins, Pol Vandenbroucke Malaria Journal 2013, 12:122 (11 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Interesting paper contributing new insights into the trials and tribulation of a major pharmaceutical industry conducting regulatory studies for malaria in high risk populations. It is noteworthy as this is the first regulatory trial with anti-malarials for use in pregnancy, and also the first for this specific indication as IP (a mixture of treatment and prevention), which itself has unique challenges for regulators.
		Commentary Discourse on malaria elimination: where do forcibly displaced persons fit in these discussions? Holly A Williams, Heiko Hering, Paul Spiegel Malaria Journal 2013, 12:121 (10 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The paper discusses the important issue of displaced persons in malaria control - a thought provoking document.
		Commentary Measuring malaria by passive case detection: a new perspective based on Zambian experience Clive J Shiff, Cristina Stoyanov, Cornelius Choobwe, Aniset Kamanga, Victor M Mukonka Malaria Journal 2013, 12:120 (10 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This is an interesting commentary piece about the potential use of health facility collected malaria rapid diagnostic test data on identifying areas of differentially higher transmission within a particular area in Zambia.
		Research Gender differences in the use of insecticide-treated nets after a universal free distribution campaign in Kano State, Nigeria: post-campaign survey results Ashley E Garley, Elizabeth Ivanovich, Erin Eckert, Svetlana Negroustoueva, Yazoume Ye Malaria Journal 2013, 12:119 (10 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary It is clear that ITN strategies not only need to address the difference in uptake between ¿sex¿ but also among other gender inequalities, such as adolescent boys, who seem to have a lower use of ITNs than any other group.
		Research Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking Gisela Henriques, Axel Martinelli, Louise Rodrigues, Katarzyna Modrzynska, Richard Fawcett, Douglas R Houston, Sofia T Borges, Umberto d’Alessandro, Halidou Tinto, Corine Karema, Paul Hunt, Pedro Cravo Malaria Journal 2013, 12:118 (5 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In the rodent malaria parasite Plasmodium chabaudi, an increased artemisinin-resistant phenotype occurs along with a mutation in a functional element of the AP2 adaptor protein complex. This suggests that endocytosis and trafficking of membrane proteins may be involved, generating new insights into possible mechanisms of resistance.
		Research Effective treatment with a tetrandrine/chloroquine combination for chloroquine-resistant falciparum malaria in Aotus monkeys Zuguang Ye, Knox Van Dyke, Richard N Rossan Malaria Journal 2013, 12:117 (2 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This appears to be the first in vivo use of the combination of tetrandrine and chloroquine for the treatment of chloroquine resistant Plasmodium falciparum. It is preliminary, but suggests that the combination may be useful.
		Methodology Discovery-2: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria Phelelani T Mpangase, Michal J Szolkiewicz, Misha le Grange, Jeanré H Smit, Pieter B Burger, Fourie Joubert Malaria Journal 2013, 12:116 (28 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary An update of the Discovery database. This database proposes to facilitate the selection of putative drug targets by mining information with specific emphasis on drug targets, structure and protein-ligand interactions.