- Marcel Hommel, University of Liverpool
ResearchThe authors provide the readers with a solid enzymatic characterization of the first enzyme which, in the folate pathway, transforms GTP into DHNTP in a rate limiting manner. Using homology-based modelling and genetic complementation in bacteria, they have performed a nice molecular dissection of the active site and its amino acid residues which are involved in both the binding of the substrate GTP and the catalysis.
ResearchDamaged DNA cannot be transcribed without prior DNA repair; therefore, uracil-DNA glycosylase, playing an important role in base excision repair, may be a good candidate anti-malarial drug target.
ResearchBlood samples from primary school children collected during a dry season malaria survey were screened for G6PD deficiency and malaria infection. The prevalence of the genotypes for allele mutations reported in the country was between 1 and 2%, which the G6PDd phenotype was between 6.4 and 7.8%.
ResearchA topic of interest for scientists who want to detect Plasmodium-infected cells. The paper tries to demonstrate the possibilities and limitations of using dark field microscopy for the detection of haemozoin in infected cells. Important advantages are that the samples can be measured without staining and that the results show a high sensitivity (95%) and specificity (97%) and that haemozoin can be detected in fairly early ring stages.
ReviewA useful review explaining how different vector control interventions vary in effectiveness according to mosquito behaviour. It looks at control measures in terms of biological coverage of blood sources as opposed to demographic coverage of human.
ResearchThe accuracy of the WHO method of estimating malaria parasite density from thick blood smears by assuming a white blood cell count of 8,000/¿L has been questioned in several studies. Its validity was assessed as part of a trial of artemisinin-based combination therapy, which included blood smear microscopy and automated measurement of leucocyte densities.
Aims & scope
Malaria Journal is aimed at the scientific community interested in malaria in its broadest sense. It is the only journal that publishes exclusively articles on malaria and, as such, it aims to bring together knowledge from the different specialities involved in this very broad discipline, from the bench to the bedside and to the field. Malaria Journal offers a fast publication schedule while maintaining rigorous peer-review; this is achieved by managing the whole of the publication process electronically, from submission to peer-review.
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