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| Editor-in-Chief: Marcel Hommel, University of Liverpool
Latest supplementsVolume 8 Suppl 2
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Volume 8 Suppl 1
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Latest articles
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Research
Suppressive and additive effects in protection mediated by combinations of monoclonal antibodies specific for merozoite surface protein 1 of Plasmodium yoelii
Irosoki Eslava, Gilberto Payares, Beatriz M Pernia, Anthony A Holder, Lilian M Spencer
Malaria Journal 2010, 9:46 (10 February 2010)
[Abstract] [Provisional PDF]
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These results suggest that a combination of protective antibodies with either the same or different isotypes can produce either an additive or a suppressive effect in passive immunization. This phenomenon may be important in better understanding immunity in this experimental mouse model of malaria.
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Research
Chronic infection during placental malaria is associated with up-regulation of cycloxygenase-2
Demba Sarr, Delphine Aldebert, Laurence Marrama, Emilie Frealle, Alioune Gaye, Hamoud O Brahim, Makhtar Niang, Jean Marie Dangou, Odile Mercereau-Puijalon, Jean Yves Le Hesran, Ronan Jambou
Malaria Journal 2010, 9:45 (9 February 2010)
[Abstract] [Provisional PDF]
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Cyclooxygenase (COX) and lipoxygenase (LOX), which convert fatty acids to prostaglandins and leukotrienes, play important roles in pregnancy and foetal development. The role of COX during PM was questioned by quantifying at delivery COX-1, COX-2, 15-LOX, and IL-10 expression in two groups of malaria infected and uninfected placenta.
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Research
Control of pyrethroid and DDT-resistant Anopheles gambiae by application of indoor residual spraying or mosquito nets treated with a long-lasting organophosphate insecticide, chlorpyrifos-methyl
Raphael N'Guessan, Pelagie Boko, Abibathou Odjo, Joseph Chabi, Martin Akogbeto, Mark Rowland
Malaria Journal 2010, 9:44 (8 February 2010)
[Abstract] [Provisional PDF]
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The study indicates that chlorpyrifos methyl outperformed DDT and lambdacyhalothrin. In IRS campaigns, it should provode improved levels of transmission control compared to conventional formulations of DDT or pyrethroids, always assuming that the product is available for such use.
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Research
Compliance with a three-day course of artesunate-mefloquine combination and baseline anti-malarial treatment in an area of Thailand with highly multidrug resistant falciparum malaria
Kanungnit Congpuong, Pongwit Bualombai, Vick Banmairuroi, Kesara Na-Bangchang
Malaria Journal 2010, 9:43 (4 February 2010)
[Abstract] [Provisional PDF] [PubMed] [Related articles]
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The authors discuss the compliance associated with a three-day AS-MQ regimen following a recent change in the treatment guidelines for uncomplicated falciparum malaria in Thailand. The patient data are supported by whole blood/plasma drug levels. In malaria treatment compliance remains a major factor determining effectiveness.
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Case study
Using the social entrepreneurship approach to generate innovative and sustainable malaria diagnosis interventions in Tanzania: a case study
Lisa K Allen, Erin Hetherington, Mange Manyama, Jennifer M Hatfield, Guido van Marle
Malaria Journal 2010, 9:42 (3 February 2010)
[Abstract] [Provisional PDF] [PubMed] [Related articles]
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Original approach aimed at improving malaria diagnostic accuracy in sub-Saharan Africa by enhancing community involvement in a Maasai district
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Plasmodium life-cycle and natural history of malaria
This animation, which illustrates, in six short sequences, the various stages of the life-cycle of the malaria parasite in the human host and in its mosquito vector, has been conceived by Professors Christophe Rogier et Marcel Hommel.
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