- Marcel Hommel, University of Liverpool
- Elizabeth Ashley, Mahidol Oxford Tropical Medicine Research Unit
- Ulrike Fillinger, London School of Hygiene and Tropical Medicine
- Simon Hay, IHME, University of Washington
- Caroline Jones, London School of Hygiene & Tropical Medicine
- Didier Leroy, Medicines for Malaria Venture
- Georges Snounou, Universite Pierre & Marie Curie
- Marcel Tanner, Swiss Tropical Institute
ReviewThis review summarizes recent findings regarding the mechanistic aspects of this protection, as mediated through the parasites interaction with abnormal erythrocytes.
ResearchVernonia amygdalina leaves contain molecules affecting multiple stages of Plasmodium, evidencing its potential for drug discovery. Chemical modification of the identified hit molecules, in particular vernodalol, could generate a library of druggable sesquiterpene lactones.
ResearchAddresses the important and timely question of potential rebounds in morbidity and mortality following deployment of anti-malarial interventions. The authors use the well-established OpenMalaria mathematical model platform to examine the averted and excess morbidity and mortality by age and for a cohort following commencement of pre-erythrocytic vaccine (PEV) or seasonal malaria chemoprophylaxis (SMC) programmes.
ResearchDoxycycline is an important chemoprophylactic and treatment agent in French Guiana. The authors in vitro tested 800 isolates and did select a subset for DNA sequencing and copy number evaluation by standard RT PCR methods. They conclude no association can be found (unlike in Africa) between these genetic mutations/copy number and IC50, reinforcing perhaps that regional differences exist in the role of genetic mutations and in vitro susceptibility.
ResearchAnalysis of the IgG and IgM antibody response to the gSG6-P1 peptide in a group of 133 young children. The samples were collected in nine different villages through three different health centres. The study is interesting and addresses an important problem - the estimation of malaria risk in very young children.
ReviewA well-written and comprehensively review of house construction in the Amazon. A total of 32 villages of 29 different ethnicities were studied and mapped. The most important architectural characteristics influencing malaria were analysed. Among risk factors, presence of open eaves, permeable walls, open-side constructions, large number of sleepers indoors, temporary-ephemeral houses, linear villages along stream banks, houseboats villages, poor urban drainage and villages surrounded by anthropogenic environments were highlighted.
Aims & scope
Malaria Journal is aimed at the scientific community interested in malaria in its broadest sense. It is the only journal that publishes exclusively articles on malaria and, as such, it aims to bring together knowledge from the different specialities involved in this very broad discipline, from the bench to the bedside and to the field. Malaria Journal offers a fast publication schedule while maintaining rigorous peer-review; this is achieved by managing the whole of the publication process electronically, from submission to peer-review.
Malaria Journal 2015, 14:284
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