- Marcel Hommel, University of Liverpool
ResearchGolassa and colleagues report mutations that have been previously associated with chloroquine resistance in Plasmodium vivax (at the loci pvmdr-1 and pvcrt-o) in parasites from an area of emerging chloroquine resistance in Ethiopia. These observations are potentially interesting for those working on drug resistance, but the study suffers from the lack of any phenotypic correlates
ResearchFor the calculation of parasite index by microscopy, an assumed total leucocyte count of 8,000/µL is used conventionally. The study evaluated the utility of this assumed value compared to other values and concluded that the assumed value should be derived from the population under study or, when possible, the patient’s own measured leucocyte count.
ResearchThis study documented the presence of mutations in the k13 gene in parasite populations from the China-Myanmar border, including new mutations not previously described.
ResearchPaper that proposes pantetheinase inhibition as a valid path to discover new drugs for malaria. The results demonstrate that vanin inhibitors potentiate pantothenamides, yet this effect is not correlated with vanin inhibition.
ResearchThe squirrel monkey, Saimiri sciureus, represents a valuable experimental model. because it is susceptible both to Plasmodium falciparum and Plasmodium vivax , the two major human malaria parasites, to which most commonly used non-human primates are resistant. Unfortunately, the lack of appropriate and reliable immunological tools did not permit to dissect the immune responses as well as protective mechanisms induced by vaccine candidates in this model. This study is very important to help to fill this gap.
ResearchThe study compares plasma levels of malaria-specific antibodies and self-reactive antibodies, as well as cytokines levels, between asymptomatic malaria children and children with mild malaria.
Aims & scope
Malaria Journal is aimed at the scientific community interested in malaria in its broadest sense. It is the only journal that publishes exclusively articles on malaria and, as such, it aims to bring together knowledge from the different specialities involved in this very broad discipline, from the bench to the bedside and to the field. Malaria Journal offers a fast publication schedule while maintaining rigorous peer-review; this is achieved by managing the whole of the publication process electronically, from submission to peer-review.
Malaria Journal 2015, 14:158
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