- Marcel Hommel, University of Liverpool
MethodologyConditions which cause haemolysis and lead to free haemoglobin (Hb) appear to contribute to disease pathogenesis and often severe clinical manifestations.The data appears consistent with the methaemoglobin/haem hypothesis in severe malaria. The authors suggest that non-invasive bedside MetHb testing may be a simple adjuvant tool for prognosis in resource poor settings.
ResearchThis study confirmed that artesunate plus sulphadoxine-pyrimethamine treatment failure was widespread in northeast India and exceeded the threshold for changing drug policy. As a result, the expert committee of the National Vector Borne Disease Control Programme created the first subnational drug policy for India and selected artemether plus lumefantrine as the new first-line treatment in the northeast.
ReviewRDT performance is largely determined by design and quality characteristics, but parasite characteristics, such as variable or absent expression of antigens targeted by RDTs can also affect performance. Plasmodium falciparum parasites lacking the PfHRP2 protein, the most common target antigen for detection of P. falciparum, have been reported in some regions. A set of recommended procedures to apply for future investigations for parasites lacking PfHRP2, is proposed.
ResearchPaper describing the evaluation of three different implementations of day-three active surveillance for artemisinin resistance. Potential importance to those interested in programmatic implementation for malaria control and elimination in locations where artemisinin resistance has been confirmed or is suspected.
ResearchPharmacokinetics of artesunate and dihydroartemisinin after intravenous administration of artesunate in patients. Intravenous AS can provide much higher peak concentrations when compared to concentrations achieved with oral therapy; this may be crucial for the rapid elimination of parasites in patients with severe malaria.
ResearchGlobal economic integration, large numbers of people travelling to malaria-endemic countries for trade, tourism, labour and other purposes make imported malaria an increasing problem in non-endemic countries. In Brazil, mortality is 80 to 100 times higher in the extra-Amazon than in the Amazon endemic region,
Aims & scope
Malaria Journal is aimed at the scientific community interested in malaria in its broadest sense. It is the only journal that publishes exclusively articles on malaria and, as such, it aims to bring together knowledge from the different specialities involved in this very broad discipline, from the bench to the bedside and to the field. Malaria Journal offers a fast publication schedule while maintaining rigorous peer-review; this is achieved by managing the whole of the publication process electronically, from submission to peer-review.
Malaria Journal 2014, 13:283
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