Malaria Journal

Editor-in-Chief

Marcel Hommel, University of Liverpool

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Case report

Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania

Färnert A, Ursing J, Tolfvenstam T, Rono J, Karlsson L, Sparrelid E and Lindegårdh N Malaria Journal 2012, 11:176 (25 May 2012)

An interesting case of artemether-lumefantrine treatment failure in a non-immune individual returning from a malaria endemic area with uncomplicated P. falciparum malaria. Based on molecular and pharmacological evidence the authors conclude that this case may represent a failure due to a reduced parasite susceptibility to the long half-life partner drug lumefantrine rather than a failure that can be explained by pharmacokinetics.
Research

Quantitative detection of PfHRP2 in saliva of malaria patients in the Philippines

Fung AO, Damoiseaux R, Grundeen S, Panes JL, Horton DH, Judy JW and Moore TB Malaria Journal 2012, 11:175 (25 May 2012)

Describes the development of a highly sensitive ELISA assay for the detection of the P. falciparum HRP2 protein in saliva samples from malaria patients. The authors propose saliva as a promising non-invasive sample for malaria diagnosis and present procedures to improve sample quality.
Research

Efficacy of fixed-dose combination artesunateamodiaquine versus artemether-lumefantrine for uncomplicated childhood plasmodium falciparum malaria in democratic republic of congo: a randomized non-inferiority trial

Espié E, Lima A, Atua B, Dorba M, Flévaud L, Sompwe EM, Palma Urrutia PP and Guérin PJ Malaria Journal 2012, 11:174 (25 May 2012)

This is the first non-inferiority trial of the fixed dose regimen of these two drugs. The authors find that AL is non-inferior to AS-AQ and that both have high efficacy in DRC.
Research

Suppression of erythroid development in vitro by Plasmodium vivax

Panichakul T, Payuhakrit W, Panburana P, Wongborisuth C, Hongeng S and Udomsangpetch R Malaria Journal 2012, 11:173 (24 May 2012)

Severe anaemia due to dyserythropoiesis may occur in patients with vivax malaria by a poorly understood mechanism. In this study, both lysed and intact parasitized RBCs significantly inhibit erythroid growth and erythroid development.
Research

An affordable, quality-assured community-based system for high-resolution entomological surveillance of vector mosquitoes that reflects human malaria infection risk patterns

Chaki PP, Mlacha YP, Msellem D, Muhili A, Malishee AD, Mtema ZJ, Kiware SS, Zhou Y et al. Malaria Journal 2012, 11:172 (24 May 2012)

A large-scale larviciding programme in urban Dar es Salaam, Tanzania is supported by a community-based system for trapping adult mosquito densities to monitor programme performance.
Research

Quality of life and satisfaction with life of malaria patients in context of acceptance of the disease: quantitative studies

Van Damme-Ostapowicz K, Krajewska-Kułak E, Rozwadowska E, Nahorski WL and Olszański R Malaria Journal 2012, 11:171 (22 May 2012)

The purpose of the study was the evaluation of the quality of life, satisfaction with life and the acceptance of illness by malaria patients - an aspect of malaria and health care rarely looked at before in an African context.
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Comments

GMP artesunate

Comment on: Kreeftmeijer-Vegter et al. Malaria Journal 2012, 11:102
Re Analysis for genotyping Duffy blood group in inhabitants...

Comment on: Kempinska-Podhorodecka et al. Malaria Journal 2012, 11:115
Update on CF11 availability

Comment on: Venkatesan et al. Malaria Journal 2012, 11:41

Aims & scope

Malaria Journal is aimed at the scientific community interested in malaria in its broadest sense. It is the only journal that publishes exclusively articles on malaria and, as such, it aims to bring together knowledge from the different specialties involved in this very broad discipline, from the bench to the bedside and to the field. Malaria Journal offers a fast publication schedule while maintaining rigorous peer-review; this is achieved by managing the whole of the publication process electronically, from submission to peer-review.