Malaria Journal | All articles

Submit a manuscript Register Contact us Follow
BioMed Central Follow
@malariajournal Support

Explore Malaria Journal

Advertisement

Articles

Supplements

Display/download options Articles per page: 25 | 50 | 100

Display options

Editor's summary Citation

Download options

Send
To

	All
		Research Living on the edge: a longitudinal study of Anopheles funestus in an isolated area of Mozambique J Derek Charlwood, Nelson Cuamba, Elsa VE Tomás, Olivier JT Briët Malaria Journal 2013, 12:208 (17 June 2013) Abstract \| Provisional PDF \| Editor’s summary A well written paper which contributes to the shortage of biological knowledge on this major malaria vector species, Anopheles funestus. A longitudinal study over 104 weeks, where mosquito sampling was done in southern Mozambique, at the edge of distribution of this species.
		Research Spatial distribution of malaria problem in three regions of Ethiopia Dawit G Ayele, Temesgen T Zewotir, Henry G Mwambi Malaria Journal 2013, 12:207 (17 June 2013) Abstract \| Provisional PDF \| Editor’s summary More than 75% of Ethiopia is malaria-endemic. The aim of this study was to identify socio-economic, geographic and demographic risk factors of malaria and produce a prevalence map illustrating variation in malaria risk.
		Research Host immune constraints on malaria transmission: insights from population biology of within-host parasites Philip G McQueen, Kim C Williamson, F Ellis McKenzie Malaria Journal 2013, 12:206 (15 June 2013) Abstract \| Provisional PDF \| Editor’s summary Mathematical model to investigate the effects of immunity to different stages of the life cycle of P. falciparum and vivax.
		Research Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors Joseph M Bodi, Célestin N Nsibu, Roland L Longenge, Michel N Aloni, Pierre Z Akilimali, Pierre M Tshibassu, Patrick K Kayembe, Ahmeddin H Omar, Kenji Hirayama, Jan Verhaegen Malaria Journal 2013, 12:205 (15 June 2013) Abstract \| Provisional PDF \| Editor’s summary Report of a case control study of haemoglobinuria conducted over two years amongst paediatric malaria patients in Kinshasa. This may reflect an increase in the incidence of this severe complication of falciparum malaria.
		Research Equivalent susceptibility of anopheles gambiae M and S molecular forms and anopheles arabiensis to plasmodium falciparum infection in Burkina Faso Awa Gnémé, Wamdaogo M Guelbéogo, Michelle M Riehle, Antoine Sanou, Alphonse Traoré, Soumanaba Zongo, Karin Eiglmeier, Gustave B Kabré, N¿Falé Sagnon, Kenneth D Vernick Malaria Journal 2013, 12:204 (14 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The authors have tested for differences in Plasmodium falciparum infection prevalence and intensity between Anopheles gambiae M, A. gambiae S and Anopheles arabiensis, but found no difference in susceptibility between these three populations when performing experimental infections using ¿local¿ malaria strains.
		Research A good night's sleep and the habit of net use: perceptions of risk and reasons for bed net use in Bukoba and Zanzibar Hannah M Koenker, Dana Loll, Datius Rweyemamu, Abdullah S Ali Malaria Journal 2013, 12:203 (13 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The article raises the very important issue about how long and to what extent people will continue to comply with malaria preventive measures as incidence decreases.
		Research Determination of artemether and lumefantrine in anti-malarial fixed-dose combination tablets by microemulsion electrokinetic chromatography with short-end injection procedure N¿Cho Christophe Amin, Huguette Fabre, Marie-Dominique Blanchin, Jérôme Montels, Michèle Aké Malaria Journal 2013, 12:202 (13 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Describes a microemulsion electrokinetic chromatography method for the quantitation of artemether and lumefantrine in tablets, a method not previously described for the assay of these anti-malarials.
		Research Population genetics analysis during the elimination process of Plasmodium falciparum in Djibouti Bouh Abdi Khaireh, Ashenafi Assefa, Hawa Hassan Guessod, Leonardo K Basco, Mohamed Abdi Khaireh, Aurélie Pascual, Sébastien Briolant, Samatar Mohamed Bouh, Ismaïl Hassan Farah, Habib Moussa Ali, Abdoul-Ilah Ahmed Abdi, Mouna Osman Aden, Zamzam Abdillahi, Souleiman Nour Ayeh, Houssein Youssouf Darar, Jean-Louis Koeck, Christophe Rogier, Bruno Pradines, Hervé Bogreau Malaria Journal 2013, 12:201 (13 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Djibouti is a small country on the edge of the endemic distribution of malaria in the horn of Africa, which has been considered as having potential for future local malaria elimination. This study analyses the genetic diversity of P. falciparum sampled at four different time points and discusses results in the context of the possibility for future elimination.
		Research Malaria and protective behaviours: is there a malaria trap? Jean-Claude Berthélemy, Josselin Thuilliez, Ogobara Doumbo, Jean Gaudart Malaria Journal 2013, 12:200 (13 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This paper is about the theoretical existence of a malaria trap as well as the implications of this for the distribution of insecticide-treated nets. -
		Research Plasmodium vivax aldolase-specific monoclonal antibodies and its application in clinical diagnosis of malaria infections in China Emmanuel E Dzakah, Keren Kang, Chao Ni, Hong Wang, Peidian Wu, Shixing Tang, Jihua Wang, Jufang Wang, Xiaoning Wang Malaria Journal 2013, 12:199 (12 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Results of research work aimed to improve malaria diagnosis and more specifically the detection of P. vivax, with particular empasis on developing new monoclonal antibodies agains parasite aldolase.
		Research High prevalence of mutation in the Plasmodium falciparum dhfr and dhps genes in field isolates from Sabah, Northern Borneo Noor Rain Abdullah, Nor Azrina Norahmad, Jenarun Jelip, Lokman Hakim Sulaiman, Hasidah Mohd Sidek, Zakiah Ismail, Harald Noedl Malaria Journal 2013, 12:198 (12 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Analysis of the mutations in the dhfr and dhps genes in samples from Sabah, Northern Borneo, Malaysia. The overall conclusions support the interpretation that parasite populations in this region carry a wide variety of allelic combinations associated with resistance to SP and the authors recommendation that SP not be used is definitely important for local decision making.
		Opinion Imported malaria in Albania and the risk factors that could allow its reappearance Klodiana Shkurti, Gentian Vyshka, Enkelejda Velo, Arben Boçari, Majlinda Kokici, Dhimitër Kraja Malaria Journal 2013, 12:197 (12 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Comments on the risk of malaria reappearance in Albania based on three environmental and human factors: the geographical distribution of Anopheles species, the human migration and the flooding of northern lowlands close to the Adriatic coasts.
		Methodology Environmentally friendly tool to control mosquito populations without risk of insecticide resistance: the Lehmann's funnel entry trap Abdoulaye Diabaté, Etienne Bilgo, Roch K Dabiré, Fréderic Tripet Malaria Journal 2013, 12:196 (10 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This study presents the results of the use of a funnel entry trap as an alternative tool to control mosquitoes. The development of novel control tools is highly needed and the study is a proof a concept of the use of the trap.
		Research High rates of parasite recrudescence following intermittent preventive treatment with sulphadoxine-pyrimethamine during pregnancy in Benin Azizath Moussiliou, Yolande Sissinto-Savi De Tove, Justin Doritchamou, Adrian JF Luty, Achille Massougbodji, Michael Alifrangis, Philippe Deloron, Nicaise Tuikue Ndam Malaria Journal 2013, 12:195 (10 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Despite widespread parasite resistance to sulphadoxine-pyrimethamine (SP) its use for intermittent preventative treatment during pregnancy remains the policy in Benin and throughout most of sub-Saharan Africa. This study suggests that this policy needs to be changed soon.
		Research Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica Virendra K Dua, Gaurav Verma, Bikram Singh, Aswathy Rajan, Upma Bagai, Dau Dayal Agarwal, NC Gupta, Sandeep Kumar, Ayushi Rastogi Malaria Journal 2013, 12:194 (10 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The present investigation demonstrates that the compound conessine exhibited substantial anti-malarial property. The isolated compound could be chemically modified to improve its potency.
		Research Malaria and haematologic parameters of pupils at different altitudes along the slope of Mount Cameroon: a cross-sectional study Helen K Kimbi, Irene UN Sumbele, Malaika Nweboh, Judith K Anchang-Kimbi, Emmaculate Lum, Yannick Nana, Lucy M Ndip, Henry Njom, Leopold G Lehman Malaria Journal 2013, 12:193 (9 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Results of a study of the impact of altitude/malaria transmission along an altitude transect, and a discussion of the impact of malaria infections on various haematologic measurements.
		Review Land cover, land use and malaria in the Amazon: a systematic literature review of studies using remotely sensed data Aurélia Stefani, Isabelle Dusfour, Ana Paula SA Corrêa, Manoel CB Cruz, Nadine Dessay, Allan KR Galardo, Clícia D Galardo, Romain Girod, Margarete SM Gomes, Helen Gurgel, Ana Cristina F Lima, Eduardo S Moreno, Lise Musset, Mathieu Nacher, Alana CS Soares, Bernard Carme, Emmanuel Roux Malaria Journal 2013, 12:192 (8 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The authors present a well-reasoned argument for a shared land use/lang cover topology for studies of malaria risk in the Amazon region. Their detailed review of studies using remote-sensing data to identify malaria risk factors in the Amazon forest is very relevant to the field.
		Research A histological method for quantifying Plasmodium falciparum in the brain in fatal paediatric cerebral malaria Danny A Milner, Clarissa Valim, Richard A Carr, Pankaj B Chandak, Nedson G Fosiko, Richard Whitten, Krupa B Playforth, Karl B Seydel, Steve Kamiza, Malcolm E Molyneux, Terrie E Taylor Malaria Journal 2013, 12:191 (7 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This study details the histopathological quantification of parasite counts for cerebral malaria studies. Methods that involve quantitative measures of different life cycle stages are useful for distinguishing patterns within the cerebral malaria population; these subclassifications may be important for studies of disease pathogenesis and ancillary treatment.
		Methodology A novel live-dead staining methodology to study malaria parasite viability Erica M Pasini, Denise van den Ierssel, Henri J Vial, Clemens HM Kocken Malaria Journal 2013, 12:190 (7 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The authors used various dyes of different commercial sources to stain malaria parasites with the aim to differentially distinguish live from dead parasites. An underlying objective is to apply this technique in testing drug sensitivity of malaria parasite and to be used as a tool for checking quality of the long term culture of P. vivax.
		Research In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na⁺/H⁺ exchanger transporter (Pfnhe-1) gene in 393 isolates from Dakar, Senegal Aurélie Pascual, Bécaye Fall, Nathalie Wurtz, Mansour Fall, Cheikhou Camara, Aminata Nakoulima, Eric Baret, Bakary Diatta, Khadidiatou Fall, Pape Mbaye, Yaya Diémé, Raymond Bercion, Hervé Bogreau, Sébastien Briolant, Christophe Rogier, Boubacar Wade, Bruno Pradines Malaria Journal 2013, 12:189 (7 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Evaluation of the association between the Pfnhe polymorphism and quinine susceptibility in isolates from Senegal, aiming to assess the validity of Pfnhe as a molecular marker of QN susceptibility.
		Research Evaluation of the malaria rapid diagnostic test VIKIA malaria Ag Pf/Pan™ in endemic and non-endemic settings Daniel Eibach, Boubacar Traore, Mourad Bouchrik, Boubacar Coulibaly, Nianégué Coulibaly, Fanta Siby, Guillaume Bonnot, Anne-Lise Bienvenu, Stéphane Picot Malaria Journal 2013, 12:188 (6 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The authors compare the performance of VIKIA Malaria Ag Pf/Pan to LM-PCR corrected in an endemic setting and a non-endemic setting. The study concludes that VIKIA performance is comparable to the widely used CareStart test and microscopy-corrected PCR results, in both endemic and non-endemic areas.
		Review Designing the next generation of medicines for malaria control and eradication Jeremy N Burrows, Rob Hooft van Huijsduijnen, Jörg J Möhrle, Claude Oeuvray, Timothy NC Wells Malaria Journal 2013, 12:187 (6 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This paper provides an outline definition of the ideal and minimally acceptable characteristics of the types of clinical candidate molecule which are needed in various situations, both as monotherapy and combination therapy.
		Research The association between price, competition, and demand factors on private sector anti-malarial stocking and sales in western Kenya: considerations for the AMFm subsidy Wendy O’Meara, Andrew Obala, Harsha Thirumurthy, Barasa Khwa-Otsyula Malaria Journal 2013, 12:186 (5 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Information on why retailers choose to stock specific drugs and what determines the volume of different types of drugs sold in the outlets ¿ including price, which is relevant information in the context of subsidy interventions such as the AMFm.
		Research Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP) Martha Sedegah, Yohan Kim, Harini Ganeshan, Jun Huang, Maria Belmonte, Esteban Abot, Jo Banania, Fouzia Farooq, Shannon McGrath, Bjoern Peters, Alessandro Sette, Lorraine Soisson, Carter Diggs, Denise L Doolan, Cindy Tamminga, Eileen Villasante, Michael R Hollingdale, Thomas L Richie Malaria Journal 2013, 12:185 (5 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This study identified new class I epitopes restricted by six HLA supertypes on the CSP, one of the leading vaccine candidate antigens, suggesting that an adenovirus-vectored CSP vaccine would be immunogenic and potentially protective in genetically diverse populations.
		Research Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum Fabiana M Jordão, Heloisa B Gabriel, João MP Alves, Claudia B Angeli, Thaís D Bifano, Ardala Breda, Mauro F de Azevedo, Luiz A Basso, Gerhard Wunderlich, Emilia A Kimura, Alejandro M Katzin Malaria Journal 2013, 12:184 (4 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The paper presents the cloning, expression, purification, biochemical characterization of the FPPS from Plasmodium falciparum. The authors show that this enzyme has two activities that result in the production of farnesyl diphosphate/geranylgeranyl diphosphate, a key branch point of the isoprenoid synthesis and, hence, playing a central role in the regulation of a number of essential functions in Plasmodium parasites.
		Research Gestational age assessment in malaria pregnancy cohorts: a prospective ultrasound demonstration project in Malawi Blair J Wylie, Linda Kalilani-Phiri, Mwayi Madanitsa, Gladys Membe, Osward Nyirenda, Patricia Mawindo, Redson Kuyenda, Albert Malenga, Abbey Masonbrink, Bonus Makanani, Phillip Thesing, Miriam K Laufer Malaria Journal 2013, 12:183 (4 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Important methodology paper which adds to the body of knowledge on gestational age dating in resource poor settings and particularly in relation to malaria. The goal was to achieve, by the use of ultrasound, a more accurate description of rates of prematurity and rates of growth restriction ¿ each dependent on accurate dating.
		Research Cloning, expression, and immunocharacterization of surface protein containing an altered thrombospondin repeat domain (SPATR) from Plasmodium knowlesi Vanitha Palaeya, Yee Ling Lau, Rohela Mahmud, Yeng Chen, Mun Yik Fong Malaria Journal 2013, 12:182 (4 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The findings from this paper may facilitate the development of cost effective kits for the better diagnosis of knowlesi infections in humans.
		Research pLDH level of clinically isolated Plasmodium vivax and detection limit of pLDH based malaria rapid diagnostic test Jin Woo Jang, Chi Hyun Cho, Eun Taek Han, Seong Soo An, Chae Seung Lim Malaria Journal 2013, 12:181 (3 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary pLDH-detecting RDTs are widely used for diagnosing non-P. falciparum human Plasmodium infections and their performance vary. Factors such as genetic diversity of pLDH and antigen levels of pLDH could contribute to variations in sensitivities of pLDH RDTs. THis study adds to our knowledge on such issues.
		Research Natural Plasmodium infection in monkeys in the state of Rondônia (Brazilian Western Amazon) Maisa S Araújo, Mariluce R Messias, Marivaldo R Figueiró, Luiz Herman S Gil, Christian M Probst, Newton M Vidal, Tony H Katsuragawa, Marco A Krieger, Luiz H Pereira da Silva, Luiz S Ozaki Malaria Journal 2013, 12:180 (3 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Describes a PCR-based survey of Plasmodium infections in monkeys in Rondonia. Nearly 200 monkey blood samples were screened with 18S rRNA based primers designed for this study, and some individual samples were followed up with more detailed amplification and sequencing. The data adds information to our understanding of simian Plasmodium in the Amazon.
		Research Both infected and uninfected mosquitoes are attracted toward malaria infected birds Stéphane Cornet, Antoine Nicot, Ana Rivero, Sylvain Gandon Malaria Journal 2013, 12:179 (3 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Feeding behaviour of Plasmodium relictum-infected and non-infected Culex pipiens mosquitoes. The authors developed a convenient model for such research.
		Research Hyperendemic malaria transmission in areas of occupation-related travel in the Peruvian Amazon Benjamin S Parker, Maribel Paredes Olortegui, Pablo Peñataro Yori, Karin Escobedo, David Florin, Silvia Rengifo Pinedo, Roldan Cardenas Greffa, Luis Capcha Vega, Hugo Rodriguez Ferrucci, William K Pan, Cesar Banda Chavez, Joseph M Vinetz, Margaret Kosek Malaria Journal 2013, 12:178 (31 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The article identifies the primary vector and potential for transmission along a riverine system, as well as exportation of malaria to hypoendemic regions of the Iquitos area. The data confirm the focal nature of malaria transmission in the region and describe some of the factors that account for this pattern.
		Case report Activation of minority-variant Plasmodium vivax hypnozoites following artesunate + amodiaquine treatment in a 23-year old man with relapsing malaria in Antananarivo, Madagascar Voahangy Andrianaranjaka, Jessica T Lin, Christopher Golden, Jonathan J Juliano, Milijaona Randrianarivelojosia Malaria Journal 2013, 12:177 (31 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In endemic areas, Plasmodium vivax relapses are difficult to distinguish from new infections. Parasite DNA extracted from blood samples was analysed to compare the genotypic profile of the P. vivax isolates collected from the patient during each of the three malaria episodes.
		Research Vivax malaria and bacteraemia: a prospective study in Kolkata, India Sujit Kumar Bhattacharya, Dipika Sur, Shanta Dutta, Suman Kanungo, R Leon Ochiai, Deok Ryun Kim, Nicholas M Anstey, Lorenz von Seidlein, Jacqueline Deen Malaria Journal 2013, 12:176 (31 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Data from a prospective fever surveillance study in Kolkata were reanalysed for the potential association between vivax malaria and bacteraemia.This negative study required an enormous amount of work that is unlikely to be repeated without the resources of a major vaccine trial.
		Research Health care seeking patterns and determinants of out-of-pocket expenditure for Malaria for the children under-five in Uganda Juliet Nabyonga Orem, Frederick Mugisha, Albert Okui, Laurent Musango, Joses Kirigia Malaria Journal 2013, 12:175 (31 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This study looked at the patterns of treatment-seeking behaviour for children under five with malaria, and examined the relationship between out-of-pocket expenditure on malaria treatment and source of treatment, place of residence, education and wealth characteristics of Uganda households. The authors recommend that plans to improve malaria treatment should explicitly incorporate efforts to protect households from high out-of-pocket expenditures.
		Research Comparison of bioavailability between the most available generic tablet formulation containing artemether and lumefantrine on the Tanzanian market and the innovator’s product Omary MS Minzi, Ignace A Marealle, Seif Shekalaghe, Omar Juma, Eliford Ngaimisi, Mwajuma Chemba, Mastidia Rutaihwa, Salim Abdulla, Philip Sasi Malaria Journal 2013, 12:174 (30 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The study compared bioavailability of one generic tablet formulation with the original product. Both were fixed dose combination tablet formulations containing artemether and lumefantrine, and the study showed that the generic product was likely to produce a similar therapeutic response as the original combination.
		Research Triangular test design to evaluate tinidazole in the prevention of Plasmodium vivax relapse Louis Macareo, Khin Lwin, Phaik Cheah, Prayoon Yuentrakul, R Miller, Francois Nosten Malaria Journal 2013, 12:173 (29 May 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The modified triangular test sequential analysis technique can be beneficial in limiting investment, enrollment and volunteer exposure in a clinical trial of a candidate drug that turns out to ineffective for the indication in the study.
		Research Submicroscopic Plasmodium falciparum malaria and low birth weight in an area of unstable malaria transmission in Central Sudan Amal H Mohammed, Magdi M Salih, Elhassan M Elhassan, Ahmed A Mohmmed, Salah E Elzaki, Badria B El-Sayed, Ishag Adam Malaria Journal 2013, 12:172 (28 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An interesting and difficult-to-obtain data set from a case-control study of the relationship between Plasmodium falciparum infection during pregnancy and low birth weight in the delivered babies. This is important in view of the current controversy regarding the importance of submicroscopic infections on birth weight. This is a relevant issue as countries consider changing antenatal care policies from intermittent preventive treatment of malaria in pregnancy to intermittent screening and treatment of malaria in pregnancy.
		Research G6PD deficiency in Plasmodium falciparum and Plasmodium vivax malaria-infected Cambodian patients Nimol Khim, Christophe Benedet, Saorin Kim, Sim Kheng, Sovannaroth Siv, Rithea Leang, Soley Lek, Sinuon Muth, Nguon Chea, Char Chuor, Socheat Duong, Alexandra Kerleguer, Pety Tor, Pheaktra Chim, Lydie Canier, Benoit Witkowski, Walter RJ Taylor, Didier Ménard Malaria Journal 2013, 12:171 (28 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Reports the results of survey of G6PD deficiency, anaemia and haemoglobinopathies in malaria patients in Cambodia. The issue of G6PD deficiency is highly relevant in countries such as Cambodia, faced with the need to use primaquine to effectively deal with vivax malaria and to reduce transmission of falciparum, but where anxiety among doctors and nurses of primaquine-induced severe haemolysis in patients with G6PD deficiency is widespread.
		Research Community knowledge and perceptions about indoor residual spraying for malaria prevention in Soroti district, Uganda: a cross-sectional study Michael Ediau, Juliet N Babirye, Nazarius M Tumwesigye, Joseph KB Matovu, Simba Machingaidze, Olico Okui, Rhoda K Wanyenze, Peter Waiswa Malaria Journal 2013, 12:170 (27 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Knowledge about IRS is inadequate and negative perceptions about its use are prominent especially among the rural and less educated individuals. To ensure householders¿ cooperation and participation in the IRS programme, adequate community mobilization and sensitization is needed prior to use of IRS for effective malaria control.
		Research Epidemiology of Plasmodium infections in Flores Island, Indonesia using real-time PCR Maria MM Kaisar, Taniawati Supali, Aprilianto E Wiria, Firdaus Hamid, Linda J Wammes, Erliyani Sartono, Adrian JF Luty, Eric AT Brienen, Maria Yazdanbakhsh, Lisette van Lieshout, Jaco J Verweij Malaria Journal 2013, 12:169 (24 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This study provides a very useful addition to the growing body of evidence on the importance of asymptomatic carriers of malaria in hypo- to meso-endemic settings.
		Review Malaria in South America: a drug discovery perspective Luiza R Cruz, Thomas Spangenberg, Marcus VG Lacerda, Timothy NC Wells Malaria Journal 2013, 12:168 (24 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A summary of current malaria research from the viewpoint of focusing on work affecting South America and carried out by workers in South American countries. This calls to attention the many contributions from that continent and the section presenting natural products work is the most complete in the literature.
		Research Routine parallel diagnosis of malaria using microscopy and the malaria rapid diagnostic test SD 05FK60: the experience of Médecins Sans Frontières in Myanmar Cara S Kosack, Wint Naing, Erwan Piriou, Leslie Shanks Malaria Journal 2013, 12:167 (21 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary In field conditions in Myanmar, the malaria RDT described performed consistent with other reports. The test detected malaria caused by P. vivax/P. malariae to a lesser extent than P. falciparum infection.
		Research Polymorphism of the parasite lactate dehydrogenase gene from Plasmodium vivax Korean isolates Hyun-Il Shin, Jung-Yeon Kim, Won-Ja Lee, Youngjoo Sohn, Sang-Wook Lee, Yoon-Joong Kang, Hyeong-Woo Lee Malaria Journal 2013, 12:166 (21 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Parasite lactate dehydrogenase (pLDH) is widely used in rapid diagnostic tests: the genetic variation of Korean isolates was analysed. The fact that the pLDH genes of 19 isolates of P. vivax were identical, except for one for SNP at nucleotide 456 indicates that this gene is relatively stable.
		Research Characterizing PvARP, a novel Plasmodium vivax antigen Darwin A Moreno-Pérez, Ambar Saldarriaga, Manuel A Patarroyo Malaria Journal 2013, 12:165 (20 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Characterization of the P. vivax asparagine-rich protein (PvARP) by a straightforward approach using molecular biology and immunochemistry assays. The reactivity with sera from individuals infected with P. vivax indicates that it contains epitopes that are target of antibody response generated during natural exposure.
		Research A potential threat to malaria elimination: extensive deltamethrin and DDT resistance to Anopheles sinensis from the malaria-endemic areas in China Duo-quan Wang, Zhi-gui Xia, Shui-sen Zhou, Xiao-nong Zhou, Ru-bo Wang, Qing-feng Zhang Malaria Journal 2013, 12:164 (17 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A paper that highlights the problem of insecticide resistance in malaria vectors in China.
		Commentary Fulani show decreased susceptibility to Plasmodium falciparum infection versus Mossi: data from a community-wide screening and treatment of asymptomatic carriers in Burkina Faso Alfred B Tiono, Sodiomon B Sirima, Kamal Hamed Malaria Journal 2013, 12:163 (16 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This study confirmed that, in the same environment, individuals belonging to the Fulani ethnic group have a lower susceptibility to Plasmodium falciparum infection than Mossi individuals.
		Research Evaluation of the 2011 long-lasting, insecticide-treated net distribution for universal coverage in Togo Elizabeth R Stevens, Abigail Aldridge, Yawo Degbey, Akou Pignandi, Monique A Dorkenoo, Justin Hugelen-Padin Malaria Journal 2013, 12:162 (16 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Description of a largely successful campaign to distribute LLINs to all age-groups across Togo. The authors conclude that even though the campaign was unable to achieve the universal coverage target, it rapidly increased overall coverage and was far better than previous campaigns that targeted only pregnant women and under fives.
		Research Providing open access data online to advance malaria research and control Catherine L Moyes, William H Temperley, Andrew J Henry, Clara R Burgert, Simon I Hay Malaria Journal 2013, 12:161 (16 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A description of the construction of the Malaria Atlas Project's online data portal. It usefully details the data and associated products that the MAP team has made accessible to the global malaria community.
		Research A member of the Plasmodium falciparum PHIST family binds to the erythrocyte cytoskeleton component band 4.1 Lindsay A Parish, Deborah W Mai, Matthew L Jones, Erika L Kitson, Julian C Rayner Malaria Journal 2013, 12:160 (11 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Identification of a novel interaction between the erythrocyte Band 4.1 protein and a P. falciparum component from the PHIST family of proteins. The paper should be of interest to groups working on the parasite "exportome".
		Research Over-diagnosis of malaria by microscopy in the Kilombero Valley, Southern Tanzania: an evaluation of the utility and cost-effectiveness of rapid diagnostic tests Kelly Harchut, Claire Standley, Andrew Dobson, Belia Klaassen, Clotilde Rambaud-Althaus, Fabrice Althaus, Katarzyna Nowak Malaria Journal 2013, 12:159 (10 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Presumptive treatment used to be recommended by WHO, on the assumption that it is safer to treat non-malarial patients with anti-malarials than missing a true case of malaria. With a reduced incidence of malaria, a much increased cost of treatment and the realization of the risks of not identifying the true cause of febrile illness, there is now greater emphasis on accurate biological diagnosis. This study shows the advantages of using RDTs compared to poor quality microscopy.

	All
		Research Living on the edge: a longitudinal study of Anopheles funestus in an isolated area of Mozambique J Derek Charlwood, Nelson Cuamba, Elsa VE Tomás, Olivier JT Briët Malaria Journal 2013, 12:208 (17 June 2013) Abstract \| Provisional PDF \| Editor’s summary A well written paper which contributes to the shortage of biological knowledge on this major malaria vector species, Anopheles funestus. A longitudinal study over 104 weeks, where mosquito sampling was done in southern Mozambique, at the edge of distribution of this species.
		Research Spatial distribution of malaria problem in three regions of Ethiopia Dawit G Ayele, Temesgen T Zewotir, Henry G Mwambi Malaria Journal 2013, 12:207 (17 June 2013) Abstract \| Provisional PDF \| Editor’s summary More than 75% of Ethiopia is malaria-endemic. The aim of this study was to identify socio-economic, geographic and demographic risk factors of malaria and produce a prevalence map illustrating variation in malaria risk.
		Research Host immune constraints on malaria transmission: insights from population biology of within-host parasites Philip G McQueen, Kim C Williamson, F Ellis McKenzie Malaria Journal 2013, 12:206 (15 June 2013) Abstract \| Provisional PDF \| Editor’s summary Mathematical model to investigate the effects of immunity to different stages of the life cycle of P. falciparum and vivax.
		Research Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors Joseph M Bodi, Célestin N Nsibu, Roland L Longenge, Michel N Aloni, Pierre Z Akilimali, Pierre M Tshibassu, Patrick K Kayembe, Ahmeddin H Omar, Kenji Hirayama, Jan Verhaegen Malaria Journal 2013, 12:205 (15 June 2013) Abstract \| Provisional PDF \| Editor’s summary Report of a case control study of haemoglobinuria conducted over two years amongst paediatric malaria patients in Kinshasa. This may reflect an increase in the incidence of this severe complication of falciparum malaria.
		Research Equivalent susceptibility of anopheles gambiae M and S molecular forms and anopheles arabiensis to plasmodium falciparum infection in Burkina Faso Awa Gnémé, Wamdaogo M Guelbéogo, Michelle M Riehle, Antoine Sanou, Alphonse Traoré, Soumanaba Zongo, Karin Eiglmeier, Gustave B Kabré, N¿Falé Sagnon, Kenneth D Vernick Malaria Journal 2013, 12:204 (14 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The authors have tested for differences in Plasmodium falciparum infection prevalence and intensity between Anopheles gambiae M, A. gambiae S and Anopheles arabiensis, but found no difference in susceptibility between these three populations when performing experimental infections using ¿local¿ malaria strains.
		Research A good night's sleep and the habit of net use: perceptions of risk and reasons for bed net use in Bukoba and Zanzibar Hannah M Koenker, Dana Loll, Datius Rweyemamu, Abdullah S Ali Malaria Journal 2013, 12:203 (13 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The article raises the very important issue about how long and to what extent people will continue to comply with malaria preventive measures as incidence decreases.
		Research Determination of artemether and lumefantrine in anti-malarial fixed-dose combination tablets by microemulsion electrokinetic chromatography with short-end injection procedure N¿Cho Christophe Amin, Huguette Fabre, Marie-Dominique Blanchin, Jérôme Montels, Michèle Aké Malaria Journal 2013, 12:202 (13 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Describes a microemulsion electrokinetic chromatography method for the quantitation of artemether and lumefantrine in tablets, a method not previously described for the assay of these anti-malarials.
		Research Population genetics analysis during the elimination process of Plasmodium falciparum in Djibouti Bouh Abdi Khaireh, Ashenafi Assefa, Hawa Hassan Guessod, Leonardo K Basco, Mohamed Abdi Khaireh, Aurélie Pascual, Sébastien Briolant, Samatar Mohamed Bouh, Ismaïl Hassan Farah, Habib Moussa Ali, Abdoul-Ilah Ahmed Abdi, Mouna Osman Aden, Zamzam Abdillahi, Souleiman Nour Ayeh, Houssein Youssouf Darar, Jean-Louis Koeck, Christophe Rogier, Bruno Pradines, Hervé Bogreau Malaria Journal 2013, 12:201 (13 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Djibouti is a small country on the edge of the endemic distribution of malaria in the horn of Africa, which has been considered as having potential for future local malaria elimination. This study analyses the genetic diversity of P. falciparum sampled at four different time points and discusses results in the context of the possibility for future elimination.
		Research Malaria and protective behaviours: is there a malaria trap? Jean-Claude Berthélemy, Josselin Thuilliez, Ogobara Doumbo, Jean Gaudart Malaria Journal 2013, 12:200 (13 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This paper is about the theoretical existence of a malaria trap as well as the implications of this for the distribution of insecticide-treated nets. -
		Research Plasmodium vivax aldolase-specific monoclonal antibodies and its application in clinical diagnosis of malaria infections in China Emmanuel E Dzakah, Keren Kang, Chao Ni, Hong Wang, Peidian Wu, Shixing Tang, Jihua Wang, Jufang Wang, Xiaoning Wang Malaria Journal 2013, 12:199 (12 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Results of research work aimed to improve malaria diagnosis and more specifically the detection of P. vivax, with particular empasis on developing new monoclonal antibodies agains parasite aldolase.
		Research High prevalence of mutation in the Plasmodium falciparum dhfr and dhps genes in field isolates from Sabah, Northern Borneo Noor Rain Abdullah, Nor Azrina Norahmad, Jenarun Jelip, Lokman Hakim Sulaiman, Hasidah Mohd Sidek, Zakiah Ismail, Harald Noedl Malaria Journal 2013, 12:198 (12 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Analysis of the mutations in the dhfr and dhps genes in samples from Sabah, Northern Borneo, Malaysia. The overall conclusions support the interpretation that parasite populations in this region carry a wide variety of allelic combinations associated with resistance to SP and the authors recommendation that SP not be used is definitely important for local decision making.
		Opinion Imported malaria in Albania and the risk factors that could allow its reappearance Klodiana Shkurti, Gentian Vyshka, Enkelejda Velo, Arben Boçari, Majlinda Kokici, Dhimitër Kraja Malaria Journal 2013, 12:197 (12 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Comments on the risk of malaria reappearance in Albania based on three environmental and human factors: the geographical distribution of Anopheles species, the human migration and the flooding of northern lowlands close to the Adriatic coasts.
		Methodology Environmentally friendly tool to control mosquito populations without risk of insecticide resistance: the Lehmann's funnel entry trap Abdoulaye Diabaté, Etienne Bilgo, Roch K Dabiré, Fréderic Tripet Malaria Journal 2013, 12:196 (10 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This study presents the results of the use of a funnel entry trap as an alternative tool to control mosquitoes. The development of novel control tools is highly needed and the study is a proof a concept of the use of the trap.
		Research High rates of parasite recrudescence following intermittent preventive treatment with sulphadoxine-pyrimethamine during pregnancy in Benin Azizath Moussiliou, Yolande Sissinto-Savi De Tove, Justin Doritchamou, Adrian JF Luty, Achille Massougbodji, Michael Alifrangis, Philippe Deloron, Nicaise Tuikue Ndam Malaria Journal 2013, 12:195 (10 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Despite widespread parasite resistance to sulphadoxine-pyrimethamine (SP) its use for intermittent preventative treatment during pregnancy remains the policy in Benin and throughout most of sub-Saharan Africa. This study suggests that this policy needs to be changed soon.
		Research Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica Virendra K Dua, Gaurav Verma, Bikram Singh, Aswathy Rajan, Upma Bagai, Dau Dayal Agarwal, NC Gupta, Sandeep Kumar, Ayushi Rastogi Malaria Journal 2013, 12:194 (10 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The present investigation demonstrates that the compound conessine exhibited substantial anti-malarial property. The isolated compound could be chemically modified to improve its potency.
		Research Malaria and haematologic parameters of pupils at different altitudes along the slope of Mount Cameroon: a cross-sectional study Helen K Kimbi, Irene UN Sumbele, Malaika Nweboh, Judith K Anchang-Kimbi, Emmaculate Lum, Yannick Nana, Lucy M Ndip, Henry Njom, Leopold G Lehman Malaria Journal 2013, 12:193 (9 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Results of a study of the impact of altitude/malaria transmission along an altitude transect, and a discussion of the impact of malaria infections on various haematologic measurements.
		Review Land cover, land use and malaria in the Amazon: a systematic literature review of studies using remotely sensed data Aurélia Stefani, Isabelle Dusfour, Ana Paula SA Corrêa, Manoel CB Cruz, Nadine Dessay, Allan KR Galardo, Clícia D Galardo, Romain Girod, Margarete SM Gomes, Helen Gurgel, Ana Cristina F Lima, Eduardo S Moreno, Lise Musset, Mathieu Nacher, Alana CS Soares, Bernard Carme, Emmanuel Roux Malaria Journal 2013, 12:192 (8 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The authors present a well-reasoned argument for a shared land use/lang cover topology for studies of malaria risk in the Amazon region. Their detailed review of studies using remote-sensing data to identify malaria risk factors in the Amazon forest is very relevant to the field.
		Research A histological method for quantifying Plasmodium falciparum in the brain in fatal paediatric cerebral malaria Danny A Milner, Clarissa Valim, Richard A Carr, Pankaj B Chandak, Nedson G Fosiko, Richard Whitten, Krupa B Playforth, Karl B Seydel, Steve Kamiza, Malcolm E Molyneux, Terrie E Taylor Malaria Journal 2013, 12:191 (7 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This study details the histopathological quantification of parasite counts for cerebral malaria studies. Methods that involve quantitative measures of different life cycle stages are useful for distinguishing patterns within the cerebral malaria population; these subclassifications may be important for studies of disease pathogenesis and ancillary treatment.
		Methodology A novel live-dead staining methodology to study malaria parasite viability Erica M Pasini, Denise van den Ierssel, Henri J Vial, Clemens HM Kocken Malaria Journal 2013, 12:190 (7 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The authors used various dyes of different commercial sources to stain malaria parasites with the aim to differentially distinguish live from dead parasites. An underlying objective is to apply this technique in testing drug sensitivity of malaria parasite and to be used as a tool for checking quality of the long term culture of P. vivax.
		Research In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na⁺/H⁺ exchanger transporter (Pfnhe-1) gene in 393 isolates from Dakar, Senegal Aurélie Pascual, Bécaye Fall, Nathalie Wurtz, Mansour Fall, Cheikhou Camara, Aminata Nakoulima, Eric Baret, Bakary Diatta, Khadidiatou Fall, Pape Mbaye, Yaya Diémé, Raymond Bercion, Hervé Bogreau, Sébastien Briolant, Christophe Rogier, Boubacar Wade, Bruno Pradines Malaria Journal 2013, 12:189 (7 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Evaluation of the association between the Pfnhe polymorphism and quinine susceptibility in isolates from Senegal, aiming to assess the validity of Pfnhe as a molecular marker of QN susceptibility.
		Research Evaluation of the malaria rapid diagnostic test VIKIA malaria Ag Pf/Pan™ in endemic and non-endemic settings Daniel Eibach, Boubacar Traore, Mourad Bouchrik, Boubacar Coulibaly, Nianégué Coulibaly, Fanta Siby, Guillaume Bonnot, Anne-Lise Bienvenu, Stéphane Picot Malaria Journal 2013, 12:188 (6 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The authors compare the performance of VIKIA Malaria Ag Pf/Pan to LM-PCR corrected in an endemic setting and a non-endemic setting. The study concludes that VIKIA performance is comparable to the widely used CareStart test and microscopy-corrected PCR results, in both endemic and non-endemic areas.
		Review Designing the next generation of medicines for malaria control and eradication Jeremy N Burrows, Rob Hooft van Huijsduijnen, Jörg J Möhrle, Claude Oeuvray, Timothy NC Wells Malaria Journal 2013, 12:187 (6 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This paper provides an outline definition of the ideal and minimally acceptable characteristics of the types of clinical candidate molecule which are needed in various situations, both as monotherapy and combination therapy.
		Research The association between price, competition, and demand factors on private sector anti-malarial stocking and sales in western Kenya: considerations for the AMFm subsidy Wendy O’Meara, Andrew Obala, Harsha Thirumurthy, Barasa Khwa-Otsyula Malaria Journal 2013, 12:186 (5 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Information on why retailers choose to stock specific drugs and what determines the volume of different types of drugs sold in the outlets ¿ including price, which is relevant information in the context of subsidy interventions such as the AMFm.
		Research Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP) Martha Sedegah, Yohan Kim, Harini Ganeshan, Jun Huang, Maria Belmonte, Esteban Abot, Jo Banania, Fouzia Farooq, Shannon McGrath, Bjoern Peters, Alessandro Sette, Lorraine Soisson, Carter Diggs, Denise L Doolan, Cindy Tamminga, Eileen Villasante, Michael R Hollingdale, Thomas L Richie Malaria Journal 2013, 12:185 (5 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This study identified new class I epitopes restricted by six HLA supertypes on the CSP, one of the leading vaccine candidate antigens, suggesting that an adenovirus-vectored CSP vaccine would be immunogenic and potentially protective in genetically diverse populations.
		Research Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum Fabiana M Jordão, Heloisa B Gabriel, João MP Alves, Claudia B Angeli, Thaís D Bifano, Ardala Breda, Mauro F de Azevedo, Luiz A Basso, Gerhard Wunderlich, Emilia A Kimura, Alejandro M Katzin Malaria Journal 2013, 12:184 (4 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The paper presents the cloning, expression, purification, biochemical characterization of the FPPS from Plasmodium falciparum. The authors show that this enzyme has two activities that result in the production of farnesyl diphosphate/geranylgeranyl diphosphate, a key branch point of the isoprenoid synthesis and, hence, playing a central role in the regulation of a number of essential functions in Plasmodium parasites.
		Research Gestational age assessment in malaria pregnancy cohorts: a prospective ultrasound demonstration project in Malawi Blair J Wylie, Linda Kalilani-Phiri, Mwayi Madanitsa, Gladys Membe, Osward Nyirenda, Patricia Mawindo, Redson Kuyenda, Albert Malenga, Abbey Masonbrink, Bonus Makanani, Phillip Thesing, Miriam K Laufer Malaria Journal 2013, 12:183 (4 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Important methodology paper which adds to the body of knowledge on gestational age dating in resource poor settings and particularly in relation to malaria. The goal was to achieve, by the use of ultrasound, a more accurate description of rates of prematurity and rates of growth restriction ¿ each dependent on accurate dating.
		Research Cloning, expression, and immunocharacterization of surface protein containing an altered thrombospondin repeat domain (SPATR) from Plasmodium knowlesi Vanitha Palaeya, Yee Ling Lau, Rohela Mahmud, Yeng Chen, Mun Yik Fong Malaria Journal 2013, 12:182 (4 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The findings from this paper may facilitate the development of cost effective kits for the better diagnosis of knowlesi infections in humans.
		Research pLDH level of clinically isolated Plasmodium vivax and detection limit of pLDH based malaria rapid diagnostic test Jin Woo Jang, Chi Hyun Cho, Eun Taek Han, Seong Soo An, Chae Seung Lim Malaria Journal 2013, 12:181 (3 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary pLDH-detecting RDTs are widely used for diagnosing non-P. falciparum human Plasmodium infections and their performance vary. Factors such as genetic diversity of pLDH and antigen levels of pLDH could contribute to variations in sensitivities of pLDH RDTs. THis study adds to our knowledge on such issues.
		Research Natural Plasmodium infection in monkeys in the state of Rondônia (Brazilian Western Amazon) Maisa S Araújo, Mariluce R Messias, Marivaldo R Figueiró, Luiz Herman S Gil, Christian M Probst, Newton M Vidal, Tony H Katsuragawa, Marco A Krieger, Luiz H Pereira da Silva, Luiz S Ozaki Malaria Journal 2013, 12:180 (3 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Describes a PCR-based survey of Plasmodium infections in monkeys in Rondonia. Nearly 200 monkey blood samples were screened with 18S rRNA based primers designed for this study, and some individual samples were followed up with more detailed amplification and sequencing. The data adds information to our understanding of simian Plasmodium in the Amazon.
		Research Both infected and uninfected mosquitoes are attracted toward malaria infected birds Stéphane Cornet, Antoine Nicot, Ana Rivero, Sylvain Gandon Malaria Journal 2013, 12:179 (3 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Feeding behaviour of Plasmodium relictum-infected and non-infected Culex pipiens mosquitoes. The authors developed a convenient model for such research.
		Research Hyperendemic malaria transmission in areas of occupation-related travel in the Peruvian Amazon Benjamin S Parker, Maribel Paredes Olortegui, Pablo Peñataro Yori, Karin Escobedo, David Florin, Silvia Rengifo Pinedo, Roldan Cardenas Greffa, Luis Capcha Vega, Hugo Rodriguez Ferrucci, William K Pan, Cesar Banda Chavez, Joseph M Vinetz, Margaret Kosek Malaria Journal 2013, 12:178 (31 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The article identifies the primary vector and potential for transmission along a riverine system, as well as exportation of malaria to hypoendemic regions of the Iquitos area. The data confirm the focal nature of malaria transmission in the region and describe some of the factors that account for this pattern.
		Case report Activation of minority-variant Plasmodium vivax hypnozoites following artesunate + amodiaquine treatment in a 23-year old man with relapsing malaria in Antananarivo, Madagascar Voahangy Andrianaranjaka, Jessica T Lin, Christopher Golden, Jonathan J Juliano, Milijaona Randrianarivelojosia Malaria Journal 2013, 12:177 (31 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In endemic areas, Plasmodium vivax relapses are difficult to distinguish from new infections. Parasite DNA extracted from blood samples was analysed to compare the genotypic profile of the P. vivax isolates collected from the patient during each of the three malaria episodes.
		Research Vivax malaria and bacteraemia: a prospective study in Kolkata, India Sujit Kumar Bhattacharya, Dipika Sur, Shanta Dutta, Suman Kanungo, R Leon Ochiai, Deok Ryun Kim, Nicholas M Anstey, Lorenz von Seidlein, Jacqueline Deen Malaria Journal 2013, 12:176 (31 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Data from a prospective fever surveillance study in Kolkata were reanalysed for the potential association between vivax malaria and bacteraemia.This negative study required an enormous amount of work that is unlikely to be repeated without the resources of a major vaccine trial.
		Research Health care seeking patterns and determinants of out-of-pocket expenditure for Malaria for the children under-five in Uganda Juliet Nabyonga Orem, Frederick Mugisha, Albert Okui, Laurent Musango, Joses Kirigia Malaria Journal 2013, 12:175 (31 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This study looked at the patterns of treatment-seeking behaviour for children under five with malaria, and examined the relationship between out-of-pocket expenditure on malaria treatment and source of treatment, place of residence, education and wealth characteristics of Uganda households. The authors recommend that plans to improve malaria treatment should explicitly incorporate efforts to protect households from high out-of-pocket expenditures.
		Research Comparison of bioavailability between the most available generic tablet formulation containing artemether and lumefantrine on the Tanzanian market and the innovator’s product Omary MS Minzi, Ignace A Marealle, Seif Shekalaghe, Omar Juma, Eliford Ngaimisi, Mwajuma Chemba, Mastidia Rutaihwa, Salim Abdulla, Philip Sasi Malaria Journal 2013, 12:174 (30 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The study compared bioavailability of one generic tablet formulation with the original product. Both were fixed dose combination tablet formulations containing artemether and lumefantrine, and the study showed that the generic product was likely to produce a similar therapeutic response as the original combination.
		Research Triangular test design to evaluate tinidazole in the prevention of Plasmodium vivax relapse Louis Macareo, Khin Lwin, Phaik Cheah, Prayoon Yuentrakul, R Miller, Francois Nosten Malaria Journal 2013, 12:173 (29 May 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The modified triangular test sequential analysis technique can be beneficial in limiting investment, enrollment and volunteer exposure in a clinical trial of a candidate drug that turns out to ineffective for the indication in the study.
		Research Submicroscopic Plasmodium falciparum malaria and low birth weight in an area of unstable malaria transmission in Central Sudan Amal H Mohammed, Magdi M Salih, Elhassan M Elhassan, Ahmed A Mohmmed, Salah E Elzaki, Badria B El-Sayed, Ishag Adam Malaria Journal 2013, 12:172 (28 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An interesting and difficult-to-obtain data set from a case-control study of the relationship between Plasmodium falciparum infection during pregnancy and low birth weight in the delivered babies. This is important in view of the current controversy regarding the importance of submicroscopic infections on birth weight. This is a relevant issue as countries consider changing antenatal care policies from intermittent preventive treatment of malaria in pregnancy to intermittent screening and treatment of malaria in pregnancy.
		Research G6PD deficiency in Plasmodium falciparum and Plasmodium vivax malaria-infected Cambodian patients Nimol Khim, Christophe Benedet, Saorin Kim, Sim Kheng, Sovannaroth Siv, Rithea Leang, Soley Lek, Sinuon Muth, Nguon Chea, Char Chuor, Socheat Duong, Alexandra Kerleguer, Pety Tor, Pheaktra Chim, Lydie Canier, Benoit Witkowski, Walter RJ Taylor, Didier Ménard Malaria Journal 2013, 12:171 (28 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Reports the results of survey of G6PD deficiency, anaemia and haemoglobinopathies in malaria patients in Cambodia. The issue of G6PD deficiency is highly relevant in countries such as Cambodia, faced with the need to use primaquine to effectively deal with vivax malaria and to reduce transmission of falciparum, but where anxiety among doctors and nurses of primaquine-induced severe haemolysis in patients with G6PD deficiency is widespread.
		Research Community knowledge and perceptions about indoor residual spraying for malaria prevention in Soroti district, Uganda: a cross-sectional study Michael Ediau, Juliet N Babirye, Nazarius M Tumwesigye, Joseph KB Matovu, Simba Machingaidze, Olico Okui, Rhoda K Wanyenze, Peter Waiswa Malaria Journal 2013, 12:170 (27 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Knowledge about IRS is inadequate and negative perceptions about its use are prominent especially among the rural and less educated individuals. To ensure householders¿ cooperation and participation in the IRS programme, adequate community mobilization and sensitization is needed prior to use of IRS for effective malaria control.
		Research Epidemiology of Plasmodium infections in Flores Island, Indonesia using real-time PCR Maria MM Kaisar, Taniawati Supali, Aprilianto E Wiria, Firdaus Hamid, Linda J Wammes, Erliyani Sartono, Adrian JF Luty, Eric AT Brienen, Maria Yazdanbakhsh, Lisette van Lieshout, Jaco J Verweij Malaria Journal 2013, 12:169 (24 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This study provides a very useful addition to the growing body of evidence on the importance of asymptomatic carriers of malaria in hypo- to meso-endemic settings.
		Review Malaria in South America: a drug discovery perspective Luiza R Cruz, Thomas Spangenberg, Marcus VG Lacerda, Timothy NC Wells Malaria Journal 2013, 12:168 (24 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A summary of current malaria research from the viewpoint of focusing on work affecting South America and carried out by workers in South American countries. This calls to attention the many contributions from that continent and the section presenting natural products work is the most complete in the literature.
		Research Routine parallel diagnosis of malaria using microscopy and the malaria rapid diagnostic test SD 05FK60: the experience of Médecins Sans Frontières in Myanmar Cara S Kosack, Wint Naing, Erwan Piriou, Leslie Shanks Malaria Journal 2013, 12:167 (21 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary In field conditions in Myanmar, the malaria RDT described performed consistent with other reports. The test detected malaria caused by P. vivax/P. malariae to a lesser extent than P. falciparum infection.
		Research Polymorphism of the parasite lactate dehydrogenase gene from Plasmodium vivax Korean isolates Hyun-Il Shin, Jung-Yeon Kim, Won-Ja Lee, Youngjoo Sohn, Sang-Wook Lee, Yoon-Joong Kang, Hyeong-Woo Lee Malaria Journal 2013, 12:166 (21 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Parasite lactate dehydrogenase (pLDH) is widely used in rapid diagnostic tests: the genetic variation of Korean isolates was analysed. The fact that the pLDH genes of 19 isolates of P. vivax were identical, except for one for SNP at nucleotide 456 indicates that this gene is relatively stable.
		Research Characterizing PvARP, a novel Plasmodium vivax antigen Darwin A Moreno-Pérez, Ambar Saldarriaga, Manuel A Patarroyo Malaria Journal 2013, 12:165 (20 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Characterization of the P. vivax asparagine-rich protein (PvARP) by a straightforward approach using molecular biology and immunochemistry assays. The reactivity with sera from individuals infected with P. vivax indicates that it contains epitopes that are target of antibody response generated during natural exposure.
		Research A potential threat to malaria elimination: extensive deltamethrin and DDT resistance to Anopheles sinensis from the malaria-endemic areas in China Duo-quan Wang, Zhi-gui Xia, Shui-sen Zhou, Xiao-nong Zhou, Ru-bo Wang, Qing-feng Zhang Malaria Journal 2013, 12:164 (17 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A paper that highlights the problem of insecticide resistance in malaria vectors in China.
		Commentary Fulani show decreased susceptibility to Plasmodium falciparum infection versus Mossi: data from a community-wide screening and treatment of asymptomatic carriers in Burkina Faso Alfred B Tiono, Sodiomon B Sirima, Kamal Hamed Malaria Journal 2013, 12:163 (16 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This study confirmed that, in the same environment, individuals belonging to the Fulani ethnic group have a lower susceptibility to Plasmodium falciparum infection than Mossi individuals.
		Research Evaluation of the 2011 long-lasting, insecticide-treated net distribution for universal coverage in Togo Elizabeth R Stevens, Abigail Aldridge, Yawo Degbey, Akou Pignandi, Monique A Dorkenoo, Justin Hugelen-Padin Malaria Journal 2013, 12:162 (16 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Description of a largely successful campaign to distribute LLINs to all age-groups across Togo. The authors conclude that even though the campaign was unable to achieve the universal coverage target, it rapidly increased overall coverage and was far better than previous campaigns that targeted only pregnant women and under fives.
		Research Providing open access data online to advance malaria research and control Catherine L Moyes, William H Temperley, Andrew J Henry, Clara R Burgert, Simon I Hay Malaria Journal 2013, 12:161 (16 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A description of the construction of the Malaria Atlas Project's online data portal. It usefully details the data and associated products that the MAP team has made accessible to the global malaria community.
		Research A member of the Plasmodium falciparum PHIST family binds to the erythrocyte cytoskeleton component band 4.1 Lindsay A Parish, Deborah W Mai, Matthew L Jones, Erika L Kitson, Julian C Rayner Malaria Journal 2013, 12:160 (11 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Identification of a novel interaction between the erythrocyte Band 4.1 protein and a P. falciparum component from the PHIST family of proteins. The paper should be of interest to groups working on the parasite "exportome".
		Research Over-diagnosis of malaria by microscopy in the Kilombero Valley, Southern Tanzania: an evaluation of the utility and cost-effectiveness of rapid diagnostic tests Kelly Harchut, Claire Standley, Andrew Dobson, Belia Klaassen, Clotilde Rambaud-Althaus, Fabrice Althaus, Katarzyna Nowak Malaria Journal 2013, 12:159 (10 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Presumptive treatment used to be recommended by WHO, on the assumption that it is safer to treat non-malarial patients with anti-malarials than missing a true case of malaria. With a reduced incidence of malaria, a much increased cost of treatment and the realization of the risks of not identifying the true cause of febrile illness, there is now greater emphasis on accurate biological diagnosis. This study shows the advantages of using RDTs compared to poor quality microscopy.