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		Research Effective treatment with a tetrandrine/chloroquine combination for chloroquine-resistant falciparum malaria in Aotus monkeys Zuguang Ye, Knox Van Dyke, Richard N Rossan Malaria Journal 2013, 12:117 (2 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This appears to be the first in vivo use of the combination of tetrandrine and chloroquine for the treatment of chloroquine resistant Plasmodium falciparum. It is preliminary, but suggests that the combination may be useful.
		Methodology Discovery-2: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria Phelelani T Mpangase, Michal J Szolkiewicz, Misha le Grange, Jeanré H Smit, Pieter B Burger, Fourie Joubert Malaria Journal 2013, 12:116 (28 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary An update of the Discovery database. This database proposes to facilitate the selection of putative drug targets by mining information with specific emphasis on drug targets, structure and protein-ligand interactions.
		Research Manual blood exchange transfusion does not significantly contribute to parasite clearance in artesunate-treated individuals with imported severe Plasmodium falciparum malaria Annemarie R Kreeftmeijer-Vegter, Mariana de Mendonça Melo, Peter J de Vries, Rob Koelewijn, Jaap J van Hellemond, Perry JJ van Genderen Malaria Journal 2013, 12:115 (27 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary It is important to obtain further data on quinine and artesunate in the treatment of imported severe malaria in non-immune travellers. It is also relevant to clarify the role of exchange transfusions, which is not a routine treatment in most tropical medicine clinics.
		Research Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea Cristina Mendes, Patrícia Salgueiro, Vicenta Gonzalez, Pedro Berzosa, Agustin Benito, Virgílio E do Rosário, Bruno de Sousa, Jorge Cano, Ana Paula Arez Malaria Journal 2013, 12:114 (27 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Describes genetic relationships among malaria parasites isolated from both human and mosquito populations. This is a very interesting body of work that has generated a huge amount of data. The uniqueness of the study is that the authors were able to genotype malaria parasites from the host and the vector and develop a thorough genetic analysis.
		Case study Misclassification of Plasmodium infections by conventional microscopy and the impact of remedial training on the proficiency of laboratory technicians in species identification Peter Obare, Bernhards Ogutu, Mohammed Adams, James Sande Odera, Ken Lilley, David Dosoo, Christine Adhiambo, Seth Owusu-Agyei, Fred Binka, Elizabeth Wanja, Jacob Johnson Malaria Journal 2013, 12:113 (27 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The major problem related to microscopy for malaria diagnosis is the quality of the training of microscopists. This work explores misclassifications of four Plasmodium species by conventional microscopy in relation to the proficiency of microscopists and morphological characteristics of the parasites on Giemsa-stained blood films.
		Review Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report Lorenz von Seidlein, Sarah Auburn, Fe Espino, Dennis Shanks, Qin Cheng, James McCarthy, Kevin Baird, Catherine Moyes, Rosalind Howes, Didier Ménard, Germana Bancone, Ari Winasti-Satyahraha, Lasse S Vestergaard, Justin Green, Gonzalo Domingo, Shunmay Yeung, Ric Price Malaria Journal 2013, 12:112 (27 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A review based on the conclusions of an important meeting looking at the knowledge gaps in G6PD deficiency with regards to the safe implementation of 8 - aminoquinolines.
		Case report Hypokalaemic paralysis in an adult case of Plasmodium vivax malaria Sagar Sinha, Ananya Mukherji, Santwana Chandrakar Malaria Journal 2013, 12:111 (26 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Case report of a rarely described complication of P. vivax infection. The appropriate description of this case and discussion of the possible pathophysiological mechanisms can be of important use for clinicians working in endemic areas and direct future research.
		Research Anti-malarial IgG subclasses pattern and FcγRIIa (CD32) polymorphism among pregnancy-associated malaria in semi-immune Saudi women Amre Nasr, Osama Hamid, Abdelhamid Al-Ghamdi, Gamal Allam Malaria Journal 2013, 12:110 (21 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A study to examine the association between specific anti-malarial IgG antibodies against AMA-1 in pregnant Saudi women living in the southern part of Saudi Arabia.
		Research Effect of blood meal digestion and DNA extraction protocol on the success of blood meal source determination in the malaria vector Anopheles atroparvus Josué Martínez-de la Puente, Santiago Ruiz, Ramón Soriguer, Jordi Figuerola Malaria Journal 2013, 12:109 (21 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Evaluation of two DNA extraction techniques and the effect of blood meal digestion in the context of a mosquito blood meal analysis using PCR-sequencing. The authors found that Qiagen DNA extraction kit was superior to the HotSHOT technique and the mosquitoes with a fresher blood meal produced higher percent success with the blood meal analysis result.
		Research A high-resolution geospatial surveillance-response system for malaria elimination in Solomon Islands and Vanuatu Gerard C Kelly, Erick Hale, Wesley Donald, Willie Batarii, Hugo Bugoro, Johnny Nausien, John Smale, Kevin Palmer, Albino Bobogare, George Taleo, Andrew Vallely, Marcel Tanner, Lasse S Vestergaard, Archie CA Clements Malaria Journal 2013, 12:108 (21 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Cited on BioMed Central \| Editor’s summary Development of a spatial decision support systems to support malaria elimination efforts in the Pacific.
		Research Plasmodium falciparum susceptibility to anti-malarial drugs in Dakar, Senegal, in 2010: an ex vivo and drug resistance molecular markers study Bécaye Fall, Aurélie Pascual, Fatoumata D Sarr, Nathalie Wurtz, Vincent Richard, Eric Baret, Yaya Diémé, Sébastien Briolant, Raymond Bercion, Boubacar Wade, Adama Tall, Bruno Pradines Malaria Journal 2013, 12:107 (20 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Results of the genetic analyses of several genetic markers of drug resistance in Plasmodium falciparum isolates from Senegal after the official introduction of ACT in the country in 2006. In parallel, the authors also evaluated the ex vivo response of the isolates to several anti-malarials.
		Research Rapid diagnostic tests for molecular surveillance of Plasmodium falciparum malaria -assessment of DNA extraction methods and field applicability Ulrika Morris, Berit Aydin-Schmidt, Delér Shakely, Andreas Mårtensson, Louise Jörnhagen, Abdullah S Ali, Mwinyi I Msellem, Max Petzold, José P Gil, Pedro E Ferreira, Anders Björkman Malaria Journal 2013, 12:106 (19 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The paper compares different methods for extracting genomic DNA from used malaria RDTs for subsequent molecular analysis. Overall, the study provides useful information for those undertaking epidemiological studies and carrying out surveillance of anti-malarial resistance.
		Research Systemic release of high mobility group box 1 (HMGB1) protein is associated with severe and fatal Plasmodium falciparum malaria Sarah J Higgins, Katharine Xing, Hani Kim, Dylan C Kain, Feng Wang, Aggrey Dhabangi, Charles Musoke, Christine M Cserti-Gazdewich, Kevin J Tracey, Kevin C Kain, W Conrad Liles Malaria Journal 2013, 12:105 (19 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This is a valuable study based on the results obtained for levels of HMGB1 in a highly defined patient population. These data suggest that elevated HMGB1 is an informative prognostic marker of disease severity.
		Research *T1BT structural study of an anti-plasmodial peptide through NMR and molecular dynamics** Elena Topchiy, Geoffrey S Armstrong, Katherine I Boswell, Ginka S Buchner, Jan Kubelka, Teresa E Lehmann Malaria Journal 2013, 12:104 (18 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Describes the use of NMR, CD spectra and molecular modelling to explore the structure of a malaria peptide T1BT* (forms of the CS protein repeat region), which has been tested in preclinical studies in mice and Phase I vaccination studies in volunteers.
		Research Temporal trends of molecular markers associated with artemether-lumefantrine tolerance/resistance in Bagamoyo district, Tanzania Maja Malmberg, Billy Ngasala, Pedro E Ferreira, Erik Larsson, Irina Jovel, Angelica Hjalmarsson, Max Petzold, Zul Premji, José P Gil, Anders Björkman, Andreas Mårtensson Malaria Journal 2013, 12:103 (18 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The authors explore the temporal trends of molecular markers of anti-malarial drug resistance (Pfmdr and Pfcrt) in a Tanzanian setting from 2004 to 2011 and suggest that the significant changes observed are associated with both the lack of chloroquine pressure and the wide-scale use of ACT. The results confirm other studies in the region.
		Research Health impact and cost-effectiveness of a private sector bed net distribution: experimental evidence from Zambia Richard Sedlmayr, Günther Fink, John M Miller, Duncan Earle, Richard W Steketee Malaria Journal 2013, 12:102 (18 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Relatively few programmes have attempted to actively engage the private sector in national malaria control efforts. This paper evaluates the health impact of a large-scale distribution of insecticide-treated nets conducted in partnership with a Zambian agribusiness, and its cost-effectiveness from the perspective of the National Malaria Control Programme
		Research Predictive value of lymphocytopenia and the neutrophil-lymphocyte count ratio for severe imported malaria Marlies E van Wolfswinkel, Klaske Vliegenthart-Jongbloed, Mariana de Mendonça Melo, Peter C Wever, Matthew B McCall, Rob Koelewijn, Jaap J van Hellemond, Perry J van Genderen Malaria Journal 2013, 12:101 (18 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A careful retrospective survey of neutrophil and lymphocyte counts in severe imported malaria compared to patients from the same centre who had uncomplicated malaria.
		Research Immunoproteomic analysis of Plasmodium falciparum antigens using sera from patients with clinical history of imported malaria Rita M Costa, Fátima Nogueira, Karina P de Sousa, Rui Vitorino, Marcelo S Silva Malaria Journal 2013, 12:100 (18 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A study conducted in 227 individuals with imported malaria compared to controls, had for objective to evaluate the serological reactivity of sera and identify major immunogenic proteins using patterns on immunoblots.
		Research Netting barriers to prevent mosquito entry into houses in southern Mozambique: a pilot study Ayubo Kampango, Mauro Bragança, Bruno de Sousa, J Derek Charlwood Malaria Journal 2013, 12:99 (16 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Original research about a useful piece of technology suitable for screening houses made from local materials that are generally difficult to screen. This work has potential for application for other vector borne diseases transmitted outside of sleeping hours, and provides a useful way to recycle old bed nets to reduce indoor mosquito densities.
		Research Malaria epidemiology in Lihir Island, Papua New Guinea Oriol Mitjà, Raymond Paru, Billy Selve, Inoni Betuela, Peter Siba, Elisa De Lazzari, Quique Bassat Malaria Journal 2013, 12:98 (15 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Report on malaria epidemiology on Lihir Island, PNG, before and after a malaria control intervention carried out by the local gold mining company. An integrated vector control intervention was put in place in the villages within the mining area only.
		Research Sex-specific induction of CYP6 cytochrome P450 genes in cadmium and lead tolerant Anopheles gambiae Fauzia K Musasia, Alfred O Isaac, Daniel K Masiga, Irene A Omedo, Ramadhan Mwakubambanya, Richard Ochieng, Paul O Mireji Malaria Journal 2013, 12:97 (15 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Analysis of gene transcription levels on three cytochrome P450s in three strains of Anopheles gambiae. The first strain was maintained without any selection pressure, while the second was selected for lead tolerance and the third strain for cadmium tolerance.These findings suggest that tolerance to cadmium or lead can influence the metabolism of pyrethroids in the mosquito in a sex-specific manner, with potential implications in mosquito vector control operations.
		Research Prevalence of antifolate resistance mutations in Plasmodium falciparum isolates in Afghanistan Ghulam R Awab, Sasithon Pukrittayakamee, Natsuda Jamornthanyawat, Fazel Yamin, Arjen M Dondorp, Nicholas PJ Day, Nicholas J White, Charles J Woodrow, Mallika Imwong Malaria Journal 2013, 12:96 (15 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This study indicates that shortly after the adoption of AS+SP as first-line treatment in Afghanistan, most parasites had a double mutation haplotype in dhfr, and a small number of isolates from eastern Afghanistan harboured a triple mutation haplotype in dhps. These results are clearly concerning since they suggest a higher degree of SP resistance than previously detected.
		Research Barriers to community case management of malaria in Saraya, Senegal: training, and supply-chains Demetri A Blanas, Youssoupha Ndiaye, Kim Nichols, Andrew Jensen, Ammar Siddiqui, Nils Hennig Malaria Journal 2013, 12:95 (14 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Paper provides useful, pragmatic information on barriers to success of one community case management of malaria programme in Senegal. Findings from this "case report" from a single location are likely generalizable to other sub-Saharan African contexts.
		Research Dose–response tests and semi-field evaluation of lethal and sub-lethal effects of slow release pyriproxyfen granules (Sumilarv^®0.5G) for the control of the malaria vectors Anopheles gambiae sensu lato Oscar Mbare, Steven W Lindsay, Ulrike Fillinger Malaria Journal 2013, 12:94 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Research has shown that larviciding can be an effective tool for integrated malaria vector control, but the uptake of this intervention has been hampered by the need to re-apply larvicides frequently. There is a need to explore persistent, environmentally friendly larvicides for malaria vector control and the efficacy of a 0.5% pyriproxyfen granule was assessed here for the control of major malaria vectors in sub-Saharan Africa.
		Research Imported malaria in Finland 2003-2011: prospective nationwide data with rechecked background information Heli Siikamäki, Pia Kivelä, Outi Lyytikäinen, Anu Kantele Malaria Journal 2013, 12:93 (14 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A prospective nationwide survey of imported malaria in Finland, where compliance data was double-checked.

	All
		Research Effective treatment with a tetrandrine/chloroquine combination for chloroquine-resistant falciparum malaria in Aotus monkeys Zuguang Ye, Knox Van Dyke, Richard N Rossan Malaria Journal 2013, 12:117 (2 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This appears to be the first in vivo use of the combination of tetrandrine and chloroquine for the treatment of chloroquine resistant Plasmodium falciparum. It is preliminary, but suggests that the combination may be useful.
		Methodology Discovery-2: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria Phelelani T Mpangase, Michal J Szolkiewicz, Misha le Grange, Jeanré H Smit, Pieter B Burger, Fourie Joubert Malaria Journal 2013, 12:116 (28 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary An update of the Discovery database. This database proposes to facilitate the selection of putative drug targets by mining information with specific emphasis on drug targets, structure and protein-ligand interactions.
		Research Manual blood exchange transfusion does not significantly contribute to parasite clearance in artesunate-treated individuals with imported severe Plasmodium falciparum malaria Annemarie R Kreeftmeijer-Vegter, Mariana de Mendonça Melo, Peter J de Vries, Rob Koelewijn, Jaap J van Hellemond, Perry JJ van Genderen Malaria Journal 2013, 12:115 (27 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary It is important to obtain further data on quinine and artesunate in the treatment of imported severe malaria in non-immune travellers. It is also relevant to clarify the role of exchange transfusions, which is not a routine treatment in most tropical medicine clinics.
		Research Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea Cristina Mendes, Patrícia Salgueiro, Vicenta Gonzalez, Pedro Berzosa, Agustin Benito, Virgílio E do Rosário, Bruno de Sousa, Jorge Cano, Ana Paula Arez Malaria Journal 2013, 12:114 (27 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Describes genetic relationships among malaria parasites isolated from both human and mosquito populations. This is a very interesting body of work that has generated a huge amount of data. The uniqueness of the study is that the authors were able to genotype malaria parasites from the host and the vector and develop a thorough genetic analysis.
		Case study Misclassification of Plasmodium infections by conventional microscopy and the impact of remedial training on the proficiency of laboratory technicians in species identification Peter Obare, Bernhards Ogutu, Mohammed Adams, James Sande Odera, Ken Lilley, David Dosoo, Christine Adhiambo, Seth Owusu-Agyei, Fred Binka, Elizabeth Wanja, Jacob Johnson Malaria Journal 2013, 12:113 (27 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The major problem related to microscopy for malaria diagnosis is the quality of the training of microscopists. This work explores misclassifications of four Plasmodium species by conventional microscopy in relation to the proficiency of microscopists and morphological characteristics of the parasites on Giemsa-stained blood films.
		Review Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report Lorenz von Seidlein, Sarah Auburn, Fe Espino, Dennis Shanks, Qin Cheng, James McCarthy, Kevin Baird, Catherine Moyes, Rosalind Howes, Didier Ménard, Germana Bancone, Ari Winasti-Satyahraha, Lasse S Vestergaard, Justin Green, Gonzalo Domingo, Shunmay Yeung, Ric Price Malaria Journal 2013, 12:112 (27 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A review based on the conclusions of an important meeting looking at the knowledge gaps in G6PD deficiency with regards to the safe implementation of 8 - aminoquinolines.
		Case report Hypokalaemic paralysis in an adult case of Plasmodium vivax malaria Sagar Sinha, Ananya Mukherji, Santwana Chandrakar Malaria Journal 2013, 12:111 (26 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Case report of a rarely described complication of P. vivax infection. The appropriate description of this case and discussion of the possible pathophysiological mechanisms can be of important use for clinicians working in endemic areas and direct future research.
		Research Anti-malarial IgG subclasses pattern and FcγRIIa (CD32) polymorphism among pregnancy-associated malaria in semi-immune Saudi women Amre Nasr, Osama Hamid, Abdelhamid Al-Ghamdi, Gamal Allam Malaria Journal 2013, 12:110 (21 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A study to examine the association between specific anti-malarial IgG antibodies against AMA-1 in pregnant Saudi women living in the southern part of Saudi Arabia.
		Research Effect of blood meal digestion and DNA extraction protocol on the success of blood meal source determination in the malaria vector Anopheles atroparvus Josué Martínez-de la Puente, Santiago Ruiz, Ramón Soriguer, Jordi Figuerola Malaria Journal 2013, 12:109 (21 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Evaluation of two DNA extraction techniques and the effect of blood meal digestion in the context of a mosquito blood meal analysis using PCR-sequencing. The authors found that Qiagen DNA extraction kit was superior to the HotSHOT technique and the mosquitoes with a fresher blood meal produced higher percent success with the blood meal analysis result.
		Research A high-resolution geospatial surveillance-response system for malaria elimination in Solomon Islands and Vanuatu Gerard C Kelly, Erick Hale, Wesley Donald, Willie Batarii, Hugo Bugoro, Johnny Nausien, John Smale, Kevin Palmer, Albino Bobogare, George Taleo, Andrew Vallely, Marcel Tanner, Lasse S Vestergaard, Archie CA Clements Malaria Journal 2013, 12:108 (21 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Cited on BioMed Central \| Editor’s summary Development of a spatial decision support systems to support malaria elimination efforts in the Pacific.
		Research Plasmodium falciparum susceptibility to anti-malarial drugs in Dakar, Senegal, in 2010: an ex vivo and drug resistance molecular markers study Bécaye Fall, Aurélie Pascual, Fatoumata D Sarr, Nathalie Wurtz, Vincent Richard, Eric Baret, Yaya Diémé, Sébastien Briolant, Raymond Bercion, Boubacar Wade, Adama Tall, Bruno Pradines Malaria Journal 2013, 12:107 (20 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Results of the genetic analyses of several genetic markers of drug resistance in Plasmodium falciparum isolates from Senegal after the official introduction of ACT in the country in 2006. In parallel, the authors also evaluated the ex vivo response of the isolates to several anti-malarials.
		Research Rapid diagnostic tests for molecular surveillance of Plasmodium falciparum malaria -assessment of DNA extraction methods and field applicability Ulrika Morris, Berit Aydin-Schmidt, Delér Shakely, Andreas Mårtensson, Louise Jörnhagen, Abdullah S Ali, Mwinyi I Msellem, Max Petzold, José P Gil, Pedro E Ferreira, Anders Björkman Malaria Journal 2013, 12:106 (19 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The paper compares different methods for extracting genomic DNA from used malaria RDTs for subsequent molecular analysis. Overall, the study provides useful information for those undertaking epidemiological studies and carrying out surveillance of anti-malarial resistance.
		Research Systemic release of high mobility group box 1 (HMGB1) protein is associated with severe and fatal Plasmodium falciparum malaria Sarah J Higgins, Katharine Xing, Hani Kim, Dylan C Kain, Feng Wang, Aggrey Dhabangi, Charles Musoke, Christine M Cserti-Gazdewich, Kevin J Tracey, Kevin C Kain, W Conrad Liles Malaria Journal 2013, 12:105 (19 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This is a valuable study based on the results obtained for levels of HMGB1 in a highly defined patient population. These data suggest that elevated HMGB1 is an informative prognostic marker of disease severity.
		Research *T1BT structural study of an anti-plasmodial peptide through NMR and molecular dynamics** Elena Topchiy, Geoffrey S Armstrong, Katherine I Boswell, Ginka S Buchner, Jan Kubelka, Teresa E Lehmann Malaria Journal 2013, 12:104 (18 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Describes the use of NMR, CD spectra and molecular modelling to explore the structure of a malaria peptide T1BT* (forms of the CS protein repeat region), which has been tested in preclinical studies in mice and Phase I vaccination studies in volunteers.
		Research Temporal trends of molecular markers associated with artemether-lumefantrine tolerance/resistance in Bagamoyo district, Tanzania Maja Malmberg, Billy Ngasala, Pedro E Ferreira, Erik Larsson, Irina Jovel, Angelica Hjalmarsson, Max Petzold, Zul Premji, José P Gil, Anders Björkman, Andreas Mårtensson Malaria Journal 2013, 12:103 (18 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The authors explore the temporal trends of molecular markers of anti-malarial drug resistance (Pfmdr and Pfcrt) in a Tanzanian setting from 2004 to 2011 and suggest that the significant changes observed are associated with both the lack of chloroquine pressure and the wide-scale use of ACT. The results confirm other studies in the region.
		Research Health impact and cost-effectiveness of a private sector bed net distribution: experimental evidence from Zambia Richard Sedlmayr, Günther Fink, John M Miller, Duncan Earle, Richard W Steketee Malaria Journal 2013, 12:102 (18 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Relatively few programmes have attempted to actively engage the private sector in national malaria control efforts. This paper evaluates the health impact of a large-scale distribution of insecticide-treated nets conducted in partnership with a Zambian agribusiness, and its cost-effectiveness from the perspective of the National Malaria Control Programme
		Research Predictive value of lymphocytopenia and the neutrophil-lymphocyte count ratio for severe imported malaria Marlies E van Wolfswinkel, Klaske Vliegenthart-Jongbloed, Mariana de Mendonça Melo, Peter C Wever, Matthew B McCall, Rob Koelewijn, Jaap J van Hellemond, Perry J van Genderen Malaria Journal 2013, 12:101 (18 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A careful retrospective survey of neutrophil and lymphocyte counts in severe imported malaria compared to patients from the same centre who had uncomplicated malaria.
		Research Immunoproteomic analysis of Plasmodium falciparum antigens using sera from patients with clinical history of imported malaria Rita M Costa, Fátima Nogueira, Karina P de Sousa, Rui Vitorino, Marcelo S Silva Malaria Journal 2013, 12:100 (18 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A study conducted in 227 individuals with imported malaria compared to controls, had for objective to evaluate the serological reactivity of sera and identify major immunogenic proteins using patterns on immunoblots.
		Research Netting barriers to prevent mosquito entry into houses in southern Mozambique: a pilot study Ayubo Kampango, Mauro Bragança, Bruno de Sousa, J Derek Charlwood Malaria Journal 2013, 12:99 (16 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Original research about a useful piece of technology suitable for screening houses made from local materials that are generally difficult to screen. This work has potential for application for other vector borne diseases transmitted outside of sleeping hours, and provides a useful way to recycle old bed nets to reduce indoor mosquito densities.
		Research Malaria epidemiology in Lihir Island, Papua New Guinea Oriol Mitjà, Raymond Paru, Billy Selve, Inoni Betuela, Peter Siba, Elisa De Lazzari, Quique Bassat Malaria Journal 2013, 12:98 (15 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Report on malaria epidemiology on Lihir Island, PNG, before and after a malaria control intervention carried out by the local gold mining company. An integrated vector control intervention was put in place in the villages within the mining area only.
		Research Sex-specific induction of CYP6 cytochrome P450 genes in cadmium and lead tolerant Anopheles gambiae Fauzia K Musasia, Alfred O Isaac, Daniel K Masiga, Irene A Omedo, Ramadhan Mwakubambanya, Richard Ochieng, Paul O Mireji Malaria Journal 2013, 12:97 (15 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Analysis of gene transcription levels on three cytochrome P450s in three strains of Anopheles gambiae. The first strain was maintained without any selection pressure, while the second was selected for lead tolerance and the third strain for cadmium tolerance.These findings suggest that tolerance to cadmium or lead can influence the metabolism of pyrethroids in the mosquito in a sex-specific manner, with potential implications in mosquito vector control operations.
		Research Prevalence of antifolate resistance mutations in Plasmodium falciparum isolates in Afghanistan Ghulam R Awab, Sasithon Pukrittayakamee, Natsuda Jamornthanyawat, Fazel Yamin, Arjen M Dondorp, Nicholas PJ Day, Nicholas J White, Charles J Woodrow, Mallika Imwong Malaria Journal 2013, 12:96 (15 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This study indicates that shortly after the adoption of AS+SP as first-line treatment in Afghanistan, most parasites had a double mutation haplotype in dhfr, and a small number of isolates from eastern Afghanistan harboured a triple mutation haplotype in dhps. These results are clearly concerning since they suggest a higher degree of SP resistance than previously detected.
		Research Barriers to community case management of malaria in Saraya, Senegal: training, and supply-chains Demetri A Blanas, Youssoupha Ndiaye, Kim Nichols, Andrew Jensen, Ammar Siddiqui, Nils Hennig Malaria Journal 2013, 12:95 (14 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Paper provides useful, pragmatic information on barriers to success of one community case management of malaria programme in Senegal. Findings from this "case report" from a single location are likely generalizable to other sub-Saharan African contexts.
		Research Dose–response tests and semi-field evaluation of lethal and sub-lethal effects of slow release pyriproxyfen granules (Sumilarv^®0.5G) for the control of the malaria vectors Anopheles gambiae sensu lato Oscar Mbare, Steven W Lindsay, Ulrike Fillinger Malaria Journal 2013, 12:94 (14 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Research has shown that larviciding can be an effective tool for integrated malaria vector control, but the uptake of this intervention has been hampered by the need to re-apply larvicides frequently. There is a need to explore persistent, environmentally friendly larvicides for malaria vector control and the efficacy of a 0.5% pyriproxyfen granule was assessed here for the control of major malaria vectors in sub-Saharan Africa.
		Research Imported malaria in Finland 2003-2011: prospective nationwide data with rechecked background information Heli Siikamäki, Pia Kivelä, Outi Lyytikäinen, Anu Kantele Malaria Journal 2013, 12:93 (14 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary A prospective nationwide survey of imported malaria in Finland, where compliance data was double-checked.