Table 1 |
||||
|
Demographic, clinical, and laboratory characteristics of study groups |
||||
|
Characteristics |
Study groups |
|||
|
|
||||
|
SM |
UM |
p Value |
HC |
|
|
|
||||
|
Number of subjects |
50 |
39 |
25 |
|
|
Gender female/male |
20/30 |
23/16 |
NS× |
14/11 |
|
+Age (months) |
30 (9–86) |
35 (9–83.5) |
NS‡ |
31.5 (10–77) |
|
+Onset of signs and symptoms in days before admission |
3 (0–30) |
3 (0–21) |
NS |
|
|
+sMODS |
18 (13–26) |
13 (10–20) |
< 0.001 |
|
|
+Parasite count (μL-1) |
69,225 (155–900,000) |
23,910 (425–180,000) |
< 0.05 |
|
|
WBC × 103 (μL-1) |
10.5 ± 5.9 |
7.7 ± 3.1 |
< 0.05 |
8.9 ± 2.6 |
|
RBC × 106 (μl-1) |
2.9 ± 1.1 |
3.8 ± 0.6 |
< 0.001 |
4.7 ± 0.5 |
|
Mean Hb (g/dL) |
6.8 ± 2.5 |
8.7 ± 1.5 |
< 0.001 |
10.7 ± 1.0 |
|
Platelets × 103 (μl-1) |
159 ± 109 |
220 ± 132 |
< 0.005 |
381 ± 98 |
|
|
||||
|
ET-1 on admission (fmol/ml) |
0.76 ± 0.48 |
1.11 ± 0.98 |
<0.001‡ |
0.49 ± 0.31 |
|
|
||||
|
ET-1 after 24 hours (fmol/ml) |
0.72 ± 0.49 |
0.95 ± 0.71 |
NS‡ |
|
|
|
||||
|
CNP on admission (pmol/l) |
11.05 ± 6.58 |
11.49 ± 4.55 |
<0.05‡ |
14.29 ± 6.4 |
|
|
||||
|
CNP after 24 hours (pmol/l) |
11.5 ± 6.83 |
9.92 ± 3.64 |
NS‡ |
|
|
|
||||
|
Data are mean (standard deviation), unless otherwise indicated. +Median (interquartile range). Wilcoxon rank sum test was used for testing of statistical significance unless not otherwise indicated. ×Chi-Square test; ‡ANOVA. NS: not significant. SM: severe malaria; UM: uncomplicated malaria; HC healthy control; sMODS: simplified Multi-Organ-Dysfunction-Score; RBC: red blood cells; Hb: haemoglobin; WBC: white blood cells. |
||||
|
Dietmann et al. Malaria Journal 2008 7:253 doi:10.1186/1475-2875-7-253 |
||||
