Table 1 |
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Pharmacokinetics of fosmidomycin analysed by model-independent and model-dependent approach in patients with sensitive responses in Group-I and II. |
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| Pharmacokinetic Parameters |
Model-independent |
Model-dependent |
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| Group-I (n = 23) |
Group-II (n = 45) |
Group-I (n = 23) |
Group-II (n = 45) |
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|
|
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| tmax (hr) |
2.0 (1.0–4.0) |
3.0 (1.0–6.0) |
2.6 (1.0–3.8)a |
3.2 (0.8–4.3) |
| tlag (hr) |
NA |
NA |
0.3 (0.001–0.8) |
0.55 (0.001–1.6) |
| K01 (/hr) |
NA |
NA |
0.35 (0.15–3.00) |
0.56 (0.09–4.00) |
| t1/2a (hr) |
NA |
NA |
2.0 (0.2–8.0) |
1.97 (0.1–7.7) |
| Cmax (μg/ml) |
2.41 (0.91–16.23)b |
3.74(1.49–8.94) |
1.77 (0.96–2.97)c |
2.92 (1.40–6.93) |
| AUC (μg.hr/ml) |
10.63 (4.27–53.85) |
23.31 (11.42–66.13) |
13.30 (6.89–24.33)d |
26.18 (14.72–54.49) |
| K10 (/hr) |
NA |
NA |
0.37 (0.09–1.92) |
0.36 (0.08–2.00) |
| t1/2z (hr) |
3.5 (0.8–14.9)e |
4.2 (2.1–7.9) |
NA |
NA |
| t1/2e (hr) |
NA |
NA |
1.6 (0.2–5.3)f |
2.2 (0.3–8.2) |
| CL/F (l/hr) |
47.51 (16.46)g |
57.69 (9.29–132.54) |
67.62 (23.39–130.57) |
68.27 (33.03–122.31) |
| Vz/F (l) |
272.64 (20.22–702.25)h |
338.56 (131.65–895.17) |
NA |
NA |
| V/F (l) |
NA |
NA |
194.50 (34.17–855.40) |
174.11 (30.23–924.62) |
| Cmin-ss (μg/ml) |
1.37 (1.08–5.09)i |
0.80 (0.20–2.11) |
1.62 (0.66–2.69)j |
0.97 (0.20–2.25) |
| Cmax-ss (μg/ml) |
2.28 (1.34–9.43)k |
2.80 (1.18–6.52) |
2.63 (1.46–4.64)l |
3.26 (1.83–7.27) |
| Cave-ss (μg/ml) |
1.77 (0.71–8.98) |
1.94 (0.95–5.51) |
2.22(1.45–4.06) |
2.18(0.51–4.54) |
| Cmax-min-ss (μg/ml) |
0.71 (0.05–4.34)m |
2.03 (0.59–5.41) |
1.11 (0.39–2.23)n |
2.24 (0.04–5.76) |
| Fluctuation (%) |
41.9 (40.1–203.6)° |
110.0 (30.8–223.4) |
49.2 (50.8–191.5)p |
118.7 (41.2–218.5) |
|
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Data are presented as median (95% CI). NA = Not applicable a Statistically significant difference from Group-II with p = 0.009, 95%CI = 0.9 (0.2–1.5); b p = 0.029, 95%CI = 1.45(0.77–2.04); c p < 0.0001, 95%CI = 0.78(0.15–2.11); d p < 0.0001, 95%CI = 15.99(4.15–26.77); e p = 0.022, 95%CI = 0.8(0.4–6.5),;f p < 0.0001, 95%CI = 0.2(0.09–0.9); g p = 0.006, 95%CI = 14.77(6.11–122.14); h p = 0.0001, 95%CI = 76.66(33.48–48.77); i p = 0.0001, 95%CI = 0.78(0.34–2.25); j p < 0.0001, 95%CI = 0.32(0.11–1.02); k p = 0.048, 95%CI = 0.45(0.20–0.79); l p ≤ 0.0001, 95%CI = 0.98(0.45–1.45); m p = 0.033, 95%CI = 0.64(0.23–1.78); n p = 0.039, 95%CI = 0.67(0.23–1.12); ° p = 0.001, 95%CI-65.8(23.1–102.3); p p = 0.0001, 95%CI = 62.1(24.6–123.6) (Mann-Whitney U-test) |
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Ruangweerayut et al. Malaria Journal 2008 7:225 doi:10.1186/1475-2875-7-225 |
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