Table 2 |
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|
The prevalence of single nucleotide polymorphisms (SNP) at codon 51, 59 and 108 of Pfdhfr and codon 436/437 and 540 of Pfdhps in the two cross sectional surveys |
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| Pfdhfr codon |
Cross1 |
Cross2 |
P |
|||
|
|
||||||
| N |
(%) |
N |
(%) |
|||
|
|
||||||
| 51 |
N |
43 |
32.3 |
33 |
27.8 |
0.169 |
| I |
49 |
36.8 |
58 |
46.0 |
0.507 |
|
| Mixed (N/I) |
41 |
30.8 |
33 |
26.2 |
||
| 59 |
C |
16 |
12.7 |
14 |
11.0 |
0.853 |
| R |
66 |
52.4 |
69 |
54.3 |
0.828 |
|
| Mixed (C/R) |
44 |
87.3 |
44 |
34.6 |
||
| 108 |
S |
14 |
11.0 |
8 |
6.2 |
0.080 |
| N |
64 |
50.4 |
80 |
62.0 |
0.249 |
|
| Mixed (S/N) |
49 |
38.6 |
41 |
31.8 |
||
|
|
||||||
| Pfdhps codon |
N |
(%) |
N |
(%) |
||
|
|
||||||
| 436/437 |
AA |
3 |
2.4 |
1 |
0.8 |
0.746 |
| SA |
50 |
39.7 |
37 |
29.8 |
0.007 |
|
| SG |
15 |
11.9 |
35 |
28.2 |
0.063 |
|
| Mixed |
||||||
| AA/SA |
2 |
1.6 |
1 |
0.8 |
||
| SA/SG |
56 |
44.4 |
45 |
36.3 |
||
| AA/SA/SG |
0 |
0 |
5 |
4.0 |
||
| 540 |
K |
80 |
63.5 |
73 |
54.5 |
< 0.001 |
| E |
10 |
7.9 |
38 |
28.4 |
0.117 |
|
| Mixed (K/E) |
36 |
28.6 |
23 |
17.2 |
||
|
|
||||||
|
The data are given as total numbers and as percentages and including genotype infections where the identification of SNP/haplotypes for a few samples were not complete. Mixed: Prevalence of infections with mixed SNP for each codon. P: P-values of χ2-tests of prevalence comparisons between the two cross sectional surveys where the prevalence of infections of each SNP including mixed infections are set against prevalence of infections without the particular SNP. |
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|
Enosse et al. Malaria Journal 2008 7:115 doi:10.1186/1475-2875-7-115 |
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