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Artesunate – amodiaquine combination therapy for falciparum malaria in young Gabonese children

Sunny Oyakhirome, Marc Pötschke, Norbert G Schwarz, Jenny Dörnemann, Matthias Laengin, Carmen Ospina Salazar, Bertrand Lell, Jürgen FJ Kun, Peter G Kremsner and Martin P Grobusch*

Malaria Journal 2007, 6:29  doi:10.1186/1475-2875-6-29

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Artesunate-amodiaquine efficacy in Congolese children with acute uncomplicated falciparum malaria in Brazzaville

Mathieu Ndounga, Pembe Issamou Mayengue, Prisca Nadine Casimiro, Dieudonné Loumouamou, Leonardo K Basco, Francine Ntoumi, Philippe Brasseur Malaria Journal 2013, 12:53 (5 February 2013)

Straightforward evaluation of the efficacy and tolerability of the AS+AQ combination therapy for the treatment of falciparum malaria in two health centres of Brazzaville.

Research   Open Access

Multicentre study evaluating the non-inferiority of the new paediatric formulation of artesunate/amodiaquine versus artemether/lumefantrine for the management of uncomplicated Plasmodium falciparum malaria in children in Cameroon, Ivory Coast and Senegal

Babacar Faye, Thomas Kuété, Christiane P Kiki-Barro, Roger C Tine, Thérèse Nkoa, Jean Louis A Ndiaye, Claude A Kakpo, Khadime Sylla, Hervé EI Menan, Oumar Gaye, Oumar Faye, Albert Same-Ekobo, Koné Moussa Malaria Journal 2012, 11:433 (27 December 2012)

A randomized, controlled, non-inferiority, multi-centre, open-label comparison of two presentations of ACT in African children.

Research   Open Access

Application of loop-mediated isothermal amplification for malaria diagnosis during a follow-up study in São Tomé

Pei-Wen Lee, Dar-Der Ji, Chia-Tai Liu, Herodes S Rampao, Virgilio E do Rosario, I-Feng Lin, Men-Fang Shaio Malaria Journal 2012, 11:408 (6 December 2012)

A reliable and simple test for the detection of malaria parasite is crucial in providing effective treatment and therapeutic follow-up: the authors use four methods, including nested polymerase chain reaction (PCR) and loop-mediated isothermal amplification (LAMP) for the malaria diagnosis and treatment in Sao Tome and Principe, during a successful pre-elimination campaign. They concluded that LAMP is simpler and faster for the detection of low parasitaemia and can be a potential point-of-care test for treatment follow-up.

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Intermittent screening and treatment versus intermittent preventive treatment of malaria in pregnancy: user acceptability

Lucy A Smith, Caroline Jones, Rose O Adjei, Gifty D Antwi, Nana A Afrah, Brian Greenwood, Daniel Chandramohan, Harry Tagbor, Jayne Webster Malaria Journal 2010, 9:18 (14 January 2010)

Due to very high and increasing resistance of malaria parasites to SP in Africa there is a need for alternative methods to protect pregnant women from the effects of malaria in pregnancy. This study describes pregnant women’s acceptability of such an alternative method based on intermittent RDT screening followed by treatment of those found positive.

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A randomized trial on effectiveness of artemether-lumefantrine versus artesunate plus amodiaquine for unsupervised treatment of uncomplicated Plasmodium falciparum malaria in Ghanaian children

Robin Kobbe, Philipp Klein, Samuel Adjei, Solomon Amemasor, William Thompson, Hanna Heidemann, Maja V Nielsen, Julia Vohwinkel, Benedikt Hogan, Benno Kreuels, Martina Bührlen, Wibke Loag, Daniel Ansong, Jürgen May Malaria Journal 2008, 7:261 (19 December 2008)

Numerous trials have demonstrated high efficacy and safety of artemisinin-based combination therapy (ACT) under supervised treatment but looking how these treatments are applied unsupervised are scarce. Unobserved AL and ASAQ treatment showed high adequate clinical and parasitological responses, though AL was inferior in preventing late clinical failures.

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