Table 2 |
||
|
|
||
|
Influenza encephalopathy |
Cerebral malaria |
|
|
|
||
|
seizures/coma after high grade fever |
+ |
+ |
|
metabolic acidosis |
+ |
+ |
|
hyperlactataemia |
+ |
+ |
|
serum TNF, IL-6, sTNFRI up |
+ |
+ |
|
serum nitrite/nitrate up |
+ |
+ |
|
CSF TNF, IL-6, sTNFRI up |
+ |
+ |
|
multiple organ failure, sequelae |
+ |
+ |
|
thrombocytopaenia |
+ |
+ |
|
damage to vascular endothelial cells |
+ |
+ |
|
brain oedema/damage to BBB |
+ |
+ |
|
apoptosis in neurons/glial cells |
+ |
+ |
|
evidence of active caspase-3 (brain) |
+ |
+ |
|
caspase-cleaved PARP (brain) |
+ |
+ |
|
|
||
|
Clark et al. Malaria Journal 2006 5:85 doi:10.1186/1475-2875-5-85 |
||
