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		Research Efficacy of ICON(R) Maxx in the laboratory and against insecticide-resistant Anopheles gambiae in central Cote d'Ivoire Mirko S Winkler, Emile Tchicaya, Benjamin G Koudou, Jennifer Donze, Christian Nsanzabana, Pie Muller, Akre M Adja, Jurg Utzinger Malaria Journal 2012, 11:167 (15 May 2012) Abstract \| Provisional PDF \| Editor’s summary The WHO Global vector control strategy recommends the scaling-up of insecticide-treated nets.One of the key issues for the use of conventional ITNs on a large-scale was the impregnation itself and the re-impregnation. Manufacturers have developed insecticide treatment kits to render untreated net into LLINs after simple dipping and the present study reports on the efficacy on such a kit-treatment.
		Research Improved methods for haemozoin quantification in tissues yield organ- and parasite-specific information in malariainfected mice Katrien Deroost, Natacha Lays, Sam Noppen, Erik Martens, Ghislain Opdenakker, Philippe E Van den Steen Malaria Journal 2012, 11:166 (14 May 2012) Abstract \| Provisional PDF \| Editor’s summary Paper describes a new methodology to quantify the content of malaria pigment on tissue homogenates of organs from C57Bl6 mice infected rodent malaria parasites. The authors then use this methodology to compare malaria infection caused by three Plasmodium species with different pathogenicity- with the intent to clarify the pathogenetic role of haemozoin.
		Research Remote sensing-based time series models for malaria early warning in the highlands of Ethiopia Alemayehu Midekisa, Gabriel Senay, Geoffrey M Henebry, Paulos Semuniguse, Michael C Wimberly Malaria Journal 2012, 11:165 (14 May 2012) Abstract \| Provisional PDF \| Editor’s summary The paper reports an attempt to anticipate the number of malaria cases in 12 districts health centres of the Amhara Ethiopian region, based on 12 temporal models including historical malaria cases as well as remotely sensed meteorological and environmental variables.
		Review Spatial repellents: from discovery and development to evidence-based validation Nicole L Achee, Michael J Bangs, Robert Farlow, Gerry F Killeen, Steve Lindsay, James G Logan, Sarah J Moore, Mark Rowland, Kevin Sweeney, Steve J Torr, Larry Zwiebel, John P Grieco Malaria Journal 2012, 11:164 (14 May 2012) Abstract \| Provisional PDF \| Editor’s summary An extensive review on the use of repellents, which aims to re-open the debate on the benefits of spatial repellency
		Methodology Isolation of Plasmodium falciparum by flow-cytometry: implications for single-trophozoite genotyping and parasite DNA purification for whole-genome high-throughput sequencing of archival samples Anne Boissière, Céline Arnathau, Christophe Duperray, Laurence Berry, Laurence Lachaud, François Renaud, Patrick Durand, Franck Prugnolle Malaria Journal 2012, 11:163 (14 May 2012) Abstract \| Provisional PDF \| Editor’s summary A pertinent and important subject, the problem of genotyping malaria parasites in mixed infections. This describes the application of flow cytometry methods to isolate single trophozoites for subsequent genetic analyses.
		Research B cell analysis of ethnic groups in Mali with differential susceptibility to malaria Silvia Portugal, Didier Doumtabe, Boubacar Traore, Louis H Miller, Marita Troye-Blomberg, Ogobara K Doumbo, Amagana Dolo, Susan K Pierce, Peter D Crompton Malaria Journal 2012, 11:162 (11 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A further description of differences between the Fulani and Dogon in regards to their susceptibility to malaria in Mali. The results show a significant difference in B cell subsets that can explain higher antibody responses to malaria in the Fulani compared to the Dogon. These findings have profound implications for understanding protective humoral immunity to malaria.
		Research Is malaria illness among young children a cause or a consequence of low socioeconomic status? Evidence from the United Republic of Tanzania Marcia Caldas de Castro, Monica G Fisher Malaria Journal 2012, 11:161 (9 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary If malaria is indeed a cause of poverty, as the findings of this study suggest, then malaria control activities are much more than just a public health policy, but also a poverty alleviation strategy.
		Research Mapping malaria risk among children in Cote d'Ivoire using Bayesian geo-statistical models Giovanna Raso, Nadine Schur, Jürg Utzinger, Benjamin G Koudou, Emile S Tchicaya, Fabian Rohner, Eliézer K N'Goran, Kigbafori D Silué, Barbara Matthys, Serge Assi, Marcel Tanner, Penelope Vounatsou Malaria Journal 2012, 11:160 (9 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The malaria risk map at high spatial resolution gives an important overview of the geographical distribution of the disease in C¿te d¿Ivoire. It is a useful tool for the national malaria control programme and can be utilized for spatial targeting of control interventions and rational resource allocation.
		Research Genetic variation of aldolase from Korean isolates of Plasmodium vivax and its usefulness in serodiagnosis Jung-Yeon Kim, Hyung-Hwan Kim, Hyun-il Shin, Youngjoo Sohn, Hyuck Kim, Sang-Wook Lee, Won-Ja Lee, Hyeong-Woo Lee Malaria Journal 2012, 11:159 (8 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The paper evaluated recombinant Plasmodium vivax aldolase as a tool for serodiagnostis of vivax malaria in Korea. There was much variation in results and the authors discuss the possible reasons for this, contrasting variability of the gene and a possible low seroconversion
		Research Automated red blood cell exchange as an adjunctive treatment for severe Plasmodium falciparum malaria at the Vienna General Hospital in Austria: a retrospective cohort study Lorenz Auer-Hackenberg, Thomas Staudinger, Andja Bojic, Gottfried Locker, Gerda C Leitner, Wolfgang Graninger, Stefan Winkler, Michael Ramharter, Nina Worel Malaria Journal 2012, 11:158 (7 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This is a well-justified review of the experience with erythrocytapheresis as an adjunct therapy in severe and complicated malaria in returning travellers. The study centre of Vienna saw over 100 cases in the 10 years planned for this review and carried out exchange in 6 patients, although a slightly higher number were eligible for exchange.
		Research Malaria case management in Papua New Guinea prior to the introduction of a revised treatment protocol Justin Pulford, Ivo Mueller, Peter M Siba, Manuel W Hetzel Malaria Journal 2012, 11:157 (7 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Paper reporting findings of cross-sectional health facility survey on malaria case management in Papua New Guinea. The paper highlights various gaps in health workers¿ practices prior to introduction of new case management guidelines in the country.
		Research Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins Piero Bagnaresi, Nilana MT de Barros, Diego M Assis, Pollyana MS Melo, Raphael G Fonseca, Maria A Juliano, João B Pesquero, Luiz Juliano, Philip J Rosenthal, Adriana K Carmona, Marcos L Gazarini Malaria Journal 2012, 11:156 (7 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The paper describes the production of active kinin by a specific mechanism which involves the uptake of precursors from the blood and their proteolysis to bioactive kinins.
		Research Performance of a malaria microscopy image analysis slide reading device William R Prescott, Robert G Jordan, Martin P Grobusch, Vernon M Chinchilli, Immo Kleinschmidt, Joseph Borovsky, Mark Plaskow, Miguel Torres, Maximo Mico, Christopher Schwabe Malaria Journal 2012, 11:155 (6 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Accurate machine reading of malaria blood films would revolutionize malaria diagnosis and this study is an excellent examination of the state of this art.
		Research Haemoglobin variants and Plasmodium falciparum malaria in children under five years of age living in a high and seasonal malaria transmission area of Burkina Faso Edith C Bougouma, Alfred B Tiono, Alphonse Ouédraogo, Issiaka Soulama, Amidou Diarra, Jean-Baptiste Yaro, Espérance Ouédaogo, Souleymane Sanon, Ammadou T Konaté, Issa Nébié, Nora Watson, Megan Sanza, Tina JT Dube, Sodiomon B Sirima Malaria Journal 2012, 11:154 (4 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The paper describes a longitudinal study of children below five years of age in Burkina Faso, in whom the relationship between Hb type and malaria risk is investigated. The study provides important and interesting epidemiologic data on the prevalence of Hb polymorphisms and malaria risk in Burkina Faso.
		Research Efficacy and safety of artemisinin-naphthoquine versus dihydroartemisinin-piperaquine in adult patients with uncomplicated malaria: a multi-centre study in Indonesia Emiliana Tjitra, Armedy R Hasugian, Hadjar Siswantoro, Budi Prasetyorini, Riyanti Ekowatiningsih, Endah A Yusnita, Telly Purnamasari, Srilaning Driyah, Ervi Salwati, Nurhayati Nurhayati, Eni Yuwarni, Lidwina Yanuar, Joseph Labora, Bambang Wijayanto, Fajar Amansyah, Tersila AD Dedang, Asep Purnama, Trihono Trihono Malaria Journal 2012, 11:153 (3 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Report on a standard comparative trial of artemisinin napthoquine versus dihydroartemisinin piperaquine. At a time when drug resistance is receiving increasing attention, new trials of different forms of ACT are sorely needed.
		Research Using community-owned resource persons to provide early diagnosis and treatment and estimate malaria burden at community level in north-eastern Tanzania Acleus SM Rutta, Filbert Francis, Bruno P Mmbando, Deus S Ishengoma, Samwel H Sembuche, Ezekiel K Malecela, Johari Y Sadi, Mathias L Kamugisha, Martha M Lemnge Malaria Journal 2012, 11:152 (3 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Outlines important aspects of the changing epidemiological profiles of malaria and the role of community-based interventions in malaria control.
		Research The polymorphism and the geographical distribution of the knockdown resistance (kdr) of Anopheles sinensis in the Republic of Korea Seunghyun Kang, Jongwoo Jung, Sanghui Lee, Heeseung Hwang, Won Kim Malaria Journal 2012, 11:151 (3 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A well-designed study on Anopheles species from Republic of Korea and their kdr frequency.
		Research Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial Atis Muehlenbachs, Carolyn Nabasumba, Rose McGready, Eleanor Turyakira, Benon Tumwebaze, Mehul Dhorda, Dan Nyehangane, Aisha Nalusaji, Francois Nosten, Philippe J Guerin, Patrice Piola Malaria Journal 2012, 11:150 (3 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary An innovative approach to assessing treatment efficacy with antimalarial therapy in pregnancy: treatment with AL is associated with reduced placental haemozoin deposition compared to haemozoin levels in placentas at term and those treated with quinine.
		Research Capillary electrophoresis for the assay of fixed-dose combination tablets of artesunate and amodiaquine N’Cho Christophe Amin, Marie-Dominique Blanchin, Michèle Aké, Jérôme Montels, Huguette Fabre Malaria Journal 2012, 11:149 (3 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The paper describes the development and validation of a method to analyse fixed-dose combination tablets containing artesunate and amodiaquine.
		Research Host immune response in returning travellers infected with malaria Gregory McMullin, Ronald Mackenzie, Rachel Lau, Julie Khang, Haibo Zhang, Nimerta Rajwans, W Conrad Liles, Dylan R Pillai Malaria Journal 2012, 11:148 (3 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Description of an interesting synergist effect of pfatp6 SNPs and pfmdr1 duplications concerning associations with IC50 for the main artemisinin drugs (ART). The study was performed with clinical malaria cases among travellers returning from malaria endemic regions, mostly from sub-Saharan Africa.
		Methodology Multiple treatment comparisons in a series of anti-malarials trials with an ordinal primary outcome and repeated treatment evaluations Solange Whegang Youdom, Adeline Samson, Leonardo K Basco, Jean-Christophe Thalabard Malaria Journal 2012, 11:147 (3 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The method of analysis for multiple treatment comparisons that is presented could be useful and is of significant value. It is a new application of a method of analysis that has been used elsewhere and that has been adapted to the analysis of the WHO in vivo tests of malaria drug resistance.
		Case report Early treatment failure during treatment of plasmodium falciparum malaria with atovaquoneproguanil in the republic of ivory coast Nathalie Wurtz, Aurélie Pascual, Adeline Marin-Jauffre, Housem Bouchiba, Nicolas Benoit, Marc Desbordes, Maryse Martelloni, Vincent Pommier de Santi, Georges Richa, Nicolas Taudon, Bruno Pradines, Sébastien Briolant Malaria Journal 2012, 11:146 (2 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary An interesting and useful case report on a failure of anti-malarial treatment in a single individual resident for 6 months in C¿te d'Ivoire. The principal finding is that none of the usual reasons for AP treatment failure were implicated.
		Methodology Mosquito bisection as a variable in estimates of PCR-derived malaria sporozoite rates Desmond H Foley, Genelle Harrison, Jittawadee R Murphy, Megan Dowler, Leopoldo M Rueda, Richard C Wilkerson Malaria Journal 2012, 11:145 (2 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This technical study represents a useful analysis, specifically relevant to workers interested in detecting sporozoite infection in field-caught samples of mosquitoes.
		Research Severe disease in children hospitalized with a diagnosis of Plasmodium vivax in south-eastern Pakistan Salma Shaikh, Hafeezullah Memon, Amna Shaikh, Imran Ahmed, Bhagchand Iohano, Kevin J Baird Malaria Journal 2012, 11:144 (2 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary An interesting collection of cases which makes an important point about the need to revise our thinking about the relative 'non-pathogenicity' of vivax malaria in children
		Methodology Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria Kris M Jamsen, Stephen B Duffull, Joel Tarning, Niklas Lindegardh, Nicholas J White, Julie A Simpson Malaria Journal 2012, 11:143 (2 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This article represents a worthwhile contribution to the literature - it provides a practical guide to those designing population PK studies specifically of oral artesunate, and a "proof of principle" for applying optimal design methodology for anti-malarials in general.

	All
		Research Efficacy of ICON(R) Maxx in the laboratory and against insecticide-resistant Anopheles gambiae in central Cote d'Ivoire Mirko S Winkler, Emile Tchicaya, Benjamin G Koudou, Jennifer Donze, Christian Nsanzabana, Pie Muller, Akre M Adja, Jurg Utzinger Malaria Journal 2012, 11:167 (15 May 2012) Abstract \| Provisional PDF \| Editor’s summary The WHO Global vector control strategy recommends the scaling-up of insecticide-treated nets.One of the key issues for the use of conventional ITNs on a large-scale was the impregnation itself and the re-impregnation. Manufacturers have developed insecticide treatment kits to render untreated net into LLINs after simple dipping and the present study reports on the efficacy on such a kit-treatment.
		Research Improved methods for haemozoin quantification in tissues yield organ- and parasite-specific information in malariainfected mice Katrien Deroost, Natacha Lays, Sam Noppen, Erik Martens, Ghislain Opdenakker, Philippe E Van den Steen Malaria Journal 2012, 11:166 (14 May 2012) Abstract \| Provisional PDF \| Editor’s summary Paper describes a new methodology to quantify the content of malaria pigment on tissue homogenates of organs from C57Bl6 mice infected rodent malaria parasites. The authors then use this methodology to compare malaria infection caused by three Plasmodium species with different pathogenicity- with the intent to clarify the pathogenetic role of haemozoin.
		Research Remote sensing-based time series models for malaria early warning in the highlands of Ethiopia Alemayehu Midekisa, Gabriel Senay, Geoffrey M Henebry, Paulos Semuniguse, Michael C Wimberly Malaria Journal 2012, 11:165 (14 May 2012) Abstract \| Provisional PDF \| Editor’s summary The paper reports an attempt to anticipate the number of malaria cases in 12 districts health centres of the Amhara Ethiopian region, based on 12 temporal models including historical malaria cases as well as remotely sensed meteorological and environmental variables.
		Review Spatial repellents: from discovery and development to evidence-based validation Nicole L Achee, Michael J Bangs, Robert Farlow, Gerry F Killeen, Steve Lindsay, James G Logan, Sarah J Moore, Mark Rowland, Kevin Sweeney, Steve J Torr, Larry Zwiebel, John P Grieco Malaria Journal 2012, 11:164 (14 May 2012) Abstract \| Provisional PDF \| Editor’s summary An extensive review on the use of repellents, which aims to re-open the debate on the benefits of spatial repellency
		Methodology Isolation of Plasmodium falciparum by flow-cytometry: implications for single-trophozoite genotyping and parasite DNA purification for whole-genome high-throughput sequencing of archival samples Anne Boissière, Céline Arnathau, Christophe Duperray, Laurence Berry, Laurence Lachaud, François Renaud, Patrick Durand, Franck Prugnolle Malaria Journal 2012, 11:163 (14 May 2012) Abstract \| Provisional PDF \| Editor’s summary A pertinent and important subject, the problem of genotyping malaria parasites in mixed infections. This describes the application of flow cytometry methods to isolate single trophozoites for subsequent genetic analyses.
		Research B cell analysis of ethnic groups in Mali with differential susceptibility to malaria Silvia Portugal, Didier Doumtabe, Boubacar Traore, Louis H Miller, Marita Troye-Blomberg, Ogobara K Doumbo, Amagana Dolo, Susan K Pierce, Peter D Crompton Malaria Journal 2012, 11:162 (11 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A further description of differences between the Fulani and Dogon in regards to their susceptibility to malaria in Mali. The results show a significant difference in B cell subsets that can explain higher antibody responses to malaria in the Fulani compared to the Dogon. These findings have profound implications for understanding protective humoral immunity to malaria.
		Research Is malaria illness among young children a cause or a consequence of low socioeconomic status? Evidence from the United Republic of Tanzania Marcia Caldas de Castro, Monica G Fisher Malaria Journal 2012, 11:161 (9 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary If malaria is indeed a cause of poverty, as the findings of this study suggest, then malaria control activities are much more than just a public health policy, but also a poverty alleviation strategy.
		Research Mapping malaria risk among children in Cote d'Ivoire using Bayesian geo-statistical models Giovanna Raso, Nadine Schur, Jürg Utzinger, Benjamin G Koudou, Emile S Tchicaya, Fabian Rohner, Eliézer K N'Goran, Kigbafori D Silué, Barbara Matthys, Serge Assi, Marcel Tanner, Penelope Vounatsou Malaria Journal 2012, 11:160 (9 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The malaria risk map at high spatial resolution gives an important overview of the geographical distribution of the disease in C¿te d¿Ivoire. It is a useful tool for the national malaria control programme and can be utilized for spatial targeting of control interventions and rational resource allocation.
		Research Genetic variation of aldolase from Korean isolates of Plasmodium vivax and its usefulness in serodiagnosis Jung-Yeon Kim, Hyung-Hwan Kim, Hyun-il Shin, Youngjoo Sohn, Hyuck Kim, Sang-Wook Lee, Won-Ja Lee, Hyeong-Woo Lee Malaria Journal 2012, 11:159 (8 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The paper evaluated recombinant Plasmodium vivax aldolase as a tool for serodiagnostis of vivax malaria in Korea. There was much variation in results and the authors discuss the possible reasons for this, contrasting variability of the gene and a possible low seroconversion
		Research Automated red blood cell exchange as an adjunctive treatment for severe Plasmodium falciparum malaria at the Vienna General Hospital in Austria: a retrospective cohort study Lorenz Auer-Hackenberg, Thomas Staudinger, Andja Bojic, Gottfried Locker, Gerda C Leitner, Wolfgang Graninger, Stefan Winkler, Michael Ramharter, Nina Worel Malaria Journal 2012, 11:158 (7 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This is a well-justified review of the experience with erythrocytapheresis as an adjunct therapy in severe and complicated malaria in returning travellers. The study centre of Vienna saw over 100 cases in the 10 years planned for this review and carried out exchange in 6 patients, although a slightly higher number were eligible for exchange.
		Research Malaria case management in Papua New Guinea prior to the introduction of a revised treatment protocol Justin Pulford, Ivo Mueller, Peter M Siba, Manuel W Hetzel Malaria Journal 2012, 11:157 (7 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Paper reporting findings of cross-sectional health facility survey on malaria case management in Papua New Guinea. The paper highlights various gaps in health workers¿ practices prior to introduction of new case management guidelines in the country.
		Research Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins Piero Bagnaresi, Nilana MT de Barros, Diego M Assis, Pollyana MS Melo, Raphael G Fonseca, Maria A Juliano, João B Pesquero, Luiz Juliano, Philip J Rosenthal, Adriana K Carmona, Marcos L Gazarini Malaria Journal 2012, 11:156 (7 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The paper describes the production of active kinin by a specific mechanism which involves the uptake of precursors from the blood and their proteolysis to bioactive kinins.
		Research Performance of a malaria microscopy image analysis slide reading device William R Prescott, Robert G Jordan, Martin P Grobusch, Vernon M Chinchilli, Immo Kleinschmidt, Joseph Borovsky, Mark Plaskow, Miguel Torres, Maximo Mico, Christopher Schwabe Malaria Journal 2012, 11:155 (6 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Accurate machine reading of malaria blood films would revolutionize malaria diagnosis and this study is an excellent examination of the state of this art.
		Research Haemoglobin variants and Plasmodium falciparum malaria in children under five years of age living in a high and seasonal malaria transmission area of Burkina Faso Edith C Bougouma, Alfred B Tiono, Alphonse Ouédraogo, Issiaka Soulama, Amidou Diarra, Jean-Baptiste Yaro, Espérance Ouédaogo, Souleymane Sanon, Ammadou T Konaté, Issa Nébié, Nora Watson, Megan Sanza, Tina JT Dube, Sodiomon B Sirima Malaria Journal 2012, 11:154 (4 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The paper describes a longitudinal study of children below five years of age in Burkina Faso, in whom the relationship between Hb type and malaria risk is investigated. The study provides important and interesting epidemiologic data on the prevalence of Hb polymorphisms and malaria risk in Burkina Faso.
		Research Efficacy and safety of artemisinin-naphthoquine versus dihydroartemisinin-piperaquine in adult patients with uncomplicated malaria: a multi-centre study in Indonesia Emiliana Tjitra, Armedy R Hasugian, Hadjar Siswantoro, Budi Prasetyorini, Riyanti Ekowatiningsih, Endah A Yusnita, Telly Purnamasari, Srilaning Driyah, Ervi Salwati, Nurhayati Nurhayati, Eni Yuwarni, Lidwina Yanuar, Joseph Labora, Bambang Wijayanto, Fajar Amansyah, Tersila AD Dedang, Asep Purnama, Trihono Trihono Malaria Journal 2012, 11:153 (3 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Report on a standard comparative trial of artemisinin napthoquine versus dihydroartemisinin piperaquine. At a time when drug resistance is receiving increasing attention, new trials of different forms of ACT are sorely needed.
		Research Using community-owned resource persons to provide early diagnosis and treatment and estimate malaria burden at community level in north-eastern Tanzania Acleus SM Rutta, Filbert Francis, Bruno P Mmbando, Deus S Ishengoma, Samwel H Sembuche, Ezekiel K Malecela, Johari Y Sadi, Mathias L Kamugisha, Martha M Lemnge Malaria Journal 2012, 11:152 (3 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Outlines important aspects of the changing epidemiological profiles of malaria and the role of community-based interventions in malaria control.
		Research The polymorphism and the geographical distribution of the knockdown resistance (kdr) of Anopheles sinensis in the Republic of Korea Seunghyun Kang, Jongwoo Jung, Sanghui Lee, Heeseung Hwang, Won Kim Malaria Journal 2012, 11:151 (3 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A well-designed study on Anopheles species from Republic of Korea and their kdr frequency.
		Research Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial Atis Muehlenbachs, Carolyn Nabasumba, Rose McGready, Eleanor Turyakira, Benon Tumwebaze, Mehul Dhorda, Dan Nyehangane, Aisha Nalusaji, Francois Nosten, Philippe J Guerin, Patrice Piola Malaria Journal 2012, 11:150 (3 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary An innovative approach to assessing treatment efficacy with antimalarial therapy in pregnancy: treatment with AL is associated with reduced placental haemozoin deposition compared to haemozoin levels in placentas at term and those treated with quinine.
		Research Capillary electrophoresis for the assay of fixed-dose combination tablets of artesunate and amodiaquine N’Cho Christophe Amin, Marie-Dominique Blanchin, Michèle Aké, Jérôme Montels, Huguette Fabre Malaria Journal 2012, 11:149 (3 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The paper describes the development and validation of a method to analyse fixed-dose combination tablets containing artesunate and amodiaquine.
		Research Host immune response in returning travellers infected with malaria Gregory McMullin, Ronald Mackenzie, Rachel Lau, Julie Khang, Haibo Zhang, Nimerta Rajwans, W Conrad Liles, Dylan R Pillai Malaria Journal 2012, 11:148 (3 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Description of an interesting synergist effect of pfatp6 SNPs and pfmdr1 duplications concerning associations with IC50 for the main artemisinin drugs (ART). The study was performed with clinical malaria cases among travellers returning from malaria endemic regions, mostly from sub-Saharan Africa.
		Methodology Multiple treatment comparisons in a series of anti-malarials trials with an ordinal primary outcome and repeated treatment evaluations Solange Whegang Youdom, Adeline Samson, Leonardo K Basco, Jean-Christophe Thalabard Malaria Journal 2012, 11:147 (3 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The method of analysis for multiple treatment comparisons that is presented could be useful and is of significant value. It is a new application of a method of analysis that has been used elsewhere and that has been adapted to the analysis of the WHO in vivo tests of malaria drug resistance.
		Case report Early treatment failure during treatment of plasmodium falciparum malaria with atovaquoneproguanil in the republic of ivory coast Nathalie Wurtz, Aurélie Pascual, Adeline Marin-Jauffre, Housem Bouchiba, Nicolas Benoit, Marc Desbordes, Maryse Martelloni, Vincent Pommier de Santi, Georges Richa, Nicolas Taudon, Bruno Pradines, Sébastien Briolant Malaria Journal 2012, 11:146 (2 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary An interesting and useful case report on a failure of anti-malarial treatment in a single individual resident for 6 months in C¿te d'Ivoire. The principal finding is that none of the usual reasons for AP treatment failure were implicated.
		Methodology Mosquito bisection as a variable in estimates of PCR-derived malaria sporozoite rates Desmond H Foley, Genelle Harrison, Jittawadee R Murphy, Megan Dowler, Leopoldo M Rueda, Richard C Wilkerson Malaria Journal 2012, 11:145 (2 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This technical study represents a useful analysis, specifically relevant to workers interested in detecting sporozoite infection in field-caught samples of mosquitoes.
		Research Severe disease in children hospitalized with a diagnosis of Plasmodium vivax in south-eastern Pakistan Salma Shaikh, Hafeezullah Memon, Amna Shaikh, Imran Ahmed, Bhagchand Iohano, Kevin J Baird Malaria Journal 2012, 11:144 (2 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary An interesting collection of cases which makes an important point about the need to revise our thinking about the relative 'non-pathogenicity' of vivax malaria in children
		Methodology Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria Kris M Jamsen, Stephen B Duffull, Joel Tarning, Niklas Lindegardh, Nicholas J White, Julie A Simpson Malaria Journal 2012, 11:143 (2 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This article represents a worthwhile contribution to the literature - it provides a practical guide to those designing population PK studies specifically of oral artesunate, and a "proof of principle" for applying optimal design methodology for anti-malarials in general.