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		Research Living on the edge: a longitudinal study of Anopheles funestus in an isolated area of Mozambique J Derek Charlwood, Nelson Cuamba, Elsa VE Tomás, Olivier JT Briët Malaria Journal 2013, 12:208 (17 June 2013) Abstract \| Provisional PDF \| Editor’s summary A well written paper which contributes to the shortage of biological knowledge on this major malaria vector species, Anopheles funestus. A longitudinal study over 104 weeks, where mosquito sampling was done in southern Mozambique, at the edge of distribution of this species.
		Research Spatial distribution of malaria problem in three regions of Ethiopia Dawit G Ayele, Temesgen T Zewotir, Henry G Mwambi Malaria Journal 2013, 12:207 (17 June 2013) Abstract \| Provisional PDF \| Editor’s summary More than 75% of Ethiopia is malaria-endemic. The aim of this study was to identify socio-economic, geographic and demographic risk factors of malaria and produce a prevalence map illustrating variation in malaria risk.
		Research Host immune constraints on malaria transmission: insights from population biology of within-host parasites Philip G McQueen, Kim C Williamson, F Ellis McKenzie Malaria Journal 2013, 12:206 (15 June 2013) Abstract \| Provisional PDF \| Editor’s summary Mathematical model to investigate the effects of immunity to different stages of the life cycle of P. falciparum and vivax.
		Research Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors Joseph M Bodi, Célestin N Nsibu, Roland L Longenge, Michel N Aloni, Pierre Z Akilimali, Pierre M Tshibassu, Patrick K Kayembe, Ahmeddin H Omar, Kenji Hirayama, Jan Verhaegen Malaria Journal 2013, 12:205 (15 June 2013) Abstract \| Provisional PDF \| Editor’s summary Report of a case control study of haemoglobinuria conducted over two years amongst paediatric malaria patients in Kinshasa. This may reflect an increase in the incidence of this severe complication of falciparum malaria.
		Research Equivalent susceptibility of anopheles gambiae M and S molecular forms and anopheles arabiensis to plasmodium falciparum infection in Burkina Faso Awa Gnémé, Wamdaogo M Guelbéogo, Michelle M Riehle, Antoine Sanou, Alphonse Traoré, Soumanaba Zongo, Karin Eiglmeier, Gustave B Kabré, N¿Falé Sagnon, Kenneth D Vernick Malaria Journal 2013, 12:204 (14 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The authors have tested for differences in Plasmodium falciparum infection prevalence and intensity between Anopheles gambiae M, A. gambiae S and Anopheles arabiensis, but found no difference in susceptibility between these three populations when performing experimental infections using ¿local¿ malaria strains.
		Research A good night's sleep and the habit of net use: perceptions of risk and reasons for bed net use in Bukoba and Zanzibar Hannah M Koenker, Dana Loll, Datius Rweyemamu, Abdullah S Ali Malaria Journal 2013, 12:203 (13 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The article raises the very important issue about how long and to what extent people will continue to comply with malaria preventive measures as incidence decreases.
		Research Determination of artemether and lumefantrine in anti-malarial fixed-dose combination tablets by microemulsion electrokinetic chromatography with short-end injection procedure N¿Cho Christophe Amin, Huguette Fabre, Marie-Dominique Blanchin, Jérôme Montels, Michèle Aké Malaria Journal 2013, 12:202 (13 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Describes a microemulsion electrokinetic chromatography method for the quantitation of artemether and lumefantrine in tablets, a method not previously described for the assay of these anti-malarials.
		Research Population genetics analysis during the elimination process of Plasmodium falciparum in Djibouti Bouh Abdi Khaireh, Ashenafi Assefa, Hawa Hassan Guessod, Leonardo K Basco, Mohamed Abdi Khaireh, Aurélie Pascual, Sébastien Briolant, Samatar Mohamed Bouh, Ismaïl Hassan Farah, Habib Moussa Ali, Abdoul-Ilah Ahmed Abdi, Mouna Osman Aden, Zamzam Abdillahi, Souleiman Nour Ayeh, Houssein Youssouf Darar, Jean-Louis Koeck, Christophe Rogier, Bruno Pradines, Hervé Bogreau Malaria Journal 2013, 12:201 (13 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Djibouti is a small country on the edge of the endemic distribution of malaria in the horn of Africa, which has been considered as having potential for future local malaria elimination. This study analyses the genetic diversity of P. falciparum sampled at four different time points and discusses results in the context of the possibility for future elimination.
		Research Malaria and protective behaviours: is there a malaria trap? Jean-Claude Berthélemy, Josselin Thuilliez, Ogobara Doumbo, Jean Gaudart Malaria Journal 2013, 12:200 (13 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This paper is about the theoretical existence of a malaria trap as well as the implications of this for the distribution of insecticide-treated nets. -
		Research Plasmodium vivax aldolase-specific monoclonal antibodies and its application in clinical diagnosis of malaria infections in China Emmanuel E Dzakah, Keren Kang, Chao Ni, Hong Wang, Peidian Wu, Shixing Tang, Jihua Wang, Jufang Wang, Xiaoning Wang Malaria Journal 2013, 12:199 (12 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Results of research work aimed to improve malaria diagnosis and more specifically the detection of P. vivax, with particular empasis on developing new monoclonal antibodies agains parasite aldolase.
		Research High prevalence of mutation in the Plasmodium falciparum dhfr and dhps genes in field isolates from Sabah, Northern Borneo Noor Rain Abdullah, Nor Azrina Norahmad, Jenarun Jelip, Lokman Hakim Sulaiman, Hasidah Mohd Sidek, Zakiah Ismail, Harald Noedl Malaria Journal 2013, 12:198 (12 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Analysis of the mutations in the dhfr and dhps genes in samples from Sabah, Northern Borneo, Malaysia. The overall conclusions support the interpretation that parasite populations in this region carry a wide variety of allelic combinations associated with resistance to SP and the authors recommendation that SP not be used is definitely important for local decision making.
		Opinion Imported malaria in Albania and the risk factors that could allow its reappearance Klodiana Shkurti, Gentian Vyshka, Enkelejda Velo, Arben Boçari, Majlinda Kokici, Dhimitër Kraja Malaria Journal 2013, 12:197 (12 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Comments on the risk of malaria reappearance in Albania based on three environmental and human factors: the geographical distribution of Anopheles species, the human migration and the flooding of northern lowlands close to the Adriatic coasts.
		Methodology Environmentally friendly tool to control mosquito populations without risk of insecticide resistance: the Lehmann's funnel entry trap Abdoulaye Diabaté, Etienne Bilgo, Roch K Dabiré, Fréderic Tripet Malaria Journal 2013, 12:196 (10 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This study presents the results of the use of a funnel entry trap as an alternative tool to control mosquitoes. The development of novel control tools is highly needed and the study is a proof a concept of the use of the trap.
		Research High rates of parasite recrudescence following intermittent preventive treatment with sulphadoxine-pyrimethamine during pregnancy in Benin Azizath Moussiliou, Yolande Sissinto-Savi De Tove, Justin Doritchamou, Adrian JF Luty, Achille Massougbodji, Michael Alifrangis, Philippe Deloron, Nicaise Tuikue Ndam Malaria Journal 2013, 12:195 (10 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Despite widespread parasite resistance to sulphadoxine-pyrimethamine (SP) its use for intermittent preventative treatment during pregnancy remains the policy in Benin and throughout most of sub-Saharan Africa. This study suggests that this policy needs to be changed soon.
		Research Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica Virendra K Dua, Gaurav Verma, Bikram Singh, Aswathy Rajan, Upma Bagai, Dau Agarwal, NC Gupta, Sandeep Kumar, Ayushi Rastogi Malaria Journal 2013, 12:194 (10 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The present investigation demonstrates that the compound conessine exhibited substantial anti-malarial property. The isolated compound could be chemically modified to improve its potency.
		Research Malaria and haematologic parameters of pupils at different altitudes along the slope of Mount Cameroon: a cross-sectional study Helen K Kimbi, Irene UN Sumbele, Malaika Nweboh, Judith K Anchang-Kimbi, Emmaculate Lum, Yannick Nana, Lucy M Ndip, Henry Njom, Leopold G Lehman Malaria Journal 2013, 12:193 (9 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Results of a study of the impact of altitude/malaria transmission along an altitude transect, and a discussion of the impact of malaria infections on various haematologic measurements.
		Review Land cover, land use and malaria in the Amazon: a systematic literature review of studies using remotely sensed data Aurélia Stefani, Isabelle Dusfour, Ana Paula SA Corrêa, Manoel CB Cruz, Nadine Dessay, Allan KR Galardo, Clícia D Galardo, Romain Girod, Margarete SM Gomes, Helen Gurgel, Ana Cristina F Lima, Eduardo S Moreno, Lise Musset, Mathieu Nacher, Alana CS Soares, Bernard Carme, Emmanuel Roux Malaria Journal 2013, 12:192 (8 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The authors present a well-reasoned argument for a shared land use/lang cover topology for studies of malaria risk in the Amazon region. Their detailed review of studies using remote-sensing data to identify malaria risk factors in the Amazon forest is very relevant to the field.
		Research A histological method for quantifying Plasmodium falciparum in the brain in fatal paediatric cerebral malaria Danny A Milner, Clarissa Valim, Richard A Carr, Pankaj B Chandak, Nedson G Fosiko, Richard Whitten, Krupa B Playforth, Karl B Seydel, Steve Kamiza, Malcolm E Molyneux, Terrie E Taylor Malaria Journal 2013, 12:191 (7 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This study details the histopathological quantification of parasite counts for cerebral malaria studies. Methods that involve quantitative measures of different life cycle stages are useful for distinguishing patterns within the cerebral malaria population; these subclassifications may be important for studies of disease pathogenesis and ancillary treatment.
		Methodology A novel live-dead staining methodology to study malaria parasite viability Erica M Pasini, Denise van den Ierssel, Henri J Vial, Clemens HM Kocken Malaria Journal 2013, 12:190 (7 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The authors used various dyes of different commercial sources to stain malaria parasites with the aim to differentially distinguish live from dead parasites. An underlying objective is to apply this technique in testing drug sensitivity of malaria parasite and to be used as a tool for checking quality of the long term culture of P. vivax.
		Research In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na⁺/H⁺ exchanger transporter (Pfnhe-1) gene in 393 isolates from Dakar, Senegal Aurélie Pascual, Bécaye Fall, Nathalie Wurtz, Mansour Fall, Cheikhou Camara, Aminata Nakoulima, Eric Baret, Bakary Diatta, Khadidiatou Fall, Pape Mbaye, Yaya Diémé, Raymond Bercion, Hervé Bogreau, Sébastien Briolant, Christophe Rogier, Boubacar Wade, Bruno Pradines Malaria Journal 2013, 12:189 (7 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Evaluation of the association between the Pfnhe polymorphism and quinine susceptibility in isolates from Senegal, aiming to assess the validity of Pfnhe as a molecular marker of QN susceptibility.
		Research Evaluation of the malaria rapid diagnostic test VIKIA malaria Ag Pf/Pan™ in endemic and non-endemic settings Daniel Eibach, Boubacar Traore, Mourad Bouchrik, Boubacar Coulibaly, Nianégué Coulibaly, Fanta Siby, Guillaume Bonnot, Anne-Lise Bienvenu, Stéphane Picot Malaria Journal 2013, 12:188 (6 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The authors compare the performance of VIKIA Malaria Ag Pf/Pan to LM-PCR corrected in an endemic setting and a non-endemic setting. The study concludes that VIKIA performance is comparable to the widely used CareStart test and microscopy-corrected PCR results, in both endemic and non-endemic areas.
		Review Designing the next generation of medicines for malaria control and eradication Jeremy N Burrows, Rob Hooft van Huijsduijnen, Jörg J Möhrle, Claude Oeuvray, Timothy NC Wells Malaria Journal 2013, 12:187 (6 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper provides an outline definition of the ideal and minimally acceptable characteristics of the types of clinical candidate molecule which are needed in various situations, both as monotherapy and combination therapy.
		Research The association between price, competition, and demand factors on private sector anti-malarial stocking and sales in western Kenya: considerations for the AMFm subsidy Wendy O’Meara, Andrew Obala, Harsha Thirumurthy, Barasa Khwa-Otsyula Malaria Journal 2013, 12:186 (5 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Information on why retailers choose to stock specific drugs and what determines the volume of different types of drugs sold in the outlets ¿ including price, which is relevant information in the context of subsidy interventions such as the AMFm.
		Research Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP) Martha Sedegah, Yohan Kim, Harini Ganeshan, Jun Huang, Maria Belmonte, Esteban Abot, Jo Banania, Fouzia Farooq, Shannon McGrath, Bjoern Peters, Alessandro Sette, Lorraine Soisson, Carter Diggs, Denise L Doolan, Cindy Tamminga, Eileen Villasante, Michael R Hollingdale, Thomas L Richie Malaria Journal 2013, 12:185 (5 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This study identified new class I epitopes restricted by six HLA supertypes on the CSP, one of the leading vaccine candidate antigens, suggesting that an adenovirus-vectored CSP vaccine would be immunogenic and potentially protective in genetically diverse populations.
		Research Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum Fabiana M Jordão, Heloisa B Gabriel, João MP Alves, Claudia B Angeli, Thaís D Bifano, Ardala Breda, Mauro F de Azevedo, Luiz A Basso, Gerhard Wunderlich, Emilia A Kimura, Alejandro M Katzin Malaria Journal 2013, 12:184 (4 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The paper presents the cloning, expression, purification, biochemical characterization of the FPPS from Plasmodium falciparum. The authors show that this enzyme has two activities that result in the production of farnesyl diphosphate/geranylgeranyl diphosphate, a key branch point of the isoprenoid synthesis and, hence, playing a central role in the regulation of a number of essential functions in Plasmodium parasites.

	All
		Research Living on the edge: a longitudinal study of Anopheles funestus in an isolated area of Mozambique J Derek Charlwood, Nelson Cuamba, Elsa VE Tomás, Olivier JT Briët Malaria Journal 2013, 12:208 (17 June 2013) Abstract \| Provisional PDF \| Editor’s summary A well written paper which contributes to the shortage of biological knowledge on this major malaria vector species, Anopheles funestus. A longitudinal study over 104 weeks, where mosquito sampling was done in southern Mozambique, at the edge of distribution of this species.
		Research Spatial distribution of malaria problem in three regions of Ethiopia Dawit G Ayele, Temesgen T Zewotir, Henry G Mwambi Malaria Journal 2013, 12:207 (17 June 2013) Abstract \| Provisional PDF \| Editor’s summary More than 75% of Ethiopia is malaria-endemic. The aim of this study was to identify socio-economic, geographic and demographic risk factors of malaria and produce a prevalence map illustrating variation in malaria risk.
		Research Host immune constraints on malaria transmission: insights from population biology of within-host parasites Philip G McQueen, Kim C Williamson, F Ellis McKenzie Malaria Journal 2013, 12:206 (15 June 2013) Abstract \| Provisional PDF \| Editor’s summary Mathematical model to investigate the effects of immunity to different stages of the life cycle of P. falciparum and vivax.
		Research Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors Joseph M Bodi, Célestin N Nsibu, Roland L Longenge, Michel N Aloni, Pierre Z Akilimali, Pierre M Tshibassu, Patrick K Kayembe, Ahmeddin H Omar, Kenji Hirayama, Jan Verhaegen Malaria Journal 2013, 12:205 (15 June 2013) Abstract \| Provisional PDF \| Editor’s summary Report of a case control study of haemoglobinuria conducted over two years amongst paediatric malaria patients in Kinshasa. This may reflect an increase in the incidence of this severe complication of falciparum malaria.
		Research Equivalent susceptibility of anopheles gambiae M and S molecular forms and anopheles arabiensis to plasmodium falciparum infection in Burkina Faso Awa Gnémé, Wamdaogo M Guelbéogo, Michelle M Riehle, Antoine Sanou, Alphonse Traoré, Soumanaba Zongo, Karin Eiglmeier, Gustave B Kabré, N¿Falé Sagnon, Kenneth D Vernick Malaria Journal 2013, 12:204 (14 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The authors have tested for differences in Plasmodium falciparum infection prevalence and intensity between Anopheles gambiae M, A. gambiae S and Anopheles arabiensis, but found no difference in susceptibility between these three populations when performing experimental infections using ¿local¿ malaria strains.
		Research A good night's sleep and the habit of net use: perceptions of risk and reasons for bed net use in Bukoba and Zanzibar Hannah M Koenker, Dana Loll, Datius Rweyemamu, Abdullah S Ali Malaria Journal 2013, 12:203 (13 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The article raises the very important issue about how long and to what extent people will continue to comply with malaria preventive measures as incidence decreases.
		Research Determination of artemether and lumefantrine in anti-malarial fixed-dose combination tablets by microemulsion electrokinetic chromatography with short-end injection procedure N¿Cho Christophe Amin, Huguette Fabre, Marie-Dominique Blanchin, Jérôme Montels, Michèle Aké Malaria Journal 2013, 12:202 (13 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Describes a microemulsion electrokinetic chromatography method for the quantitation of artemether and lumefantrine in tablets, a method not previously described for the assay of these anti-malarials.
		Research Population genetics analysis during the elimination process of Plasmodium falciparum in Djibouti Bouh Abdi Khaireh, Ashenafi Assefa, Hawa Hassan Guessod, Leonardo K Basco, Mohamed Abdi Khaireh, Aurélie Pascual, Sébastien Briolant, Samatar Mohamed Bouh, Ismaïl Hassan Farah, Habib Moussa Ali, Abdoul-Ilah Ahmed Abdi, Mouna Osman Aden, Zamzam Abdillahi, Souleiman Nour Ayeh, Houssein Youssouf Darar, Jean-Louis Koeck, Christophe Rogier, Bruno Pradines, Hervé Bogreau Malaria Journal 2013, 12:201 (13 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Djibouti is a small country on the edge of the endemic distribution of malaria in the horn of Africa, which has been considered as having potential for future local malaria elimination. This study analyses the genetic diversity of P. falciparum sampled at four different time points and discusses results in the context of the possibility for future elimination.
		Research Malaria and protective behaviours: is there a malaria trap? Jean-Claude Berthélemy, Josselin Thuilliez, Ogobara Doumbo, Jean Gaudart Malaria Journal 2013, 12:200 (13 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This paper is about the theoretical existence of a malaria trap as well as the implications of this for the distribution of insecticide-treated nets. -
		Research Plasmodium vivax aldolase-specific monoclonal antibodies and its application in clinical diagnosis of malaria infections in China Emmanuel E Dzakah, Keren Kang, Chao Ni, Hong Wang, Peidian Wu, Shixing Tang, Jihua Wang, Jufang Wang, Xiaoning Wang Malaria Journal 2013, 12:199 (12 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Results of research work aimed to improve malaria diagnosis and more specifically the detection of P. vivax, with particular empasis on developing new monoclonal antibodies agains parasite aldolase.
		Research High prevalence of mutation in the Plasmodium falciparum dhfr and dhps genes in field isolates from Sabah, Northern Borneo Noor Rain Abdullah, Nor Azrina Norahmad, Jenarun Jelip, Lokman Hakim Sulaiman, Hasidah Mohd Sidek, Zakiah Ismail, Harald Noedl Malaria Journal 2013, 12:198 (12 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Analysis of the mutations in the dhfr and dhps genes in samples from Sabah, Northern Borneo, Malaysia. The overall conclusions support the interpretation that parasite populations in this region carry a wide variety of allelic combinations associated with resistance to SP and the authors recommendation that SP not be used is definitely important for local decision making.
		Opinion Imported malaria in Albania and the risk factors that could allow its reappearance Klodiana Shkurti, Gentian Vyshka, Enkelejda Velo, Arben Boçari, Majlinda Kokici, Dhimitër Kraja Malaria Journal 2013, 12:197 (12 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Comments on the risk of malaria reappearance in Albania based on three environmental and human factors: the geographical distribution of Anopheles species, the human migration and the flooding of northern lowlands close to the Adriatic coasts.
		Methodology Environmentally friendly tool to control mosquito populations without risk of insecticide resistance: the Lehmann's funnel entry trap Abdoulaye Diabaté, Etienne Bilgo, Roch K Dabiré, Fréderic Tripet Malaria Journal 2013, 12:196 (10 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This study presents the results of the use of a funnel entry trap as an alternative tool to control mosquitoes. The development of novel control tools is highly needed and the study is a proof a concept of the use of the trap.
		Research High rates of parasite recrudescence following intermittent preventive treatment with sulphadoxine-pyrimethamine during pregnancy in Benin Azizath Moussiliou, Yolande Sissinto-Savi De Tove, Justin Doritchamou, Adrian JF Luty, Achille Massougbodji, Michael Alifrangis, Philippe Deloron, Nicaise Tuikue Ndam Malaria Journal 2013, 12:195 (10 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Despite widespread parasite resistance to sulphadoxine-pyrimethamine (SP) its use for intermittent preventative treatment during pregnancy remains the policy in Benin and throughout most of sub-Saharan Africa. This study suggests that this policy needs to be changed soon.
		Research Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica Virendra K Dua, Gaurav Verma, Bikram Singh, Aswathy Rajan, Upma Bagai, Dau Agarwal, NC Gupta, Sandeep Kumar, Ayushi Rastogi Malaria Journal 2013, 12:194 (10 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The present investigation demonstrates that the compound conessine exhibited substantial anti-malarial property. The isolated compound could be chemically modified to improve its potency.
		Research Malaria and haematologic parameters of pupils at different altitudes along the slope of Mount Cameroon: a cross-sectional study Helen K Kimbi, Irene UN Sumbele, Malaika Nweboh, Judith K Anchang-Kimbi, Emmaculate Lum, Yannick Nana, Lucy M Ndip, Henry Njom, Leopold G Lehman Malaria Journal 2013, 12:193 (9 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Results of a study of the impact of altitude/malaria transmission along an altitude transect, and a discussion of the impact of malaria infections on various haematologic measurements.
		Review Land cover, land use and malaria in the Amazon: a systematic literature review of studies using remotely sensed data Aurélia Stefani, Isabelle Dusfour, Ana Paula SA Corrêa, Manoel CB Cruz, Nadine Dessay, Allan KR Galardo, Clícia D Galardo, Romain Girod, Margarete SM Gomes, Helen Gurgel, Ana Cristina F Lima, Eduardo S Moreno, Lise Musset, Mathieu Nacher, Alana CS Soares, Bernard Carme, Emmanuel Roux Malaria Journal 2013, 12:192 (8 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The authors present a well-reasoned argument for a shared land use/lang cover topology for studies of malaria risk in the Amazon region. Their detailed review of studies using remote-sensing data to identify malaria risk factors in the Amazon forest is very relevant to the field.
		Research A histological method for quantifying Plasmodium falciparum in the brain in fatal paediatric cerebral malaria Danny A Milner, Clarissa Valim, Richard A Carr, Pankaj B Chandak, Nedson G Fosiko, Richard Whitten, Krupa B Playforth, Karl B Seydel, Steve Kamiza, Malcolm E Molyneux, Terrie E Taylor Malaria Journal 2013, 12:191 (7 June 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary This study details the histopathological quantification of parasite counts for cerebral malaria studies. Methods that involve quantitative measures of different life cycle stages are useful for distinguishing patterns within the cerebral malaria population; these subclassifications may be important for studies of disease pathogenesis and ancillary treatment.
		Methodology A novel live-dead staining methodology to study malaria parasite viability Erica M Pasini, Denise van den Ierssel, Henri J Vial, Clemens HM Kocken Malaria Journal 2013, 12:190 (7 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The authors used various dyes of different commercial sources to stain malaria parasites with the aim to differentially distinguish live from dead parasites. An underlying objective is to apply this technique in testing drug sensitivity of malaria parasite and to be used as a tool for checking quality of the long term culture of P. vivax.
		Research In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na⁺/H⁺ exchanger transporter (Pfnhe-1) gene in 393 isolates from Dakar, Senegal Aurélie Pascual, Bécaye Fall, Nathalie Wurtz, Mansour Fall, Cheikhou Camara, Aminata Nakoulima, Eric Baret, Bakary Diatta, Khadidiatou Fall, Pape Mbaye, Yaya Diémé, Raymond Bercion, Hervé Bogreau, Sébastien Briolant, Christophe Rogier, Boubacar Wade, Bruno Pradines Malaria Journal 2013, 12:189 (7 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Evaluation of the association between the Pfnhe polymorphism and quinine susceptibility in isolates from Senegal, aiming to assess the validity of Pfnhe as a molecular marker of QN susceptibility.
		Research Evaluation of the malaria rapid diagnostic test VIKIA malaria Ag Pf/Pan™ in endemic and non-endemic settings Daniel Eibach, Boubacar Traore, Mourad Bouchrik, Boubacar Coulibaly, Nianégué Coulibaly, Fanta Siby, Guillaume Bonnot, Anne-Lise Bienvenu, Stéphane Picot Malaria Journal 2013, 12:188 (6 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The authors compare the performance of VIKIA Malaria Ag Pf/Pan to LM-PCR corrected in an endemic setting and a non-endemic setting. The study concludes that VIKIA performance is comparable to the widely used CareStart test and microscopy-corrected PCR results, in both endemic and non-endemic areas.
		Review Designing the next generation of medicines for malaria control and eradication Jeremy N Burrows, Rob Hooft van Huijsduijnen, Jörg J Möhrle, Claude Oeuvray, Timothy NC Wells Malaria Journal 2013, 12:187 (6 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper provides an outline definition of the ideal and minimally acceptable characteristics of the types of clinical candidate molecule which are needed in various situations, both as monotherapy and combination therapy.
		Research The association between price, competition, and demand factors on private sector anti-malarial stocking and sales in western Kenya: considerations for the AMFm subsidy Wendy O’Meara, Andrew Obala, Harsha Thirumurthy, Barasa Khwa-Otsyula Malaria Journal 2013, 12:186 (5 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Information on why retailers choose to stock specific drugs and what determines the volume of different types of drugs sold in the outlets ¿ including price, which is relevant information in the context of subsidy interventions such as the AMFm.
		Research Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP) Martha Sedegah, Yohan Kim, Harini Ganeshan, Jun Huang, Maria Belmonte, Esteban Abot, Jo Banania, Fouzia Farooq, Shannon McGrath, Bjoern Peters, Alessandro Sette, Lorraine Soisson, Carter Diggs, Denise L Doolan, Cindy Tamminga, Eileen Villasante, Michael R Hollingdale, Thomas L Richie Malaria Journal 2013, 12:185 (5 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This study identified new class I epitopes restricted by six HLA supertypes on the CSP, one of the leading vaccine candidate antigens, suggesting that an adenovirus-vectored CSP vaccine would be immunogenic and potentially protective in genetically diverse populations.
		Research Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum Fabiana M Jordão, Heloisa B Gabriel, João MP Alves, Claudia B Angeli, Thaís D Bifano, Ardala Breda, Mauro F de Azevedo, Luiz A Basso, Gerhard Wunderlich, Emilia A Kimura, Alejandro M Katzin Malaria Journal 2013, 12:184 (4 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary The paper presents the cloning, expression, purification, biochemical characterization of the FPPS from Plasmodium falciparum. The authors show that this enzyme has two activities that result in the production of farnesyl diphosphate/geranylgeranyl diphosphate, a key branch point of the isoprenoid synthesis and, hence, playing a central role in the regulation of a number of essential functions in Plasmodium parasites.