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1:

Island-wide diversity in single nucleotide polymorphisms of the Plasmodium vivax dihydrofolate reductase and dihydropteroate synthetase genes in Sri Lanka.

Schousboe ML, Rajakaruna RS, Salanti A, Hapuarachchi HC, Galappaththy GN, Bygbjerg IC, Amerasinghe PH, Konradsen F, Alifrangis M.

Malar J. 2007 Mar 9;6:28.

PMID: 17349045 [PubMed - indexed for MEDLINE]

2:

Plasmodium vivax dhfr and dhps mutations in isolates from Madagascar and therapeutic response to sulphadoxine-pyrimethamine.

Barnadas C, Tichit M, Bouchier C, Ratsimbasoa A, Randrianasolo L, Raherinjafy R, Jahevitra M, Picot S, Ménard D.

Malar J. 2008 Feb 26;7:35.

PMID: 18302746 [PubMed - indexed for MEDLINE]

3:

Rapid increase of Plasmodium falciparum dhfr/dhps resistant haplotypes, after the adoption of sulphadoxine-pyrimethamine as first line treatment in 2002, in southern Mozambique.

Enosse S, Magnussen P, Abacassamo F, Gómez-Olivé X, Rønn AM, Thompson R, Alifrangis M.

Malar J. 2008 Jul 1;7:115.

PMID: 18590577 [PubMed - indexed for MEDLINE]

4:

Point mutations in the dihydrofolate reductase and dihydropteroate synthase genes of Plasmodium falciparum and resistance to sulfadoxine-pyrimethamine in Sri Lanka.

Hapuarachchi HC, Dayanath MY, Bandara KB, Abeysundara S, Abeyewickreme W, de Silva NR, Hunt SY, Sibley CH.

Am J Trop Med Hyg. 2006 Feb;74(2):198-204.

PMID: 16474070 [PubMed - indexed for MEDLINE]

5:

Amino acid mutations in Plasmodium vivax DHFR and DHPS from several geographical regions and susceptibility to antifolate drugs.

Auliff A, Wilson DW, Russell B, Gao Q, Chen N, Anh le N, Maguire J, Bell D, O'Neil MT, Cheng Q.

Am J Trop Med Hyg. 2006 Oct;75(4):617-21.

PMID: 17038682 [PubMed - indexed for MEDLINE]

6:

Limited polymorphism in the dihydropteroate synthetase gene (dhps) of Plasmodium vivax isolates from Thailand.

Imwong M, Pukrittayakamee S, Cheng Q, Moore C, Looareesuwan S, Snounou G, White NJ, Day NP.

Antimicrob Agents Chemother. 2005 Oct;49(10):4393-5.

PMID: 16189131 [PubMed - indexed for MEDLINE]

8:

Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase.

Hawkins VN, Auliff A, Prajapati SK, Rungsihirunrat K, Hapuarachchi HC, Maestre A, O'Neil MT, Cheng Q, Joshi H, Na-Bangchang K, Sibley CH.

Malar J. 2008 Apr 28;7:72.

PMID: 18442404 [PubMed - indexed for MEDLINE]

9:

Drug resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum malaria in Mlimba, Tanzania.

Mbugi EV, Mutayoba BM, Malisa AL, Balthazary ST, Nyambo TB, Mshinda H.

Malar J. 2006 Oct 31;5:94.

PMID: 17076899 [PubMed - indexed for MEDLINE]

10:

High prevalence of quintuple mutant dhps/dhfr genes in Plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in Malawi.

Bwijo B, Kaneko A, Takechi M, Zungu IL, Moriyama Y, Lum JK, Tsukahara T, Mita T, Takahashi N, Bergqvist Y, Björkman A, Kobayakawa T.

Acta Trop. 2003 Mar;85(3):363-73.

PMID: 12659974 [PubMed - indexed for MEDLINE]

11:

Association of genetic mutations in Plasmodium vivax dhfr with resistance to sulfadoxine-pyrimethamine: geographical and clinical correlates.

Imwong M, Pukrittakayamee S, Looareesuwan S, Pasvol G, Poirreiz J, White NJ, Snounou G.

Antimicrob Agents Chemother. 2001 Nov;45(11):3122-7.

PMID: 11600366 [PubMed - indexed for MEDLINE]

14:

Therapeutic efficacies of artesunate-sulfadoxine-pyrimethamine and chloroquine-sulfadoxine-pyrimethamine in vivax malaria pilot studies: relationship to Plasmodium vivax dhfr mutations.

Tjitra E, Baker J, Suprianto S, Cheng Q, Anstey NM.

Antimicrob Agents Chemother. 2002 Dec;46(12):3947-53.

PMID: 12435700 [PubMed - indexed for MEDLINE]

15:

High prevalence of drug-resistance mutations in Plasmodium falciparum and Plasmodium vivax in southern Ethiopia.

Schunk M, Kumma WP, Miranda IB, Osman ME, Roewer S, Alano A, Löscher T, Bienzle U, Mockenhaupt FP.

Malar J. 2006 Jul 3;5:54.

PMID: 16817953 [PubMed - indexed for MEDLINE]

16:

Real-time PCR for dihydrofolate reductase gene single-nucleotide polymorphisms in Plasmodium vivax isolates.

Brega S, de Monbrison F, Severini C, Udomsangpetch R, Sutanto I, Ruckert P, Peyron F, Picot S.

Antimicrob Agents Chemother. 2004 Jul;48(7):2581-7.

PMID: 15215112 [PubMed - indexed for MEDLINE]

17:

Antifolates can have a role in the treatment of Plasmodium vivax.

Hawkins VN, Joshi H, Rungsihirunrat K, Na-Bangchang K, Sibley CH.

Trends Parasitol. 2007 May;23(5):213-22. Epub 2007 Mar 26. Review.

PMID: 17368986 [PubMed - indexed for MEDLINE]

18:

Molecular determination of point mutation haplotypes in the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum in three districts of northern Tanzania.

Pearce RJ, Drakeley C, Chandramohan D, Mosha F, Roper C.

Antimicrob Agents Chemother. 2003 Apr;47(4):1347-54.

PMID: 12654669 [PubMed - indexed for MEDLINE]

19:

Therapeutic efficacy of sulfadoxine-pyrimethamine and prevalence of resistance markers in Tanzania prior to revision of malaria treatment policy: Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase mutations in monitoring in vivo resistance.

Mugittu K, Ndejembi M, Malisa A, Lemnge M, Premji Z, Mwita A, Nkya W, Kataraihya J, Abdulla S, Beck HP, Mshinda H.

Am J Trop Med Hyg. 2004 Dec;71(6):696-702.

PMID: 15642957 [PubMed - indexed for MEDLINE]

20:

Geographical distribution of amino acid mutations in Plasmodium vivax DHFR and DHPS from malaria endemic areas of Thailand.

Rungsihirunrat K, Sibley CH, Mungthin M, Na-Bangchang K.

Am J Trop Med Hyg. 2008 Mar;78(3):462-7.

PMID: 18337344 [PubMed - indexed for MEDLINE]

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