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1:

The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids.

Warhurst DC, Craig JC, Adagu IS, Meyer DJ, Lee SY.

Malar J. 2003 Sep 1;2:26. Epub 2003 Sep 1.

PMID: 14505493 [PubMed - indexed for MEDLINE]

2:

Conformation of epicinchonine and cinchonine in view of their antimalarial activity: x-ray and theoretical studies.

Kowalik JT, Lipińska T, Oleksyn BJ, Sliwiński J.

Enantiomer. 1999;4(5):389-410.

PMID: 10644163 [PubMed - indexed for MEDLINE]

3:

Stereochemical evaluation of the relative activities of the cinchona alkaloids against Plasmodium falciparum.

Karle JM, Karle IL, Gerena L, Milhous WK.

Antimicrob Agents Chemother. 1992 Jul;36(7):1538-44.

PMID: 1510452 [PubMed - indexed for MEDLINE]

4:

Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases.

Warhurst DC, Craig JC, Adagu IS, Guy RK, Madrid PB, Fivelman QL.

Biochem Pharmacol. 2007 Jun 15;73(12):1910-26. Epub 2007 Mar 19.

PMID: 17466277 [PubMed - indexed for MEDLINE]

5:

Stereoelectronic features of the cinchona alkaloids determine their differential antimalarial activity.

Karle JM, Bhattacharjee AK.

Bioorg Med Chem. 1999 Sep;7(9):1769-74.

PMID: 10530923 [PubMed - indexed for MEDLINE]

6:

Activity of a combination of three cinchona bark alkaloids against Plasmodium falciparum in vitro.

Druilhe P, Brandicourt O, Chongsuphajaisiddhi T, Berthe J.

Antimicrob Agents Chemother. 1988 Feb;32(2):250-4.

PMID: 3284455 [PubMed - indexed for MEDLINE]

7:

Crystal and molecular structures of trichloro-cobalt(II) complexes of epiquinine, epiquinidine, and epidihydrocinchonine.

Tesarowicz I, Oleksyn BJ, Nitek W.

Chirality. 2007 Feb;19(2):152-61.

PMID: 17152047 [PubMed - indexed for MEDLINE]

8:

A comparison of the antimalarial activity of the cinchona alkaloids against Plasmodium falciparum in vitro.

Wesche DL, Black J.

J Trop Med Hyg. 1990 Jun;93(3):153-9.

PMID: 2190002 [PubMed - indexed for MEDLINE]

9:

Synergistic interaction of a chloroquine metabolite with chloroquine against drug-resistant malaria parasites.

Kalkanidis M, Klonis N, Tschan S, Deady LW, Tilley L.

Biochem Pharmacol. 2004 Apr 1;67(7):1347-53.

PMID: 15013850 [PubMed - indexed for MEDLINE]

10:

In vitro inhibition of beta-haematin formation, DNA interactions, antiplasmodial activity, and cytotoxicity of synthetic neocryptolepine derivatives.

Van Miert S, Jonckers T, Cimanga K, Maes L, Maes B, Lemière G, Dommisse R, Vlietinck A, Pieters L.

Exp Parasitol. 2004 Nov-Dec;108(3-4):163-8.

PMID: 15582513 [PubMed - indexed for MEDLINE]

12:

Cinchona alkaloids and malaria.

Warhurst DC.

Acta Leiden. 1987;55:53-64. Review. No abstract available.

PMID: 3321841 [PubMed - indexed for MEDLINE]

13:

Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro.

Nakornchai S, Konthiang P.

Acta Trop. 2006 Dec;100(3):185-91. Epub 2006 Nov 28.

PMID: 17126280 [PubMed - indexed for MEDLINE]

14:

Enantioselective anion exchangers based on cinchona alkaloid-derived carbamates: influence of C8/C9 stereochemistry on chiral recognition.

Maier NM, Nicoletti L, Lämmerhofer M, Lindner W.

Chirality. 1999;11(7):522-8.

PMID: 10423277 [PubMed - indexed for MEDLINE]

15:

Ligand-based virtual screening and in silico design of new antimalarial compounds using nonstochastic and stochastic total and atom-type quadratic maps.

Marrero-Ponce Y, Iyarreta-Veitía M, Montero-Torres A, Romero-Zaldivar C, Brandt CA, Avila PE, Kirchgatter K, Machado Y.

J Chem Inf Model. 2005 Jul-Aug;45(4):1082-100.

PMID: 16045304 [PubMed - indexed for MEDLINE]

16:

Naturally occurring cobalamins have antimalarial activity.

Chemaly SM, Chen CT, van Zyl RL.

J Inorg Biochem. 2007 May;101(5):764-73. Epub 2007 Jan 31.

PMID: 17343914 [PubMed - indexed for MEDLINE]

17:

Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana Moens ex Trimen.

Park BS, Kim DY, Rosenthal PJ, Huh SC, Lee BJ, Park EU, Kim SM, Kim JE, Kim MH, Huh TL, Choi YJ, Suh KH, Choi WS, Lee SE.

Bioorg Med Chem Lett. 2002 May 20;12(10):1351-5.

PMID: 11992775 [PubMed - indexed for MEDLINE]

18:

Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.

Gemma S, Kukreja G, Fattorusso C, Persico M, Romano MP, Altarelli M, Savini L, Campiani G, Fattorusso E, Basilico N, Taramelli D, Yardley V, Butini S.

Bioorg Med Chem Lett. 2006 Oct 15;16(20):5384-8. Epub 2006 Aug 4.

PMID: 16890433 [PubMed - indexed for MEDLINE]

19:

In vitro studies on the mechanism of action of two compounds with antiplasmodial activity: ellagic acid and 3,4,5-trimethoxyphenyl(6'-O-aalloyl)-beta-D-glucopyranoside.

Dell'Agli M, Parapini S, Basilico N, Verotta L, Taramelli D, Berry C, Bosisio E.

Planta Med. 2003 Feb;69(2):162-4.

PMID: 12624824 [PubMed - indexed for MEDLINE]

20:

In-vitro response of Plasmodium falciparum to the main alkaloids of Cinchona in northwestern Thailand.

Knauer A, Sirichaisinthop J, Reinthaler FF, Wiedermann G, Wernsdorfer G, Wernsdorfer WH.

Wien Klin Wochenschr. 2003;115 Suppl 3:39-44.

PMID: 15508779 [PubMed - indexed for MEDLINE]

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