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1.

2915
Accesses

Commentary   Open Access Highly Accessed

It is time to rethink tactics in the fight against malaria

Laurence Slutsker, S Kachur Malaria Journal 2013, 12:140 (24 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

On world malaria day, renowned malariologists from CDC discuss dangers and resilience, despite successful control in many areas, and how we may need to rethink our strategy in order to defeat the parasite.

2.

1716
Accesses

Case study   Open Access Highly Accessed

Ivermectin to reduce malaria transmission: a research agenda for a promising new tool for elimination

Carlos J Chaccour, Kevin C Kobylinski, Quique Bassat, Teun Bousema, Chris Drakeley, Pedro Alonso, Brian D Foy Malaria Journal 2013, 12:153 (7 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A topic of high importance to the vector control community and reflects recent discussions on the current challenges in malaria prevention and control ¿ specifically, development of new tools for niche transmission settings (i.e., outdoors) where current interventions, such as ITNs and IRS may not be effective.

3.

1632
Accesses

Research   Open Access Highly Accessed

Impact of malaria during pregnancy on pregnancy outcomes in a Ugandan prospective cohort with intensive malaria screening and prompt treatment

Pierre De Beaudrap, Eleanor Turyakira, Lisa J White, Carolyn Nabasumba, Benon Tumwebaze, Atis Muehlenbachs, Philippe J Guérin, Yap Boum, Rose McGready, Patrice Piola Malaria Journal 2013, 12:139 (24 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Malaria in pregnancy is a major public health problem in endemic areas of sub-Saharan Africa and has important consequences on birth outcome. In this study, the timing, parasitaemia level and number of peripherally-detected malaria infections, but not the presence of fever, were associated with adverse birth outcomes. Hence, prompt malaria detection and treatment should be offered to pregnant women, with increased focus on mothers living in remote areas.

4.

1560
Accesses

Review   Open Access Highly Accessed

Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria

Jane Achan, Ambrose O Talisuna, Annette Erhart, Adoke Yeka, James K Tibenderana, Frederick N Baliraine, Philip J Rosenthal, Umberto D'Alessandro Malaria Journal 2011, 10:144 (24 May 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This review of quinine is useful, because the drug still plays an important role in the treatment of malaria.

5.

1485
Accesses

Review   Open Access Highly Accessed

Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report

Lorenz von Seidlein, Sarah Auburn, Fe Espino, Dennis Shanks, Qin Cheng, James McCarthy, Kevin Baird, Catherine Moyes, Rosalind Howes, Didier Ménard, Germana Bancone, Ari Winasti-Satyahraha, Lasse S Vestergaard, Justin Green, Gonzalo Domingo, Shunmay Yeung, Ric Price Malaria Journal 2013, 12:112 (27 March 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

A review based on the conclusions of an important meeting looking at the knowledge gaps in G6PD deficiency with regards to the safe implementation of 8 - aminoquinolines.

6.

1386
Accesses

Research   Open Access Highly Accessed

Over-diagnosis of malaria by microscopy in the Kilombero Valley, Southern Tanzania: an evaluation of the utility and cost-effectiveness of rapid diagnostic tests

Kelly Harchut, Claire Standley, Andrew Dobson, Belia Klaassen, Clotilde Rambaud-Althaus, Fabrice Althaus, Katarzyna Nowak Malaria Journal 2013, 12:159 (10 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Presumptive treatment used to be recommended by WHO, on the assumption that it is safer to treat non-malarial patients with anti-malarials than missing a true case of malaria. With a reduced incidence of malaria, a much increased cost of treatment and the realization of the risks of not identifying the true cause of febrile illness, there is now greater emphasis on accurate biological diagnosis. This study shows the advantages of using RDTs compared to poor quality microscopy.

7.

1258
Accesses

Research   Open Access Highly Accessed

Development of a population suppression strain of the human malaria vector mosquito, Anopheles stephensi

Osvaldo Marinotti, Nijole Jasinskiene, Aniko Fazekas, Sarah Scaife, Guoliang Fu, Stefanie T Mattingly, Karissa Chow, David M Brown, Luke Alphey, Anthony A James Malaria Journal 2013, 12:142 (26 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

The study uses a female-specific gene promoter back engineered from Aedes aegypti for the Indian urban malaria vector Anopheles stephensi. The technology uses an antibiotic-repressible lethal factor to produce a sex-specific flightless transgene phenotype.

8.

1213
Accesses

Research   Open Access Highly Accessed

Clinical performance of an automated reader in interpreting malaria rapid diagnostic tests in Tanzania

Seif Shekalaghe, Marcela Cancino, Caroline Mavere, Omar Juma, Ali Mohammed, Salim Abdulla, Santiago Ferro Malaria Journal 2013, 12:141 (24 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Paper reporting the performance of an automated malaria RDT reader with a network 'cloud' connectivity. The Deki reader is as good as an experienced visual read and can add to the issue of misinterpretation of RDT results by providing a novel mechanism for quality assurance.

9.

1108
Accesses

Review   Open Access Highly Accessed

A review of malaria vaccine clinical projects based on the WHO rainbow table

Lauren Schwartz, Graham V Brown, Blaise Genton, Vasee S Moorthy Malaria Journal 2012, 11:11 (9 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This review succeeds in its primary objective in presenting the most comprehensive review and, of necessity, is broad and goes into much more depth than might be expected. As such it complements the WHO spreadsheet, and is a valuable companion document.

10.

999
Accesses

Research   Open Access Highly Accessed

A new world malaria map: Plasmodium falciparum endemicity in 2010

Peter W Gething, Anand P Patil, David L Smith, Carlos A Guerra, Iqbal RF Elyazar, Geoffrey L Johnston, Andrew J Tatem, Simon I Hay Malaria Journal 2011, 10:378 (20 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The paper represents a Herculean effort to provide an updated map of the global distribution of malaria, based on three key malariometric indices PfPR, PfEIR and PfRC and represents a unique contribution.

11.

984
Accesses

Research   Open Access Highly Accessed

Five years of malaria control in the continental region, Equatorial Guinea

Andrea M Rehman, Andrea G Mann, Christopher Schwabe, Michael R Reddy, Irina Roncon Gomes, Michel A Slotman, Lee Yellott, Abrahan Matias, Adalgisa Caccone, Gloria Nseng Nchama, Immo Kleinschmidt Malaria Journal 2013, 12:154 (7 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

The findings that both LLINs and IRS offer individual protection, after adjusting for indicators of socio-economic status, are consistent with the literature. This study corroborates previous findings that the combination of the LLINs and IRS offers greater protection than either intervention alone.

12.

976
Accesses

Research   Open Access Highly Accessed

Physical condition of Olyset(R) nets after five years of utilization in rural western Kenya

Paola Mejia, Hailay Teklehaimanot, Yihenew Tesfaye, Awash Teklehaimanot Malaria Journal 2013, 12:158 (10 May 2013)

Abstract | Provisional PDF | PubMed

13.

955
Accesses

Research   Open Access Highly Accessed

Malaria resurgence: a systematic review and assessment of its causes

Justin M Cohen, David L Smith, Chris Cotter, Abigail Ward, Gavin Yamey, Oliver J Sabot, Bruno Moonen Malaria Journal 2012, 11:122 (24 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

There is a need for practical solutions to the operational and financial threats facing malaria elimination programmes if we are to avoid repeating the mistakes of the past, which saw the resurgence of malaria in disease free areas.

14.

949
Accesses

Research   Open Access Highly Accessed

High level of resistance in the mosquito Anopheles gambiae to pyrethroid insecticides and reduced susceptibility to bendiocarb in north-western Tanzania

Natacha Protopopoff, Johnson Matowo, Robert Malima, Reginald Kavishe, Robert Kaaya, Alexandra Wright, Philippa A West, Immo Kleinschmidt, William Kisinza, Franklin W Mosha, Mark Rowland Malaria Journal 2013, 12:149 (2 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

A report of bioassay data and kdr frequencies for An gambiae, which clearly demonstrate the presence of pyrethroid resistance.

15.

949
Accesses

Research   Open Access Highly Accessed

Urbanization and the global malaria recession

Andrew J Tatem, Peter W Gething, David L Smith, Simon I Hay Malaria Journal 2013, 12:133 (17 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Article that adds significant quantitative information to our understanding of the association of malaria and urbanization worldwide.

 

16.

931
Accesses

Research   Open Access Highly Accessed

Community perceptions on the secondary health benefits established by malaria vaccine trials (RTS,S phase 2 and phase 3) at the Korogwe site in North Eastern Tanzania

Edwin A Liheluka, John P Lusingu, Rachel N Manongi Malaria Journal 2013, 12:157 (8 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

This study explored the community perceptions on the secondary health benefits of a malaria vaccine trial at the Korogwe site in Tanzania.

17.

906
Accesses

Opinion   Open Access Highly Accessed

Made in Europe: will artemisinin resistance emerge in French Guiana?

Mathieu Nacher, Philippe J Guérin, Magalie Demar-Pierre, Félix Djossou, François Nosten, Bernard Carme Malaria Journal 2013, 12:152 (4 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

In their opinion piece, the authors outline the current malaria control strategy in French Guiana and the challenges associated with treating and controlling malaria in a setting that is constrained by European regulations and the inaccessibility of a large proportion of the population affected by malaria in the region.

18.

892
Accesses

Methodology   Open Access Highly Accessed

The parasite clearance curve

NJ White Malaria Journal 2011, 10:278 (22 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The author presents a clear and concise introduction to the parasite clearance curve, which is important in determining the therapeutic response to anti-malarials, particularly artemisinin derivatives. Given the recent reports of emerging artemisinin resistance in Western Cambodia, this is a very timely report.

19.

873
Accesses

Research   Open Access Highly Accessed

Access to artemisinin-based anti-malarial treatment and its related factors in rural Tanzania

Rashid A Khatib, Majige Selemani, Gumi A Mrisho, Irene M Masanja, Mbaraka Amuri, Mustafa H Njozi, Dan Kajungu, Irene Kuepfer, Salim M Abdulla, Don de Savigny Malaria Journal 2013, 12:155 (7 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Paper addresses the issue of fever/malaria patients¿ access to different ACTproviders in two HDSS sites in rural southern Tanzania.

20.

856
Accesses

Research   Open Access Highly Accessed

Artemisinin-based combination therapy does not measurably reduce human infectiousness to vectors in a setting of intense malaria transmission

Bernadette J Huho, Gerard F Killeen, Heather M Ferguson, Adriana Tami, Christian Lengeler, J Derek Charlwood, Aniset Kihonda, Japhet Kihonda, S Patrick Kachur, Thomas A Smith, Salim MK Abdulla Malaria Journal 2012, 11:118 (18 April 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A study of the impact of artesunate/SP use on oocyst/sporozoite carriage in mosquitoes. It is not unexpected that in an area of intense malaria transmission, with presumed large numbers of asymptomatic gametocyte carriers, that ACT does not result in a marked reduction in transmission indices. Whilst the result in not unexpected the methodology is thorough and is likely to be useful to others.

21.

837
Accesses

Research   Open Access Highly Accessed

Community perceptions of a malaria vaccine in the Kintampo districts of Ghana

Lawrence G Febir, Kwaku P Asante, Dan-Bright S Dzorgbo, Kojo A Senah, Timothy S Letsa, Seth Owusu-Agyei Malaria Journal 2013, 12:156 (7 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

A sound contribution to our understanding about community perceptions of a malaria vaccine in the Brong-Ahafo Region of Ghana. The study results are of significant interest to the scientific community as our knowledge on acceptance/rejection of malaria vaccines is limited to date. Furthermore, the data on the role of religious leaders in promoting health-seeking behaviour and participation in vaccination initiatives like EPI is highly relevant for policy makers in the light of earlier vaccination controversies in West Africa and elsewhere.

22.

826
Accesses

Research   Open Access Highly Accessed

Standardizing operational vector sampling techniques for measuring malaria transmission intensity: evaluation of six mosquito collection methods in western Kenya

Jacklyn Wong, Nabie Bayoh, George Olang, Gerry F Killeen, Mary J Hamel, John M Vulule, John E Gimnig Malaria Journal 2013, 12:143 (30 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Compared to the gold standard, human landing catches, evaluations were made for the following five methods: CDC light trap, Ifakara tent trap, window exit trap, pot resting trap, and box resting trap. The discussion is strong with details on study limitations.

23.

816
Accesses

Research   Open Access Highly Accessed

Malaria is an uncommon cause of adult sepsis in south-western Uganda

Mary A Auma, Mark J Siedner, Dan Nyehangane, Aisha Nalusaji, Martha Nakaye, Juliet Mwanga-Amumpaire, Rose Muhindo, L Wilson, Yap Boum, Christopher C Moore Malaria Journal 2013, 12:146 (1 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

The paper makes a point which should not need making, that adults severe febrile illness is seldom malaria in mesoendemic areas. In effect, the negative predictive value of a RDT result was very high (98.6%), because the prevalence of malaria was so low in this population. Therefore, a negative RDT result effectively rules-out malaria and treatment can be reserved for patients with a positive test result.

24.

804
Accesses

Research   Open Access Highly Accessed

Analysing and recommending options for maintaining universal coverage with long-lasting insecticidal nets: the case of Tanzania in 2011

Hannah M Koenker, Joshua O Yukich, Alex Mkindi, Renata Mandike, Nick Brown, Albert Kilian, Christian Lengeler Malaria Journal 2013, 12:150 (4 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

After three years of free mass net distribution campaigns and policy-makers are now faced with the challenge of maintaining high coverage as nets wear out and the population grows. A process of exploring options for a continuous or ¿Keep-Up¿ distribution system was initiated in early 2011. This paper suggests practical applications of the Netcalc software tool to help influence these policy discussions.

25.

798
Accesses

Research   Open Access Highly Accessed

Prevalence and risk factors of malaria in Ethiopia

Dawit G Ayele, Temesgen T Zewotir, Henry G Mwambi Malaria Journal 2012, 11:195 (12 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The stated objective of the paper was to investigate the prevalence rate and the associated socio-economic, geographic and demographic factors associated with malaria based on RDT survey results.

26.

785
Accesses

Reviews   Open Access Highly Accessed

Plant-based insect repellents: a review of their efficacy, development and testing

Marta Maia, Sarah J Moore Malaria Journal 2011, 10(Suppl 1):S11 (15 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

27.

735
Accesses

Research   Open Access Highly Accessed

Early parasitological response following artemisinin-containing regimens: a critical review of the literature

Debashish Das, Ric N Price, Delia Bethell, Philippe J Guerin, Kasia Stepniewska Malaria Journal 2013, 12:125 (19 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

A literature review of prospective clinical trials of artemisinin combination therapy trials with the aim of determining the incidence persistent parasitaemia after treatment. Although crude, the proportion of patients remaining parasitaemic on D3 has been proposed as a marker possibly signalling the presence of resistance to the artemisinin component of ACT therapy. This is the first published large review of its kind.

28.

721
Accesses

Research   Open Access Highly Accessed

Paracheck-Pf® accuracy and recently treated Plasmodium falciparum infections: is there a risk of over-diagnosis?

Todd D Swarthout, Helen Counihan, Raphael Senga, Ingrid van den Broek Malaria Journal 2007, 6:58 (16 May 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Though the RDT is as sensitive as microscopy in detecting true malaria cases, low specificity resulted in a high frequency of false-positive results. This was aggravated by a duration of RDT false-positivity after effective treatment that was significantly longer than reported by the manufacturer. Presence of false positive results show the need to avoid clinicians inappropriately focusing on malaria, not identifying the true cause of illness and providing unnecessary treatment.

29.

705
Accesses

Research   Open Access

Providing open access data online to advance malaria research and control

Catherine L Moyes, William H Temperley, Andrew J Henry, Clara R Burgert, Simon I Hay Malaria Journal 2013, 12:161 (16 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A description of the construction of the Malaria Atlas Project's online data portal. It usefully details the data and associated products that the MAP team has made accessible to the global malaria community.

30.

686
Accesses

Research   Open Access Highly Accessed

Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccine

Margaret E McCoy, Hannah E Golden, Tais APF Doll, Yongkun Yang, Stephen A Kaba, Peter Burkhard, David E Lanar Malaria Journal 2013, 12:136 (22 April 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

An important paper describing aspects of the mechanism of action for a traditional malaria vaccine (CSP) delivered in the context of a novel and exciting platform (self-assembling protein nanoparticle).

31.

674
Accesses

Research   Open Access

Sex-specific induction of CYP6 cytochrome P450 genes in cadmium and lead tolerant Anopheles gambiae

Fauzia K Musasia, Alfred O Isaac, Daniel K Masiga, Irene A Omedo, Ramadhan Mwakubambanya, Richard Ochieng, Paul O Mireji Malaria Journal 2013, 12:97 (15 March 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Analysis of gene transcription levels on three cytochrome P450s in three strains of Anopheles gambiae. The first strain was maintained without any selection pressure, while the second was selected for lead tolerance and the third strain for cadmium tolerance.These findings suggest that tolerance to cadmium or lead can influence the metabolism of pyrethroids in the mosquito in a sex-specific manner, with potential implications in mosquito vector control operations.

32.

674
Accesses

Research   Open Access

Prevalence of the molecular marker of Plasmodium falciparum resistance to chloroquine and sulphadoxine/pyrimethamine in Benin seven years after the change of malaria treatment policy

Aurore Ogouyèmi-Hounto, Nicaise Tuikue Ndam, Dorothée Kinde Gazard, Sitou d’Almeida, Lucette Koussihoude, Elvire Ollo, Carmine Azagnandji, Mourchidath Bello, Jean-Phillipe Chippaux, Achille Massougbodji Malaria Journal 2013, 12:147 (1 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Evaluation of the current level of resistance of local parasite populations through by analysing point mutations in pfcrt, pfmdr1, pfdhfr and pfdhps.

33.

647
Accesses

Review   Open Access Highly Accessed

The global pipeline of new medicines for the control and elimination of malaria

Melinda P Anthony, Jeremy N Burrows, Stephan Duparc, Joerg JMoehrle, Timothy NC Wells Malaria Journal 2012, 11:316 (7 September 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A very comprehensive and useful paper on the status and prospects of anti-malarial drugs in various stages of development presented in the context of the current needs.

34.

651
Accesses

Review   Open Access Highly Accessed

Malaria in Brazil: an overview

Joseli Oliveira-Ferreira, Marcus VG Lacerda, Patrícia Brasil, José LB Ladislau, Pedro L Tauil, Cláudio Daniel-Ribeiro Malaria Journal 2010, 9:115 (30 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A review of the current malaria situation in Brazil, with particular reference to the switch to a predominance of vivax malaria.

35.

640
Accesses

Research   Open Access

Severe Plasmodium falciparum and Plasmodium vivax malaria among adults at Kassala Hospital, eastern Sudan

Tajeldin M Abdallah, Mohamed T Abdeen, Ikhlas S Ahmed, Hamdan Z Hamdan, Mamoun Magzoub, Ishag Adam Malaria Journal 2013, 12:148 (1 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

This paper is important because it provides an opportunity to compare falciparum and vivax cases in a same setting in a continent which traditionally has always only reported severe falciparum malaria.

36.

635
Accesses

Research   Open Access

Insecticide resistance status of Anopheles gambiae s.s population from M’Bé: a WHOPES-labelled experimental hut station, 10 years after the political crisis in Côte d’Ivoire

Alphonsine A Koffi, Ludovic P Ahoua Alou, Maurice A Adja, Fabrice Chandre, Cédric Pennetier Malaria Journal 2013, 12:151 (4 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In a 10-year period, the Anopheles gambiae population of M¿B¿ area shifted from susceptibility to high resistance to three insecticide families usually used in public health control programmes

37.

615
Accesses

Research   Open Access

A member of the Plasmodium falciparum PHIST family binds to the erythrocyte cytoskeleton component band 4.1

Lindsay A Parish, Deborah W Mai, Matthew L Jones, Erika L Kitson, Julian C Rayner Malaria Journal 2013, 12:160 (11 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Identification of a novel interaction between the erythrocyte Band 4.1 protein and a P. falciparum component from the PHIST family of proteins. The paper should be of interest to groups working on the parasite "exportome".

38.

605
Accesses

Research   Open Access Highly Accessed

Mobile phones improve case detection and management of malaria in rural Bangladesh

Chai S Prue, Kerry L Shannon, Jacob Khyang, Laura J Edwards, Sabeena Ahmed, Malathi Ram, Timothy Shields, Mohammad S Hossain, Gregory E Glass, Myaing M Nyunt, David A Sack, David J Sullivan, Wasif A Khan Malaria Journal 2013, 12:48 (4 February 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Mobile phone technology, when combined with local knowledge and field support, may be applicable for improving malaria control in hard-to-reach areas.

39.

607
Accesses

Research   Open Access

A rapid stability-indicating, fused-core HPLC method for simultaneous determination of β-artemether and lumefantrine in anti-malarial fixed dose combination products

Sultan Suleman, Kirsten Vandercruyssen, Evelien Wynendaele, Matthias D’Hondt, Nathalie Bracke, Luc Duchateau, Christian Burvenich, Kathelijne Peremans, Bart De Spiegeleer Malaria Journal 2013, 12:145 (30 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

The paper describes the development and validation of a stability-indicating method for artemether and lumefantrine in pharmaceutical products, using HPLC-UV.

40.

599
Accesses

Research   Open Access Highly Accessed

Is the current decline in malaria burden in sub-Saharan Africa due to a decrease in vector population?

Dan W Meyrowitsch, Erling M Pedersen, Michael Alifrangis, Thomas H Scheike, Mwelecele N Malecela, Stephen M Magesa, Yahya A Derua, Rwehumbiza T Rwegoshora, Edwin Michael, Paul E Simonsen Malaria Journal 2011, 10:188 (13 July 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 3 comments |  Editor’s summary

A challenging paper discussing whether the observed decline in malaria vector densities, in the absence of organized vector control interventions, could contribute to the decrease in levels of malaria infection

41.

589
Accesses

Research   Open Access Highly Accessed

Habitat characterization and spatial distribution of Anopheles sp. mosquito larvae in Dar es Salaam (Tanzania) during an extended dry period

Michael A Sattler, Deo Mtasiwa, Michael Kiama, Zul Premji, Marcel Tanner, Gerry F Killeen, Christian Lengeler Malaria Journal 2005, 4:4 (14 January 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Urban populations in Africa are set to rise inexorably over the coming decades, with a greater proportion of the populations living within cities and conurbations and an increase of urban agriculture in some cities. It is suggested that urban malaria is likely to become increasingly important.

42.

585
Accesses

Review   Open Access Highly Accessed

Global warming and malaria: knowing the horse before hitching the cart

Paul Reiter Malaria Journal 2008, 7(Suppl 1):S3 (11 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

43.

579
Accesses

Research   Open Access

Prevalence of molecular markers of drug resistance in an area of seasonal malaria chemoprevention in children in Senegal

Aminata C Lo, Babacar Faye, El-Hadj Ba, Badara Cisse, Roger Tine, Annie Abiola, Magatte Ndiaye, Jean LA Ndiaye, Daouda Ndiaye, Cheikh Sokhna, Jules F Gomis, Yemou Dieng, Omar Faye, Omar Ndir, Paul Milligan, Matthew Cairns, Rachel Hallett, Colin Sutherland, Oumar Gaye Malaria Journal 2013, 12:137 (23 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Description of the prevalence of molecular markers of CQ/AQ and SP resistance in Senegal, where seasonal malaria chemoprevention has been introduced, and present prevalence ratio estimates derived from data collected by cross-sectional surveys in children for three consecutive years after implementation of seasonal chemoprevention.

44.

567
Accesses

Commentary   Open Access

Fulani show decreased susceptibility to Plasmodium falciparum infection versus Mossi: data from a community-wide screening and treatment of asymptomatic carriers in Burkina Faso

Alfred B Tiono, Sodiomon B Sirima, Kamal Hamed Malaria Journal 2013, 12:163 (16 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

This study confirmed that, in the same environment, individuals belonging to the Fulani ethnic group have a lower susceptibility to Plasmodium falciparum infection than Mossi individuals.

45.

540
Accesses

Research   Open Access Highly Accessed

Scaling-up malaria treatment: a review of the performance of different providers

Mohga M Kamal-Yanni, Julien Potet, Philippa M Saunders Malaria Journal 2012, 11:414 (12 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Access to life saving malaria treatment within 24 hours of symptom onset is still far below the RBM targets. Improved case management requires a strengthened health system including community health initiatives and working with non-public sector compartments of the health system. The paper reviews different aspects of provider performance in the different compartments: public sector, community health workers and the private sector.

46.

536
Accesses

Research   Open Access Highly Accessed

Safety of artemether-lumefantrine in pregnant women with malaria: results of a prospective cohort study in Zambia

Christine Manyando, Rhoda Mkandawire, Lwipa Puma, Moses Sinkala, Evans Mpabalwani, Eric Njunju, Melba Gomes, Isabela Ribeiro, Verena Walter, Mailis Virtanen, Raymond Schlienger, Marc Cousin, Miriam Chipimo, Frank M Sullivan Malaria Journal 2010, 9:249 (1 September 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

An important study of the safety of artemether-lumefantrine (AL) in pregnant women: relatively large sample size, prospective follow-up to 12 months for the infants, and careful screening for overt clinical birth deformities and neurodevelopmental outcomes.

47.

534
Accesses

Review   Open Access Highly Accessed

Determinants of relapse periodicity in Plasmodium vivax malaria

Nicholas J White Malaria Journal 2011, 10:297 (11 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A review describing current and, more importantly, past (and forgotten) understanding of the biology of relapse in P. vivax malaria. It provides a welcome treasure trove of citations to that older literature, in addition to putting forth an interesting new hypothesis worthy of testing, i.e., activation of hypnozoites by febrile illness.

48.

522
Accesses

Research   Open Access

Evaluation of the 2011 long-lasting, insecticide-treated net distribution for universal coverage in Togo

Elizabeth R Stevens, Abigail Aldridge, Yawo Degbey, Akou Pignandi, Monique A Dorkenoo, Justin Hugelen-Padin Malaria Journal 2013, 12:162 (16 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Description of a largely successful campaign to distribute LLINs to all age-groups across Togo. The authors conclude that even though the campaign was unable to achieve the universal coverage target, it rapidly increased overall coverage and was far better than previous campaigns that targeted only pregnant women and under fives.

49.

520
Accesses

Research   Open Access Highly Accessed

Patterns of anti-malarial drug treatment among pregnant women in Uganda

Laura R Sangaré, Noel S Weiss, Paula E Brentlinger, Barbra A Richardson, Sarah G Staedke, Mpungu S Kiwuwa, Andy Stergachis Malaria Journal 2011, 10:152 (6 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Overuse of anti-malarial drugs, especially ones that are no longer recommended, undermines malaria control efforts by fueling the spread of drug resistance and delaying appropriate treatment of non-malarial febrile illnesses. Improved diagnostic capacity is essential to ultimately improving the management of malaria-like symptoms during pregnancy and appropriate use of currently available anti-malarials.

50.

519
Accesses

Research   Open Access Highly Accessed

Sugar-fermenting yeast as an organic source of carbon dioxide to attract the malaria mosquito Anopheles gambiae

Renate C Smallegange, Wolfgang H Schmied, Karel J van Roey, Niels O Verhulst, Jeroen Spitzen, Wolfgang R Mukabana, Willem Takken Malaria Journal 2010, 9:292 (25 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Carbon dioxide plays an important role in the host-seeking process of mosquito species and is commonly added to mosquito sampling tools. This study showed that traps baited with yeast-produced CO2 caught significantly more mosquitoes than unbaited traps and traps baited with industrial CO2, both in the laboratory and semi-field conditions.

51.

512
Accesses

Review   Open Access Highly Accessed

Mathematical models of malaria - a review

Sandip Mandal, Ram Sarkar, Somdatta Sinha Malaria Journal 2011, 10:202 (21 July 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A timely review article that aims to assess the current state of the malaria modelling field, predominantly focusing on mathematical (rather than statistical) models.

52.

501
Accesses

Research   Open Access

Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria

Yuri C Martins, Leah Clemmer, Pamela Orjuela-Sánchez, Graziela M Zanini, Peng Kai Ong, John A Frangos, Leonardo JM Carvalho Malaria Journal 2013, 12:138 (24 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

This paper presents original and interesting data on the cardiac effect of experimental cerebral malaria in mice, and that nimodipine at low doses shows a safe profile in terms of cardiovascular effects.

53.

508
Accesses

Research   Open Access

Artemisinin-based combination therapy availability and use in the private sector of five AMFm phase 1 countries

Ben Davis, Joel Ladner, Kelley Sams, Ebru Tekinturhan, Donald de Korte, Joseph Saba Malaria Journal 2013, 12:135 (22 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

The objective of this study was to assess anti-malarial stock and purchase patterns at private outlets in five Phase 1 countries in the Affordable Medicines Facility-malaria programme, in regard to three of the core AMFm goals: increase the affordability of quality-assured artemisinin combination therapy, increase the availability of ACT, and crowd out artemisinin monotherapies and other substandard therapies.

54.

487
Accesses

Case report   Open Access Highly Accessed

First case of Plasmodium knowlesi infection in a Japanese traveller returning from Malaysia

Ryutaro Tanizaki, Mugen Ujiie, Yasuyuki Kato, Moritoshi Iwagami, Aki Hashimoto, Satoshi Kutsuna, Nozomi Takeshita, Kayoko Hayakawa, Shuzo Kanagawa, Shigeyuki Kano, Norio Ohmagari Malaria Journal 2013, 12:128 (15 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

There have now been many reports of knowlesi malaria in travellers returning from endemic to non-endemic countries (eg. New Zealand, Australia, Spain, Finland, Taiwan, United States). The authors report that this is the first case of knowlesi malaria in a Japanese traveller.

55.

486
Accesses

Research   Open Access

Limited sequence polymorphisms of four transmission-blocking vaccine candidate antigens in Plasmodium vivax Korean isolates

Jung-Mi Kang, Hye-Lim Ju, Sung-Ung Moon, Pyo-Yun Cho, Young-Yil Bahk, Woon-Mok Sohn, Yun-Kyu Park, Seok Cha, Tong-Soo Kim, Byoung-Kuk Na Malaria Journal 2013, 12:144 (30 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Malaria transmission-blocking vaccines have been regarded as useful strategy towards malaria elimination. In this study, genetic diversity of four candidate antigens(Pvs25, Pvs28, Pvs48/45, and PvWARP) were analysed in Korean isolates. Limited sequence polymorphisms of these candidate antigens provide baseline information for developing an effective vaccine malaria based on these antigens.

56.

482
Accesses

Research   Open Access Highly Accessed

Thick blood film examination for Plasmodium falciparum malaria has reduced sensitivity and underestimates parasite density

Philip Bejon, Laura Andrews, Angela Hunt-Cooke, Frances Sanderson, Sarah C Gilbert, Adrian VS Hill Malaria Journal 2006, 5:104 (8 November 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

This comparison between thick films and quantitative PCR shows that large numbers of parasites are lost in the staining process. This limits the sensitivity and leads to erroneous estimates of parasite density.

57.

483
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Research   Open Access Highly Accessed

Morphological features and differential counts of Plasmodium knowlesi parasites in naturally acquired human infections

Kim-Sung Lee, Janet Cox-Singh, Balbir Singh Malaria Journal 2009, 8:73 (21 April 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The morphological resemblance of early trophozoites of P. knowlesi to P. falciparum and later erythrocytic stages to P. malariae makes it extremely difficult to identify P. knowlesi infections by microscopy alone. This is the first, extensive description of the various stages of the parasite as seen in stained blood films.

58.

482
Accesses

Research   Open Access

A potential threat to malaria elimination: extensive deltamethrin and DDT resistance to Anopheles sinensis from the malaria-endemic areas in China

Duo-quan Wang, Zhi-gui Xia, Shui-sen Zhou, Xiao-nong Zhou, Ru-bo Wang, Qing-feng Zhang Malaria Journal 2013, 12:164 (17 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

A paper that highlights the problem of insecticide resistance in malaria vectors in China.

59.

472
Accesses

Research   Open Access

'A mate or a meal' – Pre-gravid behaviour of female Anopheles gambiae from the islands of São Tomé and Príncipe, West Africa

J Derek Charlwood, Joao Pinto, Carla A Sousa, Conceicao Ferreira, Vincenso Petrarca, Virgilio do E Rosario Malaria Journal 2003, 2:9 (7 May 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Much is still unknown about the ecology of malaria vectors. This paper gives a thoughtful account of the first days of imaginal bionomics of the mosquito female.

60.

463
Accesses

Review   Open Access Highly Accessed

Human malarial disease: a consequence of inflammatory cytokine release

Ian A Clark, Alison C Budd, Lisa M Alleva, William B Cowden Malaria Journal 2006, 5:85 (10 October 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Malariologists tend to think that the pathophysiology of malaria is unique. This thought-provoking review shows that much can be learned from events described with other pathogens and that falciparum malaria is primarily an inflammatory cytokine-driven disease. In particular, the inability of mitochondria, through the effects of inflammatory cytokines, to utilise available oxygen may play a crucial role.

61.

460
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Research   Open Access Highly Accessed

Gender differences in the use of insecticide-treated nets after a universal free distribution campaign in Kano State, Nigeria: post-campaign survey results

Ashley E Garley, Elizabeth Ivanovich, Erin Eckert, Svetlana Negroustoueva, Yazoume Ye Malaria Journal 2013, 12:119 (10 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

It is clear that ITN strategies not only need to address the difference in uptake between ¿sex¿ but also among other gender inequalities, such as adolescent boys, who seem to have a lower use of ITNs than any other group.

62.

461
Accesses

Research   Open Access

Temporal evaluation of commitment to sexual development in Plasmodium falciparum

Christopher L Peatey, Matthew WA Dixon, Donald L Gardiner, Katharine R Trenholme Malaria Journal 2013, 12:134 (22 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

This paper revisits old experiments on the role of cholera toxin in inducing gametocyte production.

63.

459
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Research   Open Access Highly Accessed

Intermittent preventive treatment of malaria during pregnancy: a qualitative study of knowledge, attitudes and practices of district health managers, antenatal care staff and pregnant women in Korogwe District, North-Eastern Tanzania

Godfrey Mubyazi, Paul Bloch, Mathias Kamugisha, Andrew Kitua, Jasper Ijumba Malaria Journal 2005, 4:31 (20 July 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The paper provides a qualitative analysis of the programmatic issues faced when implementing IPT during pregnancy, from both provider and user perspectives. Of particular interest is the Tanzanian experience of the specific link made between SP-IPT and Steven Johnson¿s Syndrome by pregnant women, which is unique and has been one of the most important barriers to the effective uptake of ITP, as a result of media spin. The paper highlights the need for much greater attention to awareness creation among pregnant women, which is all too often an afterthought to the delivery of IPT.

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454
Accesses

Case study   Open Access Highly Accessed

Progress towards malaria elimination in Sabang Municipality, Aceh, Indonesia

Herdiana Herdiana, Anis Fuad, Puji BS Asih, Siti Zubaedah, Risalia Reni Arisanti, Din Syafruddin, Hari Kusnanto, Maria Endang Sumiwi, Titik Yuniarti, Ali Imran, Rahmadyani Rahmadyani, Muhammad Yani, Rita Kusriastuti, Siti Nadia Tarmizi, Ferdinand J Laihad, William A Hawley Malaria Journal 2013, 12:42 (30 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

An important article outlining the progress made towards malaria elimination in Sabang municipality, Aceh, Indonesia. The details of this article will serve as an example to much of the rest of Indonesia, as well as the rest of SE Asia.

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441
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Research   Open Access Highly Accessed

Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking

Gisela Henriques, Axel Martinelli, Louise Rodrigues, Katarzyna Modrzynska, Richard Fawcett, Douglas R Houston, Sofia T Borges, Umberto d’Alessandro, Halidou Tinto, Corine Karema, Paul Hunt, Pedro Cravo Malaria Journal 2013, 12:118 (5 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

In the rodent malaria parasite Plasmodium chabaudi, an increased artemisinin-resistant phenotype occurs along with a mutation in a functional element of the AP2 adaptor protein complex. This suggests that endocytosis and trafficking of membrane proteins may be involved, generating new insights into possible mechanisms of resistance.

66.

438
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Research   Open Access Highly Accessed

Prospective malaria control using entomopathogenic fungi: comparative evaluation of impact on transmission and selection for resistance

Penelope A Lynch, Uwe Grimm, Matthew B Thomas, Andrew F Read Malaria Journal 2012, 11:383 (22 November 2012)

Abstract | Full text | PDF | PubMed | 1 comment |  Editor’s summary

The authors compare the effectiveness of entomopathogenic fungi as a biological control tool with conventional pesticides by means of a model that consists of a mosquito feeding component and a mosquito population component.

67.

439
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Research   Open Access

The decline of malaria in Finland – the impact of the vector and social variables

Lena Hulden, Larry Hulden Malaria Journal 2009, 8:94 (7 May 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Indigenous malaria in Finland faded out evenly in the whole country over the past 200 years with limited or no counter-measures or medication. It appears that malaria in Finland was basically a social disease and that malaria trends were strongly linked to changes in human behaviour.

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429
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Review   Open Access Highly Accessed

Costs and cost-effectiveness of malaria control interventions - a systematic review

Michael T White, Lesong Conteh, Richard Cibulskis, Azra C Ghani Malaria Journal 2011, 10:337 (3 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

This paper covers a systematic review on the costs and cost-effectiveness of malaria control interventions. The interventions covered include insecticide-treated bed nets Indoor residual spraying and Intermittent preventative treatment, diagnostic testing and appropriate treatment.

69.

428
Accesses

Methodology   Open Access Highly Accessed

A new double-antibody sandwich ELISA targeting Plasmodium falciparum aldolase to evaluate anti-malarial drug sensitivity

Lucienne Tritten, Hugues Matile, Reto Brun, Sergio Wittlin Malaria Journal 2009, 8:226 (12 October 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In their paper, the authors report the use of a newly developed aldolase ELISA for drug sensitivity testing in P. falciparum. The new assay adds to the panel of available ELISA-based malaria drug sensitivity assays.

70.

426
Accesses

Opinion   Open Access Highly Accessed

Malaria in infants aged less than six months - is it an area of unmet medical need?

Umberto D’Alessandro, David Ubben, Kamal Hamed, Serign Jawo Ceesay, Joseph Okebe, Makie Taal, Eugene Kaman Lama, Moussa Keita, Lamine Koivogui, Alain Nahum, Kalifa Bojang, Aja Adam Jagne Sonko, Honorat Francis Lalya, Bernard Brabin Malaria Journal 2012, 11:400 (2 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Review covering several issue relating to malaria in young infants, including difficulties in diagnosing the infection in this age group, uncertainty as to the burden of disease in young infants, and optimal treatment and prevention (currently anti-malarial use in this age group is current ¿off-label¿).

71.

424
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Meeting report   Open Access Highly Accessed

Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of September 2012 meeting

WHO Malaria Policy Advisory Committee and Secretariat Malaria Journal 2012, 11:424 (19 December 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This article provides a summary of the discussions, conclusions and recommendations from the second meeting of the WHO Malaria Policy Advisory Committee

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424
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Research   Open Access Highly Accessed

Plants traditionally prescribed to treat tazo (malaria) in the eastern region of Madagascar

Milijaona Randrianarivelojosia, Valérie T Rasidimanana, Harison Rabarison, Peter K Cheplogoi, Michel Ratsimbason, Dulcie A Mulholland, Philippe Mauclère Malaria Journal 2003, 2:25 (24 July 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This is a useful contribution to the study of Madagascan medicinal plants, which shows care and sensitivity in collecting the ethnobotanical data.

73.

422
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Research   Open Access Highly Accessed

Community-directed educational intervention for malaria elimination in Bhutan: quasi-experimental study in malaria endemic areas of Sarpang district

Tashi Tobgay, Deki Pem, Ugyen Dophu, Shyam P Dumre, Kesara Na-Bangchang, Cristina E Torres Malaria Journal 2013, 12:132 (17 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

The findings from this study corroborate that community-directed interventions can be utilized as an effective means for improving knowledge, attitude and practice in the malaria-endemic areas of Bhutan.

74.

421
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Review   Open Access Highly Accessed

Management of imported malaria in Europe

Helena H Askling, Fabrice Bruneel, Gerd Burchard, Francesco Castelli, Peter L Chiodini, Martin P Grobusch, Rogelio Lopez-Vélez, Margaret Paul, Eskild Petersen, Corneliu Popescu, Michael Ramharter, Patricia Schlagenhauf, on behalf of the European Society for Clinical Microbiology and Infectious Diseases Study Group on Clinical Parasitology Malaria Journal 2012, 11:328 (17 September 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A very comprehensive review on imported malaria and recommendation for its management.

75.

419
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Research   Open Access Highly Accessed

A dynamic model of some malaria-transmitting anopheline mosquitoes of the Afrotropical region. II. Validation of species distribution and seasonal variations

Torleif M Lunde, Meshesha Balkew, Diriba Korecha, Teshome Gebre-Michael, Fekadu Massebo, Asgeir Sorteberg, Bernt Lindtjørn Malaria Journal 2013, 12:78 (25 February 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Validation of a mathematical model described earlier. Overall, the model gives a realistic representation of seasonal and year-to-year variability in mosquito densities and it can accurately predict the distribution of An. gambiae s.s. and An. arabiensis in sub-Saharan Africa. It may be used for seasonal and long-term predictions of changes in the burden of malaria.

76.

410
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Research   Open Access Highly Accessed

Treatment of fevers prior to introducing rapid diagnostic tests for malaria in registered drug shops in Uganda

Anthony K Mbonye, Sham Lal, Bonnie Cundill, Kristian Schultz Hansen, Siân Clarke, Pascal Magnussen Malaria Journal 2013, 12:131 (16 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

In this setting, the proportion of malaria patients receiving appropriate ACT treatment at drug shops was low. This was due to the practice of presumptive treatment, inadequate training on malaria management and lack of knowledge that ACT was the recommended first-line treatment for malaria.

77.

408
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Case study   Open Access Highly Accessed

Experience and challenges from clinical trials with malaria vaccines in Africa

Grace Mwangoka, Bernhards Ogutu, Beverly Msambichaka, Tutu Mzee, Nahya Salim, Shubis Kafuruki, Maxmillian Mpina, Seif Shekalaghe, Marcel Tanner, Salim Abdulla Malaria Journal 2013, 12:86 (4 March 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The paper provides an important insight from an African research centre about lessons learned after an era of clinical trials experience. It touches upon very important issues such as sustainability of capacity built, among others.

78.

406
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Research   Open Access Highly Accessed

A dynamic model of some malaria-transmitting anopheline mosquitoes of the Afrotropical region. I. Model description and sensitivity analysis

Torleif Markussen Lunde, Diriba Korecha, Eskindir Loha, Asgeir Sorteberg, Bernt Lindtjørn Malaria Journal 2013, 12:28 (23 January 2013)

Abstract | Provisional PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This study highlights some of the assumptions commonly used when constructing mosquito-malaria models and presents a realistic model of Anopheles gambiae s.s. and Anopheles arabiensis, and their interaction. The authors make a case that this new mosquito model, OMaWa, may improve the understanding of vector dynamics, which in turn can be used to better understand the dynamics of malaria.

79.

408
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Research   Open Access Highly Accessed

Reliable enumeration of malaria parasites in thick blood films using digital image analysis

John A Frean Malaria Journal 2009, 8:218 (23 September 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

This paper describes the definition and evaluation of a computer-based imaging algorithm for enumeration of malaria parasites in thick films. While still a long way to go from routine use, the accuracy afforded by the technique may be relevant for clinical studies of vaccines or drugs

80.

402
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Research   Open Access Highly Accessed

Successful field trial of attractive toxic sugar bait (ATSB) plant-spraying methods against malaria vectors in the Anopheles gambiae complex in Mali, West Africa

Günter C Müller, John C Beier, Sekou F Traore, Mahamoudou B Toure, Mohamed M Traore, Sekou Bah, Seydou Doumbia, Yosef Schlein Malaria Journal 2010, 9:210 (21 July 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This study in Mali shows that even a single application of ATSB can substantially decrease malaria vector population densities and longevity. It is likely that ATSB methods can be used as a new powerful tool for the control of malaria vectors, particularly since this approach is highly effective for mosquito control, technologically simple, inexpensive, and environmentally safe.

81.

396
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Research   Open Access Highly Accessed

A mathematical model of the impact of present and future malaria vaccines

Edward A Wenger, Philip A Eckhoff Malaria Journal 2013, 12:126 (15 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A mathematical modelling exercise to evaluate the impact of a vaccine with properties like RTS,S across a range of transmission settings and in the presence of other interventions. The model makes sensible assumptions, and it is explained in terms that are reasonably easy for a non-expert to grasp.

82.

391
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Research   Open Access Highly Accessed

Poor quality vital anti-malarials in Africa - an urgent neglected public health priority

Paul N Newton, Michael D Green, Dallas C Mildenhall, Aline Plançon, Henry Nettey, Leonard Nyadong, Dana M Hostetler, Isabel Swamidoss, Glenn A Harris, Kristen Powell, Ans E Timmermans, Abdinasir A Amin, Stephen K Opuni, Serge Barbereau, Claude Faurant, Ray CW Soong, Kevin Faure, Jonarthan Thevanayagam, Peter Fernandes, Harparkash Kaur, Brian Angus, Kasia Stepniewska, Philippe J Guerin, Facundo M Fernández Malaria Journal 2011, 10:352 (13 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Criminals are producing diverse harmful anti-malarial counterfeits with important public health consequences. With the threatening spread of artemisinin resistance to Africa, much greater investment is required to ensure the quality of ACT and removal of artemisinin monotherapies.

83.

387
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Methodology   Open Access Highly Accessed

Estimating malaria parasite density: assumed white blood cell count of 10,000/μl of blood is appropriate measure in Central Ghana

Dennis Adu-Gyasi, Mohammed Adams, Sabastina Amoako, Emmanuel Mahama, Maxwell Nsoh, Seeba Amenga-Etego, Frank Baiden, Kwaku Asante, Sam Newton, Seth Owusu-Agyei Malaria Journal 2012, 11:238 (23 July 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Analysis of the use of an assumed WBC count compared to the actual WBC for estimating parasitaemia in children aged 0-5 years in Ghana. Questioning the accuracy of this widely used method for estimating malaria parasitaemia is an important research topic since it is commonly used to guide important policy and practice decisions.

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387
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Research   Open Access

Effect of malaria in pregnancy on foetal cortical brain development: a longitudinal observational study

Marcus J Rijken, Merel de Wit, Eduard JH Mulder, Suporn Kiricharoen, Noaeni Karunkonkowit, Tamalar Paw, Gerard HA Visser, Rose McGready, François H Nosten, Lourens R Pistorius Malaria Journal 2012, 11:222 (2 July 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The authors studied brain development, using a portable ultrasound machine and a 3D ultrasound transducer, in foetuses of mothers with treated malaria as compared to control mother without malaria. They were not able to found significant differences in terms of supratentorial brain volume or delay in sulcation.

85.

391
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Opinion   Open Access Highly Accessed

Entomological surveillance of behavioural resilience and resistance in residual malaria vector populations

Nicodem J Govella, Prosper P Chaki, Gerry F Killeen Malaria Journal 2013, 12:124 (11 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

In this opinion piece, the authors indicate that caution should be exercised before over-interpreting most existing reports of increased frequency of behavioural traits which enable mosquitoes to evade fatal contact with insecticides: this may simply be the result of suppressing the most behaviourally vulnerable of the vector taxa that constituted the original transmission system.

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382
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Research   Open Access Highly Accessed

Prevalence of congenital malaria in high-risk Ghanaian newborns: a cross-sectional study

Christabel C Enweronu-Laryea, George O Adjei, Benjamin Mensah, Nancy Duah, Neils B Quashie Malaria Journal 2013, 12:17 (11 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A very interesting study of two populations of newborns - one in a neonatal intensive care unit, the other studied during the first week of life. The paper was able to address an important question: how often are newborns at risk of dying from congenital malaria? The answer is, rarely.

87.

381
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Research   Open Access Highly Accessed

Malaria epidemiology in Lihir Island, Papua New Guinea

Oriol Mitjà, Raymond Paru, Billy Selve, Inoni Betuela, Peter Siba, Elisa De Lazzari, Quique Bassat Malaria Journal 2013, 12:98 (15 March 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Report on malaria epidemiology on Lihir Island, PNG, before and after a malaria control intervention carried out by the local gold mining company. An integrated vector control intervention was put in place in the villages within the mining area only.

88.

382
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Opinion   Open Access Highly Accessed

Roll Back Malaria? The scarcity of international aid for malaria control

Vasant Narasimhan, Amir Attaran Malaria Journal 2003, 2:8 (15 April 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

This provocative paper outlines how the failure of governments and funding agencies to honour the promises of financial support of the Abuja Declaration risks ultimately to have a negative impact on the RBM programme.

89.

376
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Review   Open Access Highly Accessed

Primaquine in vivax malaria: an update and review on management issues

Deepika Fernando, Chaturaka Rodrigo, Senaka Rajapakse Malaria Journal 2011, 10:351 (12 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Paper reviews the published literature on the use of primaquine as an agent for prophylaxis and radical cure. The detailed section on G6PD deficiency as a barrier for mass administration of primaquine and the section on the use of primaquine with blood schizontocidals other than chloroquine is useful.

90.

377
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Research   Open Access Highly Accessed

Malaria rapid diagnostic kits: quality of packaging, design and labelling of boxes and components and readability and accuracy of information inserts

Philippe Gillet, Jessica Maltha, Veerle Hermans, Raffaella Ravinetto, Cathrien Bruggeman, Jan Jacobs Malaria Journal 2011, 10:39 (13 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This study reports on the characteristics of malaria RDTs that are commercially available in terms of their packaging, labelling and inserts. Clear instructions for end-users may help in the correct use of RDTs and ultimately improve the diagnostic accuracy.

91.

373
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Research   Open Access Highly Accessed

Malaria in pregnant women in an area with sustained high coverage of insecticide-treated bed nets

Abdunoor M Kabanywanyi, John R MacArthur, Wilma A Stolk, J Dik F Habbema, Hassan Mshinda, Peter B Bloland, Salim Abdulla, S Patrick Kachur Malaria Journal 2008, 7:133 (21 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This study of a group of pregnant women who have not taken IPTp with SP during their pregnancy shows that malaria remains a problem even in an area with high bed net coverage.

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Research   Open Access

Characterizing PvARP, a novel Plasmodium vivax antigen

Darwin A Moreno-Pérez, Ambar Saldarriaga, Manuel A Patarroyo Malaria Journal 2013, 12:165 (20 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Characterization of the P. vivax asparagine-rich protein (PvARP) by a straightforward approach using molecular biology and immunochemistry assays. The reactivity with sera from individuals infected with P. vivax indicates that it contains epitopes that are target of antibody response generated during natural exposure.

93.

370
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Review   Open Access Highly Accessed

Best practices for an insecticide-treated bed net distribution programme in sub-Saharan eastern Africa

Alexis R Sexton Malaria Journal 2011, 10:157 (8 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This review assessed literature on recent insecticide-treated bed net distribution programmes throughout sub-Saharan Eastern Africa. Forty-two studies were identified and reviewed. Studies revealed consistent inequities between urban and rural populations; which were most effectively alleviated through a free insecticide-treated bed net delivery and distribution framework

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366
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Case study   Open Access Highly Accessed

Misclassification of Plasmodium infections by conventional microscopy and the impact of remedial training on the proficiency of laboratory technicians in species identification

Peter Obare, Bernhards Ogutu, Mohammed Adams, James Sande Odera, Ken Lilley, David Dosoo, Christine Adhiambo, Seth Owusu-Agyei, Fred Binka, Elizabeth Wanja, Jacob Johnson Malaria Journal 2013, 12:113 (27 March 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

The major problem related to microscopy for malaria diagnosis is the quality of the training of microscopists. This work explores misclassifications of four Plasmodium species by conventional microscopy in relation to the proficiency of microscopists and morphological characteristics of the parasites on Giemsa-stained blood films.

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363
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Review   Open Access Highly Accessed

Integrated vector management for malaria control

John C Beier, Joseph Keating, John I Githure, Michael B Macdonald, Daniel E Impoinvil, Robert J Novak Malaria Journal 2008, 7(Suppl 1):S4 (11 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

96.

361
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Review   Open Access Highly Accessed

Challenges in using geographic information systems (GIS) to understand and control malaria in Indonesia

Neil G Sipe, Pat Dale Malaria Journal 2003, 2:36 (4 November 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Most studies on the use of GIS for malaria control have been performed in Africa and the application of the technique in Indonesia raised important issues. This comprehensive review looks at the limitations of GIS and how best to solve various problems to make this approach more user-friendly.

97.

360
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Review   Open Access Highly Accessed

Statics and dynamics of malaria infection in Anopheles mosquitoes

David L Smith, F Ellis McKenzie Malaria Journal 2004, 3:13 (4 June 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This theoretical and mathematical review provides a new look at the Ross-Macdonald models, the basis of malaria epidemiology. The models describe the processes that drive malaria transmission, mainly from an entomological perspective, and they are, therefore, particularly useful to evaluate intervention programmes that reduce transmission.

98.

355
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Research   Open Access Highly Accessed

Community knowledge, attitudes and practices (KAP) on malaria in Swaziland: A country earmarked for malaria elimination

Khumbulani W Hlongwana, Musawenkosi LH Mabaso, Simon Kunene, Dayanandan Govender, Rajendra Maharaj Malaria Journal 2009, 8:29 (19 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Despite fair knowledge of malaria in Swaziland, there is a need for improving the availability of information through the preferred community channels, such as the traditional community district meetings or tinkhundlas. There is documented evidence suggesting that as the level transmission and disease decreases, so does the perception about the importance of malaria control activities.

99.

353
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Research   Open Access Highly Accessed

Detection of malaria parasites by nested PCR in south-eastern, Iran: Evidence of highly mixed infections in Chahbahar district

Sedigheh Zakeri, Sohaila Najafabadi, Ahmad Zare, Navid Djadid Malaria Journal 2002, 1:2 (8 February 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

100.

351
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Review   Open Access Highly Accessed

Reported reasons for not using a mosquito net when one is available: a review of the published literature

Justin Pulford, Manuel W Hetzel, Miranda Bryant, Peter M Siba, Ivo Mueller Malaria Journal 2011, 10:83 (11 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This review highlights a gap in understanding of community perceptions and barriers to the use of bed nets for malaria control and elimination and the lack of empirical research to inform behaviour change communication strategies. The authors importantly recognize the need for programmes to look beyond coverage of bed nets and locally investigate reasons for their non-use if they are to maximize the impact of this key intervention.

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