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1.

15376
Accesses

Review   Open Access Highly Accessed

Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria

Jane Achan, Ambrose O Talisuna, Annette Erhart, Adoke Yeka, James K Tibenderana, Frederick N Baliraine, Philip J Rosenthal, Umberto D'Alessandro Malaria Journal 2011, 10:144 (24 May 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This review of quinine is useful, because the drug still plays an important role in the treatment of malaria.

2.

10105
Accesses

Methodology   Open Access Highly Accessed

The parasite clearance curve

NJ White Malaria Journal 2011, 10:278 (22 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The author presents a clear and concise introduction to the parasite clearance curve, which is important in determining the therapeutic response to anti-malarials, particularly artemisinin derivatives. Given the recent reports of emerging artemisinin resistance in Western Cambodia, this is a very timely report.

3.

10032
Accesses

Reviews   Open Access Highly Accessed

Plant-based insect repellents: a review of their efficacy, development and testing

Marta Maia, Sarah J Moore Malaria Journal 2011, 10(Suppl 1):S11 (15 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

4.

9446
Accesses

Review   Open Access Highly Accessed

A review of malaria vaccine clinical projects based on the WHO rainbow table

Lauren Schwartz, Graham V Brown, Blaise Genton, Vasee S Moorthy Malaria Journal 2012, 11:11 (9 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This review succeeds in its primary objective in presenting the most comprehensive review and, of necessity, is broad and goes into much more depth than might be expected. As such it complements the WHO spreadsheet, and is a valuable companion document.

5.

9321
Accesses

Research   Open Access Highly Accessed

Malaria resurgence: a systematic review and assessment of its causes

Justin M Cohen, David L Smith, Chris Cotter, Abigail Ward, Gavin Yamey, Oliver J Sabot, Bruno Moonen Malaria Journal 2012, 11:122 (24 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

There is a need for practical solutions to the operational and financial threats facing malaria elimination programmes if we are to avoid repeating the mistakes of the past, which saw the resurgence of malaria in disease free areas.

6.

8987
Accesses

Research   Open Access Highly Accessed

A new world malaria map: Plasmodium falciparum endemicity in 2010

Peter W Gething, Anand P Patil, David L Smith, Carlos A Guerra, Iqbal RF Elyazar, Geoffrey L Johnston, Andrew J Tatem, Simon I Hay Malaria Journal 2011, 10:378 (20 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The paper represents a Herculean effort to provide an updated map of the global distribution of malaria, based on three key malariometric indices PfPR, PfEIR and PfRC and represents a unique contribution.

7.

7622
Accesses

Review   Open Access Highly Accessed

Malaria in Brazil: an overview

Joseli Oliveira-Ferreira, Marcus VG Lacerda, Patrícia Brasil, José LB Ladislau, Pedro L Tauil, Cláudio Daniel-Ribeiro Malaria Journal 2010, 9:115 (30 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A review of the current malaria situation in Brazil, with particular reference to the switch to a predominance of vivax malaria.

8.

7573
Accesses

Review   Open Access Highly Accessed

Global warming and malaria: knowing the horse before hitching the cart

Paul Reiter Malaria Journal 2008, 7(Suppl 1):S3 (11 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

7441
Accesses

Research   Open Access Highly Accessed

Is the current decline in malaria burden in sub-Saharan Africa due to a decrease in vector population?

Dan W Meyrowitsch, Erling M Pedersen, Michael Alifrangis, Thomas H Scheike, Mwelecele N Malecela, Stephen M Magesa, Yahya A Derua, Rwehumbiza T Rwegoshora, Edwin Michael, Paul E Simonsen Malaria Journal 2011, 10:188 (13 July 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 3 comments |  Editor’s summary

A challenging paper discussing whether the observed decline in malaria vector densities, in the absence of organized vector control interventions, could contribute to the decrease in levels of malaria infection

10.

6234
Accesses

Research   Open Access Highly Accessed

Morphological features and differential counts of Plasmodium knowlesi parasites in naturally acquired human infections

Kim-Sung Lee, Janet Cox-Singh, Balbir Singh Malaria Journal 2009, 8:73 (21 April 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The morphological resemblance of early trophozoites of P. knowlesi to P. falciparum and later erythrocytic stages to P. malariae makes it extremely difficult to identify P. knowlesi infections by microscopy alone. This is the first, extensive description of the various stages of the parasite as seen in stained blood films.

11.

5996
Accesses

Research   Open Access Highly Accessed

Prevalence and risk factors of malaria in Ethiopia

Dawit G Ayele, Temesgen T Zewotir, Henry G Mwambi Malaria Journal 2012, 11:195 (12 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The stated objective of the paper was to investigate the prevalence rate and the associated socio-economic, geographic and demographic factors associated with malaria based on RDT survey results.

12.

5968
Accesses

Research   Open Access Highly Accessed

Patterns of anti-malarial drug treatment among pregnant women in Uganda

Laura R Sangaré, Noel S Weiss, Paula E Brentlinger, Barbra A Richardson, Sarah G Staedke, Mpungu S Kiwuwa, Andy Stergachis Malaria Journal 2011, 10:152 (6 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Overuse of anti-malarial drugs, especially ones that are no longer recommended, undermines malaria control efforts by fueling the spread of drug resistance and delaying appropriate treatment of non-malarial febrile illnesses. Improved diagnostic capacity is essential to ultimately improving the management of malaria-like symptoms during pregnancy and appropriate use of currently available anti-malarials.

13.

5781
Accesses

Review   Open Access Highly Accessed

Mathematical models of malaria - a review

Sandip Mandal, Ram Sarkar, Somdatta Sinha Malaria Journal 2011, 10:202 (21 July 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A timely review article that aims to assess the current state of the malaria modelling field, predominantly focusing on mathematical (rather than statistical) models.

14.

5762
Accesses

Review   Open Access Highly Accessed

Determinants of relapse periodicity in Plasmodium vivax malaria

Nicholas J White Malaria Journal 2011, 10:297 (11 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A review describing current and, more importantly, past (and forgotten) understanding of the biology of relapse in P. vivax malaria. It provides a welcome treasure trove of citations to that older literature, in addition to putting forth an interesting new hypothesis worthy of testing, i.e., activation of hypnozoites by febrile illness.

15.

5602
Accesses

Review   Open Access Highly Accessed

The global pipeline of new medicines for the control and elimination of malaria

Melinda P Anthony, Jeremy N Burrows, Stephan Duparc, Joerg JMoehrle, Timothy NC Wells Malaria Journal 2012, 11:316 (7 September 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A very comprehensive and useful paper on the status and prospects of anti-malarial drugs in various stages of development presented in the context of the current needs.

16.

5534
Accesses

Research   Open Access Highly Accessed

Community knowledge, attitudes and practices (KAP) on malaria in Swaziland: A country earmarked for malaria elimination

Khumbulani W Hlongwana, Musawenkosi LH Mabaso, Simon Kunene, Dayanandan Govender, Rajendra Maharaj Malaria Journal 2009, 8:29 (19 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Despite fair knowledge of malaria in Swaziland, there is a need for improving the availability of information through the preferred community channels, such as the traditional community district meetings or tinkhundlas. There is documented evidence suggesting that as the level transmission and disease decreases, so does the perception about the importance of malaria control activities.

17.

5465
Accesses

Research   Open Access Highly Accessed

Successful field trial of attractive toxic sugar bait (ATSB) plant-spraying methods against malaria vectors in the Anopheles gambiae complex in Mali, West Africa

Günter C Müller, John C Beier, Sekou F Traore, Mahamoudou B Toure, Mohamed M Traore, Sekou Bah, Seydou Doumbia, Yosef Schlein Malaria Journal 2010, 9:210 (21 July 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This study in Mali shows that even a single application of ATSB can substantially decrease malaria vector population densities and longevity. It is likely that ATSB methods can be used as a new powerful tool for the control of malaria vectors, particularly since this approach is highly effective for mosquito control, technologically simple, inexpensive, and environmentally safe.

18.

5460
Accesses

Research   Open Access Highly Accessed

Thick blood film examination for Plasmodium falciparum malaria has reduced sensitivity and underestimates parasite density

Philip Bejon, Laura Andrews, Angela Hunt-Cooke, Frances Sanderson, Sarah C Gilbert, Adrian VS Hill Malaria Journal 2006, 5:104 (8 November 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

This comparison between thick films and quantitative PCR shows that large numbers of parasites are lost in the staining process. This limits the sensitivity and leads to erroneous estimates of parasite density.

19.

5408
Accesses

Review   Open Access Highly Accessed

Human malarial disease: a consequence of inflammatory cytokine release

Ian A Clark, Alison C Budd, Lisa M Alleva, William B Cowden Malaria Journal 2006, 5:85 (10 October 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Malariologists tend to think that the pathophysiology of malaria is unique. This thought-provoking review shows that much can be learned from events described with other pathogens and that falciparum malaria is primarily an inflammatory cytokine-driven disease. In particular, the inability of mitochondria, through the effects of inflammatory cytokines, to utilise available oxygen may play a crucial role.

20.

5385
Accesses

Research   Open Access Highly Accessed

Plants traditionally prescribed to treat tazo (malaria) in the eastern region of Madagascar

Milijaona Randrianarivelojosia, Valérie T Rasidimanana, Harison Rabarison, Peter K Cheplogoi, Michel Ratsimbason, Dulcie A Mulholland, Philippe Mauclère Malaria Journal 2003, 2:25 (24 July 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This is a useful contribution to the study of Madagascan medicinal plants, which shows care and sensitivity in collecting the ethnobotanical data.

21.

5354
Accesses

Research   Open Access Highly Accessed

Safety of artemether-lumefantrine in pregnant women with malaria: results of a prospective cohort study in Zambia

Christine Manyando, Rhoda Mkandawire, Lwipa Puma, Moses Sinkala, Evans Mpabalwani, Eric Njunju, Melba Gomes, Isabela Ribeiro, Verena Walter, Mailis Virtanen, Raymond Schlienger, Marc Cousin, Miriam Chipimo, Frank M Sullivan Malaria Journal 2010, 9:249 (1 September 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

An important study of the safety of artemether-lumefantrine (AL) in pregnant women: relatively large sample size, prospective follow-up to 12 months for the infants, and careful screening for overt clinical birth deformities and neurodevelopmental outcomes.

22.

5259
Accesses

Research   Open Access Highly Accessed

Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections

Dylan R Pillai, Rachel Lau, Krishna Khairnar, Rosalba Lepore, Allegra Via, Henry M Staines, Sanjeev Krishna Malaria Journal 2012, 11:131 (27 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

23.

5090
Accesses

Review   Open Access Highly Accessed

Intermittent preventive treatment for malaria in pregnancy in Africa: What's new, what's needed?

Andrew Vallely, Lisa Vallely, John Changalucha, Brian Greenwood, Daniel Chandramohan Malaria Journal 2007, 6:16 (16 February 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A sound review on recent developments of an important malaria control intervention, looking at possible alternatives to sulphadoxine-pyrimethamine in areas where there is resistance

24.

5043
Accesses

Opinion   Open Access Highly Accessed

Roll Back Malaria? The scarcity of international aid for malaria control

Vasant Narasimhan, Amir Attaran Malaria Journal 2003, 2:8 (15 April 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

This provocative paper outlines how the failure of governments and funding agencies to honour the promises of financial support of the Abuja Declaration risks ultimately to have a negative impact on the RBM programme.

25.

4974
Accesses

Meeting report   Open Access Highly Accessed

Inaugural meeting of the malaria policy advisory committee to the WHO: conclusions and recommendations

WHO Malaria Policy Advisory Committee and Secretariat Malaria Journal 2012, 11:137 (30 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This article provides a summary of the discussions, conclusions and recommendations from the first meeting of the WHO Malaria Policy Advisory Committee

26.

4873
Accesses

Research   Open Access Highly Accessed

Habitat characterization and spatial distribution of Anopheles sp. mosquito larvae in Dar es Salaam (Tanzania) during an extended dry period

Michael A Sattler, Deo Mtasiwa, Michael Kiama, Zul Premji, Marcel Tanner, Gerry F Killeen, Christian Lengeler Malaria Journal 2005, 4:4 (14 January 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Urban populations in Africa are set to rise inexorably over the coming decades, with a greater proportion of the populations living within cities and conurbations and an increase of urban agriculture in some cities. It is suggested that urban malaria is likely to become increasingly important.

27.

4723
Accesses

Research   Open Access Highly Accessed

Artemisinin-based combination therapy does not measurably reduce human infectiousness to vectors in a setting of intense malaria transmission

Bernadette J Huho, Gerard F Killeen, Heather M Ferguson, Adriana Tami, Christian Lengeler, J Derek Charlwood, Aniset Kihonda, Japhet Kihonda, S Patrick Kachur, Thomas A Smith, Salim MK Abdulla Malaria Journal 2012, 11:118 (18 April 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A study of the impact of artesunate/SP use on oocyst/sporozoite carriage in mosquitoes. It is not unexpected that in an area of intense malaria transmission, with presumed large numbers of asymptomatic gametocyte carriers, that ACT does not result in a marked reduction in transmission indices. Whilst the result in not unexpected the methodology is thorough and is likely to be useful to others.

28.

4703
Accesses

Review   Open Access Highly Accessed

Primaquine in vivax malaria: an update and review on management issues

Deepika Fernando, Chaturaka Rodrigo, Senaka Rajapakse Malaria Journal 2011, 10:351 (12 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Paper reviews the published literature on the use of primaquine as an agent for prophylaxis and radical cure. The detailed section on G6PD deficiency as a barrier for mass administration of primaquine and the section on the use of primaquine with blood schizontocidals other than chloroquine is useful.

29.

4687
Accesses

Review   Open Access Highly Accessed

Management of imported malaria in Europe

Helena H Askling, Fabrice Bruneel, Gerd Burchard, Francesco Castelli, Peter L Chiodini, Martin P Grobusch, Rogelio Lopez-Vélez, Margaret Paul, Eskild Petersen, Corneliu Popescu, Michael Ramharter, Patricia Schlagenhauf, on behalf of the European Society for Clinical Microbiology and Infectious Diseases Study Group on Clinical Parasitology Malaria Journal 2012, 11:328 (17 September 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A very comprehensive review on imported malaria and recommendation for its management.

30.

4467
Accesses

Research   Open Access Highly Accessed

Poor quality vital anti-malarials in Africa - an urgent neglected public health priority

Paul N Newton, Michael D Green, Dallas C Mildenhall, Aline Plançon, Henry Nettey, Leonard Nyadong, Dana M Hostetler, Isabel Swamidoss, Glenn A Harris, Kristen Powell, Ans E Timmermans, Abdinasir A Amin, Stephen K Opuni, Serge Barbereau, Claude Faurant, Ray CW Soong, Kevin Faure, Jonarthan Thevanayagam, Peter Fernandes, Harparkash Kaur, Brian Angus, Kasia Stepniewska, Philippe J Guerin, Facundo M Fernández Malaria Journal 2011, 10:352 (13 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Criminals are producing diverse harmful anti-malarial counterfeits with important public health consequences. With the threatening spread of artemisinin resistance to Africa, much greater investment is required to ensure the quality of ACT and removal of artemisinin monotherapies.

31.

4452
Accesses

Research   Open Access Highly Accessed

Artesunate – amodiaquine combination therapy for falciparum malaria in young Gabonese children

Sunny Oyakhirome, Marc Pötschke, Norbert G Schwarz, Jenny Dörnemann, Matthias Laengin, Carmen Salazar, Bertrand Lell, Jürgen FJ Kun, Peter G Kremsner, Martin P Grobusch Malaria Journal 2007, 6:29 (12 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Although this combination is one of the recommended ACTs for the treatment of malaria, there is not much data on effectiveness in children. This study compares effectiveness in supervised and unsupervised drug delivery, showing that it could be augmented by increased adherence and improved formulation.

32.

4423
Accesses

Research   Open Access Highly Accessed

Sugar-fermenting yeast as an organic source of carbon dioxide to attract the malaria mosquito Anopheles gambiae

Renate C Smallegange, Wolfgang H Schmied, Karel J van Roey, Niels O Verhulst, Jeroen Spitzen, Wolfgang R Mukabana, Willem Takken Malaria Journal 2010, 9:292 (25 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Carbon dioxide plays an important role in the host-seeking process of mosquito species and is commonly added to mosquito sampling tools. This study showed that traps baited with yeast-produced CO2 caught significantly more mosquitoes than unbaited traps and traps baited with industrial CO2, both in the laboratory and semi-field conditions.

33.

4318
Accesses

Research   Open Access Highly Accessed

Sri Lanka Malaria Maps

Olivier JT Briët, Dissanayake M Gunawardena, Wim van der Hoek, Felix P Amerasinghe Malaria Journal 2003, 2:22 (22 July 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments |  Editor’s summary

This paper presents Sri Lanka's malaria incidence data and trends over the last few years from a spatial perspective. It provides a good illustration of national malaria data and also helps to highlight the features that emerge through such a presentation.

34.

4263
Accesses

Reviews   Open Access Highly Accessed

Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions

Philippe Rasoanaivo, Colin W Wright, Merlin L Willcox, Ben Gilbert Malaria Journal 2011, 10(Suppl 1):S4 (15 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

35.

4255
Accesses

Research   Open Access Highly Accessed

Community participation for malaria elimination in Tafea Province, Vanuatu: Part I. Maintaining motivation for prevention practices in the context of disappearing disease

Jo-An M Atkinson, Lisa Fitzgerald, Hilson Toaliu, George Taleo, Anna Tynan, Maxine Whittaker, Ian Riley, Andrew Vallely Malaria Journal 2010, 9:93 (12 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The study emphasizes the importance of community participation in achieving and sustaining malaria elimination. Approaches focusing exclusively on expectations of individual behaviour change are unlikely to produce substantial and long-term effects in malaria prevention and, instead, comprehensive interventions are needed that take account of the social context.

36.

4249
Accesses

Review   Open Access Highly Accessed

Best practices for an insecticide-treated bed net distribution programme in sub-Saharan eastern Africa

Alexis R Sexton Malaria Journal 2011, 10:157 (8 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This review assessed literature on recent insecticide-treated bed net distribution programmes throughout sub-Saharan Eastern Africa. Forty-two studies were identified and reviewed. Studies revealed consistent inequities between urban and rural populations; which were most effectively alleviated through a free insecticide-treated bed net delivery and distribution framework

37.

4238
Accesses

Review   Open Access Highly Accessed

Human movement data for malaria control and elimination strategic planning

Deepa K Pindolia, Andres J Garcia, Amy Wesolowski, David L Smith, Caroline O Buckee, Abdisalan M Noor, Robert W Snow, Andrew J Tatem Malaria Journal 2012, 11:205 (18 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This paper usefully documents sources of information on migration which may be of relevance to malaria transmission.

38.

4222
Accesses

Review   Open Access Highly Accessed

The safety of artemisinins during pregnancy: a pressing question

Stephanie Dellicour, Susan Hall, Daniel Chandramohan, Brian Greenwood Malaria Journal 2007, 6:15 (14 February 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Limited available data suggest that artemisinins are effective and unlikely to be cause of foetal loss or abnormalities, when used in late pregnancy. However, one cannot rule out rare serious adverse events, even in 2nd and 3rd trimesters and there is not enough evidence to assess risk-benefits of artemisinin in early pregnancy. Methodologically rigorous, larger studies and post-marketing pharmacovigilance are urgently required.

39.

4208
Accesses

Meeting report   Open Access Highly Accessed

Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of September 2012 meeting

WHO Malaria Policy Advisory Committee and Secretariat Malaria Journal 2012, 11:424 (19 December 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This article provides a summary of the discussions, conclusions and recommendations from the second meeting of the WHO Malaria Policy Advisory Committee

40.

4165
Accesses

Research   Open Access Highly Accessed

Detection of malaria parasites by nested PCR in south-eastern, Iran: Evidence of highly mixed infections in Chahbahar district

Sedigheh Zakeri, Sohaila Najafabadi, Ahmad Zare, Navid Djadid Malaria Journal 2002, 1:2 (8 February 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

41.

4153
Accesses

Review   Open Access Highly Accessed

Costs and cost-effectiveness of malaria control interventions - a systematic review

Michael T White, Lesong Conteh, Richard Cibulskis, Azra C Ghani Malaria Journal 2011, 10:337 (3 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

This paper covers a systematic review on the costs and cost-effectiveness of malaria control interventions. The interventions covered include insecticide-treated bed nets Indoor residual spraying and Intermittent preventative treatment, diagnostic testing and appropriate treatment.

42.

4110
Accesses

Research   Open Access Highly Accessed

Intermittent preventive treatment of malaria during pregnancy: a qualitative study of knowledge, attitudes and practices of district health managers, antenatal care staff and pregnant women in Korogwe District, North-Eastern Tanzania

Godfrey Mubyazi, Paul Bloch, Mathias Kamugisha, Andrew Kitua, Jasper Ijumba Malaria Journal 2005, 4:31 (20 July 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The paper provides a qualitative analysis of the programmatic issues faced when implementing IPT during pregnancy, from both provider and user perspectives. Of particular interest is the Tanzanian experience of the specific link made between SP-IPT and Steven Johnson¿s Syndrome by pregnant women, which is unique and has been one of the most important barriers to the effective uptake of ITP, as a result of media spin. The paper highlights the need for much greater attention to awareness creation among pregnant women, which is all too often an afterthought to the delivery of IPT.

43.

4050
Accesses

Review   Open Access Highly Accessed

The anaemia of Plasmodium vivax malaria

Nicholas M Douglas, Nicholas M Anstey, Pierre A Buffet, Jeanne R Poespoprodjo, Tsin W Yeo, Nicholas J White, Ric N Price Malaria Journal 2012, 11:135 (27 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

An extensive review of the literature on anaemia in vivax malaria.

44.

4024
Accesses

Review   Open Access Highly Accessed

Reported reasons for not using a mosquito net when one is available: a review of the published literature

Justin Pulford, Manuel W Hetzel, Miranda Bryant, Peter M Siba, Ivo Mueller Malaria Journal 2011, 10:83 (11 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This review highlights a gap in understanding of community perceptions and barriers to the use of bed nets for malaria control and elimination and the lack of empirical research to inform behaviour change communication strategies. The authors importantly recognize the need for programmes to look beyond coverage of bed nets and locally investigate reasons for their non-use if they are to maximize the impact of this key intervention.

45.

4023
Accesses

Review   Open Access Highly Accessed

Integrated vector management for malaria control

John C Beier, Joseph Keating, John I Githure, Michael B Macdonald, Daniel E Impoinvil, Robert J Novak Malaria Journal 2008, 7(Suppl 1):S4 (11 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

46.

3978
Accesses

Research   Open Access Highly Accessed

Performance of a malaria microscopy image analysis slide reading device

William R Prescott, Robert G Jordan, Martin P Grobusch, Vernon M Chinchilli, Immo Kleinschmidt, Joseph Borovsky, Mark Plaskow, Miguel Torrez, Maximo Mico, Christopher Schwabe Malaria Journal 2012, 11:155 (6 May 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Accurate machine reading of malaria blood films would revolutionize malaria diagnosis and this study is an excellent examination of the state of this art.

47.

3940
Accesses

Research   Open Access Highly Accessed

Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance

Bruno B Andrade, Antonio Reis-Filho, Sebastião M Souza-Neto, Jorge Clarêncio, Luis MA Camargo, Aldina Barral, Manoel Barral-Netto Malaria Journal 2010, 9:13 (13 January 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A useful contribution on severe vivax malaria in one municipality of the state of Rondonia in the Brazilian Amazon. This paper is a reminder that there is currently no WHO definition of severe vivax malaria, a disease substantially different from falciparum malaria.

48.

3917
Accesses

Research   Open Access Highly Accessed

Mobile phones improve case detection and management of malaria in rural Bangladesh

Chai S Prue, Kerry L Shannon, Jacob Khyang, Laura J Edwards, Sabeena Ahmed, Malathi Ram, Timothy Shields, Mohammad S Hossain, Gregory E Glass, Myaing M Nyunt, David A Sack, David J Sullivan, Wasif A Khan Malaria Journal 2013, 12:48 (4 February 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Mobile phone technology, when combined with local knowledge and field support, may be applicable for improving malaria control in hard-to-reach areas.

49.

3914
Accesses

Research   Open Access Highly Accessed

Reliable enumeration of malaria parasites in thick blood films using digital image analysis

John A Frean Malaria Journal 2009, 8:218 (23 September 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

This paper describes the definition and evaluation of a computer-based imaging algorithm for enumeration of malaria parasites in thick films. While still a long way to go from routine use, the accuracy afforded by the technique may be relevant for clinical studies of vaccines or drugs

50.

3882
Accesses

Research   Open Access Highly Accessed

Malaria control in Bhutan: case study of a country embarking on elimination

Thinley Yangzom, Cara Gueye, Rinzin Namgay, Gawrie NL Galappaththy, Krongthong Thimasarn, Roly Gosling, Shiva Murugasampillay, Vas Dev Malaria Journal 2012, 11:9 (9 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Moving from intensive malaria control to malaria elimination has become a question for many malaria control programmes. This is an interesting case study of a malarious country about which is little is known outside the South Asia region.

51.

3809
Accesses

Research   Open Access Highly Accessed

Treatment-seeking behaviour for malaria in children under five years of age: implication for home management in rural areas with high seasonal transmission in Sudan

Elfatih Malik, Kamal Hanafi, Salah Ali, Eldirdieri Ahmed, Khalid Mohamed Malaria Journal 2006, 5:60 (22 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Understanding the patterns of health-seeking behaviour, when and why a mother chooses to take her child for treatment in a health centre rather than traditional medicine, is crucial in any control programme. This study looks at the issue in Sudan, by means of interviews and focus group discussions.

52.

3770
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Research   Open Access Highly Accessed

Care-seeking patterns for fatal malaria in Tanzania

Don de Savigny, Charles Mayombana, Eleuther Mwageni, Honorati Masanja, Abdulatif Minhaj, Yahya Mkilindi, Conrad Mbuya, Harun Kasale, Graham Reid Malaria Journal 2004, 3:27 (28 July 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This careful analysis of malaria deaths in an area of perennial malarial transmission addresses important issues, showing for instance that the care-seeking behaviour was substantially different in the case of severe malaria and uncomplicated malarial episodes. The limitations of using verbal autopsies are well discussed.

53.

3736
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Review   Open Access Highly Accessed

Challenges in using geographic information systems (GIS) to understand and control malaria in Indonesia

Neil G Sipe, Pat Dale Malaria Journal 2003, 2:36 (4 November 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Most studies on the use of GIS for malaria control have been performed in Africa and the application of the technique in Indonesia raised important issues. This comprehensive review looks at the limitations of GIS and how best to solve various problems to make this approach more user-friendly.

54.

3671
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Review   Open Access Highly Accessed

Statics and dynamics of malaria infection in Anopheles mosquitoes

David L Smith, F Ellis McKenzie Malaria Journal 2004, 3:13 (4 June 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This theoretical and mathematical review provides a new look at the Ross-Macdonald models, the basis of malaria epidemiology. The models describe the processes that drive malaria transmission, mainly from an entomological perspective, and they are, therefore, particularly useful to evaluate intervention programmes that reduce transmission.

55.

3668
Accesses

Research   Open Access Highly Accessed

Scaling-up malaria treatment: a review of the performance of different providers

Mohga M Kamal-Yanni, Julien Potet, Philippa M Saunders Malaria Journal 2012, 11:414 (12 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Access to life saving malaria treatment within 24 hours of symptom onset is still far below the RBM targets. Improved case management requires a strengthened health system including community health initiatives and working with non-public sector compartments of the health system. The paper reviews different aspects of provider performance in the different compartments: public sector, community health workers and the private sector.

56.

3648
Accesses

Research   Open Access Highly Accessed

A dynamic model of some malaria-transmitting anopheline mosquitoes of the Afrotropical region. I. Model description and sensitivity analysis

Torleif Markussen Lunde, Diriba Korecha, Eskindir Loha, Asgeir Sorteberg, Bernt Lindtjørn Malaria Journal 2013, 12:28 (23 January 2013)

Abstract | Provisional PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This study highlights some of the assumptions commonly used when constructing mosquito-malaria models and presents a realistic model of Anopheles gambiae s.s. and Anopheles arabiensis, and their interaction. The authors make a case that this new mosquito model, OMaWa, may improve the understanding of vector dynamics, which in turn can be used to better understand the dynamics of malaria.

57.

3624
Accesses

Research   Open Access Highly Accessed

Prevalence of malaria infection in Butajira area, south-central Ethiopia

Adugna Woyessa, Wakgari Deressa, Ahmed Ali, Bernt Lindtjørn Malaria Journal 2012, 11:84 (23 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This study documents a low prevalence of malaria that varied with season and altitude in a highland-fringe area of Ethiopia. Most of the malaria infections were attributable to Plasmodium vivax.

58.

3579
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Research   Open Access Highly Accessed

A malaria transmission-directed model of mosquito life cycle and ecology

Philip A Eckhoff Malaria Journal 2011, 10:303 (17 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This paper presents a new mathematical model describing the mosquito life-cycle and ecology. The model is fairly detailed and comprehensive, and similar in its intent and scope to the Depinay model.

59.

3479
Accesses

Review   Open Access Highly Accessed

The complexities of malaria disease manifestations with a focus on asymptomatic malaria

Dolie D Laishram, Patrick L Sutton, Nutan Nanda, Vijay L Sharma, Ranbir C Sobti, Jane M Carlton, Hema Joshi Malaria Journal 2012, 11:29 (31 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The pathogenesis of malaria is complex, and the clinical presentation of disease ranges from severe malaria, to mild and uncomplicated, to asymptomatic infections. Asymptomatic malaria remains a major challenge for malaria control programmes.

60.

3419
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Research   Open Access Highly Accessed

Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria

Mario Dell'Agli, Germana V Galli, Michela Bulgari, Nicoletta Basilico, Sergio Romeo, Deepak Bhattacharya, Donatella Taramelli, Enrica Bosisio Malaria Journal 2010, 9:208 (19 July 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The study provides further explanation of the therapeutic effects of Punica granatum in malaria.

61.

3398
Accesses

Review   Open Access Highly Accessed

Genetic polymorphisms linked to susceptibility to malaria

Adel Driss, Jacqueline M Hibbert, Nana O Wilson, Shareen A Iqbal, Thomas V Adamkiewicz, Jonathan K Stiles Malaria Journal 2011, 10:271 (19 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This review describes and discusses human gene polymorphisms identified thus far that have been shown to be associated with susceptibility or resistance to P. falciparum malaria.

62.

3343
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Research   Open Access Highly Accessed

Impact of national malaria control scale-up programmes in Africa: magnitude and attribution of effects

Richard W Steketee, Carlos C Campbell Malaria Journal 2010, 9:299 (27 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

After over 5 years of intense intervention scale-up, the present paper puts together some data from a number of sub-Saharan countries to document impact on morbidity and mortality.

63.

3318
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Research   Open Access Highly Accessed

Estimates of child deaths prevented from malaria prevention scale-up in Africa 2001-2010

Thomas P Eisele, David A Larsen, Neff Walker, Richard E Cibulskis, Joshua O Yukich, Charlotte M Zikusooka, Richard W Steketee Malaria Journal 2012, 11:93 (28 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Malaria intervention programmes have saved one million African children in the last decade, a study by Eisele reveals, but increased intervention is required to halt and reverse malaria incidence by the 2015 target.

64.

3312
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Research   Open Access Highly Accessed

Initial evidence of reduction of malaria cases and deaths in Rwanda and Ethiopia due to rapid scale-up of malaria prevention and treatment

Mac Otten, Maru Aregawi, Wilson Were, Corine Karema, Ambachew Medin, Worku Bekele, Daddi Jima, Khoti Gausi, Ryuichi Komatsu, Eline Korenromp, Daniel Low-Beer, Mark Grabowsky Malaria Journal 2009, 8:14 (14 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Initial evidence indicates that the combination of mass distribution of LLIN to all children below five years and nationwide distribution of ACT in the public sector was associated with substantial declines of in-patient malaria cases and deaths in Rwanda and Ethiopia. Clinic-based data was a useful tool for local monitoring of the impact of malaria programmes.

65.

3305
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Review   Open Access Highly Accessed

Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report

Lorenz von Seidlein, Sarah Auburn, Fe Espino, Dennis Shanks, Qin Cheng, James McCarthy, Kevin Baird, Catherine Moyes, Rosalind Howes, Didier Ménard, Germana Bancone, Ari Winasti-Satyahraha, Lasse S Vestergaard, Justin Green, Gonzalo Domingo, Shunmay Yeung, Ric Price Malaria Journal 2013, 12:112 (27 March 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

A review based on the conclusions of an important meeting looking at the knowledge gaps in G6PD deficiency with regards to the safe implementation of 8 - aminoquinolines.

66.

3303
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Review   Open Access Highly Accessed

Resistance to malaria in humans: the impact of strong, recent selection

Philip W Hedrick Malaria Journal 2012, 11:349 (22 October 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Malaria resistance genes comprise some of the most widely accepted examples of strong positive selection in humans. Overall, the original ¿malaria hypothesis¿ of Haldane that diseases like thalassaemia are polymorphisms because of resistance to malaria, has been proven correct. However, much is still to be learned about actual mechanisms of protection, other genes that confer resistance, and the population genetics of this variation.

67.

3283
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Review   Open Access Highly Accessed

Automated haematology analysis to diagnose malaria

Germán Campuzano-Zuluaga, Thomas Hänscheid, Martin P Grobusch Malaria Journal 2010, 9:346 (30 November 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

An up-to-date overview of the possibilities of automated haematology to diagnose malaria.

68.

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Research   Open Access Highly Accessed

A dynamic model of some malaria-transmitting anopheline mosquitoes of the Afrotropical region. II. Validation of species distribution and seasonal variations

Torleif M Lunde, Meshesha Balkew, Diriba Korecha, Teshome Gebre-Michael, Fekadu Massebo, Asgeir Sorteberg, Bernt Lindtjørn Malaria Journal 2013, 12:78 (25 February 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Validation of a mathematical model described earlier. Overall, the model gives a realistic representation of seasonal and year-to-year variability in mosquito densities and it can accurately predict the distribution of An. gambiae s.s. and An. arabiensis in sub-Saharan Africa. It may be used for seasonal and long-term predictions of changes in the burden of malaria.

69.

3247
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Review   Open Access Highly Accessed

The architecture and effect of participation: a systematic review of community participation for communicable disease control and elimination. Implications for malaria elimination

Jo-An Atkinson, Andrew Vallely, Lisa Fitzgerald, Maxine Whittaker, Marcel Tanner Malaria Journal 2011, 10:225 (4 August 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This is a very timely paper as the international malaria control effort has significantly accelerated malaria control regarding planning, resource mobilization and availability of malaria control commodities.

70.

3243
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Research   Open Access

Use of insecticide-treated nets (ITNs) following a malaria education intervention in Piron, Mali: a control trial with systematic allocation of households

Michelle Rhee, Mahamadou Sissoko, Sharon Perry, Willi McFarland, Julie Parsonnet, Ogobara Doumbo Malaria Journal 2005, 4:35 (25 July 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Before the advent of long-lasting insecticidal nets, the need to re-impregnate bed nets regularly was a major obstacle for intervention programmes. This study from Mali shows that the education component of such programmes can substantially improve success rates.

71.

3192
Accesses

Review   Open Access Highly Accessed

Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature

Marcus VG Lacerda, Maria PG Mourão, Márcia AA Alexandre, André M Siqueira, Belisa ML Magalhães, Flor E Martinez-Espinosa, Franklin S Santana Filho, Patrícia Brasil, Ana MRS Ventura, Mauro S Tada, Vanja SCD Couto, Antônio R Silva, Rita SU Silva, Maria GC Alecrim Malaria Journal 2012, 11:12 (9 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

There has recently been a renewed interested in Plasmodium vivax malaria.The publication of grey literature is useful and the manuscript brings to light data not previously accessible in the English language literature.

72.

3182
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Research   Open Access Highly Accessed

The economic costs of malaria in four Kenyan districts: do household costs differ by disease endemicity?

Jane Chuma, Vincent Okungu, Catherine Molyneux Malaria Journal 2010, 9:149 (2 June 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In a cross-sectional household survey conducted in four districts in Kenya of varied malaria epidemiology the authors assess whether the economic burden of malaria can vary according to epidemiological setting.

73.

3171
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Research   Open Access Highly Accessed

Principal component analysis of socioeconomic factors and their association with malaria in children from the Ashanti Region, Ghana

Anne Krefis, Norbert Schwarz, Bernard Nkrumah, Samuel Acquah, Wibke Loag, Nimako Sarpong, Yaw Adu-Sarkodie, Ulrich Ranft, Jürgen May Malaria Journal 2010, 9:201 (13 July 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A contribution to the growing body of literature measuring socioeconomic data as risk factors for malaria infection and public health outcomes in endemic countries.

74.

3168
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Research   Open Access Highly Accessed

In vitro and in vivo anti-malarial activity of Boerhavia elegans and Solanum surattense

Ali Ramazani, Sedigheh Zakeri, Soroush Sardari, Nastaran Khodakarim, Navid Djadidt Malaria Journal 2010, 9:124 (12 May 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Using standard and validated in vitro and in vivo assays this work has shown activity of crude ethanolic and dichloromethane extracts of three plants to be found in Iran

75.

3152
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Research   Open Access Highly Accessed

Survey of artemisinin production by diverse Artemisia species in northern Pakistan

Abdul Mannan, Ibrar Ahmed, Waheed Arshad, Muhammad F Asim, Rizwana A Qureshi, Izhar Hussain, Bushra Mirza Malaria Journal 2010, 9:310 (4 November 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A survey of artemisinin production by diverse Artemisia species in northern Pakistan, which identifies 12 new plants as source of artemisinin.

76.

3109
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Research   Open Access Highly Accessed

Malaria indicator survey 2007, Ethiopia: coverage and use of major malaria prevention and control interventions

Daddi Jima, Asefaw Getachew, Hana Bilak, Richard W Steketee, Paul M Emerson, Patricia M Graves, Teshome Gebre, Richard Reithinger, Jimee Hwang, the Ethiopia Malaria Indicator Survey Working Group Malaria Journal 2010, 9:58 (24 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

An important finding and conclusion from this study is that although there have been massive gains in intervention coverage in Ethiopia, there is still some work required to make sure that the interventions are used.

77.

3094
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Research   Open Access Highly Accessed

Is dengue and malaria co-infection more severe than single infections? A retrospective matched-pair study in French Guiana

Loïc Epelboin, Matthieu Hanf, Philippe Dussart, Sihem Ouar-Epelboin, Félix Djossou, Mathieu Nacher, Bernard Carme Malaria Journal 2012, 11:142 (1 May 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The paper addresses an important topic with dengue and malaria increasingly co-existing in many parts of the world.

78.

3087
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Research   Open Access Highly Accessed

Remote sensing-based time series models for malaria early warning in the highlands of Ethiopia

Alemayehu Midekisa, Gabriel Senay, Geoffrey M Henebry, Paulos Semuniguse, Michael C Wimberly Malaria Journal 2012, 11:165 (14 May 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The paper reports an attempt to anticipate the number of malaria cases in 12 districts health centres of the Amhara Ethiopian region, based on 12 temporal models including historical malaria cases as well as remotely sensed meteorological and environmental variables.

79.

3086
Accesses

Methodology   Open Access Highly Accessed

Improving N-terminal protein annotation of Plasmodium species based on signal peptide prediction of orthologous proteins

Armando Neto, Denise A Alvarenga, Antônio M Rezende, Sarah S Resende, Ricardo Ribeiro, Cor JF Fontes, Luzia H Carvalho, Cristiana F de Brito Malaria Journal 2012, 11:375 (15 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The correct annotation of Plasmodium genes is a far-reaching issue that concerns a broad array of researchers, from health scientists to evolutionary biologists. The authors present novel methods and valuable results that will prove important to those studying the genus and potentially the phylum.

80.

3070
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Research   Open Access Highly Accessed

Malaria vectors and transmission dynamics in coastal south-western Cameroon

Jude D Bigoga, Lucien Manga, Vincent PK Titanji, Maureen Coetzee, Rose GF Leke Malaria Journal 2007, 6:5 (17 January 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

New data on malaria transmission dynamics in three sites in south-western Cameroon. Such data is extremely relevant and needed to better understand malaria epidemiology in Cameroon and throughout Africa, and identify putative field sites for innovative control measures testing

81.

3067
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Research   Open Access Highly Accessed

Malaria rapid diagnostic kits: quality of packaging, design and labelling of boxes and components and readability and accuracy of information inserts

Philippe Gillet, Jessica Maltha, Veerle Hermans, Raffaella Ravinetto, Cathrien Bruggeman, Jan Jacobs Malaria Journal 2011, 10:39 (13 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This study reports on the characteristics of malaria RDTs that are commercially available in terms of their packaging, labelling and inserts. Clear instructions for end-users may help in the correct use of RDTs and ultimately improve the diagnostic accuracy.

82.

3061
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Research   Open Access Highly Accessed

Larvicidal activity of neem oil (Azadirachta indica) formulation against mosquitoes

Virendra K Dua, Akhilesh C Pandey, Kamaraju Raghavendra, Ashish Gupta, Trilochan Sharma, Aditya P Dash Malaria Journal 2009, 8:124 (8 June 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Description of the effect of a neem oil formulation, shown to be effective in controlling mosquito larvae in different breeding sites under natural field conditions. Claimed to be an eco-friendly larvicide, which could be used as an additional tool for malaria control.

83.

3027
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Review   Open Access Highly Accessed

Gametocytogenesis : the puberty of Plasmodium falciparum

Arthur M Talman, Olivier Domarle, F McKenzie, Frédéric Ariey, Vincent Robert Malaria Journal 2004, 3:24 (14 July 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A review which addresses several aspects of gametocyte biology, focusing on sex differentiation and determination, transmission strategies and evolution; it highlight areas where the gametocyte might be targetted for control interventions.

84.

3027
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Research   Open Access Highly Accessed

Utilization of insecticide-treated nets by under-five children in Nigeria: Assessing progress towards the Abuja targets

Olusola B Oresanya, Moshe Hoshen, Olayemi T Sofola Malaria Journal 2008, 7:145 (30 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Despite a substantial increase in ITN utilization among children under five years of age in Nigeria, numbers are still far from the Abuja targets (11.5% for nets overall, 1.7% for ITNs).

85.

3013
Accesses

Methodology   Open Access Highly Accessed

Real-time quantitative PCR with SYBR Green I detection for estimating copy numbers of nine drug resistance candidate genes in Plasmodium falciparum

Isabel D Ferreira, Virgílio E do Rosário, Pedro VL Cravo Malaria Journal 2006, 5:1 (18 January 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

A high throughput PCR-based method to analyse genes associated with drug resistance in field samples. In this study, the relative copy number of three genes associated with drug resistance and six associated with oxidative stress have been be assessed.

86.

3010
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Commentary   Open Access Highly Accessed

Surveillance considerations for malaria elimination

Victoria C Barclay, Rachel A Smith, Jill L Findeis Malaria Journal 2012, 11:304 (31 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

This commentary highlights the importance of real-time surveillance-response systems for malaria elimination and the challenges of establishing and maintaining these systems in resource poor settings. Authors promote the use and integration of multiple data sources into a single data reservoir/platform that could be accessed by multiple stakeholders in order to optimize coordination of multiple actors and timeliness in the implementation of effective interventions to control and eliminate malaria.

87.

3004
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Review   Open Access Highly Accessed

Assessment of two malaria rapid diagnostic tests in children under five years of age, with follow-up of false-positive pLDH test results, in a hyperendemic falciparum malaria area, Sierra Leone

Sibylle Gerstl, Sophie Dunkley, Ahmed Mukhtar, Martin De Smet, Samuel Baker, Jacob Maikere Malaria Journal 2010, 9:28 (21 January 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The information is relevant, as there is an ongoing search to design and implement a malaria RDT that is appropriate in developing country settings.

88.

3000
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Review   Open Access Highly Accessed

Working without a blindfold: the critical role of diagnostics in malaria control

Mark D Perkins, David R Bell Malaria Journal 2008, 7(Suppl 1):S5 (11 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

89.

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Research   Open Access Highly Accessed

Treatment outcome of intravenous artesunate in patients with severe malaria in the Netherlands and Belgium

Annemarie R Kreeftmeijer-Vegter, Perry J van Genderen, Leo G Visser, Wouter FW Bierman, Jan Clerinx, Cees KW van Veldhuizen, Peter J de Vries Malaria Journal 2012, 11:102 (31 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Data from the named patient programme demonstrate that IV artesunate is effective and well-tolerated in European travellers lacking immunity. However, increased attention needs to be paid to the possible development of haemolytic anaemia two or three weeks after start of treatment.

90.

2985
Accesses

Methodology   Open Access Highly Accessed

Estimating malaria parasite density: assumed white blood cell count of 10,000/μl of blood is appropriate measure in Central Ghana

Dennis Adu-Gyasi, Mohammed Adams, Sabastina Amoako, Emmanuel Mahama, Maxwell Nsoh, Seeba Amenga-Etego, Frank Baiden, Kwaku Asante, Sam Newton, Seth Owusu-Agyei Malaria Journal 2012, 11:238 (23 July 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Analysis of the use of an assumed WBC count compared to the actual WBC for estimating parasitaemia in children aged 0-5 years in Ghana. Questioning the accuracy of this widely used method for estimating malaria parasitaemia is an important research topic since it is commonly used to guide important policy and practice decisions.

91.

2979
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Research   Open Access Highly Accessed

Funding for malaria control 2006–2010: A comprehensive global assessment

David M Pigott, Rifat Atun, Catherine L Moyes, Simon I Hay, Peter W Gething Malaria Journal 2012, 11:246 (28 July 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This report is an important first step in assessing financial resources used to control malaria. Documenting the amount and source of funds for malaria control is a critical description that raises many fundamental questions.

92.

2976
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Research   Open Access Highly Accessed

Primaquine radical cure of Plasmodium vivax: a critical review of the literature

George K John, Nicholas M Douglas, Lorenz von Seidlein, Francois Nosten, J Baird, Nicholas J White, Ric N Price Malaria Journal 2012, 11:280 (17 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

This review of primaquine treatment for the radical cure outlines the heterogeneity of studies in this area from the 1950s until now and the need for standardization. It tabulates the main factors of relevance to these type of studies including various aspects of the study design (treatment arms, control arms, follow-up duration, supervision of treatment) and age of study participants. It neatly summarizes the efficacies of very low, low and high dose primaquine at various time points and relates these findings to the geographical context of these studies.

93.

2942
Accesses

Research   Open Access Highly Accessed

Human population, urban settlement patterns and their impact on Plasmodium falciparum malaria endemicity

Andrew J Tatem, Carlos A Guerra, Caroline W Kabaria, Abdisalan M Noor, Simon I Hay Malaria Journal 2008, 7:218 (27 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The paper documents efforts to use a global population database, medical intelligence and urban extent maps to identify and describe spatially those areas of the malaria endemic world where human population densities are lowest and highest, resulting in modified transmission and, as such, impact upon malaria burden.

94.

2936
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Review   Open Access Highly Accessed

The position of mefloquine as a 21st century malaria chemoprophylaxis

Patricia Schlagenhauf, Miriam Adamcova, Loredana Regep, Martin T Schaerer, Hans-Georg Rhein Malaria Journal 2010, 9:357 (9 December 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A review of the use of mefloquine with emphasis on the data on adverse events. Mefloquine is effective for malaria prophylaxis in most areas, but has largely fallen out of use due to real or perceived psychiatric side effects. This study review the existing data and draws on the manufacturers post-marketing surveillance.

95.

2935
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Research   Open Access Highly Accessed

Nets, spray or both? The effectiveness of insecticide-treated nets and indoor residual spraying in reducing malaria morbidity and child mortality in sub-Saharan Africa

Nancy Fullman, Roy Burstein, Stephen S Lim, Carol Medlin, Emmanuela Gakidou Malaria Journal 2013, 12:62 (13 February 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Whether ITNs, IRS or both should be used, and under what transmission environments is an important topic in malaria control and evaluation. The authors used matched regression analyses to assess the association of vector control (ITNs and/or IRS) under routine programme conditions, using national household surveys.

96.

2933
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Research   Open Access Highly Accessed

Urban malaria and associated risk factors in Jimma town, south-west Ethiopia

Abebe Alemu, Wondewosen Tsegaye, Lemu Golassa, Gemeda Abebe Malaria Journal 2011, 10:173 (24 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A cross-sectional malariological survey in Jimma town, south-west Ethiopia, with a descriptive KAP analysis and some risk factors. The paper addresses an issue of public health importance, and the statistics are likely to be of interest to those working in malaria in similar environments.

97.

2908
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Research   Open Access Highly Accessed

The development of insecticide-treated durable wall lining for malaria control: insights from rural and urban populations in Angola and Nigeria

Louisa A Messenger, Nathan P Miller, Adedapo O Adeogun, Taiwo Awolola, Mark Rowland Malaria Journal 2012, 11:332 (18 September 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The operational success of durable wall ling as a long-lasting insecticidal substrate will be dependent on a high level of user acceptability as households must maintain correctly installed material on their walls for several years. In this study, there was a dichotomy between rural and urban respondents. Rural participants favoured wall adornments and accepted DL because of its perceived decorative value and entomological efficacy. By contrast, urban households rejected the DL based upon objections to its aesthetics and installation feasibility.

98.

2898
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Review   Open Access Highly Accessed

The 'hidden' burden of malaria: cognitive impairment following infection

Sumadhya D Fernando, Chaturaka Rodrigo, Senaka Rajapakse Malaria Journal 2010, 9:366 (20 December 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A helpful attempt to synthesize accumulating research in the area of impact of malaria on cognitive development. This work is important because the research base is growing quickly and suggests that malaria has a substantial effect on cognitive development

99.

2881
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Commentary   Open Access Highly Accessed

"Test and treat" or presumptive treatment for malaria in high transmission situations? A reflection on the latest WHO guidelines

Bertrand Graz, Merlin Willcox, Thomas Szeless, André Rougemont Malaria Journal 2011, 10:136 (20 May 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

A thought-provoking discussion about the importance of diagnosis before treatment and situations when the WHO guidelines may be confusing

100.

2880
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Methodology   Open Access Highly Accessed

Computer vision for microscopy diagnosis of malaria

F Boray Tek, Andrew G Dempster, Izzet Kale Malaria Journal 2009, 8:153 (13 July 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Improving malaria diagnostics by computer-assisted microscopy is close to becoming reality: this paper emphasizes the hopes and problems that are encountered with pattern recognition analysis of blood films.

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