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1.

56731
Accesses

Research   Open Access Highly Accessed

Sri Lanka Malaria Maps

Olivier JT Briët, Dissanayake M Gunawardena, Wim van der Hoek, Felix P Amerasinghe Malaria Journal 2003, 2:22 (22 July 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments |  Editor’s summary

This paper presents Sri Lanka's malaria incidence data and trends over the last few years from a spatial perspective. It provides a good illustration of national malaria data and also helps to highlight the features that emerge through such a presentation.

2.

34989
Accesses

Review   Open Access Highly Accessed

Global warming and malaria: knowing the horse before hitching the cart

Paul Reiter Malaria Journal 2008, 7(Suppl 1):S3 (11 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

3.

32072
Accesses

Research   Open Access Highly Accessed

Habitat characterization and spatial distribution of Anopheles sp. mosquito larvae in Dar es Salaam (Tanzania) during an extended dry period

Michael A Sattler, Deo Mtasiwa, Michael Kiama, Zul Premji, Marcel Tanner, Gerry F Killeen, Christian Lengeler Malaria Journal 2005, 4:4 (14 January 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Urban populations in Africa are set to rise inexorably over the coming decades, with a greater proportion of the populations living within cities and conurbations and an increase of urban agriculture in some cities. It is suggested that urban malaria is likely to become increasingly important.

4.

31444
Accesses

Research   Open Access Highly Accessed

Maps of the Sri Lanka malaria situation preceding the tsunami and key aspects to be considered in the emergency phase and beyond

Olivier JT Briët, Gawrie NL Galappaththy, Flemming Konradsen, Priyanie H Amerasinghe, Felix P Amerasinghe Malaria Journal 2005, 4:8 (27 January 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Sri Lankan malariologists give an authoritative view on the true risks of malaria epidemics in the country following the recent tsunami.

5.

27826
Accesses

Research   Open Access Highly Accessed

Detection of malaria parasites by nested PCR in south-eastern, Iran: Evidence of highly mixed infections in Chahbahar district

Sedigheh Zakeri, Sohaila Najafabadi, Ahmad Zare, Navid Djadid Malaria Journal 2002, 1:2 (8 February 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

6.

27344
Accesses

Opinion   Open Access Highly Accessed

Roll Back Malaria? The scarcity of international aid for malaria control

Vasant Narasimhan, Amir Attaran Malaria Journal 2003, 2:8 (15 April 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

This provocative paper outlines how the failure of governments and funding agencies to honour the promises of financial support of the Abuja Declaration risks ultimately to have a negative impact on the RBM programme.

7.

25862
Accesses

Review   Open Access Highly Accessed

Human malarial disease: a consequence of inflammatory cytokine release

Ian A Clark, Alison C Budd, Lisa M Alleva, William B Cowden Malaria Journal 2006, 5:85 (10 October 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Malariologists tend to think that the pathophysiology of malaria is unique. This thought-provoking review shows that much can be learned from events described with other pathogens and that falciparum malaria is primarily an inflammatory cytokine-driven disease. In particular, the inability of mitochondria, through the effects of inflammatory cytokines, to utilise available oxygen may play a crucial role.

8.

25153
Accesses

Research   Open Access Highly Accessed

Plants traditionally prescribed to treat tazo (malaria) in the eastern region of Madagascar

Milijaona Randrianarivelojosia, Valérie T Rasidimanana, Harison Rabarison, Peter K Cheplogoi, Michel Ratsimbason, Dulcie A Mulholland, Philippe Mauclère Malaria Journal 2003, 2:25 (24 July 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This is a useful contribution to the study of Madagascan medicinal plants, which shows care and sensitivity in collecting the ethnobotanical data.

9.

24070
Accesses

Research   Open Access Highly Accessed

Care-seeking patterns for fatal malaria in Tanzania

Don de Savigny, Charles Mayombana, Eleuther Mwageni, Honorati Masanja, Abdulatif Minhaj, Yahya Mkilindi, Conrad Mbuya, Harun Kasale, Graham Reid Malaria Journal 2004, 3:27 (28 July 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This careful analysis of malaria deaths in an area of perennial malarial transmission addresses important issues, showing for instance that the care-seeking behaviour was substantially different in the case of severe malaria and uncomplicated malarial episodes. The limitations of using verbal autopsies are well discussed.

10.

23197
Accesses

Review   Open Access Highly Accessed

Intermittent preventive treatment for malaria in pregnancy in Africa: What's new, what's needed?

Andrew Vallely, Lisa Vallely, John Changalucha, Brian Greenwood, Daniel Chandramohan Malaria Journal 2007, 6:16 (16 February 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A sound review on recent developments of an important malaria control intervention, looking at possible alternatives to sulphadoxine-pyrimethamine in areas where there is resistance

11.

22652
Accesses

Research   Open Access Highly Accessed

Epidemiological models for the spread of anti-malarial resistance

JC Koella, R Antia Malaria Journal 2003, 2:3 (19 February 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

12.

21907
Accesses

Methodology   Open Access Highly Accessed

Real-time quantitative PCR with SYBR Green I detection for estimating copy numbers of nine drug resistance candidate genes in Plasmodium falciparum

Isabel D Ferreira, Virgílio E do Rosário, Pedro VL Cravo Malaria Journal 2006, 5:1 (18 January 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

A high throughput PCR-based method to analyse genes associated with drug resistance in field samples. In this study, the relative copy number of three genes associated with drug resistance and six associated with oxidative stress have been be assessed.

13.

21503
Accesses

Review   Open Access Highly Accessed

Statics and dynamics of malaria infection in Anopheles mosquitoes

David L Smith, F Ellis McKenzie Malaria Journal 2004, 3:13 (4 June 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This theoretical and mathematical review provides a new look at the Ross-Macdonald models, the basis of malaria epidemiology. The models describe the processes that drive malaria transmission, mainly from an entomological perspective, and they are, therefore, particularly useful to evaluate intervention programmes that reduce transmission.

14.

21436
Accesses

Case report   Open Access Highly Accessed

Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria

Quinton L Fivelman, Geoffrey A Butcher, Ipemida S Adagu, David C Warhurst, Geoffrey Pasvol Malaria Journal 2002, 1:1 (8 February 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The first in vitro and genetic confirmation of Malarone resistance in P. falciparum acquired in Nigeria.

15.

21382
Accesses

Review   Open Access Highly Accessed

Challenges in using geographic information systems (GIS) to understand and control malaria in Indonesia

Neil G Sipe, Pat Dale Malaria Journal 2003, 2:36 (4 November 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Most studies on the use of GIS for malaria control have been performed in Africa and the application of the technique in Indonesia raised important issues. This comprehensive review looks at the limitations of GIS and how best to solve various problems to make this approach more user-friendly.

16.

21382
Accesses

Research   Open Access Highly Accessed

Thick blood film examination for Plasmodium falciparum malaria has reduced sensitivity and underestimates parasite density

Philip Bejon, Laura Andrews, Angela Hunt-Cooke, Frances Sanderson, Sarah C Gilbert, Adrian VS Hill Malaria Journal 2006, 5:104 (8 November 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

This comparison between thick films and quantitative PCR shows that large numbers of parasites are lost in the staining process. This limits the sensitivity and leads to erroneous estimates of parasite density.

17.

21261
Accesses

Commentary   Open Access Highly Accessed

Malaria and urbanization in sub-Saharan Africa

Martin J Donnelly, PJ McCall, Christian Lengeler, Imelda Bates, Umberto D'Alessandro, Guy Barnish, Flemming Konradsen, Eveline Klinkenberg, Harold Townson, Jean-Francois Trape, Ian M Hastings, Clifford Mutero Malaria Journal 2005, 4:12 (18 February 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The Pretoria Statement on Urban Malaria in Africa was the outcome of a multi-sectoral technical consultation and this commentary reflects the discussions held during the meeting and aims to inform researchers and policy makers of the potential for containing and reversing the emerging problem of urban malaria.

18.

21117
Accesses

Review   Open Access Highly Accessed

Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria

Jane Achan, Ambrose O Talisuna, Annette Erhart, Adoke Yeka, James K Tibenderana, Frederick N Baliraine, Philip J Rosenthal, Umberto D'Alessandro Malaria Journal 2011, 10:144 (24 May 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This review of quinine is useful, because the drug still plays an important role in the treatment of malaria.

19.

20893
Accesses

Research   Open Access Highly Accessed

Prevalence of Plasmodium falciparum infection in pregnant women in Gabon

Marielle K Bouyou-Akotet, Denisa E Ionete-Collard, Modeste Mabika-Manfoumbi, Eric Kendjo, Pierre-Blaise Matsiegui, Elie Mavoungou, Maryvonne Kombila Malaria Journal 2003, 2:18 (25 June 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A clinical study of malaria in primi- and secundigravidae, looking at correlations with anaemia, fever, levels of parasitaemia and chloroquine treatment.

20.

20769
Accesses

Review   Open Access Highly Accessed

Gametocytogenesis : the puberty of Plasmodium falciparum

Arthur M Talman, Olivier Domarle, F McKenzie, Frédéric Ariey, Vincent Robert Malaria Journal 2004, 3:24 (14 July 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A review which addresses several aspects of gametocyte biology, focusing on sex differentiation and determination, transmission strategies and evolution; it highlight areas where the gametocyte might be targetted for control interventions.

21.

20089
Accesses

Review   Open Access Highly Accessed

Malaria in Brazil: an overview

Joseli Oliveira-Ferreira, Marcus VG Lacerda, Patrícia Brasil, José LB Ladislau, Pedro L Tauil, Cláudio Daniel-Ribeiro Malaria Journal 2010, 9:115 (30 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A review of the current malaria situation in Brazil, with particular reference to the switch to a predominance of vivax malaria.

22.

20064
Accesses

Review   Open Access Highly Accessed

Monitoring and evaluation of malaria in pregnancy – developing a rational basis for control

Bernard J Brabin, Marian Warsame, Ulrika Uddenfeldt-Wort, Stephanie Dellicour, Jenny Hill, Sabine Gies Malaria Journal 2008, 7(Suppl 1):S6 (11 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

20030
Accesses

Research   Open Access Highly Accessed

The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids

David C Warhurst, John C Craig, Ipemida S Adagu, David J Meyer, Sylvia Y Lee Malaria Journal 2003, 2:26 (1 September 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The cinchona alkaloids are the longest standing antimalarial drugs in clinical use, but their mode of action is still incompletely understood. This is the first study to provide comprehensive physico-chemical information regarding these alkaloids.The results strikingly demonstrate that the antimalarially inactive threo compounds are all considerably more hydrophilic than the active erythro compounds and that they are also very weak inhibitors of beta-haematin formation in contrast to the strongly active erythro compounds that inhibit beta-haematin formation better.

24.

19722
Accesses

Research   Open Access Highly Accessed

Intermittent preventive treatment of malaria during pregnancy: a qualitative study of knowledge, attitudes and practices of district health managers, antenatal care staff and pregnant women in Korogwe District, North-Eastern Tanzania

Godfrey Mubyazi, Paul Bloch, Mathias Kamugisha, Andrew Kitua, Jasper Ijumba Malaria Journal 2005, 4:31 (20 July 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The paper provides a qualitative analysis of the programmatic issues faced when implementing IPT during pregnancy, from both provider and user perspectives. Of particular interest is the Tanzanian experience of the specific link made between SP-IPT and Steven Johnson¿s Syndrome by pregnant women, which is unique and has been one of the most important barriers to the effective uptake of ITP, as a result of media spin. The paper highlights the need for much greater attention to awareness creation among pregnant women, which is all too often an afterthought to the delivery of IPT.

25.

19186
Accesses

Research   Open Access Highly Accessed

Artesunate – amodiaquine combination therapy for falciparum malaria in young Gabonese children

Sunny Oyakhirome, Marc Pötschke, Norbert G Schwarz, Jenny Dörnemann, Matthias Laengin, Carmen Salazar, Bertrand Lell, Jürgen FJ Kun, Peter G Kremsner, Martin P Grobusch Malaria Journal 2007, 6:29 (12 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Although this combination is one of the recommended ACTs for the treatment of malaria, there is not much data on effectiveness in children. This study compares effectiveness in supervised and unsupervised drug delivery, showing that it could be augmented by increased adherence and improved formulation.

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