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		Research Malaria rapid diagnostic test transport and storage conditions in Burkina Faso, Senegal, Ethiopia and the Philippines Audrey Albertini, Evan Lee, Sheick Oumar Coulibaly, Markos Sleshi, Babacar Faye, Mary Lorraine Mationg, Kadi Ouedraogo, Abeba G Tsadik, Sendeaw Maksha Feleke, Ibrahima Diallo, Oumar Gaye, Jennifer Luchavez, Jessica Bennett, David Bell Malaria Journal 2012, 11:406 (6 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The transport and storage conditions of temperature-labile test kits are in important feature for tests to be used in tropical conditions. With millions of malaria rapid diagnostic tests deployed to the field in developing countries annually, such studies are essential for identifying factors that may threaten effective implementation of the tests in the field.
		Research Plasmodium vivax malaria in Mali: a study from three different regions Maria Bernabeu, Gloria P Gomez-Perez, Sibiri Sissoko, Mohamed B Niambélé, Allassane Ag Haibala, Ariadna Sanz, Mahamadou A Théra, Carmen Fernandez-Becerra, Klénon Traoré, Pedro L Alonso, Quique Bassat, Hernando A del Portillo, Ogobara Doumbo Malaria Journal 2012, 11:405 (5 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nested-PCR and DNA-sequence analyses of selected samples unequivocally confirmed the presence of Plasmodium vivax in Mali. The authors suggest that this feature should be taken into account in the context of malaria control and elimination efforts in sub-Saharan Africa.
		Research Efficacy of artemether-lumefantrine as a treatment for uncomplicated Plasmodium vivax malaria in eastern Sudan Tajeldin M Abdallah, Abdel Aziem A Ali, Mohammed Bakri, Gasim I Gasim, Imad R Musa, Ishag Adam Malaria Journal 2012, 11:404 (5 December 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A small clinical trialconducted at a health centre in Kassala, eastern Sudan showed that artemether-lumefantrine was fully effective for treatment of P. vivax malaria.
		Research The effects of urbanization on global Plasmodium vivax malaria transmission Qiuyin Qi, Carlos A Guerra, Catherine L Moyes, Iqbal R F Elyazar, Peter W Gething, Simon I Hay, Andrew J Tatem Malaria Journal 2012, 11:403 (5 December 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The study shows a consistently lower P. vivax transmission with increasing urbanization, mirroring results found for P. falciparum, pointing towards global declines in P. vivax transmission as urbanization permanently alters the receptivity of many areas.
		Research Anti-malarial drug safety information obtained through routine monitoring in a rural district of South-Western Senegal Philippe Brasseur, Michel T Vaillant, Piero L Olliaro Malaria Journal 2012, 11:402 (5 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Results of cohort event monitoring conducted in four health facilities in Senegal evaluating adverse events occurring in association with artesunate-amodiaquine (ASAQ). With the rapid scale-up of ACT use globally, particularly in Africa, pharmacovigilance of these drugs is essential, but adverse event monitoring of anti-malarial therapy is challenging even in controlled settings.
		Research Epidemiology of Plasmodium knowlesi malaria in north-east Sabah, Malaysia: family clusters and wide age distribution Bridget E Barber, Timothy William, Prabakaran Dhararaj, Fread Anderios, Matthew J Grigg, Tsin W Yeo, Nicholas M Anstey Malaria Journal 2012, 11:401 (5 December 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Plasmodium knowlesi is the most common cause of malaria admissions to Kudat District Hospital, Sabah. The wide age distribution and presence of family clusters suggest that transmission may be occurring close to or inside people?s homes, in contrast to previous reports from densely forested areas of Sarawak. These findings have significant implications for malaria control.
		Opinion Malaria in infants aged less than six months - is it an area of unmet medical need? Umberto D’Alessandro, David Ubben, Kamal Hamed, Serign Jawo Ceesay, Joseph Okebe, Makie Taal, Eugene Kaman Lama, Moussa Keita, Lamine Koivogui, Alain Nahum, Kalifa Bojang, Aja Adam Jagne Sonko, Honorat Francis Lalya, Bernard Brabin Malaria Journal 2012, 11:400 (2 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Review covering several issue relating to malaria in young infants, including difficulties in diagnosing the infection in this age group, uncertainty as to the burden of disease in young infants, and optimal treatment and prevention (currently anti-malarial use in this age group is current ¿off-label¿).
		Review Stabilizing supply of artemisinin and artemisinin-based combination therapy in an era of wide-spread scale-up Rima Shretta, Prashant Yadav Malaria Journal 2012, 11:399 (2 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A useful paper that provides a good overview of volatility in ACT markets and provides some helpful suggestions for how it can be overcome.
		Research A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Sudan Richard M Hoglund, Ishag Adam, Warunee Hanpithakpong, Michael Ashton, Niklas Lindegardh, Nicholas PJ Day, Nicholas J White, Francois Nosten, Joel Tarning Malaria Journal 2012, 11:398 (29 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The population pharmacokinetic properties of piperaquine were described by a three-compartment disposition model in pregnant and non-pregnant women with uncomplicated malaria. The modelling approach showed no major difference in piperaquine exposure between the two groups and data presented do not warrant a dose adjustment in this vulnerable population.
		Research A Plasmodium falciparum copper-binding membrane protein with copper transport motifs David L Choveaux, Jude M Przyborski, JP Goldring Malaria Journal 2012, 11:397 (29 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cloning and expression of the amino terminal domain of a putative P. falciparum copper transport protein. It is suggested that the localization of the protein to the erythrocyte and parasite plasma membranes could provide a mechanism for the delivery of novel anti-malarial compounds.
		Research Foetal haemoglobin and the dynamics of paediatric malaria Erica MW Billig, Philip G McQueen, F Ellis McKenzie Malaria Journal 2012, 11:396 (28 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper presents a study of the role of foetal haemoglobin containing red blood cells on the dynamics and outcomes of malaria infections. The authors show that variation in adult vs foetal haemoglobin containing RBCs can protect infants from severe malaria infections. This is in accordance with the clinical observation that very young infants have a low rate of infection despite low levels of acquired immunity.
		Research Plasmodium vivax and Plasmodium falciparum infections in the Republic of Djibouti: evaluation of their prevalence and potential determinants Bouh Abdi Khaireh, Sébastien Briolant, Aurélie Pascual, Madjid Mokrane, Vanessa Machault, Christelle Travaillé, Mohamed Abdi Khaireh, Ismail Hassan Farah, Habib Moussa Ali, Abdul-Ilah Ahmed Abdi, Souleiman Ayeh, Houssein Youssouf Darar, Lénaïck Ollivier, Mohamed Killeh Waiss, Hervé Bogreau, Christophe Rogier, Bruno Pradines Malaria Journal 2012, 11:395 (28 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The paper adds to the increasing scientific literature addressing the monitoring of naturally acquired humoral immune responses to malaria antigens as a measure of transmission and malaria risk in regions targeted for elimination.
		Research Community perceptions of malaria and vaccines in two districts of Mozambique Allison Bingham, Felisbela Gaspar, Kathryn Lancaster, Juliana Conjera, Yvette Collymore, Antoinette Ba-Nguz Malaria Journal 2012, 11:394 (28 November 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A malaria vaccine is not yet available, but planning is underway for a possible introduction. This study explored sociocultural and health communications issues among individuals at the community level who are likely to influence decisions about vaccine use. A communications strategy would need to build on existing immunization efforts and use trusted sources¿including current government dissemination arrangements¿to deliver health information.
		Research Anopheles plumbeus (Diptera: Culicidae) in Europe: a mere nuisance mosquito or potential malaria vector? Francis Schaffner, Isabelle Thiéry, Christian Kaufmann, Agnès Zettor, Christian Lengeler, Alexander Mathis, Catherine Bourgouin Malaria Journal 2012, 11:393 (26 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The results show that a sample of field-caught Anopheles plumbeus has a moderate to high receptivity towards Plasmodium falciparum. Considering the increased mobility of humans between Europe and malaria endemic countries and changes in environment and climate, these data strongly suggest that this mosquito species could act as a vector for malaria and thus significantly contribute to increasing the malaria transmission risk in Central-Western Europe.
		Research Genotype comparison of Plasmodium vivax and Plasmodium falciparum clones from pregnant and non-pregnant populations in North-west Colombia Eliana M Arango, Roshini Samuel, Olga M Agudelo, Jaime Carmona-Fonseca, Amanda Maestre, Stephanie K Yanow Malaria Journal 2012, 11:392 (26 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A study which aimed to find genetic differences between P. falciparum and P. vivax parasites in the placenta and peripheral blood. This study found differences between P. falciparum populations sampled at delivery and populations sampled during antenatal care or in non-pregnant individuals (but not between placental and peripheral Pf parasites of women at delivery). No difference between P. vivax populations was found.
		Research Genetic diversity of Plasmodium vivax and Plasmodium falciparum in Honduras Ana Lopez, Andres Ortiz, Jorge Coello, Wilfredo Sosa-Ochoa, Rosa E Torres, Engels I Banegas, Irina Jovel, Gustavo A Fontecha Malaria Journal 2012, 11:391 (26 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This study examined the genetic diversity of Plasmodium populations in Honduras through sequencing analysis of pvama1, pvcsp, and pfmsp1 & 2. These results indicate that P. vivax and P. falciparum parasite populations are highly diverse in Honduras despite the low level of transmission.
		Research Cost-effectiveness of diagnostic for malaria in Extra-Amazon Region, Brazil Maria Regina F de Oliveira, Silvana P Giozza, Henry M Peixoto, Gustavo AS Romero Malaria Journal 2012, 11:390 (23 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Results for a cost-effectiveness study of diagnostic tests for malaria in a low endemicity region in Brazil; five RDTs and thick smear microscopy were compared. This is the first study of this type in Brazil.
		Research Morbidity and mortality due to malaria in Est Mono district, Togo, from 2005 to 2010: a times series analysis Essoya D Landoh, Potougnima Tchamdja, Bayaki Saka, Khin S Tint, Sheba N Gitta, Peter Wasswa, Christiaan de Jager Malaria Journal 2012, 11:389 (23 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary It is essential to evaluate correctly the effects of interventions and the haste to implement without a proper baseline has frequently made a quality evaluation impossible. Here, the finding that the prevalence increased, probably due to incomplete reporting in the past, makes it actually impossible to see any effect of the interventions. This makes the results of the study disappointing, although for future evaluations it is good that the issue of data incompleteness will now be further addressed.
		Research Therapeutic efficacy of artemether-lumefantrine combination in the treatment of uncomplicated malaria among children under five years of age in three ecological zones in Ghana Benjamin Abuaku, Nancy Duah, Lydia Quaye, Neils Quashie, Kwadwo Koram Malaria Journal 2012, 11:388 (22 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A classic in vivo efficacy study of artemether-lumefantrine for the treatment of uncomplicated malaria in Ghana, a country interesting because of the recent introduction of a multi first-line treatment strategy with different forms of ACT.
		Research Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization Wichai Pornthanakasem, Darin Kongkasuriyachai, Chairat Uthaipibull, Yongyuth Yuthavong, Ubolsree Leartsakulpanich Malaria Journal 2012, 11:387 (22 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The folate pathway of Plasmodium is critically important for parasite viability, and it includes enzymes which have been the target of important anti-malarials - used for both treatment and prophylaxis. There has been a considerable amount of research carried out on this pathwaybut serine hydroxymethyltransferase has been the subject of less enquiry. This paper is a useful addition to this body of knowledge.
		Research Genotyping of Plasmodium falciparum using antigenic polymorphic markers and to study anti-malarial drug resistance markers in malaria endemic areas of Bangladesh Jasmin Akter, Kamala Thriemer, Wasif A Khan, David J Sullivan, Harald Noedl, Rashidul Haque Malaria Journal 2012, 11:386 (22 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A concise study of P. falciparum genotypes from treatment efficacy studies in the Chittagong Hill Tracts of Bangladesh, including an analysis of polymorphic and drug-resistance markers.
		Research Finding malaria hot-spots in northern Angola: the role of individual, household and environmental factors within a meso-endemic area Ricardo J Magalhães, Antonio Langa, José Sousa-Figueiredo, Archie CA Clements, Susana Nery Malaria Journal 2012, 11:385 (22 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper looks at small scale variation in malaria prevalence among children below 15 years of age in Angola using cross-sectional survey data. The authors show a number of predictors of prevalence that are statistically significant. The authors suggest the presence of clusters of high prevalence and recommend the targeting of these clusters for malaria control to quickly reduce the burden of disease.
		Methodology Validation of an enzyme-linked immunosorbent assay for the quantification of human IgG directed against the repeat region of the circumsporozoite protein of the parasite Plasmodium falciparum Frederic Clement, Vincent Dewar, Eva Van Braeckel, Isabelle Desombere, Marianne Dewerchin, Christine Swysen, Marie-Ange Demoitié, Erik Jongert, Joe Cohen, Geert Leroux-Roels, Pierre Cambron Malaria Journal 2012, 11:384 (22 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Paper describes the methodology for the standardization and validation of an ELISA protocol for the repetitive region of the P. falciparum circumsporozoite protein on which a present malaria vaccine in phase III clinical trial is based.
		Research Prospective malaria control using entomopathogenic fungi: comparative evaluation of impact on transmission and selection for resistance Penelope A Lynch, Uwe Grimm, Matthew B Thomas, Andrew F Read Malaria Journal 2012, 11:383 (22 November 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary The authors compare the effectiveness of entomopathogenic fungi as a biological control tool with conventional pesticides by means of a model that consists of a mosquito feeding component and a mosquito population component.
		Research Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo Raceline G Kamkumo, Alvine M Ngoutane, Lauve RY Tchokouaha, Patrick VT Fokou, Eugénie AK Madiesse, Jennifer Legac, Jean JB Kezetas, Bruno N Lenta, Fabrice F Boyom, Theophile Dimo, Wilfred F Mbacham, Jiri Gut, Philip J Rosenthal Malaria Journal 2012, 11:382 (21 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Fractions of Sorindeia juglandifolia and two compounds isolated from these fractions were active against cultured malaria parasites, the P. falciparum protease falcipain-2, and in a rodent malaria model.

	All
		Research Malaria rapid diagnostic test transport and storage conditions in Burkina Faso, Senegal, Ethiopia and the Philippines Audrey Albertini, Evan Lee, Sheick Oumar Coulibaly, Markos Sleshi, Babacar Faye, Mary Lorraine Mationg, Kadi Ouedraogo, Abeba G Tsadik, Sendeaw Maksha Feleke, Ibrahima Diallo, Oumar Gaye, Jennifer Luchavez, Jessica Bennett, David Bell Malaria Journal 2012, 11:406 (6 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The transport and storage conditions of temperature-labile test kits are in important feature for tests to be used in tropical conditions. With millions of malaria rapid diagnostic tests deployed to the field in developing countries annually, such studies are essential for identifying factors that may threaten effective implementation of the tests in the field.
		Research Plasmodium vivax malaria in Mali: a study from three different regions Maria Bernabeu, Gloria P Gomez-Perez, Sibiri Sissoko, Mohamed B Niambélé, Allassane Ag Haibala, Ariadna Sanz, Mahamadou A Théra, Carmen Fernandez-Becerra, Klénon Traoré, Pedro L Alonso, Quique Bassat, Hernando A del Portillo, Ogobara Doumbo Malaria Journal 2012, 11:405 (5 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nested-PCR and DNA-sequence analyses of selected samples unequivocally confirmed the presence of Plasmodium vivax in Mali. The authors suggest that this feature should be taken into account in the context of malaria control and elimination efforts in sub-Saharan Africa.
		Research Efficacy of artemether-lumefantrine as a treatment for uncomplicated Plasmodium vivax malaria in eastern Sudan Tajeldin M Abdallah, Abdel Aziem A Ali, Mohammed Bakri, Gasim I Gasim, Imad R Musa, Ishag Adam Malaria Journal 2012, 11:404 (5 December 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A small clinical trialconducted at a health centre in Kassala, eastern Sudan showed that artemether-lumefantrine was fully effective for treatment of P. vivax malaria.
		Research The effects of urbanization on global Plasmodium vivax malaria transmission Qiuyin Qi, Carlos A Guerra, Catherine L Moyes, Iqbal R F Elyazar, Peter W Gething, Simon I Hay, Andrew J Tatem Malaria Journal 2012, 11:403 (5 December 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The study shows a consistently lower P. vivax transmission with increasing urbanization, mirroring results found for P. falciparum, pointing towards global declines in P. vivax transmission as urbanization permanently alters the receptivity of many areas.
		Research Anti-malarial drug safety information obtained through routine monitoring in a rural district of South-Western Senegal Philippe Brasseur, Michel T Vaillant, Piero L Olliaro Malaria Journal 2012, 11:402 (5 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Results of cohort event monitoring conducted in four health facilities in Senegal evaluating adverse events occurring in association with artesunate-amodiaquine (ASAQ). With the rapid scale-up of ACT use globally, particularly in Africa, pharmacovigilance of these drugs is essential, but adverse event monitoring of anti-malarial therapy is challenging even in controlled settings.
		Research Epidemiology of Plasmodium knowlesi malaria in north-east Sabah, Malaysia: family clusters and wide age distribution Bridget E Barber, Timothy William, Prabakaran Dhararaj, Fread Anderios, Matthew J Grigg, Tsin W Yeo, Nicholas M Anstey Malaria Journal 2012, 11:401 (5 December 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Plasmodium knowlesi is the most common cause of malaria admissions to Kudat District Hospital, Sabah. The wide age distribution and presence of family clusters suggest that transmission may be occurring close to or inside people?s homes, in contrast to previous reports from densely forested areas of Sarawak. These findings have significant implications for malaria control.
		Opinion Malaria in infants aged less than six months - is it an area of unmet medical need? Umberto D’Alessandro, David Ubben, Kamal Hamed, Serign Jawo Ceesay, Joseph Okebe, Makie Taal, Eugene Kaman Lama, Moussa Keita, Lamine Koivogui, Alain Nahum, Kalifa Bojang, Aja Adam Jagne Sonko, Honorat Francis Lalya, Bernard Brabin Malaria Journal 2012, 11:400 (2 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Review covering several issue relating to malaria in young infants, including difficulties in diagnosing the infection in this age group, uncertainty as to the burden of disease in young infants, and optimal treatment and prevention (currently anti-malarial use in this age group is current ¿off-label¿).
		Review Stabilizing supply of artemisinin and artemisinin-based combination therapy in an era of wide-spread scale-up Rima Shretta, Prashant Yadav Malaria Journal 2012, 11:399 (2 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A useful paper that provides a good overview of volatility in ACT markets and provides some helpful suggestions for how it can be overcome.
		Research A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Sudan Richard M Hoglund, Ishag Adam, Warunee Hanpithakpong, Michael Ashton, Niklas Lindegardh, Nicholas PJ Day, Nicholas J White, Francois Nosten, Joel Tarning Malaria Journal 2012, 11:398 (29 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The population pharmacokinetic properties of piperaquine were described by a three-compartment disposition model in pregnant and non-pregnant women with uncomplicated malaria. The modelling approach showed no major difference in piperaquine exposure between the two groups and data presented do not warrant a dose adjustment in this vulnerable population.
		Research A Plasmodium falciparum copper-binding membrane protein with copper transport motifs David L Choveaux, Jude M Przyborski, JP Goldring Malaria Journal 2012, 11:397 (29 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cloning and expression of the amino terminal domain of a putative P. falciparum copper transport protein. It is suggested that the localization of the protein to the erythrocyte and parasite plasma membranes could provide a mechanism for the delivery of novel anti-malarial compounds.
		Research Foetal haemoglobin and the dynamics of paediatric malaria Erica MW Billig, Philip G McQueen, F Ellis McKenzie Malaria Journal 2012, 11:396 (28 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper presents a study of the role of foetal haemoglobin containing red blood cells on the dynamics and outcomes of malaria infections. The authors show that variation in adult vs foetal haemoglobin containing RBCs can protect infants from severe malaria infections. This is in accordance with the clinical observation that very young infants have a low rate of infection despite low levels of acquired immunity.
		Research Plasmodium vivax and Plasmodium falciparum infections in the Republic of Djibouti: evaluation of their prevalence and potential determinants Bouh Abdi Khaireh, Sébastien Briolant, Aurélie Pascual, Madjid Mokrane, Vanessa Machault, Christelle Travaillé, Mohamed Abdi Khaireh, Ismail Hassan Farah, Habib Moussa Ali, Abdul-Ilah Ahmed Abdi, Souleiman Ayeh, Houssein Youssouf Darar, Lénaïck Ollivier, Mohamed Killeh Waiss, Hervé Bogreau, Christophe Rogier, Bruno Pradines Malaria Journal 2012, 11:395 (28 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The paper adds to the increasing scientific literature addressing the monitoring of naturally acquired humoral immune responses to malaria antigens as a measure of transmission and malaria risk in regions targeted for elimination.
		Research Community perceptions of malaria and vaccines in two districts of Mozambique Allison Bingham, Felisbela Gaspar, Kathryn Lancaster, Juliana Conjera, Yvette Collymore, Antoinette Ba-Nguz Malaria Journal 2012, 11:394 (28 November 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A malaria vaccine is not yet available, but planning is underway for a possible introduction. This study explored sociocultural and health communications issues among individuals at the community level who are likely to influence decisions about vaccine use. A communications strategy would need to build on existing immunization efforts and use trusted sources¿including current government dissemination arrangements¿to deliver health information.
		Research Anopheles plumbeus (Diptera: Culicidae) in Europe: a mere nuisance mosquito or potential malaria vector? Francis Schaffner, Isabelle Thiéry, Christian Kaufmann, Agnès Zettor, Christian Lengeler, Alexander Mathis, Catherine Bourgouin Malaria Journal 2012, 11:393 (26 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The results show that a sample of field-caught Anopheles plumbeus has a moderate to high receptivity towards Plasmodium falciparum. Considering the increased mobility of humans between Europe and malaria endemic countries and changes in environment and climate, these data strongly suggest that this mosquito species could act as a vector for malaria and thus significantly contribute to increasing the malaria transmission risk in Central-Western Europe.
		Research Genotype comparison of Plasmodium vivax and Plasmodium falciparum clones from pregnant and non-pregnant populations in North-west Colombia Eliana M Arango, Roshini Samuel, Olga M Agudelo, Jaime Carmona-Fonseca, Amanda Maestre, Stephanie K Yanow Malaria Journal 2012, 11:392 (26 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A study which aimed to find genetic differences between P. falciparum and P. vivax parasites in the placenta and peripheral blood. This study found differences between P. falciparum populations sampled at delivery and populations sampled during antenatal care or in non-pregnant individuals (but not between placental and peripheral Pf parasites of women at delivery). No difference between P. vivax populations was found.
		Research Genetic diversity of Plasmodium vivax and Plasmodium falciparum in Honduras Ana Lopez, Andres Ortiz, Jorge Coello, Wilfredo Sosa-Ochoa, Rosa E Torres, Engels I Banegas, Irina Jovel, Gustavo A Fontecha Malaria Journal 2012, 11:391 (26 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This study examined the genetic diversity of Plasmodium populations in Honduras through sequencing analysis of pvama1, pvcsp, and pfmsp1 & 2. These results indicate that P. vivax and P. falciparum parasite populations are highly diverse in Honduras despite the low level of transmission.
		Research Cost-effectiveness of diagnostic for malaria in Extra-Amazon Region, Brazil Maria Regina F de Oliveira, Silvana P Giozza, Henry M Peixoto, Gustavo AS Romero Malaria Journal 2012, 11:390 (23 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Results for a cost-effectiveness study of diagnostic tests for malaria in a low endemicity region in Brazil; five RDTs and thick smear microscopy were compared. This is the first study of this type in Brazil.
		Research Morbidity and mortality due to malaria in Est Mono district, Togo, from 2005 to 2010: a times series analysis Essoya D Landoh, Potougnima Tchamdja, Bayaki Saka, Khin S Tint, Sheba N Gitta, Peter Wasswa, Christiaan de Jager Malaria Journal 2012, 11:389 (23 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary It is essential to evaluate correctly the effects of interventions and the haste to implement without a proper baseline has frequently made a quality evaluation impossible. Here, the finding that the prevalence increased, probably due to incomplete reporting in the past, makes it actually impossible to see any effect of the interventions. This makes the results of the study disappointing, although for future evaluations it is good that the issue of data incompleteness will now be further addressed.
		Research Therapeutic efficacy of artemether-lumefantrine combination in the treatment of uncomplicated malaria among children under five years of age in three ecological zones in Ghana Benjamin Abuaku, Nancy Duah, Lydia Quaye, Neils Quashie, Kwadwo Koram Malaria Journal 2012, 11:388 (22 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A classic in vivo efficacy study of artemether-lumefantrine for the treatment of uncomplicated malaria in Ghana, a country interesting because of the recent introduction of a multi first-line treatment strategy with different forms of ACT.
		Research Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization Wichai Pornthanakasem, Darin Kongkasuriyachai, Chairat Uthaipibull, Yongyuth Yuthavong, Ubolsree Leartsakulpanich Malaria Journal 2012, 11:387 (22 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The folate pathway of Plasmodium is critically important for parasite viability, and it includes enzymes which have been the target of important anti-malarials - used for both treatment and prophylaxis. There has been a considerable amount of research carried out on this pathwaybut serine hydroxymethyltransferase has been the subject of less enquiry. This paper is a useful addition to this body of knowledge.
		Research Genotyping of Plasmodium falciparum using antigenic polymorphic markers and to study anti-malarial drug resistance markers in malaria endemic areas of Bangladesh Jasmin Akter, Kamala Thriemer, Wasif A Khan, David J Sullivan, Harald Noedl, Rashidul Haque Malaria Journal 2012, 11:386 (22 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A concise study of P. falciparum genotypes from treatment efficacy studies in the Chittagong Hill Tracts of Bangladesh, including an analysis of polymorphic and drug-resistance markers.
		Research Finding malaria hot-spots in northern Angola: the role of individual, household and environmental factors within a meso-endemic area Ricardo J Magalhães, Antonio Langa, José Sousa-Figueiredo, Archie CA Clements, Susana Nery Malaria Journal 2012, 11:385 (22 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper looks at small scale variation in malaria prevalence among children below 15 years of age in Angola using cross-sectional survey data. The authors show a number of predictors of prevalence that are statistically significant. The authors suggest the presence of clusters of high prevalence and recommend the targeting of these clusters for malaria control to quickly reduce the burden of disease.
		Methodology Validation of an enzyme-linked immunosorbent assay for the quantification of human IgG directed against the repeat region of the circumsporozoite protein of the parasite Plasmodium falciparum Frederic Clement, Vincent Dewar, Eva Van Braeckel, Isabelle Desombere, Marianne Dewerchin, Christine Swysen, Marie-Ange Demoitié, Erik Jongert, Joe Cohen, Geert Leroux-Roels, Pierre Cambron Malaria Journal 2012, 11:384 (22 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Paper describes the methodology for the standardization and validation of an ELISA protocol for the repetitive region of the P. falciparum circumsporozoite protein on which a present malaria vaccine in phase III clinical trial is based.
		Research Prospective malaria control using entomopathogenic fungi: comparative evaluation of impact on transmission and selection for resistance Penelope A Lynch, Uwe Grimm, Matthew B Thomas, Andrew F Read Malaria Journal 2012, 11:383 (22 November 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary The authors compare the effectiveness of entomopathogenic fungi as a biological control tool with conventional pesticides by means of a model that consists of a mosquito feeding component and a mosquito population component.
		Research Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo Raceline G Kamkumo, Alvine M Ngoutane, Lauve RY Tchokouaha, Patrick VT Fokou, Eugénie AK Madiesse, Jennifer Legac, Jean JB Kezetas, Bruno N Lenta, Fabrice F Boyom, Theophile Dimo, Wilfred F Mbacham, Jiri Gut, Philip J Rosenthal Malaria Journal 2012, 11:382 (21 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Fractions of Sorindeia juglandifolia and two compounds isolated from these fractions were active against cultured malaria parasites, the P. falciparum protease falcipain-2, and in a rodent malaria model.