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		Research Evaluation of the association between long-lasting insecticidal nets mass distribution campaigns and child malaria in Nigeria Hmwe Hmwe Kyu, Katholiki Georgiades, Harry S Shannon, Michael H Boyle Malaria Journal 2013, 12:14 (9 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An analysis of the results from the Nigeria malaria indicator survey to measure the impact of recent mass distributions of long-lasting insecticide-treated nets on malaria morbidity in children. The authors have conscientiously attempted to control for baseline differences between districts supported in their campaigns by a variety of different organizations in order to isolate the impact of mass distribution campaigns on parasitaemia in children.
		Research Genetic evidence of regulatory gene variants of the STAT6, IL10R and FOXP3 locus as a susceptibility factor in uncomplicated malaria and parasitaemia in Congolese children Felix Koukouikila-Koussounda, Francine Ntoumi, Mathieu Ndounga, Hoang V Tong, Ange-Antoine Abena, Thirumalaisamy P Velavan Malaria Journal 2013, 12:9 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An association study on the effect of 14 genetic variants on clinical malaria. These genetic data may contribute to the understanding of molecular mechanisms that regulate immune response to P. falciparum infections.
		Research Limitations of microscopy to differentiate Plasmodium species in a region co-endemic for Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi Bridget E Barber, Timothy William, Matthew J Grigg, Tsin W Yeo, Nicholas M Anstey Malaria Journal 2013, 12:8 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary This study examines the utility of microscopic speciation of the key malaria species in Sabah, Malaysia, based on a prospective study of 304 acute malaria patients focused on P. knowlesi infections and using PCR as the gold standard.
		Research Towards the elimination of malaria in South Africa: a review of surveillance data in Mutale Municipality, Limpopo Province, 2005 to 2010 Ester Khosa, Lazarus R Kuonza, Phillip Kruger, Eric Maimela Malaria Journal 2013, 12:7 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A good, basic study on the status of malaria morbidity and mortality in a high incidence area in Limpopo Province, South Africa.
		Research Shifts in malaria vector species composition and transmission dynamics along the Kenyan coast over the past 20 years Joseph M Mwangangi, Charles M Mbogo, Benedict O Orindi, Ephantus J Muturi, Janet T Midega, Joseph Nzovu, Hellen Gatakaa, John Githure, Christian Borgemeister, Joseph Keating, John C Beier Malaria Journal 2013, 12:13 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Paper showing a change in vector species over time. Reductions in the densities of the major vectors and a shift from human to animal feeding have contributed to the decreased burden of malaria along the Kenyan coast.
		Research Association between early childhood exposure to malaria and children’s pre-school development: evidence from the Zambia early childhood development project Günther Fink, Analia Olgiati, Moonga Hawela, John M Miller, Beatrice Matafwali Malaria Journal 2013, 12:12 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Paper exploring the relationship between cluster-level malaria prevalence and individual-level physical, socio-emotional, cognitive/developmental outcomes measured in the same age cohort as were included in the Zambian Malaria Indicator Survey.This contributes useful insight into the potential long term effects of Plasmodium infection on childhood development.
		Research Randomized, controlled trial of the long term safety, immunogenicity and efficacy of RTS,S/AS02_D malaria vaccine in infants living in a malaria-endemic region Salim Abdulla, Nahya Salim, Francisca Machera, Richard Kamata, Omar Juma, Mwanajaa Shomari, Sulende Kubhoja, Ali Mohammed, Grace Mwangoka, Thomas Aebi, Hassan Mshinda, David Schellenberg, Terrell Carter, Tonya Villafana, Marie-Claude Dubois, Amanda Leach, Marc Lievens, Johan Vekemans, Joe Cohen, W Ripley Ballou, Marcel Tanner Malaria Journal 2013, 12:11 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Data from a well designed and rigorously conducted phase II trial as part of RTS,S/AS vaccine clinical development to prevent malaria in sub-Saharan African children, with further results on safety immunogenicity and efficacy of the RTSS vaccine with the AS02 adjuvant.
		Case study Operational scale entomological intervention for malaria control: strategies, achievements and challenges in Zambia Emmanuel Chanda, Victor M Mukonka, Mulakwa Kamuliwo, Michael B Macdonald, Ubydul Haque Malaria Journal 2013, 12:10 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper deals with the success and challenges of operational scale entomological intervention for malaria control in Zambia. The emphasis is on the usefulness of integrated vector management.
		Research Diagnostic performance of CareStart™ malaria HRP2/pLDH (Pf/pan) combo test versus standard microscopy on falciparum and vivax malaria between China-Myanmar endemic borders Sun Xiaodong, Ernest Tambo, Wei Chun, Cheng Zhibin, Deng Yan, Wang Jian, Wang Jiazhi, Zhou Xiaonong Malaria Journal 2013, 12:6 (7 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Although the study does not contribute much to the use of the immunochromatographic tests in the diagnosis of malaria, it addresses relevant issues in terms of monitoring of local or imported malaria in remote endemic areas.
		Research Plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum Cariosa Noone, Michael Parkinson, David J Dowling, Allison Aldridge, Patrick Kirwan, Síle F Molloy, Samuel O Asaolu, Celia Holland, Sandra M O’Neill Malaria Journal 2013, 12:5 (7 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper describes the plasma cytokines and chemokines present as well as PBMC cell population composition during uncomplicated malaria infection in pre-school children living in malaria endemic regions of Nigeria. This study confirms observations of previous studies and is consistent with immune responses during active malaria infection.
		Research Modelling the cost-effectiveness of mass screening and treatment for reducing Plasmodium falciparum malaria burden Valerie Crowell, Olivier JT Briët, Diggory Hardy, Nakul Chitnis, Nicolas Maire, Aurelio Pasquale, Thomas A Smith Malaria Journal 2013, 12:4 (3 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper presents a cost-effectiveness modelling study on the introduction of mass screening and treatment in a sub-Saharan African setting, in various transmission contexts and with varying ITN and case management coverage. This is an important potential policy question, with a thoughtful discussion of the limitations.
		Research Increase in malaria prevalence and age of at risk population in different areas of Gabon Denise P Mawili-Mboumba, Marielle K Bouyou Akotet, Eric Kendjo, Joseph Nzamba, Mathieu Owono Medang, Jean-Romain Mourou Mbina, Maryvonne Kombila, MCORU team Malaria Journal 2013, 12:3 (2 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A six year follow-up malariological survey of febrile children showing a rebound of infection rates between 2008 and 2011 and a trend to older age of patients with malaria.
		Methodology Studying fitness cost of Plasmodium falciparum infection in malaria vectors: validation of an appropriate negative control Ibrahim Sangare, Yannis Michalakis, Bienvenue Yameogo, Roch Dabire, Isabelle Morlais, Anna Cohuet Malaria Journal 2013, 12:2 (2 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Reports on an experiment designed to test for an effect of heat treating blood upon mosquito life-history.
		Research Ascaris co-infection does not alter malaria-induced anaemia in a cohort of Nigerian preschool children Francisca A Abanyie, Courtney McCracken, Patrick Kirwan, Síle F Molloy, Samuel O Asaolu, Celia V Holland, Julie Gutman, Tracey J Lamb Malaria Journal 2013, 12:1 (2 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In this cohort of Nigerian preschool children, malaria infection was the major contributor to anaemia status. Ascaris co-infection neither exacerbated nor ameliorated the severity of malarial anaemia.
		Research Assessment of Anopheles salivary antigens as individual exposure biomarkers to species-specific malaria vector bites Zakia M I Ali, Mahfoud Bakli, Albin Fontaine, Nawal Bakkali, Vinh Vu Hai, Stephane Audebert, Yvan Boublik, Frederic Pagès, Franck Remoué, Christophe Rogier, Christophe Fraisier, Lionel Almeras Malaria Journal 2012, 11:439 (31 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The authors confirm an approach for detecting IgG responses to Anopheles salivary antigens as individual exposure biomarkers to the bites of different anopheline species (An. funestus, An. gambiae s.l.) in three localities of Senegal where vector densities and species compositions vary.
		Research Temporal and spatial patterns of serologic responses to Plasmodium falciparum antigens in a region of declining malaria transmission in southern Zambia Tamaki Kobayashi, Sandra Chishimba, Timothy Shields, Harry Hamapumbu, Sungano Mharakurwa, Philip E Thuma, Gregory Glass, William J Moss Malaria Journal 2012, 11:438 (31 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This MS describes the use of antibody responses to Plasmodium falciparum together with integrated with spatial information as a way to identify foci or hotspots of malaria control.
		Research Impact assessment of malaria vector control using routine surveillance data in Zambia: implications for monitoring and evaluation Emmanuel Chanda, Michael Coleman, Immo Kleinschmidt, Janet Hemingway, Busiku Hamainza, Freddie Masaninga, Pascalina Chanda-Kapata, Kumar S Baboo, David N Dürrheim, Marlize Coleman Malaria Journal 2012, 11:437 (29 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Reductions in malaria cases, deaths and case fatality rate, in children under-five years of age following the scale-up of LLINs and IRS in Zambia in 2008 are noteworthy findings. The use of routine surveillance data in determining the temporal effects of malaria control is an important methodological way forward for malaria monitoring and evaluation.
		Research Provider knowledge of treatment policy and dosing regimen with artemether-lumefantrine and quinine in malaria-endemic areas of western Kenya Carren A Watsierah, Rosebella O Onyango, James H Ombaka, Benard O Abong’o, Collins Ouma Malaria Journal 2012, 11:436 (29 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cross-sectional survey results on anti-malarial treatment knowledge among drug dispensers across different sectors in western Kenya. It concludes that knowledge on treatment policy is substantially lower in private sector compared to the government/non-profit sector.
		Research Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda Prasanna Jagannathan, Mary K Muhindo, Abel Kakuru, Emmanuel Arinaitwe, Bryan Greenhouse, Jordan Tappero, Philip J Rosenthal, Frank Kaharuza, Moses R Kamya, Grant Dorsey Malaria Journal 2012, 11:435 (28 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A study based on the Tororo child cohort assessing incidence trends of malaria infection in under-five children with universal access to two corner stones in modern malaria control - LLINs and ACT. The finding indicate that despite the access to key malaria control interventions, the incidence of malaria is reported to have increased over time, even if the risk of complicated malaria appears to be low.
		Research Assessment of the therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in northern KwaZulu-Natal: an observational cohort study Charles H Vaughan-Williams, Jaishree Raman, Eric Raswiswi, Etienne Immelman, Holger Reichel, Kelly Gate, Steve Knight Malaria Journal 2012, 11:434 (28 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An observational study of therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in northern KwaZulu-Natal. Although based only on a small number of patients, the paper highlights the many challenges faced by researchers aiming to evaluate anti-malarial therapeutic efficacy in areas where malaria control has been highly successful and that have entered the pre-elimination phase.
		Research Multicentre study evaluating the non-inferiority of the new paediatric formulation of artesunate/amodiaquine versus artemether/lumefantrine for the management of uncomplicated Plasmodium falciparum malaria in children in Cameroon, Ivory Coast and Senegal Babacar Faye, Thomas Kuété, Christiane P Kiki-Barro, Roger C Tine, Thérèse Nkoa, Jean Louis A Ndiaye, Claude A Kakpo, Khadime Sylla, Hervé EI Menan, Oumar Gaye, Oumar Faye, Albert Same-Ekobo, Koné Moussa Malaria Journal 2012, 11:433 (27 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A randomized, controlled, non-inferiority, multi-centre, open-label comparison of two presentations of ACT in African children.
		Research Factors associated with malaria parasitaemia, malnutrition, and anaemia among HIV-exposed and unexposed Ugandan infants: a cross-sectional survey Beth Osterbauer, James Kapisi, Victor Bigira, Florence Mwangwa, Stephen Kinara, Moses R Kamya, Grant Dorsey Malaria Journal 2012, 11:432 (27 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In this is a cross-sectional study, HIV-exposed infants had a higher use of malaria preventative measures and lower odds of malaria parasitaemia compared to HIV-unexposed infants. HIV-exposure was the primary risk factor for measures of malnutrition. The primary risk factor for anaemia was malaria parasitaemia.
		Review Sustainable malaria control: transdisciplinary approaches for translational applications Lyn-Marie Birkholtz, Riana Bornman, Walter Focke, Clifford Mutero, Christiaan de Jager Malaria Journal 2012, 11:431 (26 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary If the malaria community is to achieve elimination and eradication, the key realization is that this has to be approached with the long-term goal of sustainability. This review could provide a convenient ¿first stop¿ for readers interested in an overview of the requirements and considerations for sustainable malaria control and elimination.
		Research Plasmodium vivax infection in Anajás, State of Pará: no differential resistance profile among Duffy-negative and Duffy-positive individuals Tarcisio AA Carvalho, Maíse G Queiroz, Greice L Cardoso, Isabela G Diniz, Aylla NLM Silva, Ana YN Pinto, João F Guerreiro Malaria Journal 2012, 11:430 (22 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Malaria epidemiology of an interesting region in the Amazon River basin, where it is suggested that essentially all people experience malaria annually. The heterogeneous distribution of Duffy blood group polymorphism in this study site and the high prevalence of P. vivax infection enable an interesting comparison of susceptibility to vivax malaria in Duffy-negative and Duffy-positive people.
		Research Expression of a type B RIFIN in Plasmodium falciparum merozoites and gametes Steven B Mwakalinga, Christian W Wang, Dominique C Bengtsson, Louise Turner, Bismarck Dinko, John P Lusingu, David E Arnot, Colin J Sutherland, Thor G Theander, Thomas Lavstsen Malaria Journal 2012, 11:429 (21 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The paper presents evidence to support the presence of Type B Rifins on the surface of merozoites and gametes. This is useful information as it builds a picture of the role of multigene families both in evading the host immune response and, potentially, providing specialized functions for these specific life-cycle stages.

	All
		Research Evaluation of the association between long-lasting insecticidal nets mass distribution campaigns and child malaria in Nigeria Hmwe Hmwe Kyu, Katholiki Georgiades, Harry S Shannon, Michael H Boyle Malaria Journal 2013, 12:14 (9 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An analysis of the results from the Nigeria malaria indicator survey to measure the impact of recent mass distributions of long-lasting insecticide-treated nets on malaria morbidity in children. The authors have conscientiously attempted to control for baseline differences between districts supported in their campaigns by a variety of different organizations in order to isolate the impact of mass distribution campaigns on parasitaemia in children.
		Research Genetic evidence of regulatory gene variants of the STAT6, IL10R and FOXP3 locus as a susceptibility factor in uncomplicated malaria and parasitaemia in Congolese children Felix Koukouikila-Koussounda, Francine Ntoumi, Mathieu Ndounga, Hoang V Tong, Ange-Antoine Abena, Thirumalaisamy P Velavan Malaria Journal 2013, 12:9 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An association study on the effect of 14 genetic variants on clinical malaria. These genetic data may contribute to the understanding of molecular mechanisms that regulate immune response to P. falciparum infections.
		Research Limitations of microscopy to differentiate Plasmodium species in a region co-endemic for Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi Bridget E Barber, Timothy William, Matthew J Grigg, Tsin W Yeo, Nicholas M Anstey Malaria Journal 2013, 12:8 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary This study examines the utility of microscopic speciation of the key malaria species in Sabah, Malaysia, based on a prospective study of 304 acute malaria patients focused on P. knowlesi infections and using PCR as the gold standard.
		Research Towards the elimination of malaria in South Africa: a review of surveillance data in Mutale Municipality, Limpopo Province, 2005 to 2010 Ester Khosa, Lazarus R Kuonza, Phillip Kruger, Eric Maimela Malaria Journal 2013, 12:7 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A good, basic study on the status of malaria morbidity and mortality in a high incidence area in Limpopo Province, South Africa.
		Research Shifts in malaria vector species composition and transmission dynamics along the Kenyan coast over the past 20 years Joseph M Mwangangi, Charles M Mbogo, Benedict O Orindi, Ephantus J Muturi, Janet T Midega, Joseph Nzovu, Hellen Gatakaa, John Githure, Christian Borgemeister, Joseph Keating, John C Beier Malaria Journal 2013, 12:13 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Paper showing a change in vector species over time. Reductions in the densities of the major vectors and a shift from human to animal feeding have contributed to the decreased burden of malaria along the Kenyan coast.
		Research Association between early childhood exposure to malaria and children’s pre-school development: evidence from the Zambia early childhood development project Günther Fink, Analia Olgiati, Moonga Hawela, John M Miller, Beatrice Matafwali Malaria Journal 2013, 12:12 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Paper exploring the relationship between cluster-level malaria prevalence and individual-level physical, socio-emotional, cognitive/developmental outcomes measured in the same age cohort as were included in the Zambian Malaria Indicator Survey.This contributes useful insight into the potential long term effects of Plasmodium infection on childhood development.
		Research Randomized, controlled trial of the long term safety, immunogenicity and efficacy of RTS,S/AS02_D malaria vaccine in infants living in a malaria-endemic region Salim Abdulla, Nahya Salim, Francisca Machera, Richard Kamata, Omar Juma, Mwanajaa Shomari, Sulende Kubhoja, Ali Mohammed, Grace Mwangoka, Thomas Aebi, Hassan Mshinda, David Schellenberg, Terrell Carter, Tonya Villafana, Marie-Claude Dubois, Amanda Leach, Marc Lievens, Johan Vekemans, Joe Cohen, W Ripley Ballou, Marcel Tanner Malaria Journal 2013, 12:11 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Data from a well designed and rigorously conducted phase II trial as part of RTS,S/AS vaccine clinical development to prevent malaria in sub-Saharan African children, with further results on safety immunogenicity and efficacy of the RTSS vaccine with the AS02 adjuvant.
		Case study Operational scale entomological intervention for malaria control: strategies, achievements and challenges in Zambia Emmanuel Chanda, Victor M Mukonka, Mulakwa Kamuliwo, Michael B Macdonald, Ubydul Haque Malaria Journal 2013, 12:10 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper deals with the success and challenges of operational scale entomological intervention for malaria control in Zambia. The emphasis is on the usefulness of integrated vector management.
		Research Diagnostic performance of CareStart™ malaria HRP2/pLDH (Pf/pan) combo test versus standard microscopy on falciparum and vivax malaria between China-Myanmar endemic borders Sun Xiaodong, Ernest Tambo, Wei Chun, Cheng Zhibin, Deng Yan, Wang Jian, Wang Jiazhi, Zhou Xiaonong Malaria Journal 2013, 12:6 (7 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Although the study does not contribute much to the use of the immunochromatographic tests in the diagnosis of malaria, it addresses relevant issues in terms of monitoring of local or imported malaria in remote endemic areas.
		Research Plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum Cariosa Noone, Michael Parkinson, David J Dowling, Allison Aldridge, Patrick Kirwan, Síle F Molloy, Samuel O Asaolu, Celia Holland, Sandra M O’Neill Malaria Journal 2013, 12:5 (7 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper describes the plasma cytokines and chemokines present as well as PBMC cell population composition during uncomplicated malaria infection in pre-school children living in malaria endemic regions of Nigeria. This study confirms observations of previous studies and is consistent with immune responses during active malaria infection.
		Research Modelling the cost-effectiveness of mass screening and treatment for reducing Plasmodium falciparum malaria burden Valerie Crowell, Olivier JT Briët, Diggory Hardy, Nakul Chitnis, Nicolas Maire, Aurelio Pasquale, Thomas A Smith Malaria Journal 2013, 12:4 (3 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper presents a cost-effectiveness modelling study on the introduction of mass screening and treatment in a sub-Saharan African setting, in various transmission contexts and with varying ITN and case management coverage. This is an important potential policy question, with a thoughtful discussion of the limitations.
		Research Increase in malaria prevalence and age of at risk population in different areas of Gabon Denise P Mawili-Mboumba, Marielle K Bouyou Akotet, Eric Kendjo, Joseph Nzamba, Mathieu Owono Medang, Jean-Romain Mourou Mbina, Maryvonne Kombila, MCORU team Malaria Journal 2013, 12:3 (2 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A six year follow-up malariological survey of febrile children showing a rebound of infection rates between 2008 and 2011 and a trend to older age of patients with malaria.
		Methodology Studying fitness cost of Plasmodium falciparum infection in malaria vectors: validation of an appropriate negative control Ibrahim Sangare, Yannis Michalakis, Bienvenue Yameogo, Roch Dabire, Isabelle Morlais, Anna Cohuet Malaria Journal 2013, 12:2 (2 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Reports on an experiment designed to test for an effect of heat treating blood upon mosquito life-history.
		Research Ascaris co-infection does not alter malaria-induced anaemia in a cohort of Nigerian preschool children Francisca A Abanyie, Courtney McCracken, Patrick Kirwan, Síle F Molloy, Samuel O Asaolu, Celia V Holland, Julie Gutman, Tracey J Lamb Malaria Journal 2013, 12:1 (2 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In this cohort of Nigerian preschool children, malaria infection was the major contributor to anaemia status. Ascaris co-infection neither exacerbated nor ameliorated the severity of malarial anaemia.
		Research Assessment of Anopheles salivary antigens as individual exposure biomarkers to species-specific malaria vector bites Zakia M I Ali, Mahfoud Bakli, Albin Fontaine, Nawal Bakkali, Vinh Vu Hai, Stephane Audebert, Yvan Boublik, Frederic Pagès, Franck Remoué, Christophe Rogier, Christophe Fraisier, Lionel Almeras Malaria Journal 2012, 11:439 (31 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The authors confirm an approach for detecting IgG responses to Anopheles salivary antigens as individual exposure biomarkers to the bites of different anopheline species (An. funestus, An. gambiae s.l.) in three localities of Senegal where vector densities and species compositions vary.
		Research Temporal and spatial patterns of serologic responses to Plasmodium falciparum antigens in a region of declining malaria transmission in southern Zambia Tamaki Kobayashi, Sandra Chishimba, Timothy Shields, Harry Hamapumbu, Sungano Mharakurwa, Philip E Thuma, Gregory Glass, William J Moss Malaria Journal 2012, 11:438 (31 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This MS describes the use of antibody responses to Plasmodium falciparum together with integrated with spatial information as a way to identify foci or hotspots of malaria control.
		Research Impact assessment of malaria vector control using routine surveillance data in Zambia: implications for monitoring and evaluation Emmanuel Chanda, Michael Coleman, Immo Kleinschmidt, Janet Hemingway, Busiku Hamainza, Freddie Masaninga, Pascalina Chanda-Kapata, Kumar S Baboo, David N Dürrheim, Marlize Coleman Malaria Journal 2012, 11:437 (29 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Reductions in malaria cases, deaths and case fatality rate, in children under-five years of age following the scale-up of LLINs and IRS in Zambia in 2008 are noteworthy findings. The use of routine surveillance data in determining the temporal effects of malaria control is an important methodological way forward for malaria monitoring and evaluation.
		Research Provider knowledge of treatment policy and dosing regimen with artemether-lumefantrine and quinine in malaria-endemic areas of western Kenya Carren A Watsierah, Rosebella O Onyango, James H Ombaka, Benard O Abong’o, Collins Ouma Malaria Journal 2012, 11:436 (29 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cross-sectional survey results on anti-malarial treatment knowledge among drug dispensers across different sectors in western Kenya. It concludes that knowledge on treatment policy is substantially lower in private sector compared to the government/non-profit sector.
		Research Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda Prasanna Jagannathan, Mary K Muhindo, Abel Kakuru, Emmanuel Arinaitwe, Bryan Greenhouse, Jordan Tappero, Philip J Rosenthal, Frank Kaharuza, Moses R Kamya, Grant Dorsey Malaria Journal 2012, 11:435 (28 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A study based on the Tororo child cohort assessing incidence trends of malaria infection in under-five children with universal access to two corner stones in modern malaria control - LLINs and ACT. The finding indicate that despite the access to key malaria control interventions, the incidence of malaria is reported to have increased over time, even if the risk of complicated malaria appears to be low.
		Research Assessment of the therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in northern KwaZulu-Natal: an observational cohort study Charles H Vaughan-Williams, Jaishree Raman, Eric Raswiswi, Etienne Immelman, Holger Reichel, Kelly Gate, Steve Knight Malaria Journal 2012, 11:434 (28 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An observational study of therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in northern KwaZulu-Natal. Although based only on a small number of patients, the paper highlights the many challenges faced by researchers aiming to evaluate anti-malarial therapeutic efficacy in areas where malaria control has been highly successful and that have entered the pre-elimination phase.
		Research Multicentre study evaluating the non-inferiority of the new paediatric formulation of artesunate/amodiaquine versus artemether/lumefantrine for the management of uncomplicated Plasmodium falciparum malaria in children in Cameroon, Ivory Coast and Senegal Babacar Faye, Thomas Kuété, Christiane P Kiki-Barro, Roger C Tine, Thérèse Nkoa, Jean Louis A Ndiaye, Claude A Kakpo, Khadime Sylla, Hervé EI Menan, Oumar Gaye, Oumar Faye, Albert Same-Ekobo, Koné Moussa Malaria Journal 2012, 11:433 (27 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A randomized, controlled, non-inferiority, multi-centre, open-label comparison of two presentations of ACT in African children.
		Research Factors associated with malaria parasitaemia, malnutrition, and anaemia among HIV-exposed and unexposed Ugandan infants: a cross-sectional survey Beth Osterbauer, James Kapisi, Victor Bigira, Florence Mwangwa, Stephen Kinara, Moses R Kamya, Grant Dorsey Malaria Journal 2012, 11:432 (27 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In this is a cross-sectional study, HIV-exposed infants had a higher use of malaria preventative measures and lower odds of malaria parasitaemia compared to HIV-unexposed infants. HIV-exposure was the primary risk factor for measures of malnutrition. The primary risk factor for anaemia was malaria parasitaemia.
		Review Sustainable malaria control: transdisciplinary approaches for translational applications Lyn-Marie Birkholtz, Riana Bornman, Walter Focke, Clifford Mutero, Christiaan de Jager Malaria Journal 2012, 11:431 (26 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary If the malaria community is to achieve elimination and eradication, the key realization is that this has to be approached with the long-term goal of sustainability. This review could provide a convenient ¿first stop¿ for readers interested in an overview of the requirements and considerations for sustainable malaria control and elimination.
		Research Plasmodium vivax infection in Anajás, State of Pará: no differential resistance profile among Duffy-negative and Duffy-positive individuals Tarcisio AA Carvalho, Maíse G Queiroz, Greice L Cardoso, Isabela G Diniz, Aylla NLM Silva, Ana YN Pinto, João F Guerreiro Malaria Journal 2012, 11:430 (22 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Malaria epidemiology of an interesting region in the Amazon River basin, where it is suggested that essentially all people experience malaria annually. The heterogeneous distribution of Duffy blood group polymorphism in this study site and the high prevalence of P. vivax infection enable an interesting comparison of susceptibility to vivax malaria in Duffy-negative and Duffy-positive people.
		Research Expression of a type B RIFIN in Plasmodium falciparum merozoites and gametes Steven B Mwakalinga, Christian W Wang, Dominique C Bengtsson, Louise Turner, Bismarck Dinko, John P Lusingu, David E Arnot, Colin J Sutherland, Thor G Theander, Thomas Lavstsen Malaria Journal 2012, 11:429 (21 December 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The paper presents evidence to support the presence of Type B Rifins on the surface of merozoites and gametes. This is useful information as it builds a picture of the role of multigene families both in evading the host immune response and, potentially, providing specialized functions for these specific life-cycle stages.