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		Case study Progress towards malaria elimination in Sabang Municipality, Aceh, Indonesia Herdiana Herdiana, Anis Fuad, Puji BS Asih, Siti Zubaedah, Risalia Reni Arisanti, Din Syafruddin, Hari Kusnanto, Maria Endang Sumiwi, Titik Yuniarti, Ali Imran, Rahmadyani Rahmadyani, Muhammad Yani, Rita Kusriastuti, Siti Nadia Tarmizi, Ferdinand J Laihad, William A Hawley Malaria Journal 2013, 12:42 (30 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An important article outlining the progress made towards malaria elimination in Sabang municipality, Aceh, Indonesia. The details of this article will serve as an example to much of the rest of Indonesia, as well as the rest of SE Asia.
		Research Cytoplasmic free Ca²⁺ is essential for multiple steps in malaria parasite egress from infected erythrocytes Svetlana Glushakova, Vladimir Lizunov, Paul S Blank, Kamran Melikov, Glen Humphrey, Joshua Zimmerberg Malaria Journal 2013, 12:41 (30 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Thorough exploration of the involvement of calcium in the process of Plasmodium falciparum merozoite egress from the infected erythrocyte.
		Research Avian haemosporidian persistence and co-infection in great tits at the individual level Juan van Rooyen, Fabrice Lalubin, Olivier Glaizot, Philippe Christe Malaria Journal 2013, 12:40 (30 January 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This study aimed to determine how persistent Haemosporida are in great tit individuals recaptured over several years, whether parasitaemia differed by parasite lineage (mitochondrial cytochrome b haplotype) and how co-infection (i.e. concurrent infection with multiple genera of parasites) affects parasitaemia and body mass.
		Research Community perceptions on malaria and care-seeking practices in endemic Indian settings: policy implications for the malaria control programme Ashis Das, RK Das Gupta, Jed Friedman, Madan M Pradhan, Charu C Mohapatra, Debakanta Sandhibigraha Malaria Journal 2013, 12:39 (29 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An article about community perceptions of the causes and presentation of malaria and their care-seeking practices in Odisha, India. The article gives a good presentation of community beliefs around the variety of places in which treatment maybe sought and the policy implications of these findings.
		Research High effective coverage of vector control interventions in children after achieving low malaria transmission in Zanzibar, Tanzania Netta Beer, Abdullah S Ali, Delér Shakely, Kristina Elfving, Abdul-Wahiyd H Al-Mafazy, Mwinyi Msellem, Max Petzold, Anders Björkman, Karin Källander Malaria Journal 2013, 12:38 (29 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A timely study, as it addresses people¿s behaviour in the context of malaria elimination. This adds to the current concerns about sustainable community adherence to control measure when malaria transmission is progressively being reduced.
		Research Febrile illness management in children under five years of age: a qualitative pilot study on primary health care workers’ practices in Zanzibar Kimberly Baltzell, Kristina Elfving, Deler Shakely, Abdullah S Ali, Mwinyi Msellem, Shilpa Gulati, Andreas Mårtensson Malaria Journal 2013, 12:37 (28 January 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Qualitative study of primary health workers¿ practice in relation to the management for febrile children under five years of age in Zanzibar. The management of patients who test negative for malaria addresses a topic of increasing interest to people living in areas where malaria used to be endemic, but is no longer the major health problem.
		Research Impact of a mass media campaign on bed net use in Cameroon Hannah L Bowen Malaria Journal 2013, 12:36 (25 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Research that attempts to measure the impact of a mass media campaign on the use of bed nets and address the challenge of attributing behaviour change specifically to the intervention through the use of a propensity score matching model.
		Research Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000–2011 Myriam Gharbi, Jennifer A Flegg, Véronique Hubert, Eric Kendjo, Jessica E Metcalf, Lionel Bertaux, Philippe J Guérin, Jacques Le Bras, Members of the French National Reference Centre for Imported Malaria Study Malaria Journal 2013, 12:35 (25 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Data on chloroquine resistance in an impressive number of isolates obtained from travellers returning from West Africa.
		Research Pfhrp2 and pfhrp3 polymorphisms in Plasmodium falciparum isolates from Dakar, Senegal: impact on rapid malaria diagnostic tests Nathalie Wurtz, Bécaye Fall, Kim Bui, Aurélie Pascual, Mansour Fall, Cheikhou Camara, Bakary Diatta, Khadidiatou Ba Fall, Pape Saliou Mbaye, Yaya Diémé, Raymond Bercion, Boubacar Wade, Sébastien Briolant, Bruno Pradines Malaria Journal 2013, 12:34 (24 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The study aims to assess the diagnostic accuracy of the HRP2-based RDT Palutop+4¿ by comparison with microscopic examination and real-time polymerase chain reaction and to investigate the genetic diversity of the pfhrp2 and pfhrp3 genes in clinical isolates from Dakar, and its impact on field and predictive diagnostic sensitivity.
		Research Travel history and malaria infection risk in a low-transmission setting in Ethiopia: a case control study Joshua O Yukich, Cameron Taylor, Thomas P Eisele, Richard Reithinger, Honelgn Nauhassenay, Yemane Berhane, Joseph Keating Malaria Journal 2013, 12:33 (24 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ethiopia currently has plans for elimination for specific geographic areas of the country. Human movement may lead to the maintenance of reservoirs of infection, complicating attempts to eliminate malaria.
		Research Analysis of antibody induction upon immunization with distinct NTS-DBL1α-domains of PfEMP1 from rosetting Plasmodium falciparum parasites Davide Angeletti, Letusa Albrecht, Mats Wahlgren, Kirsten Moll Malaria Journal 2013, 12:32 (24 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rosetting is a malaria virulence determinant and a vaccine target. This study used peptide arrays and parasite panels to investigate the specificity and cross-reactivity of vaccine antibodies. Antibodies had strong homologous parasite reactivity but limited or no cross-reactivity on different rosetting parasite variants.
		Research Gametocyte carriage in Plasmodium falciparum-infected travellers Catherine H Roberts, Margaret Armstrong, Ewa Zatyka, Samuel Boadi, Simon Warren, Peter L Chiodini, Colin J Sutherland, Tom Doherty Malaria Journal 2013, 12:31 (24 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper develops an original idea, assessing how many patients with P. falciparum malaria had gametocytes on presentation, or developed gametocytes during the course of their disease, and linking this occurrence with given characteristics of the population studied and of the disease itself.
		Research High frequency of the erythroid silent Duffy antigen genotype and lack of Plasmodium vivax infections in Haiti Thomas A Weppelmann, Tamar E Carter, Zhongsheng Chen, Michael E von Fricken, Yves S Victor, Alexander Existe, Bernard A Okech Malaria Journal 2013, 12:30 (24 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In this preliminary study, no cases of P. vivax were confirmed by PCR in Haiti. The high frequency of the FYES allele that silences erythroid expression of the Duffy antigen offers a biologically plausible explanation for the lack of P. vivax infections observed.
		Research Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein-1 (MSP1₄₂) administered intramuscularly with adjuvant system AS01 Nekoye Otsyula, Evelina Angov, Elke Bergmann-Leitner, Margaret Koech, Farhat Khan, Jason Bennett, Lucas Otieno, James Cummings, Ben Andagalu, Donna Tosh, John Waitumbi, Nancy Richie, Meng Shi, Lori Miller, Walter Otieno, Godfrey Allan Otieno, Lisa Ware, Brent House, Olivier Godeaux, Marie-Claude Dubois, Bernhards Ogutu, W Ripley Ballou, Lorraine Soisson, Carter Diggs, Joe Cohen, Mark Polhemus, D Gray Heppner, Christian F Ockenhouse, Michele D Spring Malaria Journal 2013, 12:29 (23 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Results of a Phase I MSP-1 vaccine trial in healthy malaria-na¿ve adults in the US and in malaria-experienced adults in Kenya. The vaccine was well tolerated, although many vaccine recipients experienced pain, and several had local and systemic symptoms after vaccination; this is consistent with other AS01 adjuvanted vaccines.
		Research A dynamic model of some malaria-transmitting anopheline mosquitoes of the Afrotropical region. I. Model description and sensitivity analysis Torleif Markussen Lunde, Diriba Korecha, Eskindir Loha, Asgeir Sorteberg, Bernt Lindtjørn Malaria Journal 2013, 12:28 (23 January 2013) Abstract \| Provisional PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary This study highlights some of the assumptions commonly used when constructing mosquito-malaria models and presents a realistic model of Anopheles gambiae s.s. and Anopheles arabiensis, and their interaction. The authors make a case that this new mosquito model, OMaWa, may improve the understanding of vector dynamics, which in turn can be used to better understand the dynamics of malaria.
		Research Declining malaria parasite prevalence and trends of asymptomatic parasitaemia in a seasonal transmission setting in north-western Burkina Faso between 2000 and 2009–2012 Carolin Geiger, Hani Kartini Agustar, Guillaume Compaoré, Boubacar Coulibaly, Ali Sié, Heiko Becher, Michael Lanzer, Thomas Jänisch Malaria Journal 2013, 12:27 (22 January 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Cited on BioMed Central \| Editor’s summary The results of this study suggest a decline of malaria transmission over the rainy seasons the region of Nouna, Burkina Faso. The decreased transmission intensity was associated with lower prevalence of Plasmodium malariae infections (both mono-infections and co-infections). Asymptomatic parasitaemia was more frequent in the dry season even adjusting for parasite density and age group in a multivariate regression.
		Methodology A novel, single-amplification PCR targeting mitochondrial genome highly sensitive and specific in diagnosing malaria among returned travellers in Bergen, Norway Christel G Haanshuus, Stein C Mohn, Kristine Mørch, Nina Langeland, Bjørn Blomberg, Kurt Hanevik Malaria Journal 2013, 12:26 (22 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The paper details a side by side comparison of three PCR primer sets and the quanitification of their limits of detection with a defined set of samples. A good example of how such tests should be carried out, given a lack of critical evaluations of such procedures in the literature base.
		Research Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast Leandro Lemgruber, Mikhail Kudryashev, Chaitali Dekiwadia, David T Riglar, Jake Baum, Henning Stahlberg, Stuart A Ralph, Friedrich Frischknecht Malaria Journal 2013, 12:25 (19 January 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The apicoplast has always been difficult to resolve in conventional electron microscopy. Cryo-electron tomography was employed to image merozoites of Plasmodium falciparum and Plasmodium berghei frozen in their near-native state. Three-dimensional reconstructions revealed the number of apicoplast membranes and the association of the apicoplast with other organelles.
		Research Geographic coincidence of increased malaria transmission hazard and vulnerability occurring at the periphery of two Tanzanian villages Tanya L Russell, Dickson W Lwetoijera, Bart GJ Knols, Willem Takken, Gerry F Killeen, Louise A Kelly-Hope Malaria Journal 2013, 12:24 (18 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Malaria elimination necessitates an improved understanding of fine-scale geographic variations in transmission risk so that complementary vector control tools can be integrated into control programmes.
		Research Freely distributed bed-net use among Chano Mille residents, south Ethiopia: a longitudinal study Eskindir Loha, Kebede Tefera, Bernt Lindtjørn Malaria Journal 2013, 12:23 (18 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The objective of this study was to characterize the pattern related to ITN use in one village in south Ethiopia. A huge discrepancy was reported between ownership versus utilization of insecticide-treated bed nets (ITNs). To acquire the benefits of ITNs, households need to use and not merely own them.
		Research Trends in multiplicity of Plasmodium falciparum infections among asymptomatic residents in the middle belt of Ghana Akua Agyeman-Budu, Charles Brown, George Adjei, Mohammed Adams, David Dosoo, Dominic Dery, Michael Wilson, Kwaku P Asante, Brian Greenwood, Seth Owusu-Agyei Malaria Journal 2013, 12:22 (17 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary This study has investigated the multiplicity of infection within asymptomatic residents of the Kintampo districts of Ghana, and the influence of age and seasonality, by studying the distribution of the polymorphic Plasmodium falciparum antigen merozoite surface protein 2
		Research Measurement of Plasmodium falciparum transmission intensity using serological cohort data from Indonesian schoolchildren Michael T Bretscher, Supargiyono Supargiyono, Mahardika A Wijayanti, Dian Nugraheni, Anis N Widyastuti, Neil F Lobo, William A Hawley, Jackie Cook, Chris J Drakeley Malaria Journal 2013, 12:21 (17 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper reports a statistical method for estimating malaria seroconversion rate using individual data in low transmission areas - a worthwhile analysis, providing a better way of dealing with uncertainty than using a specific cut-off.
		Research Hyperparasitaemia during bouts of malaria in French Guiana Bernard Carme, Magalie Demar Malaria Journal 2013, 12:20 (16 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper describes the frequency of hyperparasitemia in a French Guiana hospital. Of particular interest are a case of vivax malaria with a parasitaemia of 6.5% and a falciparum malaria case with a parasitaemia of 75%.
		Methodology Multivariable analysis of host amino acids in plasma and liver during infection of malaria parasite Plasmodium yoelii Erisha Saiki, Kenji Nagao, Hiroka Aonuma, Shinya Fukumoto, Xuenan Xuan, Makoto Bannai, Hirotaka Kanuka Malaria Journal 2013, 12:19 (16 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Plasmodium yoelii infection caused drastic change of plasma and liver aminogram, and altered intra- and inter-correlation of amino acid concentration in plasma and liver.
		Research Progress towards malaria control targets in relation to national malaria programme funding Eline L Korenromp, Mehran Hosseini, Robert D Newman, Richard E Cibulskis Malaria Journal 2013, 12:18 (14 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Description of malaria control efforts and the funding received by national government and external donors during the 2003-2009 interval for 90 malaria-endemic countries.

	All
		Case study Progress towards malaria elimination in Sabang Municipality, Aceh, Indonesia Herdiana Herdiana, Anis Fuad, Puji BS Asih, Siti Zubaedah, Risalia Reni Arisanti, Din Syafruddin, Hari Kusnanto, Maria Endang Sumiwi, Titik Yuniarti, Ali Imran, Rahmadyani Rahmadyani, Muhammad Yani, Rita Kusriastuti, Siti Nadia Tarmizi, Ferdinand J Laihad, William A Hawley Malaria Journal 2013, 12:42 (30 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An important article outlining the progress made towards malaria elimination in Sabang municipality, Aceh, Indonesia. The details of this article will serve as an example to much of the rest of Indonesia, as well as the rest of SE Asia.
		Research Cytoplasmic free Ca²⁺ is essential for multiple steps in malaria parasite egress from infected erythrocytes Svetlana Glushakova, Vladimir Lizunov, Paul S Blank, Kamran Melikov, Glen Humphrey, Joshua Zimmerberg Malaria Journal 2013, 12:41 (30 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Thorough exploration of the involvement of calcium in the process of Plasmodium falciparum merozoite egress from the infected erythrocyte.
		Research Avian haemosporidian persistence and co-infection in great tits at the individual level Juan van Rooyen, Fabrice Lalubin, Olivier Glaizot, Philippe Christe Malaria Journal 2013, 12:40 (30 January 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary This study aimed to determine how persistent Haemosporida are in great tit individuals recaptured over several years, whether parasitaemia differed by parasite lineage (mitochondrial cytochrome b haplotype) and how co-infection (i.e. concurrent infection with multiple genera of parasites) affects parasitaemia and body mass.
		Research Community perceptions on malaria and care-seeking practices in endemic Indian settings: policy implications for the malaria control programme Ashis Das, RK Das Gupta, Jed Friedman, Madan M Pradhan, Charu C Mohapatra, Debakanta Sandhibigraha Malaria Journal 2013, 12:39 (29 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An article about community perceptions of the causes and presentation of malaria and their care-seeking practices in Odisha, India. The article gives a good presentation of community beliefs around the variety of places in which treatment maybe sought and the policy implications of these findings.
		Research High effective coverage of vector control interventions in children after achieving low malaria transmission in Zanzibar, Tanzania Netta Beer, Abdullah S Ali, Delér Shakely, Kristina Elfving, Abdul-Wahiyd H Al-Mafazy, Mwinyi Msellem, Max Petzold, Anders Björkman, Karin Källander Malaria Journal 2013, 12:38 (29 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A timely study, as it addresses people¿s behaviour in the context of malaria elimination. This adds to the current concerns about sustainable community adherence to control measure when malaria transmission is progressively being reduced.
		Research Febrile illness management in children under five years of age: a qualitative pilot study on primary health care workers’ practices in Zanzibar Kimberly Baltzell, Kristina Elfving, Deler Shakely, Abdullah S Ali, Mwinyi Msellem, Shilpa Gulati, Andreas Mårtensson Malaria Journal 2013, 12:37 (28 January 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Qualitative study of primary health workers¿ practice in relation to the management for febrile children under five years of age in Zanzibar. The management of patients who test negative for malaria addresses a topic of increasing interest to people living in areas where malaria used to be endemic, but is no longer the major health problem.
		Research Impact of a mass media campaign on bed net use in Cameroon Hannah L Bowen Malaria Journal 2013, 12:36 (25 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Research that attempts to measure the impact of a mass media campaign on the use of bed nets and address the challenge of attributing behaviour change specifically to the intervention through the use of a propensity score matching model.
		Research Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000–2011 Myriam Gharbi, Jennifer A Flegg, Véronique Hubert, Eric Kendjo, Jessica E Metcalf, Lionel Bertaux, Philippe J Guérin, Jacques Le Bras, Members of the French National Reference Centre for Imported Malaria Study Malaria Journal 2013, 12:35 (25 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Data on chloroquine resistance in an impressive number of isolates obtained from travellers returning from West Africa.
		Research Pfhrp2 and pfhrp3 polymorphisms in Plasmodium falciparum isolates from Dakar, Senegal: impact on rapid malaria diagnostic tests Nathalie Wurtz, Bécaye Fall, Kim Bui, Aurélie Pascual, Mansour Fall, Cheikhou Camara, Bakary Diatta, Khadidiatou Ba Fall, Pape Saliou Mbaye, Yaya Diémé, Raymond Bercion, Boubacar Wade, Sébastien Briolant, Bruno Pradines Malaria Journal 2013, 12:34 (24 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The study aims to assess the diagnostic accuracy of the HRP2-based RDT Palutop+4¿ by comparison with microscopic examination and real-time polymerase chain reaction and to investigate the genetic diversity of the pfhrp2 and pfhrp3 genes in clinical isolates from Dakar, and its impact on field and predictive diagnostic sensitivity.
		Research Travel history and malaria infection risk in a low-transmission setting in Ethiopia: a case control study Joshua O Yukich, Cameron Taylor, Thomas P Eisele, Richard Reithinger, Honelgn Nauhassenay, Yemane Berhane, Joseph Keating Malaria Journal 2013, 12:33 (24 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ethiopia currently has plans for elimination for specific geographic areas of the country. Human movement may lead to the maintenance of reservoirs of infection, complicating attempts to eliminate malaria.
		Research Analysis of antibody induction upon immunization with distinct NTS-DBL1α-domains of PfEMP1 from rosetting Plasmodium falciparum parasites Davide Angeletti, Letusa Albrecht, Mats Wahlgren, Kirsten Moll Malaria Journal 2013, 12:32 (24 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rosetting is a malaria virulence determinant and a vaccine target. This study used peptide arrays and parasite panels to investigate the specificity and cross-reactivity of vaccine antibodies. Antibodies had strong homologous parasite reactivity but limited or no cross-reactivity on different rosetting parasite variants.
		Research Gametocyte carriage in Plasmodium falciparum-infected travellers Catherine H Roberts, Margaret Armstrong, Ewa Zatyka, Samuel Boadi, Simon Warren, Peter L Chiodini, Colin J Sutherland, Tom Doherty Malaria Journal 2013, 12:31 (24 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper develops an original idea, assessing how many patients with P. falciparum malaria had gametocytes on presentation, or developed gametocytes during the course of their disease, and linking this occurrence with given characteristics of the population studied and of the disease itself.
		Research High frequency of the erythroid silent Duffy antigen genotype and lack of Plasmodium vivax infections in Haiti Thomas A Weppelmann, Tamar E Carter, Zhongsheng Chen, Michael E von Fricken, Yves S Victor, Alexander Existe, Bernard A Okech Malaria Journal 2013, 12:30 (24 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In this preliminary study, no cases of P. vivax were confirmed by PCR in Haiti. The high frequency of the FYES allele that silences erythroid expression of the Duffy antigen offers a biologically plausible explanation for the lack of P. vivax infections observed.
		Research Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein-1 (MSP1₄₂) administered intramuscularly with adjuvant system AS01 Nekoye Otsyula, Evelina Angov, Elke Bergmann-Leitner, Margaret Koech, Farhat Khan, Jason Bennett, Lucas Otieno, James Cummings, Ben Andagalu, Donna Tosh, John Waitumbi, Nancy Richie, Meng Shi, Lori Miller, Walter Otieno, Godfrey Allan Otieno, Lisa Ware, Brent House, Olivier Godeaux, Marie-Claude Dubois, Bernhards Ogutu, W Ripley Ballou, Lorraine Soisson, Carter Diggs, Joe Cohen, Mark Polhemus, D Gray Heppner, Christian F Ockenhouse, Michele D Spring Malaria Journal 2013, 12:29 (23 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Results of a Phase I MSP-1 vaccine trial in healthy malaria-na¿ve adults in the US and in malaria-experienced adults in Kenya. The vaccine was well tolerated, although many vaccine recipients experienced pain, and several had local and systemic symptoms after vaccination; this is consistent with other AS01 adjuvanted vaccines.
		Research A dynamic model of some malaria-transmitting anopheline mosquitoes of the Afrotropical region. I. Model description and sensitivity analysis Torleif Markussen Lunde, Diriba Korecha, Eskindir Loha, Asgeir Sorteberg, Bernt Lindtjørn Malaria Journal 2013, 12:28 (23 January 2013) Abstract \| Provisional PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary This study highlights some of the assumptions commonly used when constructing mosquito-malaria models and presents a realistic model of Anopheles gambiae s.s. and Anopheles arabiensis, and their interaction. The authors make a case that this new mosquito model, OMaWa, may improve the understanding of vector dynamics, which in turn can be used to better understand the dynamics of malaria.
		Research Declining malaria parasite prevalence and trends of asymptomatic parasitaemia in a seasonal transmission setting in north-western Burkina Faso between 2000 and 2009–2012 Carolin Geiger, Hani Kartini Agustar, Guillaume Compaoré, Boubacar Coulibaly, Ali Sié, Heiko Becher, Michael Lanzer, Thomas Jänisch Malaria Journal 2013, 12:27 (22 January 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Cited on BioMed Central \| Editor’s summary The results of this study suggest a decline of malaria transmission over the rainy seasons the region of Nouna, Burkina Faso. The decreased transmission intensity was associated with lower prevalence of Plasmodium malariae infections (both mono-infections and co-infections). Asymptomatic parasitaemia was more frequent in the dry season even adjusting for parasite density and age group in a multivariate regression.
		Methodology A novel, single-amplification PCR targeting mitochondrial genome highly sensitive and specific in diagnosing malaria among returned travellers in Bergen, Norway Christel G Haanshuus, Stein C Mohn, Kristine Mørch, Nina Langeland, Bjørn Blomberg, Kurt Hanevik Malaria Journal 2013, 12:26 (22 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The paper details a side by side comparison of three PCR primer sets and the quanitification of their limits of detection with a defined set of samples. A good example of how such tests should be carried out, given a lack of critical evaluations of such procedures in the literature base.
		Research Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast Leandro Lemgruber, Mikhail Kudryashev, Chaitali Dekiwadia, David T Riglar, Jake Baum, Henning Stahlberg, Stuart A Ralph, Friedrich Frischknecht Malaria Journal 2013, 12:25 (19 January 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The apicoplast has always been difficult to resolve in conventional electron microscopy. Cryo-electron tomography was employed to image merozoites of Plasmodium falciparum and Plasmodium berghei frozen in their near-native state. Three-dimensional reconstructions revealed the number of apicoplast membranes and the association of the apicoplast with other organelles.
		Research Geographic coincidence of increased malaria transmission hazard and vulnerability occurring at the periphery of two Tanzanian villages Tanya L Russell, Dickson W Lwetoijera, Bart GJ Knols, Willem Takken, Gerry F Killeen, Louise A Kelly-Hope Malaria Journal 2013, 12:24 (18 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Malaria elimination necessitates an improved understanding of fine-scale geographic variations in transmission risk so that complementary vector control tools can be integrated into control programmes.
		Research Freely distributed bed-net use among Chano Mille residents, south Ethiopia: a longitudinal study Eskindir Loha, Kebede Tefera, Bernt Lindtjørn Malaria Journal 2013, 12:23 (18 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The objective of this study was to characterize the pattern related to ITN use in one village in south Ethiopia. A huge discrepancy was reported between ownership versus utilization of insecticide-treated bed nets (ITNs). To acquire the benefits of ITNs, households need to use and not merely own them.
		Research Trends in multiplicity of Plasmodium falciparum infections among asymptomatic residents in the middle belt of Ghana Akua Agyeman-Budu, Charles Brown, George Adjei, Mohammed Adams, David Dosoo, Dominic Dery, Michael Wilson, Kwaku P Asante, Brian Greenwood, Seth Owusu-Agyei Malaria Journal 2013, 12:22 (17 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary This study has investigated the multiplicity of infection within asymptomatic residents of the Kintampo districts of Ghana, and the influence of age and seasonality, by studying the distribution of the polymorphic Plasmodium falciparum antigen merozoite surface protein 2
		Research Measurement of Plasmodium falciparum transmission intensity using serological cohort data from Indonesian schoolchildren Michael T Bretscher, Supargiyono Supargiyono, Mahardika A Wijayanti, Dian Nugraheni, Anis N Widyastuti, Neil F Lobo, William A Hawley, Jackie Cook, Chris J Drakeley Malaria Journal 2013, 12:21 (17 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper reports a statistical method for estimating malaria seroconversion rate using individual data in low transmission areas - a worthwhile analysis, providing a better way of dealing with uncertainty than using a specific cut-off.
		Research Hyperparasitaemia during bouts of malaria in French Guiana Bernard Carme, Magalie Demar Malaria Journal 2013, 12:20 (16 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This paper describes the frequency of hyperparasitemia in a French Guiana hospital. Of particular interest are a case of vivax malaria with a parasitaemia of 6.5% and a falciparum malaria case with a parasitaemia of 75%.
		Methodology Multivariable analysis of host amino acids in plasma and liver during infection of malaria parasite Plasmodium yoelii Erisha Saiki, Kenji Nagao, Hiroka Aonuma, Shinya Fukumoto, Xuenan Xuan, Makoto Bannai, Hirotaka Kanuka Malaria Journal 2013, 12:19 (16 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Plasmodium yoelii infection caused drastic change of plasma and liver aminogram, and altered intra- and inter-correlation of amino acid concentration in plasma and liver.
		Research Progress towards malaria control targets in relation to national malaria programme funding Eline L Korenromp, Mehran Hosseini, Robert D Newman, Richard E Cibulskis Malaria Journal 2013, 12:18 (14 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Description of malaria control efforts and the funding received by national government and external donors during the 2003-2009 interval for 90 malaria-endemic countries.