Table 4 |
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|
Assessment of recovery after treatment with intramuscular artesunate or artemether. |
|||
|
Parameters |
ARTS n = 186 |
ARTM n = 184 |
P value* |
|
|
|||
|
hours |
|||
|
|
|||
|
Time to parasite clearance |
|||
|
Decrease to 50% of admission value |
0.007 |
||
|
Median (Range) |
8 (4-42) |
8 (2-60) |
|
|
Decrease to 90% of admission value |
0.004 |
||
|
Median (Range) |
16 (4-102) |
24 (2-152) |
|
|
Total clearance |
0.97 |
||
|
Median (Range) |
72 (7-330) |
72 (2-204) |
|
|
|
|||
|
Resolution of fever |
|||
|
Time first temperature < 37.5°C |
0.99 |
||
|
Median (Range) |
30 (0-768) |
20 (0-648) |
|
|
Time of fever clearance |
0.27 |
||
|
Median (Range) |
108 (0-888) |
108 (0-1088) |
|
|
|
|||
|
Time to recovery from coma |
|||
|
Time to Glasgow Coma score of 8† |
0.55 |
||
|
Median (Range) |
48 (4-2136) |
54 (2-2232) |
|
|
Time to Glasgow Coma score of 11‡ |
0.44 |
||
|
Median (Range) |
42 (4-2136) |
42 (2-2232) |
|
|
Time to Glasgow Coma score of 15¶ |
0.11 |
||
|
Median (Range) |
60 (4-2136) |
72 (2-2232) |
|
|
|
|||
|
Time to physical recovery |
|||
|
Time before patient able to drink |
|||
|
Median (Range) |
30 (0-2136) |
42 (0-2232) |
0.2 |
|
Time before patient able to eat |
|||
|
Median (Range) |
42 (0-2136) |
46 (0-2232) |
0.18 |
|
Time before patient able to sit |
|||
|
Median (Range) |
78 (0-2136) |
90 (0-2232) |
0.32 |
|
Time before patient able to stand |
|||
|
Median (Range) |
96 (0-2136) |
114 (0-2232) |
0.66 |
|
Time before patient able to walk |
|||
|
Median (Range) |
102(0-2136) |
120 (0-2232) |
0.64 |
|
Time before patient able to leave hospital |
|||
|
Median (Range) |
264(7-2136) |
288 (2-2232) |
0.68 |
|
|
|||
|
* Log-rank test † Only patients who decreased in Glasgow Coma score below 8 were included (130 pts, 58 in ATS group and 72 in ATM group) ‡ Only patients who decreased in Glasgow Coma score below 11 were included (204 pts, 93 in ATS group and 111 in ATM group) ¶Only patients who decreased in Glasgow Coma score below 15 were included (274 pts, 134 in ATS group and 140 in ATM group) |
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|
Phu et al. Malaria Journal 2010 9:97 doi:10.1186/1475-2875-9-97 |
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