Research
Computational analysis of binding between malarial dihydrofolate reductases and anti-folates
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* Corresponding author: Mallika Imwong noi@tropmedres.ac
1 Department of Biochemistry, Faculty of Science, Kasetsart University, Jatuchak, Bangkok 10900, Thailand
2 Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Phayathai, Bangkok 10400, Thailand
3 Centre for Infection, Division of Clinical Sciences, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK
4 Centre for Tropical Medicine, University of Oxford, Churchill Hospital, Oxford, UK
Malaria Journal 2010, 9:65 doi:10.1186/1475-2875-9-65
Published: 2 March 2010Additional files
Additional file 1:
Ramachandran plots of modelled structures of (A) PmDHFR and (B) PoDHFR. The data provided represent an index of model quality.
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Additional file 2:
List of Plasmodium DHFR residues and binding energies (kcal/mol) for interaction with pyrimethamine, cycloguanil and trimethoprim. The data provided represent a detailed description of the interactions between conserved residues and three inhibitory ligands.
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