Table 4 |
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|
Predictors of delay in parasite clearance on day 1 after treatment in children with acute falciparum malaria |
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|
Variables |
Number enrolled |
PC >2 d |
Crude OR (95% CI) |
P Value |
Adjusted OR (95% CI) |
P Value |
|
|
||||||
|
Axillary temperature (°C) |
||||||
|
<38.0 |
2326 |
1012 |
1 |
1 |
||
|
≥ 38.0 |
228 |
139 |
2.02 (1.53 -2.67) |
<0.0001 |
1.80 (1.30-2.50) |
< 0.001 |
|
Parasitaemia (/μl blood) |
||||||
|
≤ 20,000 |
1328 |
463 |
1 |
1 |
||
|
>20,000 |
683 |
467 |
5.25 (4.20 - 6.48) |
<0.0001 |
5.13 (4.14 - 6.35) |
< 0.001 |
|
Drug treatment * |
||||||
|
CQ |
388 |
275 |
1 |
1 |
1 |
|
|
AQ |
573 |
298 |
0.44 (0.33 - 0.58) |
<0.0001 |
0.79 (0.63 - 0.98) |
< 0.03 |
|
AQAS |
142 |
14 |
0.05 (0.03 - 0.08) |
<0.0001 |
0.24 (0.10 - 0.57) |
< 0.0001 |
|
AQPS |
69 |
26 |
0.24 (0.14 - 0.42) |
<0.0001 |
0.44 (0.26 - 0.73) |
0.002 |
|
AQSP |
91 |
34 |
0.25 (0.15 - 0.39) |
<0.0001 |
0.43 (0.29 - 0.68) |
< 0.0001 |
|
AMQ |
174 |
10 |
0.03 (0.01 - 0.05) |
<0.0001 |
0.04 (0.02 - 0.09) |
< 0.0001 |
|
AL |
90 |
6 |
0.03 (0.01 - 0.07) |
<0.0001 |
0.05 (0.02 - 0.12) |
< 0.0001 |
|
AS |
120 |
3 |
0.01 (0.00 - 0.03) |
<0.0001 |
0.02 (0.00 - 0.06) |
< 0.0001 |
|
COT |
104 |
61 |
0.58 (0.37 - 0.91) |
0.017 |
1.03 (0.68 - 1.36) |
0.877 |
|
CQCP |
315 |
189 |
0.61 (0.45 - 0.84) |
0.002 |
1.09 (0.83 - 1.42) |
0.512 |
|
CQKET |
70 |
36 |
0.43 (0.25 - 0.73) |
0.001 |
0.77 (0.47 - 1.25) |
0.029 |
|
CQPS |
107 |
46 |
0.31 (0.19 - 0.48) |
<0.0001 |
0.54 (0.36 - 0.82) |
0.004 |
|
MQ |
176 |
40 |
0.12 (0.08 - 0.18) |
<0.0001 |
0.21 (0.15 - 0.31) |
< 0.0001 |
|
SP |
291 |
186 |
0.72 (0.52 - 1.00) |
0.055 |
- |
- |
|
SPP |
42 |
13 |
0.18 (0.09 - 0.37) |
<0.0001 |
0.33 (0.17 -0.98) |
0.001 |
|
|
||||||
|
CI, confidence interval; OR, odd ratio; PC, parasite clearance * Values of OR represent chances of delay in parasite clearance |
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|
Sowunmi et al. Malaria Journal 2010 9:53 doi:10.1186/1475-2875-9-53 |
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