Table 1

Effect of immunization protocols with Plasmodium yoelii attenuated sporozoites on development of protective immunity

Route of Immunization

Exp't 1

Exp't 2

Exp't 3

Total


Non-Immunized Controls

6/6 (0%)a

[PP = 3.0]b

6/6 (0%)

[PP = 3.3]

6/6 (0%)

[PP = 3.3]

18/18 (0%)

[PP = 3.3]

IVc-Immunized

0/6 (100%)

0/6 (100%)

1/6 (83%)

[PP = 6.0]

1/18 (94%)

[PP = 6.0]

IDd-Immunized

3/6 (50%)

[PP = 5.0]

1/6 (83%)

[PP = 9.0]

0/6 (100%)

4/18 (78%)

[PP = 6.0]

ID-Immunized

+ Imiquimod

1/6 (83%)

[PP = 5.0]

1/6 (83%)

[PP = 4.0]

4/6 (33%)

[PP = 4.2]

6/18 (67%)

[PP = 4.3]

ID-Immunized

+ Tape Stripping

1/6 (83%)

[PP = 4 0]

0/6 (100%)

0/6 (100%)

1/18 (94%)

[PP = 4.0]


a Results of challenge by mosquito injection of sporozoites. # of mice with blood infection/# challenged; (% protected in parentheses)

b [Mean prepatent period in days for positive mice]

c IV = intravenous

d ID = intradermal

Voza et al. Malaria Journal 2010 9:362   doi:10.1186/1475-2875-9-362

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