Table 3 |
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|
Univariate and multivariate associations with microscopically visible, polyclonal P. falciparum infections |
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|
Parameter |
No. |
Mean MOI (median, range) |
P |
Multivariate analysisa |
Polyclonal infections (%) |
OR (95%CI) |
P |
Multivariate analysisb |
|||
|
|
|
||||||||||
|
b |
SE |
P |
aOR (95%CI) |
P |
|||||||
|
|
|||||||||||
|
Previous IPTi-SP |
|||||||||||
|
No |
142 |
2.38 (2, 1-6) |
72.5 |
1 |
1 |
||||||
|
Yes |
135 |
2.42 (2, 1-5) |
0.78 |
-0.05 |
0.22 |
0.82 |
74.8 |
1.12 (0.64-1.99) |
0.67 |
0.93 (0.52-1.64) |
0.79 |
|
Cohort |
|||||||||||
|
Tamale |
104 |
2.57 (2, 1-5) |
78.8 |
1 |
1 |
||||||
|
Afigya Sekyere |
173 |
2.30 (2, 1-6) |
0.07 |
-0.67 |
0.26 |
0.01 |
70.5 |
0.64 (0.35-1.18) |
0.13 |
0.53 (0.28-1.03) |
0.06 |
|
Current malaria episode |
|||||||||||
|
No |
114 |
2.21 (2, 1-6) |
64.0 |
1 |
1 |
||||||
|
Yes |
163 |
2.53 (2, 1-5) |
0.01 |
0.55 |
0.24 |
0.02 |
80.4 |
2.30 (1.29-4.11) |
0.002 |
2.35 (1.27-4.32) |
0.006 |
|
Parasite density (/μL) |
|||||||||||
|
Log10 |
277 |
n.a. |
0.049 |
0.24 |
0.13 |
0.07 |
n.a. |
1.48 (1.08-2.03) |
0.01 |
1.38 (0.99-1.94) |
0.06 |
|
Prior malaria episodes |
|||||||||||
|
None |
72 |
2.50 (2, 1-5) |
81.9 |
1 |
1 |
||||||
|
Any |
205 |
2.37 (2, 1-6) |
0.30 |
-0.19 |
0.26 |
0.46 |
70.7 |
0.53 (0.26-1.09) |
0.06 |
0.51 (0.25-1.05)c, d |
0.07 |
|
Season |
|||||||||||
|
Dry season |
92 |
2.49 (2, 1-5) |
79.3 |
1 |
1 |
||||||
|
Rainy season |
185 |
2.36 (2, 1-6) |
0.32 |
-0.77 |
0.27 |
0.004 |
70.8 |
1.58 (0.84-3.01) |
0.13 |
0.36 (0.18-0.72) |
0.004 |
|
|
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|
a, multivariate results are derived from non-parametric ordinal regression analysis including all listed parameters. b, adjusted odds ratios (aORs) are derived from logistic regression models including all other listed parameters; SE, standard error; OR, odds ratio; 95%CI, 95% confidence interval; n.a., not applicable; c, exchanging with number of previous malaria episodes (0-7): aOR, 0.98, 95%CI, 0.81-1.19; P = 0.84. d, The proportion of polyclonal infections according to arbitrarily set time periods from last previous episode was: <8 weeks (n = 65), 76.9%; 8-16 weeks (n = 62), 72.6%; >16 weeks (n = 78), 64.1%. Exchanging this graded parameter with prior episodes per se yielded respective aORs (95%CIs) of 0.73 (0.30-1.78), 0.72 (0.29-1.76), and 0.32 (0.14-0.73). |
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|
Buchholz et al. Malaria Journal 2010 9:244 doi:10.1186/1475-2875-9-244 |
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