Table 7 |
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|
Summary of the properties of AMA1 epitopes |
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|
Epitope |
HLA-restriction |
Amino acids |
Sequence |
Location |
Crystal face |
Accessibility |
|
|
||||||
|
E1 |
B44 |
13-21 |
FEFTYMINF |
Signal |
||
|
E2 |
B44 |
35-44 |
SDVYRPINEH |
Prodomain |
||
|
E3 |
B08 |
47-55 |
HPKEYEYPL |
Prodomain |
||
|
E4 |
B44 |
51-59 |
YEYPLHQEH |
Prodomain |
||
|
E5 |
B08 |
175-183 |
YLKDGGFAF |
Domain I |
F/B |
YnaKD |
|
E6 |
A01 |
194-202 |
TLDE+MRHFY |
Domain I |
B |
D, E, H, F |
|
E7 |
A01 |
198-207 |
MRHFYKDNKY |
Domain I |
F/B |
H, F, D, K, Y |
|
E8 |
B44 |
327-335 |
NEFPAIDLF |
Domain II |
F/B |
E, P, I |
|
E9 |
A02 |
339-346 |
KLVFELS*A |
Domain II |
F |
E, L |
|
E10 |
A01 |
389-397 |
RYKSHGKGY |
Domain II |
F |
H, K, Y |
|
E11 |
A02 |
405-414 |
ETQKCEIFNV |
Domain II |
B |
E, T, Q, N |
|
E12 |
A02 |
406-414 |
TQKCEIFNV |
Domain II |
F |
T, Q, N |
|
E13 |
A02 |
410-419 |
EIFNVK*PTCL |
Domain II |
F |
NK |
|
E14 |
B44 |
520-528 |
NEVVVKE*EY |
Domain III |
F |
VEE |
|
|
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|
Variable amino acids are highlighted in bold. *Indicated that there is only one variant of <0.001% frequency E+ is essential for binding of growth inhibitory MAb 1F9 F = front, B = back, F/B = wraps from front to back Yna Accessibility not available for amino acid Y Confirmed epitope numbers are indicated in bold |
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|
Sedegah et al. Malaria Journal 2010 9:241 doi:10.1186/1475-2875-9-241 |
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