Table 2

Data relating to post-treatment clinical and parasitological response

Variable

P. knowlesi (n = 33)

P. vivax (n = 23)

P value

Admission parasite count (geometric mean per microlitre)

3724 (1,845-7480)

4650 (2,752-7785)

0.6

Fever clearance time (hours)

26.5 [16-34]

20.8 [12-32]

0.32

Percentage given paracetamol during hospital stay

79

52

0.05

Hours before fever clearance

6 [2-13]

4 [1-12]

0.48

Time to clear 50% of admission parasite count (hours)

3.1 (2.84-3.43)

6.3 (5.3-7.8)

0.02

Time to clear 90% of admission parasite count (hours)

10.3 (9.4-11.4)

20.9 (17.6-25.9)

0.02

Calculated time to parasite count < 5 per microlitre (hours)

35.8 [30.8-51.2]

62.1 [43.0-80.2]

< 0.01

Parasite reduction ratio at 24 hours

99.3 [50-100]

95.9 [58-100]

< 0.01

Percentage negative at 24 hours

33 (16-31)

4.6 (0-14)

Parasite stages (%, range)

Immature trophozoites

49.5 (3.1-100)

64.4 (2.7-98.9)

0.06

Pigmented trophozoites

41.5 (0-88.4)

28.4 (19.1-37.6)

0.09

Schizonts

4.0 (0-38.6)

1.9 (0-36.3)

< 0.01

Gametocytes

5.6 (0-32.8)

7.1 (0-53.7)

0.15

Slope of curve for natural logarithm parasite count

All

0.223 ± 0.02

0.110 ± 0.02

0.02

Immature trophozoites

0.182 ± 0.02

0.127 ± 0.03

NT

Mature trophozoites

0.269 ± 0.02

0.147 ± 0.03

NT

Schizont

0.191 ± 0.02

0.02 ± 0.02

NT

Gametocyte

0.061 ± 0.01

0.012 ± 0.03

NT

Data are mean (range), mean ± SD or median [interquartile range] unless stated otherwise. NT not tested.

Daneshvar et al. Malaria Journal 2010 9:238   doi:10.1186/1475-2875-9-238