Table 4 |
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|
Comparative performance of Rapid Diagnostic Test kits (Parascreen, Falcivax, Malascan, First Response and ParaHIT Total) with traditional light microscopy and Polymerase Chain Reaction (PCR) for diagnosis of P.vivax |
|||||
|
Parascreen |
Falcivax |
Malascan |
First Response |
ParaHIT Total |
|
|
|
|||||
|
Light Microscopy as Gold Standard (Reference) |
|||||
|
|
|||||
|
Sensitivity |
77.2 |
68.4 |
68.4 |
84.2 |
15.8 |
|
(95% CI) |
(64.2-87.3) |
(54.8-80.1) |
(54.8-80.1) |
(72.1-92.5) |
(7.5-27.9) |
|
Specificity |
98.1 |
99.0 |
97.8 |
96.5 |
100.0 |
|
(95% CI) |
(95.9-99.3) |
(97.2-99.8) |
(95.5-99.1) |
(93.8-98.2) |
(98.8-100.0) |
|
Positive Likelihood Ratio |
40.5 |
71.8 |
30.8 |
24.1 |
|
|
(95% CI) |
(18.1-90.6) |
(23.0-224.6) |
(14.5-65.4) |
(13.4-43.6) |
|
|
Negative Likelihood Ratio |
0.23 |
0.32 |
0.32 |
0.16 |
0.84 |
|
(95% CI) |
(0.14-0.37) |
(0.22-0.47) |
(0.22-0.47) |
(0.09-0.30) |
(0.75-0.94) |
|
Positive Predictive Value |
88.0 |
92.9 |
84.8 |
81.4 |
100.0 |
|
(95% CI) |
(75.7-95.5) |
(80.5-98.5) |
(71.1-93.7) |
(69.1-90.3) |
(66.4-100.0) |
|
Negative Predictive Value |
96.0 |
94.5 |
94.5 |
97.1 |
86.8 |
|
(95% CI) |
(93.2-97.8) |
(91.5-96.7) |
(91.4-96.7) |
(94.6-98.7) |
(82.9-90.1) |
|
Percentage Agreement (Accuracy) |
94.9 |
94.4 |
93.3 |
94.6 |
87.1 |
|
Kappa |
0.80 |
0.76 |
0.72 |
0.80 |
0.24 |
|
|
|||||
|
PCR as Gold Standard (Reference) |
|||||
|
|
|||||
|
Sensitivity |
68.3 |
61.7 |
63.3 |
76.7 |
13.3 |
|
(95% CI) |
(55.0-79.7) |
(48.2-73.9) |
(49.9-75.4) |
(64.0-86.6) |
(5.9-24.6) |
|
Specificity |
97.0 |
98.4 |
97.4 |
95.7 |
99.7 |
|
(95% CI) |
(94.5-98.6) |
(96.2-99.5) |
(94.9-98.9) |
(92.8-97.7) |
(98.2-100.0) |
|
Positive Likelihood Ratio |
23.1 |
37.5 |
24.1 |
17.9 |
40.5 |
|
(95% CI) |
(11.9-44.9) |
(15.4-91.5) |
(11.8-49.0) |
(10.4-31.1) |
(5.2-318.1) |
|
Negative Likelihood Ratio |
0.33 |
0.39 |
0.38 |
0.24 |
0.87 |
|
(95% CI) |
(0.22-0.47) |
(0.28-0.54) |
(0.27-0.53) |
(0.15-0.39) |
(0.79-0.96) |
|
Positive Predictive Value |
82.0 |
88.1 |
82.6 |
78.0 |
88.9 |
|
(95% CI) |
(68.6-91.4) |
(74.4-96.0) |
(68.6.-92.2) |
(65.3-87.7) |
(51.8-99.7) |
|
Negative Predictive Value |
93.9 |
92.9 |
93.1 |
95.4 |
85.4 |
|
(95% CI) |
(90.7-96.3) |
(89.5-95.4) |
(89.7-95.6) |
(92.4-97.5) |
(81.2-88.9) |
|
Percentage Agreement (Accuracy) |
92.3 |
92.3 |
91.8 |
92.6 |
85.4 |
|
Kappa |
0.70 |
0.68 |
0.67 |
0.73 |
0.20 |
|
|
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|
Singh et al. Malaria Journal 2010 9:191 doi:10.1186/1475-2875-9-191 |
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