Research
Global sequence variation in the histidine-rich proteins 2 and 3 of Plasmodium falciparum: implications for the performance of malaria rapid diagnostic tests
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* Corresponding author: Qin Cheng qin.cheng@defence.gov.au
1 Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia
2 Clinical Tropical Medicine Laboratory, Queensland Institute of Medical Research, University of Queensland, Herston, Australia
3 Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Herston, Australia
4 Bagamoyo/Ifakara Health Research and Development Centre, Ifakara, United Republic of Tanzania
5 Foundation for Innovative and New Diagnostics, Geneva, Switzerland
6 Pasteur Institute of Cambodia, Phnom Penh, Cambodia
7 Centre for Disease Control and Prevention, Atlanta, USA
8 Global Malaria Programme, World Health Organization, Geneva, Switzerland
9 UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), Geneva, Switzerland
10 Institut Pasteur de Bangui, Bangui, Central African Republic
11 Centro Internacional de Entrenamiento e Investigaciones Medicas (CIDEIM), Cali, Colombia
12 Instituto de Medicina Tropical Alexander Von Humboldt, Universidad Peruana Cayetano Heredia, Peru
13 Departamento de Bioquimica, Biologia Molecular y Farmacologia, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Peru
14 Western Pacific Regional Office of the World Health Organization, Solomon Islands
15 Department of Medical Research (Lower Myanmar), Yangon, Myanmar
16 Research Institute for Tropical Medicine, Alabang, The Philippines
17 Institut Pasteur de Madagascar, Madagascar
18 Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya
19 College of Medicine, University of Lagos, Odoaraba, Lagos, Nigeria
20 Hainan Provincial Centre for Disease Control and Prevention, Haikou, Hainan, China
21 School of Population Health, University of Queensland, Herston, Queensland, Australia
Malaria Journal 2010, 9:129 doi:10.1186/1475-2875-9-129
Published: 17 May 2010Additional files
Additional file 1:
Table S1: Comparison of the length (aa) and number of each repeat in PFHRP2 in parasites from different geographical areas.
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Additional file 2:
Table S2: Frequency (in percentage) of different amino acid repeats (types 1-24) observed in PfHRP2 of isolates obtained from various geographic areas and countries (sample number > 10).
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Additional file 3:
Table S3: Variation of PfHRP3 sequences.
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