Table 2

Effect of concomitant medication (ketoconazole, mefloquine, quinine or lopinavir/ritonavir) on exposure to artemether, dihydroartemisinin (DHA) and lumefantrine in studies undertaken in healthy volunteers

Concomitant medication

N

Change in exposure to artemether (AUC)

Change in exposure to DHA (AUC)

Change in exposure to lumefantrine (AUC)

Change in exposure to concomitant medication (AUC)^a

Ketoconazole [8]

16

↑ 2.4-fold

↑ 1.7-fold

↑ 1.7-fold

Not measured

Mefloquine [21]

42

Unchanged

Unchanged

↓ 32%

Unchanged

Quinine [22]

42

↓ 46%

↓ 37%

Unchanged

Unchanged

Lopinavir/ritonavir [24]

13

↓ 35%

↓ 45%

↑ 2.4-fold

Unchanged

^a Ketoconazole, mefloquine, quinine or lopinavir/ritonavir, respectively

Djimdé and Lefèvre Malaria Journal 2009 8(Suppl 1):S4   doi:10.1186/1475-2875-8-S1-S4