Table 1

Pharmacokinetic parameters of artemether, dihydroartemisinin (DHA) and lumefantrine (mean or mean ± SD) among healthy volunteers and patients with malaria receiving a six-dose, three-day regimen of AL



Pharmacokinetic parameters






Artemether
 DHA



Subjects (n)
 Food or fat content (g)
 Country/Area
 Cmax
(ng/mL)
 AUC
(μg·h/mL)
 t1/2
(h)
 Cmax
(ng/mL)
 AUC
(μg·h/mL)
 t1/2
(h)
Healthy volunteers
(n = 14) [22]
 ~65 ga
 Europe
 30.8 ± 25.4
 61.4 ± 87.5
 2.0 ± 1.2
 84.5 ± 26.5
 178 ± 71
 1.2 ± 0.4
Malaria patients
(n = 13) [6]
 7 gd
 Thailand
 34.8
 66.4
 1.5
 165
 367
 1.3
Malaria patients
 Local
 Thailand
 66.2 ± 54.3
 211 ± 109
 2.2 ± 1.0
 205 ± 102
 604 ± 259
 1.6 ± 0.4



Lumefantrine



Subjects (n)
 Food or fat content (g)
 Country/Area
 Cmax
(μg/mL)
 AUC
(μg·h/mL)
 t1/2
(day)
 Day 7
concentration (ng/mL)
Healthy volunteers
(n = 14) [22]
 ~65 ga
 Europe
 10.0 ± 5.5
 383 ± 304e
 6.0 ± 1.3
 -
Malaria patients
(n = 266) [7]
 Local standard food
 Thailand
 9.0
 561
 3.2
 -
Malaria patients
(n = 74) [13]
 23 gb
 Uganda
 5.6 ± 2.7
 -
 -
 460 ± 288
Malaria patients
(n = 17) [9]
 6.4 gc
 Thailand
 7.0
 410
 4.1
 350
Malaria patients
(n = 13) [6]
 7 gd
 Thailand
 7.34
 252f
 2.83
 384

aFDA breakfast = 2 eggs, 2 strips bacon, 1 slice of toast with butter, 2 hash potatoes, 240 mL full-fat milk; b10 g (300 mL milk) + 13 g (peanuts) or breast milk; c200 mL carton chocolate milk; d250 mL chocolate milk; eAUC62 h-last; fAUC60 h-∞

Djimdé and Lefèvre Malaria Journal 2009 8(Suppl 1):S4   doi:10.1186/1475-2875-8-S1-S4

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