Table 1 |
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|
Magnitude of Hb reduction, peak reticulocyte count and peak parasitaemia in the semi-immune mice strain on day minimum Hb was observed |
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|
Parameters |
Balb/c |
B6 |
NZW |
CBA |
P valuea |
|
|
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|
n |
11 |
11 |
8 |
12 |
- |
|
Mean Hb reduction (95% CI) |
47.11b (38.12–56.1) |
28.44 (22.82–34.1) |
30.05 (16.61–43.5) |
25.1 (13.97–36.2) |
0.037 |
|
Mean Parasitaemia, % (95% CI) |
0.64c (0.2–1.1) |
3.3 (1.6–4.9) |
7.5 (5.0–10.1) |
3.1 (0.98–6.25) |
< 0.0001 |
|
Mean Reticulocyte level, % (95% CI) |
12.45d (8.9–15.97) |
3.2 (1.9–4.4) |
2.0 (0.6–3.4) |
3.1 (1.4–4.8) |
0.0016 |
|
Mean of Reticulocyte level/Hb reduction |
0.24e |
0.11 |
0.07 |
0.12 |
0.003 |
|
Mean Period, day (95% CI) at which Hbm was observed |
13.64d (12.13–15.15) |
10.6 (9.95–11.33) |
10.86 (9.2–12.5) |
10.9 (10.3–11.5) |
0.014 |
|
|
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|
Hb reduction is the difference between %Hb on day prior to first cycle infection and treatment, and day on which Hbm was observed (blood harvested for serum). The data presented here are pooled results of two separate experiments. aOne-way ANOVA with Tukey's post-test. bSignificantly higher than CBA; Significantly c lower, dhigher than B6, NZW, CBA; eSignificantly higher than B6, NZW. Hbm, minimum Hb. |
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Helegbe et al. Malaria Journal 2009 8:91 doi:10.1186/1475-2875-8-91 |
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