Table 4

The difference in risk estimates derived by intention to treat (ITT), modified Intention to Treat (mITT), and per protocol (PP).

Africa

Thailand

Overall

ITT – mITT

Unadjusted

1.8% [-0.3–11.7]

IQR: 0.7–3.9

11.4% [2.1–31.8]^a

IQR: 8.1–15.8

4.7% [-0.3–31.8]

IQR: 1.6–10.6

Adjusted

3.5% [-13.7–14.4]

IQR: 0.9–6.0

12.3% [4.1–31.8]^a

IQR: 10.2–16.0

5.4% [-13.7–31.8]

IQR: 1.9–11.6

PP – mITT

Unadjusted

0.1% [0.0–2.1]

IQR: 0–0.23

1.9% [0.0–10.6]^a

IQR: 0.9–4.3

0.3% [0.0–10.6]

IQR: 0.1–1.9

Adjusted

3.2% [0.0–0.9]

IQR: 0.7–3.9

1.0% [0.0–6.9]^b

IQR: 0.3–1.8

1.7% [0.0–30.9]

IQR: 0.5–5.6

Values represent Median [Range], and InterQuartile Range (IQR)

Comparison between Africa and Thailand: ^a p < 0.001; ^b p = 0.033

Verret et al. Malaria Journal 2009 8:77   doi:10.1186/1475-2875-8-77