A systematic classification of Plasmodium falciparum P-loop NTPases: structural and functional correlation

doi:10.1186/1475-2875-8-69

Malaria Journal

Volume 8

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Kalita MK
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Mohmmed A

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A systematic classification of Plasmodium falciparum P-loop NTPases: structural and functional correlation

Deepti Gangwar¹^* , Mridul K Kalita²^* , Dinesh Gupta² , Virander S Chauhan¹ and Asif Mohmmed¹

¹Malaria Group, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi-110067, India

²Structure & Computational Biology Group, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi-110067, India

author email corresponding author email* Contributed equally

Malaria Journal 2009, 8:69doi:10.1186/1475-2875-8-69


Published:	18 April 2009

Additional files

Additional file 1:

A brief description of different clades of P-loop NTPases showing number of proteins in each class, respective protein ID, full sequence length and the P-loop NTPase region under study. Additional table.

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Additional file 2:

Table showing repertoire of P-loop NTPases of P. falciparum and their sequence characteristics. Expression profiles of each protein across the parasitic life cycle based on the transcriptome data as well as their annotation at PlasmoDB are also given. The hypothetical proteins which are assigned functional roles in this study are boxed and highlighted in bold. Proteins orthologous to prokaryotes are marked with ± and those orthologous to Arabidopsis thaliana are marked with *. SS, Signal Sequence; TM, trans-membrane region; S, sporozoite; ER, early ring; LR, late ring; ET, early trophozoite; ES, early schizont; LS, late schizont; and M, merozoites.

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Additional file 3:

Evolutionary classification of P. falciparum ClpA/B proteins with seed ClpA/B proteins extracted from Pfam (Pfam domain id- PF10431). Additional figure.

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