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The efficacy and safety of a new fixed-dose combination of amodiaquine and artesunate in young African children with acute uncomplicated Plasmodium falciparum

Sodiomon B Sirima*, Alfred B Tiono, Adama Gansané, Amidou Diarra, Amidou Ouédraogo, Amadou T Konaté, Jean R Kiechel, Caroline C Morgan, Piero L Olliaro and Walter RJ Taylor

Malaria Journal 2009, 8:48 doi:10.1186/1475-2875-8-48

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BioMed Central: 4 citations

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Comparing changes in haematologic parameters occurring in patients included in randomized controlled trials of artesunate-amodiaquine vs single and combination treatments of uncomplicated falciparum in sub-Saharan Africa

Julien Zwang, Jean-Louis Ndiaye, Abdoulaye Djimde, Grant Dorsey, Andreas Martensson, Corine Karema, Piero Olliaro Malaria Journal 2012, 11:25 (25 January 2012)

Abstract | Provisional PDF | PubMed | Editor’s summary

Effect of different antimalarial treatments on haematologic parameters comparing artesunate-amodiaquine against various single treatment lines and combination therapies.

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Repeated treatment of recurrent uncomplicated Plasmodium falciparum malaria in Senegal with fixed-dose artesunate plus amodiaquine versus fixed-dose artemether plus lumefantrine: a randomized, open-label trial

Jean-Louis A Ndiaye, Babacar Faye, Ali Gueye, Roger Tine, Daouda Ndiaye, Corinne Tchania, Ibrahima Ndiaye, Aichatou Barry, Badara Cissé, Valérie Lameyre, Oumar Gaye Malaria Journal 2011, 10:237 (12 August 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | Editor’s summary

The paper tackles an important topic as there is a need for continuous evaluation of the safety and efficacy of ACT in malaria endemic areas.

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Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis

Julien Zwang, Piero Olliaro, Hubert Barennes, Maryline Bonnet, Philippe Brasseur, Hasifa Bukirwa, Sandra Cohuet, Umberto D'Alessandro, Abdulaye Djimdé, Corine Karema, Jean-Paul Guthmann, Sally Hamour, Jean-Louis Ndiaye, Andreas Mårtensson, Claude Rwagacondo, Issaka Sagara, Albert Same-Ekobo, Sodiomon B Sirima, Ingrid van den Broek, Adoke Yeka, Walter RJ Taylor, Grant Dorsey, Milijaona Randrianarivelojosia Malaria Journal 2009, 8:203 (23 August 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | Editor’s summary

This multi-center analysis study addresses efficacy of artesunate-amodiaquine, a very important candidate for the treatment of uncomplicated malaria globally. The analysis of patient-level data examining the efficacy of AS&AQ compared to local standard therapy, makes a strong case for the use of AS&AQ in all transmission settings.

Research   Open Access Highly Accessed

Population pharmacokinetics of artesunate and amodiaquine in African children

Kasia Stepniewska, Walter Taylor, Sodiomon B Sirima, Esperance B Ouedraogo, Alphonse Ouedraogo, Adama Gansané, Julie A Simpson, Caroline C Morgan, Nicholas J White, Jean-René Kiechel Malaria Journal 2009, 8:200 (20 August 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | Editor’s summary

A well-designed study, with a robust methodology showing the complexities of population pharmacokinetic modelling, which has important operational implications

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