Table 5

Logistic regression analysis of FcγRIIa-H/R131 genotypes in relation to anti-malarial IgG subclasses in Fulani compared with non-Fulani groups

Anti-malarial antibodies

FcγRIIa-H/R131 genotypes

OR^† (95% CI)

p value

AMA-1

IgG1

H/H

0.04 (0.02–0.12)

< 0.001

H/R

1

R/R

0.86 (0.42–1.78)

0.69

IgG2

H/H

0.70 (0.35–1.37)

0.30

H/R

1

R/R

0.61 (0.34–1.11)

0.10

IgG3

H/H

0.31 (0.17–0.57)

< 0.001

H/R

1

R/R

0.69 (0.34–1.38)

0.30

IgG4

H/H

0.59 (0.30–1.15)

0.12

H/R

1

R/R

0.90 (0.41–1.95)

0.78

3D7-MSP2

IgG1

H/H

0.10 (0.03–0.20)

< 0.001

H/R

1

R/R

0.86 (0.41–1.80)

0.69

IgG2

H/H

2.43 (1.32–4.47)

< 0.001

H/R

1

R/R

0.83 (0.41–1.69)

0.61

IgG3

H/H

0.49 (0.26–0.91)

0.03

H/R

1

R/R

0.81 (0.40–1.63)

0.55

IgG4

H/H

2.76 (1.45–5.26)

< 0.001

H/R

1

R/R

0.59 (0.28–1.25)

0.17

FC27-MSP2

IgG1

H/H

0.53 (0.28–1.01)

0.10

H/R

1

R/R

0.86 (0.42–1.78)

0.68

IgG2

H/H

0.45 (0.24–0.85)

0.01

H/R

1

R/R

0.70 (0.35–1.37)

0.30

IgG3

H/H

0.13 (0.10–0.26)

0.01

H/R

1

R/R

0.76 (0.37–1.57)

0.46

IgG4

H/H

0.70 (0.36–1.39)

0.31

H/R

1

R/R

0.97 (0.54–1.74)

0.92

Pf332-C231

IgG1

H/H

1.25 (0.67–2.30)

0.48

H/R

1

R/R

0.72 (0.36–1.44)

0.36

IgG2

H/H

0.22 (0.11–0.44)

< 0.001

H/R

1

R/R

0.69 (0.34–1.38)

0.29

IgG3

H/H

4.25 (2.28–7.91)

< 0.001

H/R

1

R/R

0.91 (0.45–1.84)

0.80

IgG4

H/H

0.10 (0.03–0.20)

< 0.001

H/R

1

R/R

0.69 (0.26–1.42)

0.25

Nasr et al. Malaria Journal 2009 8:43   doi:10.1186/1475-2875-8-43