Field-based evidence of fast and global increase of Plasmodium falciparum drug-resistance by DNA-microarrays and PCR/RFLP in Niger
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* Corresponding author: Maman L Ibrahim lamine@cermes.org
Malaria Journal 2009, 8:32 doi:10.1186/1475-2875-8-32
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BioMed Central: 3 citations
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Methodology
Jennifer A Flegg, Philippe J Guerin, Nicholas J White, Kasia Stepniewska Malaria Journal 2011, 10:339 (10 November 2011) The paper presents a new tool to estimate the parasite clearance rate of Plasmodium falciparum in subjects under treatment with an artemisinin-based combination.
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Research
Eva Hodel, Serej D Ley, Weihong Qi, Frédéric Ariey, Blaise Genton, Hans-Peter Beck Malaria Journal 2009, 8:285 (9 December 2009) As part of a search for new pharmacogenetics markers for drug resistance, this microarray methodology appears not robust enough as it stands, but it is a step in the right direction
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Methodology
Nicolas Steenkeste, Marie-Agnès Dillies, Nimol Khim, Odile Sismeiro, Sophy Chy, Pharath Lim, Andreas Crameri, Christiane Bouchier, Odile Mercereau-Puijalon, Hans-Peter Beck, Mallika Imwong, Arjen M Dondorp, Duong Socheat, Christophe Rogier, Jean-Yves Coppée, Frédéric Ariey Malaria Journal 2009, 8:229 (15 October 2009) This paper describes a new microarray system to detect mutations associated with resistance to anti-malarials. Such microarrays could be employed to monitor P. falciparum drug resistance markers with greater cost effectiveness and the possibility for high throughput analysis.
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