Table 2 |
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|
A summary of the results obtained from the final model and the bootstrap analysis. |
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|
Parameter |
Estimate |
%RSE |
Bootstrap estimate (95% CI) |
|
|
|||
|
CL/F (L/h) |
1190 |
4.20 |
1176 (1060 -- 1280) |
|
V2/F (L) |
1210 |
5.77 |
1199 (1020 -- 1370) |
|
Ka (h-1) |
3.85 |
3.61 |
4.16 (2.66 -- 6.67) |
|
CLM/F (L/h) |
93.7 |
3.30 |
92.6 (86.5 -- 99.1) |
|
V3/F (L) |
97.1 |
4.85 |
96.5 (86.7 -- 107) |
|
Q/F (L/h) |
5.74 |
12.8 |
5.69 (3.72 -- 7.53) |
|
V4/F (L) |
18.5 |
10.6 |
18.7 (14.1 -- 23.2) |
|
θFOOD-Ka |
-0.84 |
2.32 |
-0.836 (-0.915 -- -0.733) |
|
θWT-CLM/F |
1.90 |
16.3 |
1.78 (0.993 -- 2.58) |
|
IIV (Variances and % CV) |
|||
|
IIV-CL/F |
0.131 (36.2) |
17.8 |
0.130 (0.0824 -- 0.176) |
|
IIV-V2/F |
0.330 (57.4) |
20.9 |
0.347 (0.201 -- 0.497) |
|
IIV-Ka |
1.26 (112) |
15.4 |
1.32 (0.751 -- 2.00) |
|
IIV-CLM/F |
0.0786 (28.0) |
22.5 |
0.0740 (0.0411 -- 0.118) |
|
IIV-V3/F |
0.0901 (30.0) |
36.0 |
0.0776 (0.0001 -- 0.151) |
|
RV (%CV) |
|||
|
AS |
37.5 |
9.73 |
37.5 (31.0 -- 45.2) |
|
DHA |
28.2 |
11.2 |
27.7 (21.6 -- 34.8) |
|
|
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|
RSE, relative standard error; CL/F, apparent clearance for AS; F, unknown bioavailability; V2/F, apparent volume of distribution of the central compartment for AS; Ka, absorption rate constant for AS, CLM/F, apparent clearance for DHA from the central compartment; V3/F, apparent central volume of distribution for DHA; Q/F, inter-compartmental clearance for DHA; V4/F, apparent peripheral volume of distribution for DHA; θFOOD-Ka, parameter for the covariate food intake on Ka; θWT-CLM/F, parameter for the covariate weight on CLM/F; CV, coefficient of variation; IIV, inter-individual variability; RV, residual variability; AS, artesunate; DHA, dihydroartemisinin. |
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|
Tan et al. Malaria Journal 2009 8:304 doi:10.1186/1475-2875-8-304 |
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