Table 2

Optimal biomarker cut-off values for receiver operating characteristic curve sensitivity, specificity, positive likelihood ratio (LR(+)) and negative likelihood ratio (LR(-)) at the chosen cutoffs.

Cut-off

Sensitivity

Specificity

LR(+)

LR(-)

Angiopoietin-2

ng/mL

#

(95% CI)

#

(95% CI)

#

(95% CI)

#

(95% CI)

UM vs. SM

1.43

0.694

(0.531-0.820)

0.786

(0.676-0.866)

3.241

(1.969-5.333)

0.389

(0.234-0.646)

UM vs. CM

1.33

0.759

(0.659-0.836)

0.771

(0.661-0.854)

3.319

(2.124-5.186)

0.313

(0.211-0.464)

UM vs. (CM+SM)

1.33

0.740

(0.656-0.809)

0.771

(0.661-0.854)

3.237

(2.078-5.041)

0.337

(0.244-0.466)

SM vs. CM

3.14

0.472

(0.319-0.630)

0.644

(0.539-0.736)

1.325

(0.848-2.070)

0.820

(0.580-1.159)

Angiopoietin-1

ng/mL

#

(95% CI)

#

(95% CI)

#

(95% CI)

#

(95% CI)

UM vs. SM

12.38

0.861

(0.713-0.939)

0.852

(0.757-0.921)

6.028 (3.346- 10.859)

0.162

(0.071-0.368)

UM vs. CM

15.86

0.713

(0.610-0.797)

0.743

(0.630-0.831)

2.771

(1.821-4.218)

0.387

(0.270-0.554)

UM vs. (CM+SM)

15.16

0.707

(0.622-0.781)

0.771

(0.661-0.854)

3.094

(1.983-4.830)

0.379

(0.280-0.514)

SM vs. CM

11.21

0.722

(0.560-0.842)

0.655

(0.551-0.747)

2.094

(1.471-2.982)

0.424

(0.245-0.734)

Ratio

#

(95% CI)

#

(95% CI)

#

(95% CI)

#

(95% CI)

UM vs. SM

0.082

0.806

(0.650-0.903)

0.829

(0.724-0.899)

4.699

(2.74-8.059)

0.235

(0.120-0.460)

UM vs. CM

0.080

0.782

(0.684-0.856)

0.829

(0.724-0.899)

4.559

(2.692-7.722)

0.264

(0.175-0.398)

UM vs. (CM+SM)

0.080

0.789

(0.708-0.852)

0.829

(0.723-0.899)

4.600

(2.727-7.762)

0.255

(0.178-0.365)

SM vs. CM

0.448

0.444

(0.295-0.604)

0.828

(0.735-0.893)

2.578

(1.432-4.639)

0.671

(0.494-0.913)

Conroy et al. Malaria Journal 2009 8:295   doi:10.1186/1475-2875-8-295