Polymorphism of PfATPase in Niger: detection of three new point mutations
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* Corresponding author: Maman L Ibrahim lamine@cermes.ne
Malaria Journal 2009, 8:28 doi:10.1186/1475-2875-8-28
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BioMed Central: 4 citations
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Research article
Protein-based signatures of functional evolution in Plasmodium falciparum Kate B Gardner, Ipsita Sinha, Leyla Y Bustamante, Nicholas PJ Day, Nicholas J White, Charles J Woodrow BMC Evolutionary Biology 2011, 11:257 (14 September 2011) |
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Research
Bethel Kwansa-Bentum, Irene Ayi, Takashi Suzuki, Joseph Otchere, Takashi Kumagai, William K Anyan, Joseph HN Osei, Hiroko Asahi, Michael F Ofori, Nobuaki Akao, Michael D Wilson, Daniel A Boakye, Nobuo Ohta Malaria Journal 2011, 10:187 (11 July 2011) In this article, the authors sought to identify the different polymorphisms found in the pfATPase6 gene which is the major gene so far implicated in decreased susceptibility to artemisinin derivatives. They present some interesting data on Plasmodium isolates from Ghana. Very few data are already published from this area.
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Research
Bianca E Gama, Natália de Oliveira, José M de Souza, Fátima Santos, Leonardo JM de Carvalho, Yonne FC Melo, Philip J Rosenthal, Cláudio T Daniel-Ribeiro, Maria Ferreira-da-Cruz Malaria Journal 2010, 9:355 (8 December 2010) Data from a genotyping trial targeting specific genetic polymorphisms in the pfmdr1 and pfatpase6 genes among 119 Plasmodium falciparum samples from Brazil. Even if these markers are only coincidental to artemisinin resistance, the study provides a baseline snapshot of the circulating genotypes, before introducing the drug.
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Research
Maman Ibrahim, Nicolas Steenkeste, Nimol Khim, Hadiza Adam, Lassana Konaté, Jean-Yves Coppée, Fredéric Ariey, Jean-Bernard Duchemin Malaria Journal 2009, 8:32 (23 February 2009) The paper describes a study of the polymorphisms of Plasmodium falciparum genes linked to the anti-malarial drug resistance in isolates from two villages located in Niger. The study has been performed using two methods, the PCR-RFLP (for two markers only, pfcrt K76T and dhfr S108N) and the micro-array technique for a series of genetic markers, pfcrtk76t and dhfrs108n included.
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