Table 1

Clinical Laboratory findings

Haematology and biochemistry tests

Reference range

Screening

Admission

Adm +1

Adm +2

Adm +3

Adm +4 = Discharge

Haemoglobin (mmol/l)

7.3 - 9.7

7.1

6.9

7.1

6.9

Leukocytes (*10⁹/l)

3.5 - 11.0

6.6

7.9

3.9

5.4

Platelets (*10⁹/l)

120 - 350

259

160

254

302

Glucose (mmol/l)

4.0 - 5.5 (fasting)

4.6

4.9

Sodium (mmol/l)

137 - 144

142

140

137

Potassium (mmol/l)

3.4 - 4.6

4.1

3.9

3.9

Creatinin (umol/l)

45 - 90

61

55

60

Urea nitrogen (mmol/l)

3.0 - 7.0

4.9

3.2

Bilirubin (umol/l)

≤ 17

<10

<10

Alkaline phosphatase (U/l)

≤ 120

55

74

66

69

69

Aspartate aminotransferase (U/l)

≤ 40

16

132

104

111

89

83

Alanine aminotransferase (U/l)

≤ 45

15

137

134

171

166

164

Lactate dehydrogenase (U/l)

≤ 450

313

540

534

562

384

gamma GT (U/l)

≤ 35

13

29

39

36

35

Creatinin Kinase (U/l)

≤ 170

296

105

28

Troponin I (ug/l)

≤ 0.20

10.40

2.75

0.20

CRP (mg/l)

≤ 10

26

Cholesterol (mmol/l)

4.7 - 6.5

4.0

Triglycerides (mmol/l)

0.8 - 2.0

1.5

HDL cholesterol (mmol/l)

1.10 - 1.70

1.20

LDL cholesterol (mmol/l)

≤ 3.5

2.12

Coagulation assays

INR

0.9-1.1

1.0

1.0

Fibrinogen (mg/l)

2000-4000

4320

Factor VIII activity (%)

60-150

130%

Protein C activity (%)

70-150

>100%

Free protein S antigen (%)

55-115

92%

Homocystein (μmol/l)

< 13.4

9.3

Antithrombin III (%)

85-120

98%

Factor II mutation

negative

negative

Factor V (Leiden) mutation

negative

negative

von Willebrand Factor (%)

50-150

166%

ADAMTS13 activity (%)

60-140

90%

Additional tests

Convalescent microbiological tests

adenovirus, RS-virus, influenza virus, mycoplasma pneumonia, Chlamydia, Q-fever, para-influenza, enterovirus

Negative

Auto-immune antibodies

ANCA, anticardiolipin antibodies, β2 glycoprotein, lupus anticoagulans, anti-heart (rat) antibodies

Negative

Toxicology test

tetrahydrocannabinol, amphetamine-derivatives, cocaine, diazepam, methadone, tramadol, opiates

Negative

Inflammatory parameters

Interleukin 6, Interleukin 8

< detection limit

Time after last dose

7 h15

103 h45

Artemether

< detection limit

< detection limit

Dihydroartemisinin

26.5 ng/ml

< detection limit

Lumefantrine

4308 ng/ml and

443 ng/ml

Desbutyl-lumefantrine

40 ng/ml

18 ng/ml

Nieman et al. Malaria Journal 2009 8:277   doi:10.1186/1475-2875-8-277