Assessment of the prozone effect in malaria rapid diagnostic tests
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* Corresponding author: Philippe Gillet pgillet@itg.be
Malaria Journal 2009, 8:271 doi:10.1186/1475-2875-8-271
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Research
Tom van Gool, Marlies E van Wolfswinkel, Rob Koelewijn, Pieter PAM van Thiel, Jan Jacobs, Jaap J van Hellemond, Perry JJ van Genderen Malaria Journal 2011, 10:300 (14 October 2011) Assessment of HRP-2 and aldolase co-reactivity can be of help in clinical decision making in the acute care setting of returning travellers suspected of having malaria.
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Jennifer Luchavez, Joanne Baker, Sheila Alcantara, Vicente Belizario, Qin Cheng, James S McCarthy, David Bell Malaria Journal 2011, 10:286 (29 September 2011) These results suggest that false-negative malaria RDT results will rarely occur due to a prozone-like effect in high-density infections, and other causes are more likely. RDT line intensity is poorly indicative of parasite density in high-density infections and RDTs should, therefore, not be considered quantitative.
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Prozone in malaria rapid diagnostics tests: how many cases are missed? Philippe Gillet, Annelies Scheirlinck, Jocelijn Stokx, Anja De Weggheleire, Hélder S Chaúque, Oreana DJV Canhanga, Benvindo T Tadeu, Carla DD Mosse, Armindo Tiago, Samuel Mabunda, Cathrien Bruggeman, Emmanuel Bottieau, Jan Jacobs Malaria Journal 2011, 10:166 (15 June 2011) A study testing whether the prozone effect has a significant effect on the performance of malaria RDTs in "in the real world". The authors report that four of the six RDTs used in the study with fresh samples showed only a "weak" prozone effect in a minority of the samples, predominantly those with high parasitemia. Two kits produced worrisome prozone effects.
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External quality assessment on the use of malaria rapid diagnostic tests in a non-endemic setting Philippe Gillet, Pierre Mukadi, Kris Vernelen, Marjan Van Esbroeck, Jean-Jacques Muyembe, Cathrien Bruggeman, Jan Jacobs Malaria Journal 2010, 9:359 (13 December 2010) A study reporting on the results of an external quality assessment session on RDTs in a non-endemic setting.
A total of 128/133 (96.2%) of clinical laboratories using RDTs participated. Six three-band and one four-band RDT brands were used. Errors in RDT performance were mainly related to RDT test line interpretations, partly due to incorrect package insert instructions.
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Research
Jessica Maltha, Philippe Gillet, Lieselotte Cnops, Jef van den Ende, Marjan van Esbroeck, Jan Jacobs Malaria Journal 2010, 9:198 (10 July 2010) In this study, six out of nine P. vivax-specific RDTs showed false positive Pv-pLDH lines when challenged to a panel of 85 P. falciparum samples with high (≥2%) parasite densities.
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