Table 4 |
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|
Summary of neuropathological features in the brainstem of fatal severe malaria cases |
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|
Neuropathological feature |
|||||||||
|
Haemorrhages (% severe cases, n = 20) |
Astrogliosis (% severe cases, n = 19) |
Swollen Axons (% severe cases, n = 20) |
Chromatolysis (% severe cases, n = 20) |
||||||
|
Grade |
NCM |
CM |
NCM |
CM |
NCM |
CM |
No. centres effected* |
NCM |
CM |
|
0 |
40 |
20 |
15.8 |
26.3 |
20 |
10 |
1 |
25 |
10 |
|
1 |
0 |
10 |
36.8 |
15.8 |
15 |
10 |
2 |
10 |
10 |
|
2 |
0 |
15 |
0 |
5.3 |
15 |
30 |
3 |
15 |
25 |
|
3 |
10 |
5 |
0 |
0 |
0 |
0 |
4 |
0 |
5 |
|
|
|||||||||
|
* All cases had at least 1 centre with chromatolytic neurons. Brainstem centres included: oculomotor, motor Vth, VIIth, vestibular, reticular formation and raphe, lateral cuneate, deep pontine and Xth [25]. |
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|
Medana et al. Malaria Journal 2009 8:261 doi:10.1186/1475-2875-8-261 |
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