Research
Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance
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* Corresponding author: Nicholas J White nickw@tropmedres.ac
1 Mahidol - Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand
2 Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
3 Instituto Gulbenkian de Ciência, Oeiras, Portugal
Malaria Journal 2009, 8:253 doi:10.1186/1475-2875-8-253
Published: 11 November 2009Additional files
Additional file 1:
Antimalarial drug resistance emergence probabilities. An examination of the probabilities of resistance emergence in relation to parasite multiplication rates of resistant and sensitive parasites and total parasite burdens.
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Additional file 2:
Pharmacokinetics and pharmacodynamics. An examination of the relationship between the pharmacokinetic properties of the antimalarial drugs, their blood stage pharmacodynamic properties, and the anti-malarial drug resistance selection opportunities and probabilities.
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