Malaria Journal

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Plasmodium falciparum exposure in utero, maternal age and parity influence the innate activation of foetal antigen presenting cells

Nadine Fievet1,2, Stefania Varani3,4, Samad Ibitokou1, Valérie Briand2, Stéphanie Louis6, René X Perrin5, Achille Massougbogji5, Anne Hosmalin7,6, Marita Troye-Blomberg3 and Philippe Deloron2*

Author Affiliations

1 UR010, Mother and Child Health in the Tropics, Institut de Recherche pour le Développement (IRD), Cotonou, Benin

2 UR010, IRD, IFR 71 Université René Descartes, 75006 Paris, France

3 Department of Immunology, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden

4 Department of Hematology and Oncology, "L. and A. Seragnoli" University of Bologna, Bologna, Italy

5 Faculté des Science de la Santé, Cotonou, Benin

6 Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France

7 Inserm, U567, Paris, France

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Malaria Journal 2009, 8:251 doi:10.1186/1475-2875-8-251

Published: 5 November 2009

Additional files

Additional file 1:

Presence of P. falciparum parasite in maternal and/or placental blood at delivery does not influence the activation status of cord blood DC and monocytes. The expression levels of HLA-DR and CD86 were measured by flow cytometry on foetal APC from 27 P. falciparum-positive (diagonal striped bars) and 28 P. falciparum-negative mothers (white bars).

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