Table 4 |
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|
Evaluation of in vitro inhibition of sporozoite invasion (ISI) by rabbit antibodies against different regions of MB2 |
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|
IgG |
SPOROZOITES/WELL |
MEAN ± SDa |
% INHIBITIONb |
|
|
|||
|
MB2-B |
|||
|
PRE-IMMUNE |
522, 514, 593 |
543 ± 35 |
0 |
|
MB2-B |
205, 251, 238 |
231 ± 19 |
57% |
|
MB2-Cc |
|||
|
PRE-IMMUNE |
216, 312, 240 |
256 ± 40 |
0 |
|
MB2-C |
252, 177, 198 |
209 ± 31 |
18% |
|
MB2-FAc |
|||
|
PRE-IMMUNE |
472, 485, 438 |
465 ± 20 |
0 |
|
MB2-FA |
263, 354, 306 |
307 ± 37 |
33% |
|
mAb NFS1 |
11, 9, 6 |
8 ± 2 |
97% |
|
MEMdControl |
280, 350, 325 |
318 ± 29 |
0 |
|
|
|||
|
a SD, standard deviation b Inhibition expressed as % relative to pre-immune control culture (0%), and it was calculated as follows: 100 × [1 - (mean number of invaded sporozoites in test culture/mean number of invaded sporozoites in control culture)]. Pre-immune antibodies used as negative control. c These peptides contain amino acid repeat motifs. dMEM Minimal essential medium. |
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|
Nguyen et al. Malaria Journal 2009 8:235 doi:10.1186/1475-2875-8-235 |
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