Malaria Journal

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Population pharmacokinetics of artesunate and amodiaquine in African children

Kasia Stepniewska*, Walter Taylor, Sodiomon B Sirima, Esperance B Ouedraogo, Alphonse Ouedraogo, Adama Gansané, Julie A Simpson, Caroline C Morgan, Nicholas J White and Jean-René Kiechel

Malaria Journal 2009, 8:200 doi:10.1186/1475-2875-8-200

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Review   Open Access Highly Accessed

Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration

Carrie A Morris, Stephan Duparc, Isabelle Borghini-Fuhrer, Donald Jung, Chang-Sik Shin, Lawrence Fleckenstein Malaria Journal 2011, 10:263 (13 September 2011)

Abstract | Full text | PDF | PubMed | Editor’s summary

This paper gives a detailed review of the pharmacokinetic properties of artesunate, and its active metabolite dihydroartemisinin, following all routes of administration.

Methodology   Open Access Highly Accessed

Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria

Kris M Jamsen, Stephen B Duffull, Joel Tarning, Niklas Lindegardh, Nicholas J White, Julie A Simpson Malaria Journal 2011, 10:181 (1 July 2011)

Abstract | Full text | PDF | PubMed | Editor’s summary

This article presents a novel and successful attempt to rationalize the sampling schedules for PK studies of anti-malarials given unavoidable practical constraints. It provides a practical guide to those designing population PK studies specifically of oral artesunate, and a "proof of principle" for applying optimal design methodology for anti-malarials in general.

Research   Open Access

Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects

Beesan Tan, Himanshu Naik, In-Jin Jang, Kyung-Sang Yu, Lee E Kirsch, Chang-Sik Shin, J Craft, Lawrence Fleckenstein Malaria Journal 2009, 8:304 (18 December 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | Editor’s summary

Using pooled data from four phase I clinical studies (healthy subjects), this paper determines the population pharmacokinetics of artesunate and dihydroartemisinin using a parent-metabolite model and simultaneously modelling the drug concentrations of artesunate and DHA.

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