Figure 1.

Frequency distribution of the combination pvdhfr/pvdhps haplotypes obtained from 189 isolates collected in Ardebil province in north and Sistan and Baluchistan province in southeastern of Iran. The haplotype I₁₃P₃₃F₅₇S₅₈T₆₁S₁₁₇I₁₇₃/A₃₈₃A₅₅₃ was the most prevalent among northern (84.8%) and southern (59.4%) P. vivax isolates. All six haplotypes are indicated as A to F in the figure. Mutated amino acids are boldfaced. A) I₁₃P₃₃F₅₇S₅₈T₆₁S₁₁₇I₁₇₃/A₃₈₃A₅₅₃. B) I₁₃P₃₃F₅₇S₅₈T₆₁N₁₁₇I₁₇₃/A₃₈₃A₅₅₃. C) I₁₃P₃₃F₅₇R₅₈T₆₁S₁₁₇I₁₇₃/A₃₈₃A₅₅₃. D) I₁₃P₃₃F₅₇R₅₈T₆₁N₁₁₇I₁₇₃/A₃₈₃A₅₅₃. E) I₁₃P₃₃L₅₇S₅₈T₆₁S₁₁₇I₁₇₃/A₃₈₃A₅₅₃. F) I₁₃P₃₃L₅₇R₅₈T₆₁S₁₁₇I₁₇₃/A₃₈₃A₅₅₃.