Table 2 |
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|
Laboratory monitoring of biological events of ANQ and CQ+SP treatments |
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|
Laboratory parameters |
Treatments |
D0 |
D3 |
D7 |
D14 |
21 |
28 |
|
|
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|
Biochemistry |
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|
Glucose mm/L |
ANQ |
4.9 ± 0.9 |
5.5 ± 1.5 |
4.8 ± 0.8 |
4.5 ± 0.8 |
4.5 ± 0.5 |
5.0 ± 1.6 |
|
CQ+SP |
5.0 ± 1.0 |
5.5 ± 1.5 |
4.9 ± 0.8 |
4.5 ± 0.8 |
4.6 ± 0.5 |
5.2 ± 1.6 |
|
|
|
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|
Liver function |
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|
*AST Units/L |
ANQ |
43.2 ± 16.4 |
43.7 ± 22.6 |
41.6 ± 32.1 |
35.7 ± 17.9 |
31.0 ± 10.4 |
33.4 ± 10.2 |
|
CQ+SP |
44.2 ± 16.4 |
43.2 ± 16.4 |
42.2 ± 32.1 |
35.2 ± 17.9 |
31.0 ± 10.4 |
35.4 ± 10.2 |
|
|
|
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|
**ALT Units/L |
ANQ |
44.1 ± 20.9 |
47.9 ± 24.9 |
53.0 ± 49.2 |
57.3 ± 33.7 |
36.4 ± 14.8 |
36.3 ± 21.4 |
|
CQ+SP |
46.1 ± 20.9 |
47.9 ± 24.9 |
54.0 ± 49.2 |
57.3 ± 34.0 |
36.4 ± 14.9 |
35.3 ± 21.4 |
|
|
|
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|
Bilirubin μm/L |
ANQ |
19.4 ± 14.3 |
12.1 ± 8.8 |
10.7 ± 5.0 |
8.3 ± 1.5 |
8.8 ± 1.3 |
8.8 ± 1.9 |
|
CQ+SP |
18.4 ± 14.3 |
12.1 ± 8.8 |
10.6 ± 5.0 |
8.3 ± 1.5 |
8.0 ± 1.3 |
8.8 ± 2.0 |
|
|
|
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|
Alkaline phosphatase Units/L |
ANQ |
75.9 ± 18.6 |
81.8 ± 24.7 |
87.5 ± 27.5 |
91.3 ± 29.5 |
80.5 ± 24.3 |
95.1 ± 38.1 |
|
CQ+SP |
76.4 ± 20.2 |
83.4 ± 23.1 |
86.1 ± 25.2 |
91.8 ± 28.4 |
77.6 ± 21.5 |
84.0 ± 39.0 |
|
|
|
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|
#GGT Units/L |
ANQ |
39.5 ± 22.7 |
40.3 ± 24.8 |
34.7 ± 22.3 |
29.5 ± 13.5 |
16.8 ± 11.9 |
22.5 ± 7.4 |
|
CQ+SP |
40.5 ± 22.7 |
40.3 ± 24.8 |
34.7 ± 22.3 |
29.5 ± 13.5 |
16.3 ± 12.9 |
22.5 ± 7.5 |
|
|
|
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|
Renal function |
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|
Creatinine μm/L |
ANQ |
92.7 ± 19.4 |
91.8 ± 14.2 |
91.9 ± 18.1 |
87.9 ± 13.7 |
85.9 ± 10.9 |
79.3 ± 17.5 |
|
CQ+SP |
93.3 ± 19.3 |
92.8 ± 14.4 |
93.5 ± 19.1 |
88.9 ± 14.0 |
85.3 ± 11.5 |
80.4 ± 18.4 |
|
|
|
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|
Haematology |
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|
Haemoglobin g/dl |
ANQ |
10.8 ± 2.3 |
10.6 ± 1.8 |
10.4 ± 1.2 |
10.7 ± 1.0 |
11.1 ± 1.7 |
11.6 ± 1.4 |
|
CQ+SP |
11.0 ± 2.3 |
10.7 ± 1.9 |
10.5 ± 1.3 |
11.0 ± 0.9 |
11.1 ± 1.6 |
11.6 ± 1.5 |
|
|
|
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|
WBC ×109/L |
ANQ |
5.2 ± 2.4 |
5.4 ± 1.7 |
5.5 ± 1.7 |
6.5 ± 2.5 |
6.6 ± 1.6 |
6.1 ± 1.7 |
|
CQ+SP |
5.4 ± 2.3 |
5.4 ± 1.6 |
5.8 ± 1.6 |
6.5 ± 2.3 |
6.6 ± 1.7 |
6.2 ± 1.8 |
|
|
|
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|
Electrolytes |
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|
Sodium mm/L |
ANQ |
134.9 ± 5.6 |
138.2 ± 3.4 |
135.6 ± 7.6 |
137.2 ± 2.6 |
136.5 ± 3.1 |
139.6 ± 5.4 |
|
CQ+SP |
135.9 ± 5.5 |
138.3 ± 3.3 |
136.1 ± 7.1 |
137.2 ± 2.4 |
136.4 ± 2.9 |
140.0 ± 5.5 |
|
|
|
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|
Potassium mm/L |
ANQ |
3.8 ± 0.7 |
4.1 ± 1.1 |
4.2 ± 0.8 |
4.1 ± 0.7 |
3.9 ± 0.3 |
4.0 ± 0.7 |
|
CQ+SP |
3.8 ± 0.7 |
4.1 ± 0.7 |
4.2 ± 0.7 |
4.0 ± 0.7 |
4.0 ± 0.7 |
4.1 ± 1.0 |
|
|
|
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|
*AST = Aspartate aminotransferase ** ALT = Alanine aminotransferase #GGT = Gamma-glutamyltransferase |
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|
Hombhanje et al. Malaria Journal 2009 8:196 doi:10.1186/1475-2875-8-196 |
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