Table 2 |
|||||
|
Select Gene Expression Changes Mediated by 15-HETEa |
|||||
|
Gene Symbol |
Fold Change |
Probe ID |
Description |
Entrez ID |
Ref |
|
|
|||||
|
Electron Transport [21] |
|||||
|
Cyp3a11 |
3.6 |
516253 |
Cytochrome P450, family 3, subfamily a, polypeptide 11 |
13112 |
|
|
Smox |
5.1 |
560410 |
Spermine oxidase |
228608 |
|
|
Ugdh |
1.9 |
500013 |
UDP-glucose dehydrogenase |
22235 |
|
|
Regulation of Transcription, DNA-Dependent [21] |
|||||
|
Bclaf1 |
-1.9 |
549609 |
BCL2-associated transcription factor 1 |
72567 |
|
|
Cdk9 |
2.1 |
392872 |
Cyclin-dependent kinase 9 (CDC2-related kinase) |
107951 |
|
|
Creg1 |
1.9 |
760346 |
Cellular repressor of E1A-stimulated genes 1 |
433375 |
|
|
Egr1 |
-4.7 |
524988 |
Early growth response 1 |
13653 |
|
|
Fbxl11 |
-2.9 |
464056 |
F-box and leucine-rich repeat protein 11 |
225876 |
|
|
Fli1 |
2.3 |
407869 |
Friend leukemia integration 1 |
14247 |
|
|
Fliih |
4.6 |
706377 |
Flightless I homologue (Drosophila) |
14248 |
|
|
Hlx1 |
2.1 |
915372 |
H2.0-like homeo box 1 (Drosophila) |
15284 |
|
|
Mxd1 |
2.1 |
520449 |
MAX dimerization protein 1 |
17119 |
|
|
Myst2 |
5.4 |
494053 |
MYST histone acetyltransferase 2 |
217127 |
|
|
Pou2f2 |
-4.4 |
911620 |
POU domain, class 2, transcription factor 2 |
18987 |
|
|
Pparbp |
1.9 |
553770 |
Peroxisome proliferator activated receptor binding protein |
19014 |
|
|
Pspc1 |
2.0 |
474771 |
Paraspeckle protein 1 |
66645 |
|
|
Rab11a |
2.0 |
359489 |
RAB11a, member RAS oncogene family |
53869 |
|
|
Rnf4 |
2.5 |
567180 |
Ring finger protein 4 |
19822 |
|
|
Tsc22d3 |
2.0 |
700170 |
TSC22 domain family 3 |
14605 |
|
|
Zfp482 |
2.0 |
435236 |
Zinc finger protein 482 |
241322 |
|
|
Eprs |
4.9 |
455664 |
Glutamyl-prolyl-tRNA synthetase |
107508 |
|
|
Protein Folding [21] |
|||||
|
Clpx |
2.4 |
733670 |
Caseinolytic peptidase X (E. coli) |
270166 |
|
|
Hspa4 |
3.5 |
578003 |
Heat shock protein 4 |
15525 |
|
|
Ubiquitin Cycle [21] |
|||||
|
Cul7 |
0.4 |
742757 |
Cullin 7 |
66515 |
|
|
Fbxo3 |
1.9 |
832607 |
F-box only protein 3 |
57443 |
|
|
Ube2l6 |
2.0 |
401185 |
Ubiquitin-conjugating enzyme E2L 6 |
56791 |
[16] |
|
Intracellular Protein Transport [21] |
|||||
|
Ap1s2 |
2.0 |
605927 |
Adaptor-related protein complex 1, sigma 2 subunit |
108012 |
|
|
Arf3 |
4.4 |
652348 |
ADP-ribosylation factor 3 |
11842 |
|
|
Sort1 |
2.4 |
339169 |
Sortilin 1 |
20661 |
|
|
Response to Stress [21] |
|||||
|
Mapk14 |
2.2 |
755610 |
Mitogen activated protein kinase 14 |
26416 |
[16] |
|
Prdx1 |
2.1 |
530413 |
Peroxiredoxin 1 |
18477 |
[17] |
|
Prdx6 |
-2.0 |
825043 |
Peroxiredoxin 6 |
11758 |
|
|
Bst1 |
2.1 |
837914 |
Bone marrow stromal cell antigen 1 |
12182 |
|
|
Klra18 |
2.5 |
806675 |
Killer cell lectin-like receptor, subfamily A, member 18 |
93970 |
|
|
Tapbp |
2.0 |
928057 |
TAP binding protein |
21356 |
[20] |
|
Abcb1a |
2.6 |
677412 |
ATP binding cassette, sub-family B (MDR/TAP), member 1A |
97570 |
|
|
Ca2 |
4.0 |
574832 |
Carbonic anhydrase 2 |
88269 |
|
|
Card12 |
2.2 |
336709 |
Caspase recruitment domain family, member 12 |
268973 |
|
|
Cdkn1b |
3.7 |
516253 |
Cytochrome P450, family 3, subfamily a, polypeptide 11 |
104565 |
|
|
Clu |
4.0 |
379462 |
Clusterin |
88423 |
|
|
Cr1l |
1.9 |
538208 |
Complement component (3b/4b) receptor 1-like |
88513 |
|
|
Cyp3a11 |
3.7 |
516253 |
Cytochrome P450, family 3, subfamily a, polypeptide 11 |
88609 |
|
|
Fyn |
2.50 |
766362 |
Fyn proto-oncogene |
95602 |
|
|
H2-Q8 |
1.8 |
712519 |
Histocompatibility 2, Q region locus 8 |
95937 |
|
|
Hnrnpa3 |
4.8 |
903894 |
Heterogeneous nuclear ribonucleoprotein A3 |
1917171 |
|
|
Mrc1 |
2.9 |
331550 |
Mannose receptor, C type 1 |
97142 |
|
|
Pole4 |
2.3 |
508321 |
Polymerase (DNA-directed), ε 4 (p12 subunit) |
1914229 |
|
|
Ppp3r1 |
2.7 |
716541 |
Protein phospatase 3, regulatory subunit B, α isoform (calcineurin B, type I) |
107172 |
|
|
Procr |
2.0 |
431405 |
Protein C receptor, endothelial |
104596 |
|
|
Rrm1 |
5.6 |
865694 |
Ribonucleotide reductase M1 |
98180 |
|
|
Serpinb2 |
4.0 |
860577 |
Serine (or cysteine) proteinase inhibitor, clade B, member 2 |
97609 |
|
|
Leukocyte Extravasation and Signalling |
|||||
|
Arhgap12 |
2.2 |
465731 |
ρ GTPase activating protein 12 |
1922665 |
|
|
Crkl |
3.0 |
389169 |
V-crk sarcoma virus CT10 oncogene homologue (avian)-like |
104686 |
|
|
Ptk2b |
2.6 |
867483 |
PTK2 protein tyrosine kinase 2 β |
104908 |
|
|
Cxcl11 |
5.1 |
921243 |
Chemokine (C-X-C motif) ligand 11 |
56066 |
|
|
Ddx58 |
7.1 |
438990 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
230073 |
|
|
Fcgrt |
2.0 |
390657 |
Fc receptor, IgG, α chain transporter |
14132 |
[16] |
|
Gbp1 |
2.9 |
586296 |
Guanylate nucleotide binding protein 1 |
14468 |
|
|
Gbp3 |
3.0 |
405120 |
Guanylate nucleotide binding protein 3 |
55932 |
|
|
Ifit3 |
3.2 |
888038 |
Interferon-induced protein with tetratricopeptide repeats 3 |
15959 |
|
|
Il1a |
5.1 |
595893 |
Interleukin 1 α |
96542 |
|
|
Il1b |
2.4 |
734612 |
Interleukin 1 β |
16176 |
|
|
Il15 |
1.9 |
876196 |
Interleukin 15 |
16168 |
|
|
Cell Cycle [20] |
|||||
|
Ccnf |
2.4 |
767163 |
Cyclin F |
12449 |
|
|
Cdkn1b |
3.7 |
704876 |
Cyclin-dependent kinase inhibitor 1B (P27) |
12576 |
|
|
Pmp22 |
1.9 |
616997 |
Peripheral myelin protein |
18858 |
|
|
Rhob |
-2.2 |
925472 |
Ras homologue gene family, member B |
11852 |
|
|
Cell Adhesion [21] |
|||||
|
Cldn11 |
4.9 |
338333 |
Claudin 11 |
18417 |
|
|
Scarb2 |
2.5 |
561450 |
Scavenger receptor class B, member 2 |
12492 |
|
|
Tnfaip6 |
1.9 |
614886 |
Tumor necrosis factor alpha induced protein 6 |
21930 |
[16] |
|
Signal Transduction [20] |
|||||
|
Ccr4 |
2.2 |
618105 |
Chemokine (C-C motif) receptor 4 |
12773 |
[18] |
|
Cd86 |
3.2 |
908805 |
Cd86 antigen |
12524 |
|
|
Gnas |
1.8 |
646267 |
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus |
14683 |
|
|
Ms4a4c |
2.8 |
791872 495283 |
Membrane-spanning 4-domains, subfamily A, member 4C |
64380 |
|
|
Olfr472 |
-2.2 |
591718 |
Olfactory receptor 472 |
258770 |
|
|
Prkrir |
3.4 |
561755 |
Protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) |
72981 |
|
|
Ptger2 |
3.0 |
912597 |
Prostaglandin E receptor 2 (subtype EP2) |
19217 |
|
|
Rin1 |
-1.9 |
478326 |
Ras and Rab interactor 1 |
225870 |
|
|
Ywhag |
4.1 |
606287 |
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide |
22628 |
|
|
G-Protein Coupled Receptor Protein Signaling Pathway [21] |
|||||
|
Olfr1303 |
-2.0 |
366625 |
Olfactory receptor 1303 |
258397 |
|
|
Olfr316 |
-1.9 |
903210 |
Olfactory receptor 316 |
258064 |
|
|
Olfr435 |
-3.2 |
810459 |
Olfactory receptor 435 |
258647 |
|
|
Slc19a2 |
1.9 |
763767 |
Solute carrier family 19 (thiamine transporter), member 2 |
116914 |
|
|
Cell-Cell Signaling [21] |
|||||
|
Wnt6 |
2.0 |
590115 |
Wingless-related MMTV integration site 6 |
22420 |
|
|
Development [21] |
|||||
|
Egfl4 |
-2.2 |
914308 |
EGF-like-domain, multiple 4 |
269878 |
|
|
Lrp6 |
-2.3 |
691244 |
Low density lipoprotein receptor-related protein 6 |
16974 |
|
|
Pgf |
2.9 |
932795 |
Placental growth factor |
18654 |
|
|
Metabolism [20] |
|||||
|
Atp1a2 |
2.1 |
684165 |
ATPase, Na+/K+ transporting, α 2 polypeptide |
98660 |
|
|
Atp2c1 |
2.0 |
388850 |
ATPase, Ca2+ sequestering |
235574 |
|
|
Echdc3 |
2.2 |
331450 |
Enoyl Coenzyme A hydratase domain containing 3 |
67856 |
|
|
Hsd17b4 |
2.2 |
303973 |
Hydroxysteroid (17-beta) dehydrogenase 4 |
15488 |
|
|
Mmp9 |
-12.3 |
710293 |
Matrix metalloproteinase 9 |
17395 |
|
|
Oas3 |
-3.0 |
487213 |
2'-5' oligoadenylate synthetase 3 |
246727 |
[16] |
|
Carbohydrate Transport [21] |
|||||
|
Slc35a4 |
2.5 |
318829 |
Solute carrier family 35, member A4 |
67843 |
|
|
Protein Transport [21] |
|||||
|
Exoc2 |
3.0 |
498825 |
Exocyst complex component 2 |
66482 |
|
|
Nupl2 |
2.1 |
868036 |
Nucleoporin like 2 |
231042 |
|
|
Rab20 |
2.0 |
410549 |
RAB20, member RAS oncogene family |
19332 |
|
|
Rap2b |
2.2 |
471908 |
RAP2B, member of RAS oncogene family |
74012 |
|
|
Rheb |
1.9 |
653270 |
RAS-homologue enriched in brain |
19744 |
|
|
Zfyve20 |
2.9 |
669220 |
Zinc finger, FYVE domain containing 20 |
78287 |
|
|
Protein Ubiquitination [21] |
|||||
|
Trim12 |
2.7 |
454451 |
Tripartite motif protein 12 |
76681 |
|
|
Trim34 |
2.9 |
600486 |
Tripartite motif protein 34 |
94094 |
|
|
Differentiation [21] |
|||||
|
Ndrg2 |
2.1 |
468211 |
N-myc downstream regulated gene 2 |
29811 |
|
|
Other |
|||||
|
Pik3ap1 |
2.0 |
646764 |
Phosphoinositide-3-kinase adaptor protein 1 |
83490 |
[16] |
|
|
|||||
|
a Transcripts altered ≥ 1.8-fold (p ≤ 0.025) in 15(S)-HETE-treated RAW 264.7 cells that are associated with specific genes or gene products correlated to malaria (referenced in column 6) or genes that are classified with specific over-expressed GO biological processes in malaria models (referenced with biological process heading), are shown in the table. Fold changes (FC) represent the average of three independent biological experiments. Bold FC indicate that multiple probes gave analogous results (average FC is shown). |
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|
Schrimpe and Wright Malaria Journal 2009 8:195 doi:10.1186/1475-2875-8-195 |
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