Table 1 |
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Baseline and disease characteristics in the included population |
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DEMOGRAPHICS AND DISEASE CHARACTERISTICS |
STATISTICAL ANALYSIS |
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Intention to treat (n = 35) |
Surviving patients (n = 28) |
Deceased patients (n = 7) |
p-value surviving vs deceased |
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Baseline Characteristics: |
Mean ± standard deviation (range) |
Student t-test |
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Sex ratio (M/F) |
1.7 (22/13) |
2.1 (19/9) |
0.75 (3/4) |
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Age, years |
6.3 ± 2.5 (2–12) |
6.2 ± 2.7 (2–12) |
6.7 ± 2.4 (3–9) |
.60 |
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Weight, kg |
19.5 ± 6.9 (10–35) |
19.7 ± 7.5 (10–35) |
18.9 ± 6.0 (11–26) |
.62 |
|
Temperature,°C |
38.6 ± 1.3 (36.2–40.6) |
38.7 ± 1.4 (36.2–40.6) |
37.8 ± 1.0 (36.6–39.6) |
.08 |
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Clinic day 1: |
Patient ratio (%) |
Fisher F-test |
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Blantyre score = 1 |
17/35 (49%) |
12/28 (43%) |
5/7 (71%) |
.32 |
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Blantyre score = 2 |
18/35 (51%) |
16/28 (57%) |
2/7 (29%) |
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≥ 1 seizure |
23/35 (66%) |
17/28 (61%) |
6/7 (85%) |
.16 |
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Deep breathing |
7/35 (20%) |
4/28 (14%) |
3/7 (42%) |
.06 |
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Haemoglobinuria |
7/35 (20%) |
6/28 (21%) |
1/7 (14%) |
1 |
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Jaundice |
4/35 (11%) |
4/28 (14%) |
0/7 (0%) |
.55 |
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Biological values day 1 |
Mean ± standard deviation (range) |
Student t-test |
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SaO2, % |
91.0 ± 8.7 (73–98) |
89.8 ± 9.4 (73–98) |
95.1 ± 3.5 (88.7–98) |
.10 |
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asexual |
43,000 ± 62,000 |
45,000 ± 46,000 |
37,000 ± 54,000 |
.85 |
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P. falciparum/μL |
(200–250,000) |
(200–250,000) |
(625–140,000) |
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Blood pH |
7.29 ± 0.1 (7.1–7.43) |
7.3 ± 0.1 (7.2–7.4) |
7.3 ± 0.2 (7.1–7.4) |
.72 |
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Blood Lactates, mmol/L |
6.0 ± 3.6 (1.4–15.4) |
5.8 ± 3.3 (1.4–15.4) |
6.3 ± 3.6 (2–11.7) |
.78 |
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Haemoglobin, g/dL |
9.4 ± 1.4 (7.0–12.4) |
9.6 ± 1.4 (7.0–12.4) |
9.0 ± 1.2 (7.1–10.3) |
.32 |
|
Plasma glucose, mmol/L |
6.4 ± 3.6 (0.8–19.4) |
6.3 ± 2.3 (1.1–11.3) |
7.8 ± 6.1 (1.25–19.4) |
.54 |
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Plasma creatinin, μmol/L |
57 ± 28 (21–130) |
58.4 ± 26.0 (29–130) |
36.7 ± 14.8 (21–60) |
.02 |
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ALAT, IU/L |
87 ± 129 (7–600) |
100 ± 150(7–600) |
47 ± 18 (22–71) |
.11 |
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Clinical and biological data were gathered at the time of admission. Included patients were stratified according to the primary end-point outcome (surviving or died patients on day six post admission). Student t-test or Fisher F-test were used to compare the two groups when appropriate. |
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Picot et al. Malaria Journal 2009 8:169 doi:10.1186/1475-2875-8-169 |
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