Figure 5.

Parasitaemia of B6 mice is lower in the absence of IFN-γ during primary P. yoelii infection. A. Parasitaemia of B6 control mice and B6.IFN-γ^-/- mice following injection of 4,000 sporozoites of P. yoelii 265BY. B. Parasitaemia of B6 mice treated with either 2 mg of anti- IFN-γ mAb or 2 mg of rat control Ab, at day 3 p.i. with 4,000 sporozoites of P. yoelii 265BY. C. Parasitaemia of B6 mice treated with 2 mg of anti- IFN-γ mAb at day 4 p.i. with 4,000 sporozoites of P. yoelii 265BY. Regarding their parasitaemia curves, two groups of mice were identified: "high" and "low" parasitaemia. D. Parasitaemia of B6 and B6.IFN-γ^-/- mice following injection of 10⁶ P. yoelii 265BY pRBCs. Each graph is representative of two independent experiments with 3 to 9 mice per time point. Results are expressed as mean value ± SD. The statistical differences between groups were determined with the Mann-Whitney test (* = p < 0.05).